General
Shu Wang   Ph.D.,   Professor   Organic Chemistry
 
Email:wangshu@iccas.ac.cn
Telephone:010-62636680
Mobile phone:
Address:北京市海淀区中关村北一街2号
Postcode:100190

Research Areas

ØDesign, synthesis and properties of light-harvesting conjugated polymers
ØBiosensors based on the conjugated polymers
ØBioactive conjugated polymers and life chemistry

Education

1994: B.S., Hebei University
1999: Ph. D., Peking University
1999-2001: Postdoc, CAS Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences

Experience

   
Work Experience
2001-2004: Postdoc, Institute for Polymers and Organic Solids, University of California at Santa Barbara, USA
2004.10: Professor, Institute of Chemistry, Chinese Academy of Sciences
Teaching Experience
   

Honors & Distinctions

   

Publications

   
Papers

2009 

  1. Single nucleotide polymorphism (SNP) genotyping using cationic conjugated polymers in homogeneous solution Xinrui Duan, Wei Yue, Libing Liu, Zhengping Li, Yuliang Li, Fuchu He, Daoben Zhu, Gangqiao Zhou* , Shu Wang* Nature Protocols 2009, 4, 984-991.
  2. An optical approach for drug screening based on light-harvesting conjugated polyelectrolytes Lingling An, Libing Liu, Shu Wang*, G. C. Bazan*, Angew. Chem. Int. Ed. 2009 48 4372-4375.
  3. Fluorescent logic signal-based multiplex detection of nucleases with the assembly of cationic conjugated polymer and  branched DNA Xuli Feng Xinrui Duan Libing Liu Fude Feng Shu Wang* Yuliang Li Daoben Zhu Angew. Chem. Int. Ed. 2009 accepted 
  4. Conjugated polyelectrolytes as new platforms for drug screening Lingling An Shu Wang* Chem. Asian J. 2009 accepted (Invited Focus Reviews)
  5. A new light-harvesting conjugated polyelectrolyte microgel for DNA and enzyme detections Xuli Feng Qingling Xu Libing Liu Shu Wang* Langmuir 2009 accepted (Invited article for 25th Year of Langmuir Special Issue -Molecular and Macromolecular Self Assemblies
  6. Fluorescent DNA-poly(phenylenevinylene) hybrid hydrogels for monitoring drug release Hongwei Tang Xinrui Duan Xuli Feng Libing Liu Shu Wang* Yuliang Li Daoben Zhu  Chem. Commun. 2009 641-643 (Hot Article  inside front cover picture).
  7. Homogeneous and one-step fluorescent allele-specific PCR for SNP genotyping assays using conjugated polyelectrolytes Xinrui Duan Libing Liu Shu Wang* Biosensors and Bioelectronics 2009 24 2095-2099.
  8. Label-free homogeneous and fluorescence "turn-on" detection of protease using conjugated polyelectrolytes Lingling An Libing Liu Shu Wang* Biomacromolecules 2009 10 454-457.
  9. Fluorescence-amplifying assay for irradiated DNA lesions using water-soluble conjugated polymers Fude Feng Xinrui Duan Shu Wang* Macromol. Rapid Commun. 2009 30 147-151 (Cover picture)
  10. Magnetically assisted fluorescence ratiometric assays for adenosine deminase using water-soluble conjugated polymers Fang He Minghui Yu Shu Wang* Chin. Sci. Bull. 2009 54 1340-1344.
  11. Cationic conjugated polymers for homogeneous and sensitive fluorescence detection of hyaluronidase Lingling An Libing Liu Shu Wang* Sci. China Ser B-Chem. 2009 52 827-832. (invited for special issue of chemical sensors)
  12. Gadolinium (III) chelated conjugated polymer as a potential MRI contrast agent Qingling Xu Litao Zhu Minghui Yu Fude Feng Lingling An Chengfen Xing Shu Wang* Polymer 2009 accepted
  13. Water-soluble conjugated polyelectrolyte-based fluorescence enzyme coupling protocol for continuous and sensitive beta-galactosidase detection, Macromol. Chem. Phys. 2009, accepted (Invited for special issue of functional polymers)

2008 

  1. Fluorescent conjugated polyelectrolyte as an indicator for convenient detection of DNA methylation Fude Feng Hongzhong Wang Lingli Han Shu Wang*  J. Am. Chem. Soc. 2008 130 11338-11343.
  2. Ultrasensitive DNA detection using photonic crystals Mingzhu Li Fang He Qing Liao Jian Liu Lei Jiang Yanlin Song* Shu Wang* Daoben Zhu Angew. Chem. Int. Ed. 2008 47 7258-7262.
  3. Conjugated polyelectrolytes for label-free DNA microarrays Fang He Fude Feng Shu Wang* Trends Biotechnol. 2008 26 57-59.
  4. Direct visualization of glucose phosphorylation with a cationic polythiophene Yanli Tang Fude Feng Minghui Yu Lingling An Fang He Shu Wang* Yuliang Li Daoben Zhu G. C. Bazan*  Adv. Mater. 2008 20 703-705.
  5. Fluorescent conjugated polyelectrolytes for biomacromolecule detections Fude Feng Fang He Lingling An  Shu Wang* Yuliang Li Daoben Zhu Adv. Mater. 2008 20 2959-2964 (Research News).
  6. Selective and homogeneous fluorescent DNA detection by target-induced strand displacement using cationic conjugated polyelectrolytes Fang He Fude Feng Xinrui Duan Shu Wang* Yuliang Li Daoben Zhu Anal. Chem.  2008 80 2239-2243.
  7. Microorganism-based assemblies of luminescent conjugated polyelectrolytes Libing Liu Xinrui Duan Huibiao Liu Shu Wang* Yuliang Li Chem. Commun. 2008 5999-6001.
  8. Conjugated polyelectrolyte-DNA complexes for multi-color and one-tube SNP genotyping assays Xinrui Duan Shu Wang* Zhengping Li* Chem. Commun. 2008 1302-1304.
  9. Synthesis of a new water-soluble oligo(phenylenevinylene) containing tyrosine moiety for tyrosinase activity detection Xuli Feng Fude Feng Minghui Yu Fang He Qingling Xu Hongwei Tang Shu Wang* Yuliang Li Daoben Zhu. Org. Lett. 2008 10 5369-5372.
  10. Cationic conjugated polyelectrolyte/molecular beacon complex for sensitive sequence-specific and real-time DNA detection Xuli Feng Xinrui Duan Libing Liu Lingling An Fude Feng Shu Wang* Langmuir 2008 24 12138-12141.
  11. Conjugated polyelectrolytes for protein assay and manipulation of catalytic activity of enzyme Lingling An Shu Wang* Daoben Zhu* Chem. Asian J. 2008 3 1601-1606.
  12. Water-soluble dendritic conjugated polyfluorenes: synthesis characterization and interactions with DNA Minghui Yu Libing Liu Shu Wang* J. Polymer Sci. Polymer Chem. 2008 46 7462-7472.
  13. Design and synthesis of a new conjugated polyelectrolyte as a reversible pH sensor Qingling Xu Lingling An Minghui Yu Shu Wang* Macromol. Rapid Commun. 2008 29 390-395.
  14. Cationic conjugated polyelectrolyte-based fluorometric detection of copper(II) ions in aqueous solution Chengfen Xing Zhiqiang Shi* Minghui Yu Shu Wang* Polymer 2008 49 2698-2703.  
  15. Highly selective fluorescence detection for mercury (II) ions in aqueous solution using water soluble conjugated polyelectrolytes Hanyan Lv Yanli Tang Wei Xu* Deqing Zhang Shu Wang* Daoben Zhu* Macromol. Rapid Commun. 2008 29 1467-1471.
  16. A conjugated polymers-based electrochemical DNA sensor: design and application of a multi-functional and water-soluble conjugated polymer Lanyong Zhang Huan Sun Di Li Shiping Song Chunhai Fan* Shu Wang* Macromol. Rapid Commun. 2008 29 1489-1494.

 

2007

  1. Continuous fluorometric assays for acetylcholinesterase activity and inhibition using conjugated polyelectrolytes. Fude Feng Yanli Tang Shu Wang* Yuliang Li Daoben Zhu Angew. Chem. Int. Ed. 2007 46 7882-7886.
  2. Cationic Conjugated polymer/DNA complexes for amplified fluorescence assays of nucleases and methyltransferase. Fude FengYanli Tang Fang He Minghui Yu Xinrui Duan Shu Wang* Yuliang Li Daoben Zhu Adv. Mater. 2007 19 3490-3495.
  3. A sensitive and Homogeneous SNP Detection Using Cationic Conjugated Polymers. Xinrui Duan Zhengping Li* Fang He Shu Wang* J. Am. Chem. Soc. 2007 129 4154-4155.
  4. Optical Detection of Mercury (II) in Aqueous Solutions Using Conjugated Polymers and Label-Free Oligonucleotides. Xingfen Liu Yanli Tang Lihua Wang Juan Zhang Shiping Song Chunhai Fan* Shu Wang* Adv.Mater. 2007 19 1471-1474.
  5. A New Strategy for Fluorescence Detection of Diels-Alder Reaction with Conjugated Polymers. Fang He Yanli Tang Minghui Yu Shu Wang* Yuliang Li Daoben Zhu Adv. Funct. Mater. 2007 17 996-1002.
  6. Fluorescence Ratiometric Assays of Hydrogen Peroxide and Glucose in Serum Using Conjugated Polyelectrolytes. Fang He Fude Feng Shu Wang* Yuliang Li Daoben Zhu. J. Mater. Chem. 2007 17 3702-3707.
  7. Water-Soluble Conjugated Polymers for Continuous and Sensitive Fluorescence Assays for Phosphatase and Peptidase. Lingling An Yanli Tang Fude Feng Fang He Shu Wang* J. Mater. Chem. 2007 17 4147-4152 (Highlighted by Chemistry World  September 2007 pp C4)
  8. Nonionic Water-Soluble Crown Ether-Substituted Polyfluorene as Fluorescent Probe for Lead Ion Assays. Minghui Yu Fang He Yanli Tang Shu Wang* Yuliang Li Daoben Zhu Macromol. Rapid Commun. 2007 28 1333-1338.
  9. Single Base Pair Mismatch Detection Using Cationic Conjugated Polymers through Fluorescence Resonance Energy Transfer. Ning Tian Yanli Tang Qinghua Xu* Shu Wang*. Macromol. Rapid Commun. 2007 28 729-732.
  10. Fluorescence Turn-on Detection of Nitric Oxide in Aqueous Solution Using Cationic Conjugated Polyelectrolytes. Chengfen Xing Minghui Yu Shu Wang* Zhiqiang Shi* Yuliang Li Daoben Zhu. Macromol. Rapid Commun. 2007 28 241-245.
  11. Analyte-Induced Aggregation of a Water-Soluble Conjugated Polymer for Fluorescent Assay of Oxalic Acid. Huan Sun Fude Feng Minghui Yu Shu Wang* Macromol. Rapid Commun. 2007 28 1905-1911.
  12. Gold Nanoparticle-Based Monitoring of the Reduction of Oxidized to Reduced Glutathione Xiaorong He Zhifeng Zhong Yanbing Guo Jing Lv Jialiang Xu Mei Zhu Yuliang Li* Huibiao Liu Shu Wang* Yulan Zhu Daoben Zhu* Langmuir 2007 23 8815-8819.

2006

  1. Quadruplex to Duplex Transition of G-Rich Oligonucleotides Probed by Cationic Water Soluble Conjugated Polyelectrolytes. Fang He Yanli Tang Minghui Yu Fude Feng Lingling An Huan Sun Shu Wang* Yuliang Li Daoben Zhu Guillermo C. Bazan* J. Am. Chem. Soc. 2006,128 6764-6765.
  2. Direct Visualization of Enzymatic Cleavage and Oxidative Damage by Hydroxyl Radicals of Single-Stranded DNA with a Cationic Polythiophene Derivative. Yanli Tang Fude Feng Fang He Shu Wang* Yuliang Li Daoben Zhu. J. Am. Chem. Soc. 2006128 14972-14976.
  3. Multiply-Configurable Optical Logic Systems Based on Cationic Conjugated Polymer/DNA Assemblies. Yanli Tang Fang He Shu Wang* Yuliang Li Daoben Zhu Guillermo C. Bazan* Adv. Mater. 2006 18 2105-2110.
  4. Radical Scavenging Mediates Reversible Fluorescence Quenching of an Anionic Conjugated Polymer: Highly Sensitive Probe for Antioxidants. Yanli Tang Fang He Minghui Yu Shu Wang* Yuliang Li Daoben Zhu Chem. Mater. 2006 18 3605-3610.
  5. Fluorescent Amplifying Detection for Hydrogen Peroxide with Cationic Conjugated Polymers and Its Application to Glucose Sensing. Fang He Yanli Tang Minghui Yu Shu Wang*,Yuliang Li Daoben Zhu Adv. Funct. Mater. 2006 16 91-94.
  6. A Reversible and Highly Selective Fluorescent Sensor for Mercury (II) Using Poly(thiophene)s that Contain Thymine Moieties. Yanli Tang Fang He Minghui Yu Fude Feng Lingling An Huan Sun Shu Wang* Yuliang Li Daoben Zhu Macromol. Rapid Commun. 2006 27 389-392. (Highlighted by  Macromol. Chem. Phys. 2006 207 1629-1632).
  7. Synthesis of Water-Soluble Dendritic Conjugated Polymers for Fluorescent DNA Assays. Minghui Yu Yanli Tang Fang He Shu Wang* Dagui Zheng Yuliang Li* Daoben Zhu Macromol. Rapid Commun. 2006 27 1739-1745.
  8. A Fluorescence Ratiometric Protein Assa y Using Light Harvesting Conjugated Polymers. Lingling An Yanli Tang Shu Wang* Yuliang Li Daoben Zhu Macromol. Rapid Commun. 2006 27 993-997.

2005

  1. Fluorescent Amplifying Recognition for DNA G-Quadruplex Folding with a Cationic Conjugated Polymer: a Platform for Homogeneous Potassium Detection,Fang He,Yanli Tang,Shu Wang*,Yuliang Li,Daoben Zhu J. Am. Chem. Soc. 2005,127 12343-12346.
  2. Gold nanoparticle-based fluorometric and colorimetric sensing of Cu(II) ion Xiaorong He Huibiao Liu Yuliang Li* Shu Wang* Yongjun Li Ning Wang Jinchong Xiao  Xinhe Xu  and Daoben Zhu* Adv. Mater. 2005 17 2811-2815.
  3. The fluorescence resonance energy transfer (FRET) gate: A time-resolved study,Qing-Hua Xu,Shu Wang,Alexander Mikhailovsky,Guillermo C. Bazan,Daniel Moses,Alan J. Heeger,Proc. Natl. Acad. Sci. USA 2005,102(3),530-535.
  4. Synthesis of cationic water-soluble light- harvesting dendrimers,Shu Wang,Hong Janice,Guillermo C. Bazan,Org. Lett. 2005,7 (10),1907-1910.
  5. Multilayer polymer light-emitting diodes: white-light emission with high efficiency Xiong Gong Shu Wang Daniel Moses Guillermo C. Bazan Alan J. Heeger Adv. Mater. 2005 17 2053-2058. (封面形式发表 highlighted as "News and Views" in Nature 437 327-328. 

2004

  1. Fluorescein Provides a Resonance Gate for FRET from Conjugated Polymers to DNA Intercalated Dyes,Shu Wang,Brent S. Gaylord,Guillermo C. Bazan,J. Am. Chem. Soc. 2004,126,5446-5451.
  2. Collective optical behavior of cationic water-soluble dendrimers,Shu Wang,Brent S. Gaylord,Guillermo C. Bazan,Adv. Mater. 2004,16 (23-24),2127-2132. (封面形式发表
  3. Solvent-dependent aggregation of a water-soluble poly(fluorene) controls energy transfer to chromophore-labeled DNA,Shu Wang,G. C. Bazan,Chem. Commun. 2004, 2508-2509.
  4. Time-resolved energy transfer in DNA sequence detection using water-soluble conjugated polymers: The role of electrostatic and hydrophobic interactions,Qing-Hua Xu, Brent S. Gaylord,Shu Wang,Guillermo C. Bazan,Daniel Moses,Alan J. Heeger,Proc. Natl. Acad. Sci. USA 2004,101(32),11634-11639.

2003

  1. Optically Amplified RNA-Protein Detection Methods Using Light-Harvesting Conjugated Polymers,Shu Wang,G. C. Bazan,Adv. Mater. 2003,15 (17),1425-1428. 封面形式发表
  2. Size-specific interactions between single- and double-stranded oligonucleotides and cationic water-soluble oligofluorenes,Wang Shu,Liu Bin,Gaylord Brent S, Bazan Guillermo C. Adv. Funct. Mater. 2003,13(6),463-467. (封面形式发表
  3. Beyond superquenching: Hyper-efficient energy transfer from conjugated polymers to gold nanoparticles Chunhai Fan,Shu Wang,Guillermo C. Bazan,Kevin W. Plaxco,Alan J. Heeger,Proc. Natl. Acad. Sci. USA 2003,100(11),6297-6301.
  4. Shape Adaptable Water Soluble Conjugated Polymers,Bin Liu,Shu Wang,Guillermo C. Bazan,Alexander Mikhailovsky,J. Am. Chem. Soc. 2003,125(44),13306-13307.
  5. Effect of Chromophore-Charge Distance on the Energy Transfer Properties of Water-Soluble Conjugated Oligomers,Liu Bin,Gaylord Brent S,Wang Shu,Bazan Guillermo C. J. Am. Chem. Soc. 2003,125(22),6705-6714.
Patents
   

Research Interests

   

Conferences

   

Collaboration

   

Students

崇辉  硕士研究生  070303-有机化学  80032-化学研究所

段新瑞  博士研究生  070303-有机化学  80032-化学研究所

徐庆岭  博士研究生  070303-有机化学  80032-化学研究所

朱春雷  硕士研究生  070303-有机化学  80032-化学研究所

温泉山  硕士研究生  070303-有机化学  80032-化学研究所

唐红伟  博士研究生  070303-有机化学  80032-化学研究所

邢成芬  博士研究生  070303-有机化学  80032-化学研究所

冯旭利  博士研究生  070303-有机化学  80032-化学研究所