100706-药理学
071009-细胞生物学

受体药理学
受体药理学

   

-- 研究生

-- 博士

高等药理学  2010—2011学年春季学期

   

[1] 胡有洪, 谢欣, 陈泰文, 李鑫, 谢志铖, 郭世猛. 2-胺基嘧啶类衍生物及其制备方法和用途. 202310394367.5, 2023-04-13.
[2] 谢欣, 李静, 赵婷婷, 李艳利. GPR21基因敲除小鼠模型及其建立方法. CN: CN113774056A, 2021-12-10.
[3] 南发俊, 谢欣, 张晨露, 郭世猛, 卓宁, 梁晓影, 张仰明, 贠盈, 刘桦楠. 五环三萜类TGR5受体激动剂、其制备方法和用途. CN: CN112694514A, 2021-04-23.
[4] 胡有洪, 谢欣, 鲁伯埙, 张玉芳, 郭世猛, 王聪聪, 王志龙. 一种不饱和酮类化合物、其制备方法和用途. CN: CN111792990A, 2020-10-20.
[5] 于丽芳, 谢欣, 李娇娇, 计悦阳, 王志龙, 李静, 杨帆, 汤杰. 氮杂吲哚类衍生物及其制备方法和应用. CN: CN111518095A, 2020-08-11.
[6] 南发俊, 谢欣, 肖瑜峰, 张庆, 陈林海, 方友臣. 联苯磷酸酯类化合物作为GPR84拮抗剂的应用. CN: CN110680823A, 2020-01-14.
[7] 郭彬, 谢欣, 李静雅, 杨玉社, 郭世猛, 黄晶. 芳香丙酸类衍生物、及其制备方法和用途. CN: CN110092774A, 2019-08-06.
[8] 谢欣, 鲁伯埙, 胡有洪, 郭世猛, 李贺轩, 张玉芳, 何冰清. 一类环状内酯类化合物在制备用于预防和/或治疗亨廷顿病的药物中的用途. CN: CN109568307A, 2019-04-05.
[9] 南发俊, 谢欣, 陈悦婷. 螺环类化合物用于制备抗肿瘤药物的用途. CN: CN109528714A, 2019-03-29.
[10] 南发俊, 谢欣, 张晨露, 郭世猛, 张仰明. 五环三萜类化合物及其制备方法、药物组合物和用途. CN: CN109517022A, 2019-03-26.
[11] 于丽芳, 谢欣, 石英, 王志龙, 计悦阳, 段彦辉, 杨帆, 李静, 汤杰. 1H-吲哚-2-甲酰胺衍生物及其制备方法和应用. CN: CN108794379A, 2018-11-13.
[12] 南发俊, 谢欣, 陈林海, 张庆, 肖瑜峰, 杨慧. GPR84受体拮抗剂及其应用. CN: CN108530480A, 2018-09-14.
[13] 龙亚秋, 谢欣, 陈成, 郭世猛. 亚砜基乙酸或砜基乙酸类衍生物、其药物组合物、制备方法和用途. CN: CN108059607A, 2018-05-22.
[14] 南发俊, 谢欣, 陈华燕, 龚超骏, 王志龙, 郭玉娥. 一类用作GPR17和CysLT 1 双重拮抗剂的化合物、其制备方法和用途. 中国: CN106810488A, 2017.06.09.
[15] 吕伟, 金嵇煜, 章雄文, 苗春晓, 王志龙, 谢欣. 芳氧基取代丙‑2‑醇胺的衍生物作为β3肾上腺素能受体拮抗剂、制备方法和用途. CN: CN107266341A, 2017-10-20.
[16] 龙亚秋, 樊兴, 谢欣. 一种氨基丙基取代托烷胺类化合物、其药物组合物及其制备方法和用途. CN: CN106977511A, 2017-07-25.
[17] 南发俊, 谢欣, 陈华燕, 龚超骏, 王志龙, 郭玉娥. 一类用作GPR17和CysLT 1 双重拮抗剂的化合物、其制备方法和用途. CN: CN106810488A, 2017-06-09.
[18] 南发俊, 谢欣, 刘阳, 张庆, 陈林海, 杨慧. 一类对GPR84具有激动作用的化合物及其制备方法和用途. CN: CN106632082A, 2017-05-10.
[19] 陈建忠, 谢欣, 钱海燕, 陈炯炯, 王志龙. 哒嗪类衍生物及其制备方法和用途. CN: CN106187910A, 2016-12-07.
[20] 陈建忠, 谢欣, 钱海燕, 陈丽丽, 王志龙. 杂芳基并嘧啶二酮类衍生物及其用途. CN: CN106167497A, 2016-11-30.
[21] 陈建忠, 谢欣, 钱海燕, 韩爽, 王志龙. 喹唑啉二酮类衍生物及其制备方法和用途. CN: CN106146414A, 2016-11-23.
[22] 柳红, 吴蓓丽, 郑永唐, 谢欣, 蒋华良, 彭攀峰, 罗荣华, 李静, 李建, 朱亚, 陈颖, 张浩楠, 杨柳萌, 周宇, 陈凯先. 一种1-(3-氨基丙基)取代环状胺类化合物、其制备方法、药物组合物及用途. CN: CN105873924A, 2016-08-17.
[23] 南发俊, 李佳, 谢欣, 龚超骏, 周宇波, 柴辉, 张仰明, 苏明波. 一类2,2’-串联双噻唑类化合物及其制备方法和用途. CN: CN104974108A, 2015-10-14.
[24] 南发俊, 谢欣, 王霄音, 张书永, 李静. 五环三萜类化合物及其制备方法、药物组合物和用途. CN: CN104910239A, 2015-09-16.
[25] 南发俊, 谢欣, 裴钢, 王宵音, 崔进, 赵简, 张仰明, 张晨露. 一类五环三萜类化合物及其在制备治疗阿尔兹海默病的药物中的用途. CN: CN104910238A, 2015-09-16.
[26] 柳红, 吴蓓丽, 郑永唐, 谢欣, 蒋华良, 彭攀峰, 罗荣华, 李静, 李建, 朱亚, 陈颖, 张浩楠, 杨柳萌, 周宇, 陈凯先. 一种1-(3-氨基丙基)取代环状胺类化合物、其制备方法、药物组合物及用途. CN: CN104744451A, 2015-07-01.
[27] 南发俊, 谢欣, 陈悦婷, 魏小元, 湛洋, 徐雍羽, 张儒. 促进iPS细胞产生的螺环类化合物及其制备方法和用途. CN: CN104710438A, 2015-06-17.
[28] 柳红, 谢欣, 赵飞, 李静, 栗增, 陈颖, 孙海丰, 周宇, 蒋华良, 陈凯先. 一类二氢吲哚类化合物、其制备方法、药物组合物及应用. CN: CN104326963A, 2015-02-04.
[29] 柳红, 谢欣, 赵飞, 李静, 栗增, 陈颖, 孙海丰, 周宇, 蒋华良, 陈凯先. 一类吲哚类化合物、其制备方法、药物组合物及应用. CN: CN104211631A, 2014-12-17.
[30] 柳红, 谢欣, 孙海丰, 李静, 赵飞, 陈颖, 栗增, 周宇, 蒋华良, 陈凯先. 一种六氢二苯并a,g喹嗪类化合物的药物用途. CN: CN104127414A, 2014-11-05.
[31] 谢欣, 张菲菲, 魏巍. 金精三羧酸在制备靶向趋化因子受体的药物中的用途. CN: CN103800309A, 2014-05-21.
[32] 俞飚, 谢欣, 张书永, 马玉勇, 李静, 马君君. 果同尼皂苷F及其衍生物的中间体、制备方法和用途及果同尼皂苷F衍生物. CN: CN103755762A, 2014-04-30.
[33] 柳红, 谢欣, 郭涤亮, 李静, 张逸, 陈颖, 孙海丰, 栗增, 蒋华良, 陈凯先. 芳基a吲哚2,3-g并喹嗪类化合物、其制备方法、药物组合物及其应用. CN: CN103664974A, 2014-03-26.
[34] 龙亚秋, 谢欣, 曹斌, 张菲菲. 一类2,5-二取代苯磺酰胺类化合物及其制备方法和用途. CN: CN103588697A, 2014-02-19.
[35] 陈建忠, 谢欣, 韩爽, 张菲菲. 喹啉二酮类衍生物及其制备方法和用途. CN: CN103265480A, 2013-08-28.
[36] 陈建忠, 谢欣, 韩爽, 张菲菲. 3-取代香豆素类衍生物及其用途. CN: CN103265517A, 2013-08-28.
[37] 罗宇, 黄颖, 张翾, 吕伟, 谢欣, 王志龙. 手性茚满衍生物及其制备方法和用途. CN: CN103193668A, 2013-07-10.
[38] 龙亚秋, 樊兴, 谢欣. 一种氨基丙基取代托烷胺类化合物、其药物组合物及其制备方法和用途. CN: CN103159754A, 2013-06-19.
[39] 谢欣, 杜昌升, 王烈峰, 吕婕, 魏巍. 靶向CysLT1的药物在制备用于预防或治疗自身免疫性疾病的药物中的用途. CN: CN102895661A, 2013-01-30.
[40] 谢欣, 许新秀, 张儒. 诱导性多能干细胞的制备方法和用于制备诱导性多能干细胞的培养基. CN: CN102851314A, 2013-01-02.
[41] 南发俊, 陈飞, 张仰明, 李佳, 周宇波, 苏明波, 丁健, 蒙凌华, 谢欣, 王识贤. 一类噻唑类化合物及其制备方法和用途. CN: CN102775368A, 2012-11-14.
[42] 龙亚秋, 曹斌, 谢欣, 魏巍. 一类咪唑并吡啶类化合物及其制备方法和用途. CN: CN102675305A, 2012-09-19.
[43] 沈竞康, 谢欣, 方光华, 高玲焕, 孟韬, 彭红丽, 李敏, 王昕. 一类二苯甲基哌嗪类化合物及其制备方法和用途. CN: CN102603678A, 2012-07-25.
[44] 谢欣, 王荃. 诱导性多能干细胞的制备方法以及用于制备诱导性多能干细胞的培养基. CN: CN102559587A, 2012-07-11.
[45] 刘滔, 谢欣, 胡永洲, 翁志勇, 魏巍. 哌啶-4-羧基酰胺类衍生物及制备方法和用途. CN: CN102311380A, 2012-01-11.
[46] 张翱, 谢欣, 李付营, 朱婷. 一类杂环并14－羟基－吗啡喃类化合物、制备方法及用途. CN: CN101481376A, 2009-07-15.
[47] 张翱, 谢欣, 李付营. 一类螺桨烷类化合物及其制备方法和用途. CN: CN101402636A, 2009-04-08.
[48] 张翱, 丁春勇, 谢欣. 一类4－取代的2,7－二氮杂萘化合物及其制备方法和用途. CN: CN101328172A, 2008-12-24.
[49] 沈竞康, 谢欣, 孟韬, 王珏, 彭红丽, 朱婷, 王昕, 熊兵. 一类取代哌嗪类化合物、其制备方法、用途及包含此类化合物的药物组合物. CN: CN101318943A, 2008-12-10.
[50] 王明伟, 李娜, 王光星, 廖嘉渝, 谢欣, 刘青, 周彩红, 南发俊. 一类胰高血糖样肽－1受体调节剂、制备方法和用途. CN: CN1884278A, 2006-12-27.

   

[1] Xi Lin, Bo Chen, Yiran Wu, Yingqi Han, Ao Qi, Junyan Wang, Zhao Yang, Xiaohu Wei, Tingting Zhao, Lijie Wu, Xin Xie, Jinpeng Sun, Jie Zheng, Suwen Zhao, Fei Xu. Cryo-EM structures of orphan GPR21 signaling complexes. NATURE COMMUNICATIONS[J]. 2023, 14(1): 1-12, http://dx.doi.org/10.1038/s41467-023-35882-w.
[2] Mengmeng Jiang, Ren Guo, Yan Ai, Gang Wang, Peilan Tang, Xiaohui Jia, Bingqing He, Qianting Yuan, Xin Xie. Small molecule drugs promote repopulation of transplanted hepatocytes by stimulating cell dedifferentiation. JHEP REPORTS[J]. 2023, 5(4): 100670-, http://dx.doi.org/10.1016/j.jhepr.2023.100670.
[3] Guo, Ren, Jia, Xiaohui, Ding, Zhenbin, Wang, Gang, Jiang, Mengmeng, Li, Bing, Chen, Shanshan, Xia, Bingqing, Zhang, Qing, Liu, Jian, Zheng, Ruting, Gao, Zhaobing, Xie, Xin. Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation. THERANOSTICS[J]. 2022, 12(11): 5220-5236, [4] Zhang, Qing, Chen, Linhai, Yang, Hui, Fang, Youchen, Wang, Siwei, Wang, Min, Yuan, Qianting, Wu, Wei, Zhang, Yangming, Liu, Zhanju, Nan, Fajun, Xie, Xin. GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages. ACTA PHARMACOLOGICA SINICA[J]. 2022, 43(8): 2042-2054, http://dx.doi.org/10.1038/s41401-021-00825-y.
[5] Guo, Ren, Jiang, Mengmeng, Wang, Gang, Li, Bing, Jia, Xiaohui, Ai, Yan, Chen, Shanshan, Tang, Peilan, Liu, Aijie, Yuan, Qianting, Xie, Xin. IL6 supports long-term expansion of hepatocytes in vitro. NATURE COMMUNICATIONS[J]. 2022, 13(1): http://dx.doi.org/10.1038/s41467-022-35167-8.
[6] Guo, Shimeng, Zhao, Tingting, Yun, Ying, Xie, Xin. Recent progress in assays for GPCR drug discovery. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGYnull. 2022, 323(2): C583-C594, [7] Youwen Zhuang, Yue Wang, Bingqing He, Xinheng He, X Edward Zhou, Shimeng Guo, Qidi Rao, Jiaqi Yang, Jinyu Liu, Qingtong Zhou, Xiaoxi Wang, Mingliang Liu, Weiyi Liu, Xiangrui Jiang, Dehua Yang, Hualiang Jiang, Jingshan Shen, Karsten Melcher, Hong Chen, Yi Jiang, Xi Cheng, MingWei Wang, Xin Xie, H Eric Xu. Molecular recognition of morphine and fentanyl by the human μ-opioid receptor. CELL[J]. 2022, 185(23): 4361-4375.e19, http://dx.doi.org/10.1016/j.cell.2022.09.041.
[8] Duan, Jia, Shen, DanDan, Zhao, Tingting, Guo, Shimeng, He, Xinheng, Yin, Wanchao, Xu, Peiyu, Ji, Yujie, Chen, LiNan, Liu, Jinyu, Zhang, Huibing, Liu, Qiufeng, Shi, Yi, Cheng, Xi, Jiang, Hualiang, Xu, H Eric, Zhang, Yan, Xie, Xin, Jiang, Yi. Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors. NATURE COMMUNICATIONS[J]. 2022, 13(1): http://dx.doi.org/10.1038/s41467-022-29072-3.
[9] Xu, Peiyu, Huang, Sijie, Guo, Shimeng, Yun, Ying, Cheng, Xi, He, Xinheng, Cai, Pengjun, Lan, Yuan, Zhou, Hu, Jiang, Hualiang, Jiang, Yi, Xie, Xin, Xu, H Eric. Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2022, 29(9): 863-+, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000840587700001.
[10] Cai, Hongmin, Xu, Youwei, Guo, Shimeng, He, Xinheng, Sun, Jun, Li, Xin, Li, Changyao, Yin, Wanchao, Cheng, Xi, Jiang, Hualiang, Xu, H Eric, Xie, Xin, Jiang, Yi. Structures of adenosine receptor A(2B)R bound to endogenous and synthetic agonists. CELL DISCOVERYnull. 2022, 8(1): http://dx.doi.org/10.1038/s41421-022-00503-1.
[11] Ji, Sijia, Tu, Wanzhi, Huang, Chenwen, Chen, Ziyang, Ren, Xinyue, He, Bingqing, Ding, Xiaoyan, Chen, Yuelei, Xie, Xin. The Aurora Kinase Inhibitor CYC116 Promotes the Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells. MOLECULES AND CELLS[J]. 2022, 45(12): 923-934, http://dx.doi.org/10.14348/molcells.2022.0077.
[12] Suo, Na, He, Bingqing, Cui, Shihao, Yang, Ying, Wang, Min, Yuan, Qianting, Xie, Xin. The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination. GLIA[J]. 2022, 70(10): 1992-2008, http://dx.doi.org/10.1002/glia.24233.
[13] Zheng, Ruting, Kong, Miaomiao, Wang, Siwei, He, Bingqing, Xie, Xin. Spermine alleviates experimental autoimmune encephalomyelitis via regulating T cell activation and differentiation. INTERNATIONAL IMMUNOPHARMACOLOGY[J]. 2022, 107: http://dx.doi.org/10.1016/j.intimp.2022.108702.
[14] Chen, LinHai, Zhang, Qing, Xiao, YuFeng, Fang, YouChen, Xie, Xin, Nan, FaJun. Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 65(5): 3991-4006, http://dx.doi.org/10.1021/acs.jmedchem.1c01813.
[15] Zeng, Peng, Hua, Qiuhong, Gong, Junyuan, Shi, Changjie, Pi, Xiaoping, Xie, Xin, Zhang, Ru. Neonatal cortical astrocytes possess intrinsic potential in neuronal conversion in defined media. ACTA PHARMACOLOGICA SINICA[J]. 2021, 42(11): 1757-1768, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000615156100002.
[16] Wang, Congcong, Zhang, YuFang, Guo, Shimeng, Zhao, Quan, Zeng, Yanping, Xie, Zhicheng, Xie, Xin, Lu, Boxun, Hu, Youhong. GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2021, 64(2): 941-957, https://www.webofscience.com/wos/woscc/full-record/WOS:000614306000004.
[17] Yue Wang, Shimeng Guo, Youwen Zhuang, Ying Yun, Peiyu Xu, Xinheng He, Jia Guo, Wanchao Yin, H Eric Xu, Xin Xie, Yi Jiang. Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor. NATURE COMMUNICATIONS[J]. 2021, 12(1): http://dx.doi.org/10.1038/s41467-021-25364-2.
[18] Che, Jinxin, Wang, Zhilong, Shen, Zheyuan, Zhuang, Weihao, Ying, Huazhou, Hu, Yongzhou, Hu, Youhong, Xie, Xin, Dong, Xiaowu. Discovery of 1,5-Dihydro-4H-imidazol-4-one Derivatives as Potent, Selective Antagonists of CXC Chemokine Receptor 2. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2021, 12(5): 836-845, http://dx.doi.org/10.1021/acsmedchemlett.1c00113.
[19] Yun, Ying, Zhang, Chenlu, Guo, Shimeng, Liang, Xiaoying, Lan, Yuan, Wang, Min, Zhuo, Ning, Yin, Jianpeng, Liu, Huanan, Gu, Min, Li, Jing, Xie, Xin, Nan, Fajun. Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5(H88Y) Mutant Mice. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2021, 64(16): 12181-12199, http://dx.doi.org/10.1021/acs.jmedchem.1c00851.
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已指导学生

王珏  硕士研究生  100706-药理学  

徐亚珍  硕士研究生  100706-药理学  

现指导学生

王识贤  硕士研究生  077906-药理学  

陈国芳  硕士研究生  077906-药理学  

龙媛  硕士研究生  077906-药理学  

柴辉  硕士研究生  077906-药理学  

张菲菲  博士研究生  100706-药理学