Zhao, Guoping |
Academician of Chinese Academy of Sciences, professor |
Institute of Plant Physiology and Ecology gpzhao@sibs.ac.cn |
Research Areas
Based on Genomics, functional genomics and comparative genomics information, special metabolic processes of microorganisms and the related genetic and biochemical/physiological molecular mechanisms of regulation under different environmental conditions are systematically studied. Metabolic regulation models are being developed based on the knowledge of characterizing signal transduction systems and transcription factors with respect to gene transcription, protein structure and function modification and interaction, as well as the biological small molecules.
Education
1983-08--1990-12 Department of Biochemistry, Purdue University, USA, PHD
1978-10--1982-07 Department of Biology, Fudan University, China, Bachelor
Experience
Work Experience
2002-02~present, Shanghai National Engineering Research Center for Biochip, researcher, director
2002-02~present, National Southern Research Center for Human Genome, Researcher, Executive Director
2002-02~present, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China,Professor
1999-07~2002-02, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China,Professor, PI, vice president
1997-01~1999-07, Shanghai Biological Engineering Research Center, Chinese Academy of Sciences, Professor, PI
1994-12~1997-01, Shanghai Institute of Plant Physiology and Ecology, , Chinese Academy of Sciences, China, Professor, PI,
1992-11~1994-12, Promega, Shanghai , deputy researcher, production manager
1990-12~1992-11, Department of Biology, Department of Biochemistry, Purdue University , visiting lecturer, postdoctoral
Publications
Papers
(1) GlnR-Mediated Regulation of ectABCD Transcription Expands the Role of the GlnR Regulon to Osmotic Stress Management, Journal of Bacteriology, 2015
(2) A Preliminary Study of the Mechanism of Nitrate-Stimulated Remarkable Increase of Rifamycin Production in Amycolatopsis mediterranei U32 by RNA-seq, Microbial Cell Factories, 2015
(3) Precise Characterization of GlnR Box in Actinomycetes, Biochem Biophys Res Commun, 2015
(4) Subdomain II of alpha-Isopropylmalate Synthase Is Essential for Activity Inferring A Mechanism of Feedback Inhibition, Journal of Biological Chemistry, 2014
(5) Atypical OmpR/PhoB Subfamily Response Regulator GlnR of Actinomycetes Functions as a Homodimer, Stabilized by the Unphosphorylated Conserved Asp-focused Charge Interactions, Journal of Biological Chemistry, 2014,
(6) GlnR Negatively Regulates the Transcription of the Alanine Dehydrogenase Encoding Gene ald in Amycolatopsis mediterranei U32 under Nitrogen Limited Conditions via Specific Binding to Its Major Transcription Initiation Site, PloS One, 2014,
(7) Mycobacterial MazG Safeguards Genetic Stability via Housecleaning of 5-OH-dCTP, PLoS Pathgens, 2013
(8) Three of Four GlnR Binding Sites Are Essential for GlnR-Mediated Activation of Transcription of the Amycolatopsis mediterranei nas Operon, Journal of Bacteriology, 2013
(9) The MASTER (Methylation-Assisted Tailorable Ends Rational) Ligation Method for Seamless DNA Assembly, Nucleic Acids Research, 2013
Students
Songcheng ZHU
Qiaoli LI
Wei MA
Hao YU
Mingxuan XU
Qing Zhang
Jun MA
Xiang MAO
Zhihui SHAO
Ying ZOU
Ling YANG
Xiaodong SHANG
Jin WANG
Nanqiu PENG
Yunyi Zhang
Han YAN
Ying WANG
Zilong ZHANG
Hua YUAN
Wei ZHAO
Wei LIN
Xufeng CEN
Xiaobiao HAN
Lei CHAO
Honors & Distinctions
(1) Tan Jiazhen Life Science Award, , 2015
(2) International Genetic Engineering Machinery Competition (2011 Hong Kong) Gold Award, first prize, 2011
(3) University of Natural Science Award (biology) - biological experimental technology first prize, first prize, Institute (school), 2010
(4) Shanghai Natural Science Award Second Prize, provincial, 2008
(5) Shanghai Natural Science Award first prize, provincial, 2006
(6) He-Liang-He-Li Award for Science and Technology , 2005
(7) Guangdong Science and Technology Progress Award, the provincial, 2004
(8) Shanghai Science and Technology Progress Award, provincial, 2004
(9) National Science and Technology Progress Award, the national level, 2002
(10) Shanghai Science and Technology Progress Award, provincial, 2002
(11) Shanghai Science and Technology Progress Award, provincial, 2001