071010-生物化学与分子生物学

多肽生物学及进化
多肽新分子设计

1997-09--2001-04   武汉大学   博士

   

2001-10~2004-04,Leuven University, 博士后
1997-09~2001-04,武汉大学, 博士

2017-01-01-今,Scientific reports, 编委
2015-10-01-今,昆虫学报, 编委

进化生态学：分子、化学和行为适应机制

   

（1） 东亚钳蝎的毒素组学研究, 一等奖, 省级, 2005

（ 1 ） 一种抗真菌肽突变体及其制备方法和应用, 2021, 第 1 作者, 专利号: CN112794892A

（ 2 ） 蝎α‑型神经毒素的突变体及其用途, 2017, 第 1 作者, 专利号: CN107304226A

（ 3 ） 一种抗菌肽及其制备方法和应用, 2013, 第 1 作者, 专利号: CN103421100A

   

（1） Molecular Diversity and Evolution of Antimicrobial Peptides in Musca domestica, DIVERSITY-BASEL, 2021, 通讯作者
（2） How a Scorpion Toxin Selectively Captures a Prey Sodium Channel: The Molecular and Evolutionary Basis Uncovered, MOLECULAR BIOLOGY AND EVOLUTION, 2020, 通讯作者
（3） Scorpion Toxins: Positive Selection at a Distal Site Modulates Functional Evolution at a Bioactive Site, MOLECULAR BIOLOGY AND EVOLUTION, 2019, 通讯作者
（4） 蛇三指环毒素家族的研究进展, The research progress of three finger toxin family in snakes, 云南大学学报. 自然科学版, 2019, 第 3 作者
（5） Did cis- and trans-defensins derive from a common ancestor?, IMMUNOGENETICS, 2019, 通讯作者
（6） Characterization of bi-domain drosomycin-type antifungal peptides in nematodes: An example of convergent evolution, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2018, 通讯作者
（7） Receptor variability-driven evolution of snake toxins, Receptor variability-driven evolution of snake toxins, 动物学研究, 2018, 第 4 作者
（8） Loop Replacement Enhances the Ancestral Antibacterial Function of a Bifunctional Scorpion Toxin, TOXINS, 2018, 通讯作者
（9） Meucin-49, a multifunctional scorpion venom peptide with bactericidal synergy with neurotoxins, AMINO ACIDS, 2018, 通讯作者
（10） Mesobuthus Venom-Derived Antimicrobial Peptides Possess Intrinsic Multifunctionality and Differential Potential as Drugs, FRONTIERS IN MICROBIOLOGY, 2018, 通讯作者
（11） Characterization of bi-domain drosomycin-type antifungal peptides in nematodes: An example of convergent evolution, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2018, 通讯作者
（12） 抑制剂胱氨酸结多肽的抗菌和杀虫活性及进化, Antimicrobial and insecticidal activities and evolution of inhibitor cystine knot peptides, 昆虫学报, 2018, 第 4 作者
（13） Molecular diversity of fungal inhibitor cystine knot peptides evolved by domain repeat and fusion, FEMS MICROBIOLOGY LETTERS, 2018, 通讯作者
（14） Molecular Dynamics Simulation Reveals Specific Interaction Sites between Scorpion Toxins and Kv1.2 Channel: Implications for Design of Highly Selective Drugs, TOXINS, 2017, 通讯作者
（15） New Fungal Defensin-Like Peptides Provide Evidence for Fold Change of Proteins in Evolution, BIOSCIENCE REPORTS, 2017, 通讯作者
（16） Expanding the Pharmacological Profile of κ-Hefutoxin 1 and Analogues: A Focus on the Inhibitory Effect on the Oncogenic Channel Kv10.1, PEPTIDES, 2017, 第 6 作者
（17） Expanding the pharmacological profile of kappa-hefutoxin 1 and analogues: A focus on the inhibitory effect on the oncogenic channel K(v)10.1, PEPTIDES, 2017, 第 6 作者
（18） Evaluating the Potential of a Loop-Extended Scorpion Toxin-Like Peptide as a Protein Scaffold, PROTEIN ENGINEERING DESIGN & SELECTION, 2016, 通讯作者
（19） Target-Driven Positive Selection at Hot Spots of Scorpion Toxins Uncovers Their Potential in Design of Insecticides, MOLECULAR BIOLOGY AND EVOLUTION, 2016, 通讯作者
（20） A Single-Point Mutation Enhances Dual Functionality of a Scorpion Toxin, COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 2016, 通讯作者
（21） Single-Point Mutation-Mediated Local Amphipathic Adjustment Dramatically Enhances Antibacterial Activity of a Fungal Defensin, FASEB JOURNAL, 2016, 通讯作者
（22） The Drosomycin Multigene Family: Three-Disulfide Variants from Drosophila takahashii Possess Antibacterial Activity, SCIENTIFIC REPORTS, 2016, 通讯作者
（23） 靶向离子通道的神经毒素起源于抗微生物防御肽（英文）, 生理学报, 2015, 第 2 作者
（24） Mesomartoxin, a New Kv1.2-Selective Scorpion Toxin Interacting with the Channel Selectivity Filter, BIOCHEMICAL PHARMACOLOGY, 2015, 通讯作者
（25） 靶向离子通道的神经毒素起源于抗微生物防御肽, Origin of neurotoxins from defensins, ACTA PHYSIOLOGICA SINICA, 2015, 第 3 作者
（26） Target-Driven Evolution of Scorpion Toxins, SCIENTIFIC REPORTS, 2015, 通讯作者
（27） An Insect Defensin-Derived beta-Hairpin Peptide with Enhanced Antibacterial Activity, ACS CHEMICAL BIOLOGY, 2014, 通讯作者
（28） Nrf2/Maf-Binding-Site-Containing Functional Cyp6a2 Allele Is Associated with DDT Resistance in Drosophila melanogaster, PEST MANAGEMENT SCIENCE, 2014, 第 4 作者
（29） Characterization of NADPH-Cytochrome P450 Reductase Gene from the Cotton Bollworm, Helicoverpa armigera, GENE, 2014, 第 4 作者
（30） Experimental Conversion of a Defensin into a Neurotoxin: Implications for Origin of Toxic Function, MOLECULAR BIOLOGY AND EVOLUTION, 2014, 通讯作者
（31） Fungal Defensins, an Emerging Source of Anti-Infective Drugs, CHINESE SCIENCE BULLETIN, 2014, 通讯作者
（32） Nematode-Derived Drosomycin-Type Antifungal Peptides Provide Evidence for Plant-to-Ecdysozoan Horizontal Transfer of a Disease Resistance Gene, NATURECOMMUNICATIONS, 2014, 通讯作者
（33） Evolutionary origin of beta-defensins, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2013, 通讯作者
（34） Two recombinant alpha-like scorpion toxins from Mesobuthus eupeus with differential affinity toward insect and mammalian Na+ channels, BIOCHIMIE, 2013, 通讯作者
（35） Functional Evolution of Scorpion Venom Peptides with an Inhibitor Cystine Knot Fold, BIOSCIENCE REPORTS, 2013, 通讯作者
（36） Characterization of a chimeric antimicrobial peptide uncovers evolutionary significance of exon-shuffling, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 通讯作者
（37） Dermatophytic defensin with antiinfective potential, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 通讯作者
（38） Comparative genomics analysis of five families of antimicrobial peptide-like genes in seven ant species, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2012, 通讯作者
（39） Alteration of the mode of antibacterial action of a defensin by the amino-terminal loop substitution, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 通讯作者
（40） Evolutionary Diversification of Mesobuthus alpha-Scorpion Toxins Affecting Sodium Channels, MOLECULAR & CELLULAR PROTEOMICS, 2012, 通讯作者
（41） Accelerated evolution and functional divergence of scorpion short-chain K+ channel toxins after speciation, COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 2012, 通讯作者
（42） Evolution of a Neurotoxin from a Defensin, TOXICON, 2012, 第 1 作者
（43） Two dyad-free Shaker-type K+ channel blockers from scorpion venom, TOXICON, 2012, 通讯作者
（44） Mutational Analysis of the Analgesic Peptide DrTx(1-42) Revealing a Functional Role of the Amino-Terminal Turn, PLOS ONE, 2012, 第 2 作者
（45） Positive selection-guided mutational analysis revealing two key functional sites of scorpion ERG K+ channel toxins, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 第 5 作者
（46） Convergent Evolution-Guided Design of Antimicrobial Peptides Derived from Influenza A Virus Hemagglutinin, JOURNAL OF MEDICINAL CHEMISTRY, 2011, 通讯作者
（47） A naturally-occurring carboxyl-terminally truncated alpha-scorpion toxin is a blocker of sodium channels, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 通讯作者
（48） Molecular divergence of two orthologous scorpion toxins affecting potassium channels, COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 2011, 通讯作者
（49） The defensin gene family expansion in the tick Ixodes scapularis, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2011, 通讯作者
（50） Molecular Diversity and Functional Evolution of Scorpion Potassium Channel Toxins, MOLECULAR & CELLULAR PROTEOMICS, 2011, 通讯作者
（51） DrTx(1–42), a C-terminally truncated analogue of drosotoxin, is a candidate of analgesic drugs, BIOCHEMICAL PHARMACOLOGY, 2011, 通讯作者
（52） Convergent Evolution-Guided Design of Antimicrobial Peptides Derived from Influenza A Virus Hemagglutinin, JOURNAL OF MEDICINAL CHEMISTRY, 2011, 通讯作者
（53） Molecular design of new sodium channel blockers, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 通讯作者
（54） DrTx(1–42), a C-terminally truncated analogue of drosotoxin, is a candidate of analgesic drugs, BIOCHEMICAL PHARMACOLOGY, 2011, 通讯作者
（55） Drosotoxin, a selective inhibitor of tetrodotoxin-resistant sodium channels, BIOCHEMICAL PHARMACOLOGY, 2010, 通讯作者
（56） Inhibition of melanization by a Nasonia defensin-like peptide: Implications for host immune suppression, JOURNAL OF INSECT PHYSIOLOGY, 2010, 通讯作者
（57） Functional role of charged residues in drosomycin, a Drosophila antifungal peptide, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2010, 通讯作者
（58） Inhibition of melanization by a Nasonia defensin-like peptide: Implications for host immune suppression, JOURNAL OF INSECT PHYSIOLOGY, 2010, 通讯作者
（59） Characterization of a hymenoptaecin-like antimicrobial peptide in the parasitic wasp Nasonia vitripennis, PROCESS BIOCHEMISTRY, 2010, 通讯作者
（60） Two recombinant depressant scorpion neurotoxins differentially affecting mammalian sodium channels, TOXICON, 2010, 通讯作者
（61） Antimicrobial peptide-like genes in Nasonia vitripennis: a genomic perspective, BMC GENOMICS, 2010, 通讯作者
（62） Identification and characterization of the parasitic wasp Nasonia defensins: Positive selection targeting the functional region?, DEVELOPMENTALANDCOMPARATIVEIMMUNOLOGY, 2010, 通讯作者
（63） MeuTXK beta 1, a scorpion venom-derived two-domain potassium channel toxin-like peptide with cytolytic activity, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2010, 通讯作者
（64） Characterization of two linear cationic antimalarial peptides in the scorpion Mesobuthus eupeus, BIOCHIMIE, 2010, 通讯作者
（65） A potent potassium channel blocker from Mesobuthus eupeus scorpion venom, BIOCHIMIE, 2010, 通讯作者
（66） A fossil antibacterial peptide gives clues to structural diversity of cathelicidin-derived host defense peptides, FASEB JOURNAL, 2009, 通讯作者
（67） Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides, FASEB JOURNAL, 2009, 通讯作者
（68） AdDLP, a bacterial defensin-like peptide, exhibits anti-Plasmodium activity, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 通讯作者
（69） Activation of cathepsin L by the cathelin-like domain of protegrin-3, MOLECULAR IMMUNOLOGY, 2008, 通讯作者
（70） Did cathelicidins, a family of multifunctional host-defense peptides, arise from a cysteine protease inhibitor?, TRENDS IN MICROBIOLOGY, 2008, 通讯作者
（71） Discovery of six families of fungal defensin-like peptides provides insights into origin and evolution of the CS alpha beta defensins, MOLECULAR IMMUNOLOGY, 2008, 通讯作者
（72） Gene expression, antiparasitic activity, and functional evolution of the drosomycin family, MOLECULAR IMMUNOLOGY, 2008, 通讯作者
（73） Positively selected sites of scorpion depressant toxins: Possible roles in toxin functional divergence, TOXICON, 2008, 通讯作者
（74） Inducible antibacterial response of scorpion venom gland, PEPTIDES, 2007, 通讯作者
（75） Functional expression of a Drosophila antifungal peptide in Escherichia coli, PROTEIN EXPRESSION AND PURIFICATION, 2007, 通讯作者
（76） 进化基因组学在昆虫天然免疫研究中的应用前景, Evolutionary genomics-based approaches for studies of insect innate immunity, 昆虫知识, 2007, 第 1 作者
（77） Evidence for myxobacterial origin of eukaryotic defensins, IMMUNOGENETICS, 2007, 通讯作者

Evolution of Venomous Animals and Their Toxins, Springer Science+Business Media Dordrecht, 2016-06, 第 3 作者

   

（ 1 ） 动物神经毒素起源的实验室模拟, 负责人, 国家任务, 2008-01--2011-12
（ 2 ） 寄主-寄生蜂间免疫抑制交互作用的分子机制, 负责人, 国家任务, 2007-07--2009-12
（ 3 ） 应用进化基因组学研究免疫系统发育的关键分子, 负责人, 国家任务, 2010-01--2015-12
（ 4 ） 基于一种新的蝎毒素支架的抗感染分子设计, 负责人, 国家任务, 2016-01--2019-12
（ 5 ） 孢子霉素的工程化改造, 负责人, 国家任务, 2019-01--2022-12

（1）Antimicrobial peptides in scorpion venom   国家自然科学基金委国际合作与交流项目会议   2016-01-12
（2）A multigene family of Caenorhabditis remanei-specific antifungal peptides with therapeutic potential    中比双边合作项目   高斌   2012-05-25