天然药物生物合成，天然药物合成生物学，天然药物发现

   

100701-药物化学

天然药物发现与生物合成

2000-09--2003-07   中国科学院成都有机化学研究所   博士
1997-09--2000-07   中国科学院成都生物研究所   硕士
1993-09--1997-07   西南师范大学   学士

   

[1] 罗应刚, 蒲祥, 杨云, 屈细兴, 陈菲, 张国林. 利用喜树悬浮细胞生产喜树碱和10-羟基喜树碱的方法. CN: CN107043795B, 2020-10-09.

[2] 罗应刚, 姜良珍, 庞静, 张国林. 高产反式-4-羟基-L-脯氨酸的大肠杆菌菌株及其构建方法. CN: CN110551672A, 2019-12-10.

[3] 罗应刚, 姜良珍, 张国林. 一种利用大肠杆菌合成反式‑4‑羟基‑L‑脯氨酸的方法. 中国: CN107805621A, 2018-03-16.

[4] 罗应刚, 蒲祥, 杨云, 屈细兴, 陈菲, 张国林. 利用喜树悬浮细胞生产N 1 ‑乙酰犬尿胺的方法. 中国: CN106995828A, 2017-08-01.

[5] 罗应刚, 蒲祥, 陈菲, 屈细兴, 张国林. 一株产喜树碱的喜树内生细菌-LY214及其用途. 中国: CN103146614A, 2013-06-12.

[6] 罗应刚, 蒲祥, 屈细兴, 陈菲, 张国林. 一种产喜树碱的喜树内生真菌及其应用. 中国: CN103074236A, 2013-05-01.

[7] 罗应刚, 张国林. 一类降血脂化合物及其制备方法和用途. 中国: CN102399148A, 2012-04-04.

[8] 罗应刚, 张国林, 陶飞燕. 一种丝氨酸的制备方法. 中国: CN101624349, 2010-01-13.

[9] 陶飞燕, 罗应刚, 魏其艳, 张国林. 一种制备L－磺基丙氨酸及其酯的方法. 中国: CN1309707, 2007-04-11.

[10] 罗应刚, 高小平, 刘燕, 田雅娟, 顾健, 周敏, 李伯刚, 张国林. 抗肿瘤植物提取物及其提取方法. 中国: CN1233642, 2005-12-28.

   

[1] Qiao, Chong, Chen, Fei, Liu, Zhan, Huang, Tianfang, Li, Wei, Zhang, Guolin, Luo, Yinggang. Functional characterization of a catalytically promiscuous tryptophan decarboxylase from camptothecin-producing Camptotheca acuminata. FRONTIERS IN PLANT SCIENCE[J]. 2022, 13: http://dx.doi.org/10.3389/fpls.2022.987348.
[2] Zhang, Xuejian, Cao, Yu, Pan, Dabo, Yao, Xiaojun, Wang, Fei, Zhang, Guolin, Luo, Yinggang. Antifibrotic pyridine-containing monoterpene alkaloids from Caryopteris glutinosa. PHYTOCHEMISTRY[J]. 2022, 203: http://dx.doi.org/10.1016/j.phytochem.2022.113378.
[3] Pu, Xiang, Gao, HuChuan, Wang, MinJi, Zhang, JiaHua, Shan, JiaHeng, Chen, MengHan, Zhang, Li, Wang, HanGuang, Wen, AnXiang, Luo, YingGang, Huang, QianMing. Integrative Analysis of Elicitor-Induced Camptothecin Biosynthesis in Camptotheca acuminata Plantlets Through a Combined Omics Approach. FRONTIERS IN PLANT SCIENCE[J]. 2022, 13: http://dx.doi.org/10.3389/fpls.2022.851077.
[4] Zhang, Xuejian, Luo, Guoyong, Cao, Yu, Mishig, Dumaa, Lodonjav, Munkhgerel, Pan, Dabo, Yao, Xiaojun, Wang, Fei, Zhang, Guolin, Luo, Yinggang. (+/-)-Caryopterisines A and B, dimeric monoterpene alkaloids with unprecedented 6/5/5/5/6 pentacyclic rings scaffold from Caryopteris glutinosa. BIOORGANIC CHEMISTRY[J]. 2021, 116: http://dx.doi.org/10.1016/j.bioorg.2021.105364.
[5] 李伟, 乔崇, 刘展, 刘梦洁, 李艺, 魏代静, 罗应刚. 红花石蒜苯丙氨酸解氨酶催化合成N-甲基-L-苯丙氨酸（英文）. 微生物学通报. 2021, 2398-2406, https://t.cnki.net/kcms/detail?v=3uoqIhG8C46NmWw7YpEsKMypi3qVj28LEUDxQXHYyS3fbyEOrIfBzEERSqQmQDs0Vt6xITtinLTCFadPJ_48AlTop52WWYH7.
[6] 胡佳伟, 李伟, 张倩, 刘展, 乔崇, 张国林, 罗应刚. 糖基转移酶ASP OleD催化朝藿定C的区域选择性O-糖基化合成Acuminatoside. 应用与环境生物学报[J]. 2021, 27(6): 1427-1433, http://lib.cqvip.com/Qikan/Article/Detail?id=7106484681.
[7] Jiang, Liangzhen, Pang, Jing, Yang, Lixia, Li, Wei, Duan, Lili, Zhang, Guolin, Luo, Yinggang. Engineering endogenous L-proline biosynthetic pathway to boost trans-4-hydroxy-L-proline production in Escherichia coli. JOURNAL OF BIOTECHNOLOGY[J]. 2021, 329: 104-117, http://dx.doi.org/10.1016/j.jbiotec.2021.01.015.
[8] 李伟, 乔崇, 刘展, 刘梦洁, 李艺, 魏代静, 罗应刚. 红花石蒜苯丙氨酸解氨酶催化合成N-甲基-L-苯丙氨酸. 微生物学通报[J]. 2021, 48(7): 2398-2406, http://lib.cqvip.com/Qikan/Article/Detail?id=7105380937.
[9] Hu, Jiawei, Li, Wei, Liu, Zhan, Zhang, Guolin, Luo, Yinggang. Molecular cloning and functional characterization of tyrosine decarboxylases from galanthamine-producing Lycoris radiata. ACTA PHYSIOLOGIAE PLANTARUM[J]. 2021, 43(6): http://dx.doi.org/10.1007/s11738-021-03258-6.
[10] Wang, Dongmei, Yang, Yun, Shi, Xiaoke, Yang, Kaitai, Yin, Kaipu, Wang, Fei, Zhang, Guolin, Luo, Yinggang. Viburnumfocesides A - D, 1-O-isovaleroylated iridoid 11-O-alloside derivatives from Viburnum foetidum var. ceanothoides. FITOTERAPIA[J]. 2020, 143: http://dx.doi.org/10.1016/j.fitote.2020.104601.
[11] Awadasseid, Annoor, Li, Wei, Liu, Zhan, Qiao, Chong, Pang, Jing, Zhang, Guolin, Luo, Yinggang. Characterization of Camptotheca acuminata 10-hydroxygeraniol oxidoreductase and iridoid synthase and their application in biological preparation of nepetalactol in Escherichia coli featuring NADP(+)- NADPH cofactors recycling. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2020, 162: 1076-1085, http://dx.doi.org/10.1016/j.ijbiomac.2020.06.223.
[12] Zhang, Xuejian, Peng, Ting, Shi, Xiaoke, Fang, Dongmei, Tang, Lin, Chen, Fang, Wang, Fei, Zhang, Guolin, Luo, Yinggang. Diterpenoids caryopterisoids D - Q and iridoid glucoside derivatives caryopterisides F - H from Caryopteris glutinosa. PHYTOCHEMISTRY[J]. 2020, 180: http://dx.doi.org/10.1016/j.phytochem.2020.112534.
[13] 杨凤, 张玲利, 王东梅, 刘燕, 周敏, 张国林, 代玉梅, 罗应刚. 小麦内生菌Pedobacter chitinilyticus CM134L-2T的次级代谢产物分离与鉴定. 应用与环境生物学报[J]. 2020, 26(5): 1226-1229, http://lib.cqvip.com/Qikan/Article/Detail?id=7103380745.
[14] Yang, Yun, Li, Wei, Pang, Jing, Jiang, Liangzhen, Qu, Xixing, Pu, Xiang, Zhang, Guolin, Luo, Yinggang. Bifunctional Cytochrome P450 Enzymes Involved in Camptothecin Biosynthesis. ACS CHEMICAL BIOLOGY[J]. 2019, 14(6): 1091-1096, https://www.webofscience.com/wos/woscc/full-record/WOS:000473115900003.
[15] Yinggang Luo. The versatile O-methyltransferase LrOMT catalyzes multiple O-methylation reactions in Amaryllidaceae alkaloid biosynthesis. International Journal of Biological Macromolecules. 2019, [16] 王东梅, 周敏, 刘燕, 戚华溢, 张国林, 罗应刚. 聚花野丁香的化学成分及其抗氧化活性. 应用与环境生物学报[J]. 2019, 25(6): 1492-1496, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFDLAST2020&filename=YYHS201906031&v=MjA5MDlEaDFUM3FUcldNMUZyQ1VSN3FlWitkdkZpbmhVYnpPUERURGZiRzRIOWpNcVk5R1pZUjhlWDFMdXhZUzc=.
[17] Li, Wei, Qiao, Chong, Pang, Jing, Zhang, Guolin, Luo, Yinggang. The versatile O-methyltransferase LrOMT catalyzes multiple O-methylation reactions in amaryllidaceae alkaloids biosynthesis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2019, 141: 680-692, http://dx.doi.org/10.1016/j.ijbiomac.2019.09.011.
[18] Pu, Xiang, Zhang, ChengRui, Zhu, Lin, Li, QiLong, Huang, QianMing, Zhang, Li, Luo, YingGang. Possible clues for camptothecin biosynthesis from the metabolites in camptothecin-producing plants. FITOTERAPIAnull. 2019, 134: 113-128, http://dx.doi.org/10.1016/j.fitote.2019.02.014.
[19] Li, Wei, Yang, Yun, Qiao, Chong, Zhang, Guolin, Luo, Yinggang. Functional characterization of phenylalanine ammonia-lyase- and cinnamate 4-hydroxylase-encoding genes from Lycoris radiata, a galanthamine-producing plant. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2018, 117: 1264-1279, http://dx.doi.org/10.1016/j.ijbiomac.2018.06.046.
[20] Li, Wei, Yang, Yun, Qiao, Chong, Zhang, Guolin, Luo, Yinggang. Functional characterization of phenylalanine ammonia-lyase- and cinnamate 4-hydroxylase-encoding genes from Lycoris radiata, a galanthamine-producing plant. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2018, 117: 1264-1279, http://dx.doi.org/10.1016/j.ijbiomac.2018.06.046.
[21] Zhao, Jinzhi, Yang, Yun, Yu, Mengyao, Yao, Ke, Luo, Xia, Qi, Huayi, Zhang, Guolin, Luo, Yinggang. Lanostane-type C-31 triterpenoid derivatives from the fruiting bodies of cultivated Fomitopsis palustris. PHYTOCHEMISTRY[J]. 2018, 152(2018): 10-21, http://dx.doi.org/10.1016/j.phytochem.2018.04.012.
[22] Yinggang Luo. Functional characterization of phenylalanine ammonia-lyase- and cinnamate 4-hydroxylase-encodiing genes from Lycoris radiata, a galanthamine-producing plant. International Journal of Biological Macromolecules. 2018, [23] Yang, Lixia, Jiang, Liangzhen, Li, Wei, Yang, Yun, Zhang, Guolin, Luo, Yinggang. A homomeric geranyl diphosphate synthase-encoding gene from Camptotheca acuminata and its combinatorial optimization for production of geraniol in Escherichia coli. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY[J]. 2017, 44(10): 1431-1441, https://www.webofscience.com/wos/woscc/full-record/WOS:000410473000004.
[24] Yang, Yun, Pu, Xiang, Qu, Xixing, Chen, Fei, Zhang, Guolin, Luo, Yinggang. Enhanced production of camptothecin and biological preparation of N-1-acetylkynuramine in Camptotheca acuminata cell suspension cultures. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2017, 101(10): 4053-4062, https://www.webofscience.com/wos/woscc/full-record/WOS:000400069500008.
[25] Shinwari, Shehla, Ahmad, Mushtaq, Luo, Yinggang, Zaman, Wajid. QUANTITATIVE ANALYSES OF MEDICINAL PLANTS CONSUMPTION AMONG THE INHABITANTS OF SHANGLA-KOHISTAN AREAS IN NORTHERN-PAKISTAN. PAKISTAN JOURNAL OF BOTANY[J]. 2017, 49(2): 725-734, https://www.webofscience.com/wos/woscc/full-record/WOS:000400110600042.
[26] Yinggang Luo. A homomeric geranyl diphosphate synthase-encoding gene from Camptotheca acuminata and its combinatorial application in geraniol production in Escherichia coli. Journal of Industrial Microbiology & Biotechnology. 2017, [27] 刘燕, 张国林, 罗国勇, 郎天琼, 周敏, 罗应刚. 黄药子的化学成分研究. 天然产物研究与开发[J]. 2017, 29(9): 1504-1511, [28] Li, Wei, Yang, Lixia, Jiang, Liangzhen, Zhang, Guolin, Luo, Yinggang. Molecular cloning and functional characterization of a cinnamate 4-hydroxylase-encoding gene from Camptotheca acuminata. ACTA PHYSIOLOGIAE PLANTARUM[J]. 2016, 38(11): http://dx.doi.org/10.1007/s11738-016-2275-7.
[29] Chen Fei, Li Wei, Jiang Liangzhen, Pu Xiang, Yang Yun, Zhang Guolin, Luo Yinggang. Functional characterization of a geraniol synthase-encoding gene from Camptotheca acuminata and its application in production of geraniol in Escherichia coli. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY[J]. 2016, [30] 罗应刚, 罗国勇, 郎天琼, 周敏, 刘燕, 张国林. 粘叶莸的化学成分研究. 天然产物研究与开发[J]. 2016, 28(10): 1520-1525, http://www.chinair.org.cn/handle/1471x/1748863.
[31] Yinggang Luo. Iridoid glucosides and diteropenoids from Caryopteris glutinosa. Journal of Natural Products. 2016, [32] Chen, Fei, Li, Wei, Jiang, Liangzhen, Pu, Xiang, Yang, Yun, Zhang, Guolin, Luo, Yinggang. Functional characterization of a geraniol synthase-encoding gene from Camptotheca acuminata and its application in production of geraniol in Escherichia coli. JOURNALOFINDUSTRIALMICROBIOLOGYBIOTECHNOLOGY[J]. 2016, 43(9): 1281-1292, https://www.webofscience.com/wos/woscc/full-record/WOS:000384417500009.
[33] Luo, Guoyong, Ye, Qi, Du, Baowen, Wang, Fei, Zhang, Guolin, Luo, Yinggang. Iridoid Glucosides and Diterpenoids from Caryopteris glutinosa. JOURNAL OF NATURAL PRODUCTS[J]. 2016, 79(4): 886-893, http://dx.doi.org/10.1021/acs.jnatprod.5b00946.
[34] Cai, Tian, Luo, YingGang, Zhou, Min, Wu, ZhiJun, Fang, DongMei, Zhang, GuoLin. Analysis of sesquiterpene pyridine alkaloids using ESI-MS/MS: The product ion at m/z 310 formed by an ion-dipole intermediate. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY[J]. 2015, 376: 54-57, http://dx.doi.org/10.1016/j.ijms.2014.11.014.
[35] Cai, Tian, Luo, YingGang, Zhou, Min, Wang, Dan, Wu, ZhiJun, Fang, DongMei, Zhang, GuoLin. Untargeted analysis of sesquiterpene pyridine alkaloids from the dried roots of Tripterygium wilfordii using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY[J]. 2015, 29(10): 965-972, http://210.75.237.14/handle/351003/27582.
[36] Luo, GuoYong, Luo, YingGang, Zhou, Rong, Zhou, Min, Gu, Jian, Ye, Qi, Dai, Ya, Zhang, GuoLin. Antioxidant compounds from ethanol extracts of bamboo (Neosinocalamus affinis) leaves. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2015, 17(3): 248-255, http://210.75.237.14/handle/351003/27596.
[37] Xixing Qu, Xiang Pu, Fei Chen, Yun Yang, Lixia Yang, Guolin Zhang, Yinggang Luo. Molecular Cloning, Heterologous Expression, and Functional Characterization of an NADPH-Cytochrome P450 Reductase Gene from Camptotheca acuminata, a Camptothecin-Producing Plant. PLOSONE[J]. 2015, 10(8): http://dx.doi.org/10.1371/journal.pone.0135397.
[38] Luo, Guoyong, Zhou, Min, Ye, Qi, Mi, Jun, Fang, Dongmei, Zhang, Guolin, Luo, Yinggang. Phenolic Derivatives from Hypericum japonicum. NATURAL PRODUCT COMMUNICATIONS[J]. 2015, 10(12): 2109-2112, http://210.75.237.14/handle/351003/27556.
[39] Xixing Qu, Xiang Pu, Fei Chen, Yun Yang, Lixia Yang, Guolin Zhang, Yinggang Luo. Correction: Molecular Cloning, Heterologous Expression, and Functional Characterization of an NADPH-Cytochrome P450 Reductase Gene from Camptotheca acuminata , a Camptothecin-Producing Plant. PLOS ONE[J]. 2015, 10(9): https://doaj.org/article/606d795bb7da49fc9459b241b0079c1a.
[40] Pu, Xiang, Chen, Fei, Yang, Yun, Qu, Xixing, Zhang, Guolin, Luo, Yinggang. Isolation and characterization of Paenibacillus polymyxa LY214, a camptothecin-producing endophytic bacterium from Camptotheca acuminata. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY[J]. 2015, 42(8): 1197-1202, http://210.75.237.14/handle/351003/27575.
[41] Munkhgerel Lodonjav, Luo Guoyong, Zhou Min, Regdel Duger, Zhang Guolin, Luo Yinggang. Chemical components from an edible mushroom Agaricus silvaticus. CHINESE JOURNAL OF APPLIED AND ENVIRONMENTAL BIOLOGY[J]. 2014, 20(4): 629-632, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5234921&detailType=1.
[42] Yinggang Luo. Dimeric 2-Arylbenzofurans and Polyisoprenylated Flavanones from Sophora tonkinensis. Fitoterapia. 2014, [43] Luo, Yinggang, Pu, Xiang, Luo, Guoyong, Zhou, Min, Ye, Qi, Liu, Yan, Gu, Jian, Qi, Huayi, Li, Guoyou, Zhang, Guolin. Nitrogen-Containing Dihydro-beta-agarofuran Derivatives from Tripterygium wilfordii. JOURNAL OF NATURAL PRODUCTS[J]. 2014, 77(7): 1650-1657, http://210.75.237.14/handle/351003/26676.
[44] Munkhgerel Lodonjav, 罗国勇, 周敏, Regdel Duger, 张国林, 罗应刚. 食用林地菇的化学成分（英文）. 应用与环境生物学报[J]. 2014, 20(4): 629-632, http://210.75.237.14/handle/351003/26716.
[45] Luo, Guoyong, Yang, Yun, Zhou, Min, Ye, Qi, Liu, Yan, Gu, Jian, Zhang, Guolin, Luo, Yinggang. Novel 2-arylbenzofuran dimers and polyisoprenylated flavanones from Sophora tonkinensis. FITOTERAPIA[J]. 2014, 99: 21-27, http://210.75.237.14/handle/351003/26657.
[46] Yinggang Luo. Nitrogen-containing Dihydro-?-agarofuran Derivatives from Tripterygium wilfordii. Journal of Natural Product. 2014, [47] Luo, Guoyong, Zhou, Min, Liu, Yan, Ye, Qi, Gu, Jian, Huang, Tianfang, Zhang, Guolin, Luo, Yinggang. 3-Formyl-2-arylbenzofurans from the aerial parts of Itea ilicifolia. PHYTOCHEMISTRY LETTERS[J]. 2014, 10: 19-22, http://dx.doi.org/10.1016/j.phytol.2014.06.019.
[48] Pu, Xiang, Li, Guangzhou, Yang, Tao, Li, Guoyou, Yi, Jinhai, Zhang, Guolin, Luo, Yinggang. A new cyclododecadoxazole derivative from Streptomyces spp. CIBYL1. NATURAL PRODUCT RESEARCH[J]. 2013, 27(7): 603-608, http://www.irgrid.ac.cn/handle/1471x/900494.
[49] Pu, Xiang, Qu, Xixing, Chen, Fei, Bao, Jinku, Zhang, Guolin, Luo, Yinggang. Camptothecin-producing endophytic fungus Trichoderma atroviride LY357: isolation, identification, and fermentation conditions optimization for camptothecin production. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2013, 97(21): 9365-9375, http://www.irgrid.ac.cn/handle/1471x/900529.
[50] Tian, ShouZheng, Pu, Xiang, Luo, Guoyong, Zhao, LiXing, Xu, LiHua, Li, WenJun, Luo, Yinggang. Isolation and Characterization of New p-Terphenyls with Antifungal, Antibacterial, and Antioxidant Activities from Halophilic Actinomycete Nocardiopsis gilva YIM 90087. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2013, 61(12): 3006-3012, http://www.irgrid.ac.cn/handle/1471x/900495.
[51] 蒲祥, 李光州, 肖青, 易进海, 田永强, 张国林, 赵立兴, 罗应刚. 产喜树碱的喜树内生真菌Aspergillus sp.LY013的分离、退化及退化后的次级代谢产物（英文）. 应用与环境生物学报[J]. 2013, 19(5): 787-793, http://210.75.237.14/handle/351003/24039.
[52] 马磊, 张翔, 田永强, 张国林, 罗应刚. 拟南芥基因组中注释为异胡豆苷合成酶的基因克隆及异源表达. 应用与环境生物学报[J]. 2013, 19(2): 224-230, http://210.75.237.14/handle/351003/24051.
[53] 张翔, 马磊, 田永强, 张国林, 罗应刚. 拟南芥基因组中注释为（S）-去甲乌药碱合成酶的分子克隆与异源表达（英文）. 应用与环境生物学报[J]. 2013, 19(1): 61-68, http://210.75.237.14/handle/351003/24049.
[54] 陈晓珍, 张婷婷, 李国友, 方冬梅, 张国林, 罗应刚. 甘遂中激活NF-κB信号通路的化学成分. 天然产物研究与开发[J]. 2013, 25(2): 151-155, http://210.75.237.14/handle/351003/24046.
[55] 张翔, 马磊, 田永强, 张国林, 罗应刚. 拟南芥基因组中注释为（S）-去甲乌药碱合成酶的分子克隆与异源表达. 应用与环境生物学报[J]. 2013, 19(1): 61-68, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=4780222&detailType=1.
[56] 蒲祥, 李光州, 肖青, 易进海, 田永强, 张国林, 赵立兴, 罗应刚. 产喜树碱的喜树内生真菌Aspergillus sp. LY013的分离、退化及退化后的次级代谢产物. 应用与环境生物学报[J]. 2013, 19(5): 787-793, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=4972953&detailType=1.
[57] Luo, Yinggang, Zhou, Min, Ye, Qi, Pu, Qiang, Zhang, Guolin. Dihydroagarofuran Derivatives from the Dried Roots of Tripterygium wilfordii. JOURNAL OF NATURAL PRODUCTS[J]. 2012, 75(1): 98-102, http://www.irgrid.ac.cn/handle/1471x/656423.
[58] Yinggang Luo. A new cyclododecap[d]oxazole derivative from Streptomyces spp. CIBYL1. Natural Products Research. 2012, [59] 李光州, 陈晓珍, Mishig Dumaa, 易进海, 张国林, 罗应刚. 冬青叶兔唇花地上部分非极性成分的GC-MS分析. 天然产物研究与开发[J]. 2012, 24(11): 1578-1581, http://210.75.237.14/handle/351003/23950.
[60] 李光州, MISHIG Dumaa, 蒲祥, 易进海, 张国林, 罗应刚. 冬青叶兔唇花地上部分的化学成分（英文）. 应用与环境生物学报[J]. 2012, 18(6): 924-927, http://210.75.237.14/handle/351003/23949.
[61] 张翔, 马磊, 田永强, 张国林, 罗应刚. 拟南芥基因组中注释为小檗碱桥环酶基因的分子克隆及异源表达. 世界科技研究与发展[J]. 2012, 第5期(5): 807-811, http://www.corc.org.cn/handle/1471x/2020073.
[62] Liu, Sijiu, Yu, Zhihong, Yu, Xiao, Huang, ShengXiong, Luo, Yinggang, Wu, Li, Shen, Weihua, Yang, Zhenyun, Wang, Lina, Gunawan, Andrea M, Chan, Rebecca J, Shen, Ben, Zhang, ZhongYin. SHP2 Is a Target of the Immunosuppressant Tautomycetin. CHEMISTRY & BIOLOGY[J]. 2011, 18(1): 101-110, http://dx.doi.org/10.1016/j.chembiol.2010.10.015.
[63] 张婷婷, 陈晓珍, 罗应刚. 禹白附生品和制品挥发油成分及稳定性. 中国中药杂志[J]. 2011, 36(10): 1337-1341, http://lib.cqvip.com/Qikan/Article/Detail?id=37953548.
[64] Zhao, Jianyu, Zhou, Min, Liu, Yan, Zhang, Guolin, Luo, Yinggang. Chromones and coumarins from the dried fructus of Cnidium monnieri. FITOTERAPIA[J]. 2011, 82(5): 767-771, http://www.irgrid.ac.cn/handle/1471x/517879.
[65] Luo, Yinggang, Li, Guangzhou, Li, Guoyou, Yan, Jufang, Yi, Jinhai, Zhang, Guolin. Discovery and Identification of 2-Phenylethyl 2,6-Dihydroxybenzoate as a Natural Lipid-Lowering Lead. PLANTA MEDICA[J]. 2011, 77(18): 2047-2049, http://www.irgrid.ac.cn/handle/1471x/517858.
[66] 张婷婷, 罗应刚. 禹白附的化学成分与药理作用研究进展. 时珍国医国药[J]. 2010, 21(10): 2642-2644, http://lib.cqvip.com/Qikan/Article/Detail?id=35757876.
[67] Luo, Yinggang, Li, Wenli, Ju, Jianhua, Yuan, Qiuping, Peters, Noel R, Hoffmann, F Michael, Huang, ShengXiong, Bugni, Tim S, Rajski, Scott, Osada, Hiroyuki, Shen, Ben. Functional Characterization of TtnD and TtnF, Unveiling New Insights into Tautomycetin Biosynthesis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2010, 132(19): 6663-6671, http://www.irgrid.ac.cn/handle/1471x/256630.
[68] Ling, Jianya, Horsman, Geoffrey P, Huang, ShengXiong, Luo, Yinggang, Lin, Shuangjun, Shen, Ben. Enediyne Antitumor Antibiotic Maduropeptin Biosynthesis Featuring a C-Methyltransferase That Acts on a CoA-Tethered Aromatic Substrate. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2010, 132(36): 12534-12536, https://www.webofscience.com/wos/woscc/full-record/WOS:000282074200006.
[69] Wu, HuaFang, Lin, WenBin, Xia, LiZi, Luo, YingGang, Chen, XiaoZhen, Li, CuoYon, Zhang, GuoLin, Pan, XinFu. 'N-Stereogenic Quaternary Ammonium Salts' from L-Amino Acids: Synthesis, Separation, and Absolute Configuration. HELVETICA CHIMICA ACTA[J]. 2009, 92(4): 677-688, http://www.irgrid.ac.cn/handle/1471x/256562.
[70] Li, GuoYou, Yang, Tao, Luo, YingGang, Chen, XiaoZhen, Fang, DongMei, Zhang, GuoLin. Brevianamide J, A New Indole Alkaloid Dimer from Fungus Aspergillus versicolor. ORGANIC LETTERS[J]. 2009, 11(16): 3714-3717, http://www.irgrid.ac.cn/handle/1471x/256544.
[71] Tao, Feiyan, Luo, Yinggang, Huang, Qingchun, Liu, Yan, Li, Bogang, Zhang, Guolin. Facile syntheses of l-beta-haloalanine derivatives from l-cysteine or l-cystine. AMINO ACIDS[J]. 2009, 37(4): 603-607, http://www.irgrid.ac.cn/handle/1471x/256554.
[72] YiPeng Xie, BoGang Li, YingGang Luo, XiaoZhen Chen, GuoLin Zhang. Preparation of Two Diastereoisomeric Decalin Synthons and( )-Ambrox. HELVETICA CHIMIA ACTA[J]. 2008, 91(4): 734-740, http://210.75.237.14/handle/351003/26771.
[73] 陈睿, 罗应刚, 胡晓玉, 陈晓珍, 张国林. 尼泊尔杞木的化学成分研究. 天然产物研究与开发[J]. 2008, 20(4): 578-581,591, http://lib.cqvip.com/Qikan/Article/Detail?id=28113789.
[74] Luo, Yinggang, Lin, Shuangjun, Zhang, Jian, Cooke, Heather A, Bruner, Steven D, Shen, Ben. Regiospecific O-methylation of naphthoic acids catalyzed by NcsB1, an O-methyltransferase involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2008, 283(21): 14694-14702, http://dx.doi.org/10.1074/jbc.M802206200.
[75] 张国林, 罗应刚, 吴凤鄂, 丁立生, 郑颖. 生物碱化学. 2008, 538-, http://210.75.237.14/handle/351003/22848.
[76] Wu, HuaFang, Luo, YingGang, Yu, KaiBei, Zhang, GuoLin, Pan, XinFu. 2S,NS)-N-allyl-N-benzyl-1-hydroxy-3-(4-hydroxyphenyl)-N-methylpropan-2-aminium bromide. ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS[J]. 2008, 64: O1621-U3383, https://www.webofscience.com/wos/woscc/full-record/WOS:000258064300323.
[77] 吴划方, 冯春, 陈晓珍, 林文彬, 罗应刚, 潘鑫复. 基于链状氨基酸N-手性季铵盐合成中的取代反应研究. 化学研究与应用[J]. 2008, 20(9): 1220-1223, http://lib.cqvip.com/Qikan/Article/Detail?id=28235770.
[78] Xie, YiPeng, Li, BoGang, Luo, YingGang, Chen, XiaoZhen, Zhang, GuoLin. Preparation of two diastereoisomeric decalin synthons and (-)-ambrox. HELVETICA CHIMICA ACTA[J]. 2008, 91(4): 734-740, https://www.webofscience.com/wos/woscc/full-record/WOS:000255731700013.
[79] 陈睿, 罗应刚, 胡晓玉, 陈晓珍, 张国林. 尼泊尔杞木的化学成分研究（英文）. 天然产物研究与开发[J]. 2008, 578-581+591, http://210.75.237.14/handle/351003/18171.
[80] Tao, FeiYan, Li, BoGang, Liu, Yan, Luo, YingGang. Facile synthesis of 4-acetyl-2-nitrobenzaidehyde. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2007, 27(11): 1441-1443, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000250972800023.
[81] 陶飞燕, 李伯刚, 刘燕, 罗应刚. 4-乙酰基-2-硝基苯甲醛的简便合成. 有机化学[J]. 2007, 27(11): 1441-1443, http://lib.cqvip.com/Qikan/Article/Detail?id=25796926.
[82] 李洪娟, 罗应刚, 何志恒, 张国林. 袋花忍冬的化学成分研究（英文）. 应用与环境生物学报[J]. 2007, 188-191, http://210.75.237.14/handle/351003/18009.
[83] LI Hongjuan, LUO Yinggang, HE Zhiheng, ZHANG Guolin. 袋花忍冬的化学成分研究. 应用与环境生物学报[J]. 2007, 13(2): 188-191, http://lib.cqvip.com/Qikan/Article/Detail?id=24270016.
[84] 胡晓玉, 罗应刚, 陈睿, 周乐. 蒲公英赛烷型五环三萜及其波谱特征的研究进展. 天然产物研究与开发[J]. 2007, 19(B05): 170-178, http://lib.cqvip.com/Qikan/Article/Detail?id=26471001.
[85] Luo, Yinggang, He, Zhiheng, Li, Hongjuan. 2-Aryl benzofurans and their derivatives from seeds of Styrax macranthus. FITOTERAPIA[J]. 2007, 78(3): 211-214, http://www.irgrid.ac.cn/handle/1471x/256388.
[86] 李洪娟, 罗应刚, 何志恒　, 张国林. 袋花忍冬的化学成分研究. 应用与环境生物学报[J]. 2007, 13(2): 188-191, http://lib.cqvip.com/Qikan/Article/Detail?id=24270016.
[87] 何志恒, 罗应刚, 李洪娟, 张国林. 攀援孔药花化学成分研究（英文）. 天然产物研究与开发[J]. 2006, 238-242, http://210.75.237.14/handle/351003/17889.
[88] 郜晓峰, 罗应刚, 官家发. 微生物发酵法生产辅酶Q_（10）研究进展. 天然产物研究与开发[J]. 2006, 18(5): 858-862+872, http://210.75.237.14/handle/351003/17897.
[89] 何志恒, 罗应刚, 李洪娟, 张国林. 攀援孔药花化学成分研究. 天然产物研究与开发[J]. 2006, 18(2): 238-242, http://lib.cqvip.com/Qikan/Article/Detail?id=21671795.
[90] 李洪娟, 罗应刚, 何志恒, 张国林. 钮子瓜化学成分研究（英文）. 天然产物研究与开发[J]. 2006, 411-414, http://210.75.237.14/handle/351003/17887.
[91] 李洪娟, 罗应刚, 何志恒, 张国林. 钮子瓜化学成分研究. 天然产物研究与开发[J]. 2006, 18(3): 411-414, http://lib.cqvip.com/Qikan/Article/Detail?id=22182339.
[92] Yang, HaiJun, Li, BoGang, Cai, XiaoHua, Qi, HuaYi, Luo, YingGang, Zhang, GuoLin. Chiral decalins: Preparation from oleanolic acid and application in the synthesis of (-)-9-epi-ambrox. JOURNAL OF NATURAL PRODUCTS[J]. 2006, 69(11): 1531-1538, http://www.irgrid.ac.cn/handle/1471x/256319.
[93] He Zhiheng, Luo Yinggang, Li Hongjuan, Zhang Guolin. 攀援孔药花化学成分研究. 天然产物研究与开发[J]. 2006, 18(2): 238-242, http://lib.cqvip.com/Qikan/Article/Detail?id=21671795.
[94] Luo, Yinggang, Tao, Feiyan, Liu, Yan, Li, Bogang, Zhang, Guolin. Intramolecular amidation - An efficient synthesis of 3-aryl-2-quinolinones. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE[J]. 2006, 84(12): 1620-1625, https://www.webofscience.com/wos/woscc/full-record/WOS:000244345900005.
[95] Li Hongjuan, Luo Yinggang, He Zhiheng, Zhang Guolin. 钮子瓜化学成分研究. 天然产物研究与开发[J]. 2006, 18(3): 411-414, http://lib.cqvip.com/Qikan/Article/Detail?id=22182339.
[96] 魏其艳, 罗应刚, 张国林. 菲醌的生物活性. 天然产物研究与开发[J]. 2005, 17(5): 665-668, http://lib.cqvip.com/Qikan/Article/Detail?id=20383238.
[97] 田雅娟, 罗应刚, 李伯刚, 张国林. 山荔枝化学成分的研究. 天然产物研究与开发[J]. 2002, 18-20, http://lib.cqvip.com/Qikan/Article/Detail?id=1001073988.
[98] 罗应刚, 李伯刚, 张国林. 云南假鹰爪的生物碱成分. 天然产物研究与开发[J]. 2000, 12(6): 1-5, http://lib.cqvip.com/Qikan/Article/Detail?id=4801848.

   

（ 1 ） 喜树碱的生物合成研究, 主持, 国家级, 2012-01--2015-12
（ 2 ） 微生物发酵生产反式-4-羟基-L-脯氨酸, 主持, 省级, 2015-01--2017-12
（ 3 ） 中药化学对照品, 主持, 研究所（学校）, 2014-10--2017-10
（ 4 ） 药物前期研发, 主持, 研究所（学校）, 2015-06--2019-12
（ 5 ） 针对阿尔茨海默症多靶点的先导化合物研究, 主持, 部委级, 2016-11--2018-06
（ 6 ） 酶催化合成卤代色胺, 主持, 市地级, 2017-08--2020-08
（ 7 ） 苷类化合物生物活性与生物利用度改进, 参与, 部委级, 2018-11--2019-11
（ 8 ） 基于天然产物的老年性疾病候选药物研究, 参与, 国家级, 2019-01--2021-12

已指导学生

张翔  硕士研究生  077901-药物化学  

屈细兴  硕士研究生  077901-药物化学  

陈菲  硕士研究生  085235-制药工程  

杨利霞  硕士研究生  078001-药物化学  

现指导学生

庞静  硕士研究生  085238-生物工程  

胡佳伟  硕士研究生  078001-药物化学  

刘梦洁  硕士研究生  085238-生物工程  

李艺  硕士研究生  078001-药物化学