071002-动物学

动物分子遗传学

1990-09--1993-10   中国科学院上海昆虫所   博士学位课程学习
1984-09--1987-06   中南林业科技大学   获得硕士学位
1980-09--1984-06   西北农林科技大学   学士学位

   

2001-04~现在, 中国科学院上海生命科学研究院, 研究员
1998-04~2001-03,日本IKARI环境事业集团, 主任研究员
1995-07~1998-03,日本东京大学, 日本学术振兴会资助博士后
1993-11~1995-07,中南林业科技大学, 任讲师、副教授
1990-09~1993-10,中国科学院上海昆虫所, 博士学位课程学习
1987-07~1990-08,中南林业科技大学, 任助教、讲师
1984-09~1987-06,中南林业科技大学, 获得硕士学位
1980-09~1984-06,西北农林科技大学, 学士学位

2018-01-01-今,第十三届上海市政协, 上海市政协常委、人口资源委员会副主任
2012-06-01-2017-05-31,九三学社上海市委, 副主委
2012-01-01-2017-12-31,第十二届上海市政治协商会, 上海市政协常委、提案委员会副主任
2007-01-01-2017-12-31,中国昆虫学会, 副理事长
2006-01-01-2016-07-31,中国生态学会化学生态学专业委员会, 主任委员

   

（ 1 ） 一种制备雌性不育的鳞翅目昆虫的方法及其核酸构建物, 2021, 第 1 作者, 专利号: CN112553250A

（ 2 ） 一种应用于黑水虻的CRISPR/Cas9基因编辑系统的标记基因, 2020, 第 1 作者, 专利号: CN112111526A

（ 3 ） 规模化饲养黑水虻的集成装置, 2020, 第 1 作者, 专利号: CN112106731A

（ 4 ） 一种基于基因编辑的获得翅膀缺失的黑水虻的方法, 2020, 第 1 作者, 专利号: CN112111527A

（ 5 ） 亮斑扁角水虻胚胎显微注射平台的建立, 2020, 第 1 作者, 专利号: CN112111525A

（ 6 ） 一种抑制核型多角体病毒的方法, 2017, 第 1 作者, 专利号: CN107384919A

   

（1） BmPMFBP1 regulates the development of eupyrene sperm in the silkworm, Bombyx mori, PLOS GENETICS, 2022, 通讯作者
（2） Construction of Baculovirus-Inducible CRISPR/Cas9 Antiviral System Targeting BmNPV in Bombyx mori, Viruses, 2022, 第11作者
（3） Disruption of egg-specific protein causes female sterility in Bombyx mori, Disruption of egg-specific protein causes female sterility in Bombyx mori, INSECT SCIENCE, 2022, 通讯作者
（4） Black soldier fly larvae effectively degrade lincomycin from pharmaceutical industry wastes, JOURNAL OF ENVIRONMENTAL MANAGEMENT, 2022, 通讯作者
（5） piggyBac-based transgenic RNAi of serine protease 2 results in male sterility in Hyphantria cunea, INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2022, 通讯作者
（6） Mutation of P-element somatic inhibitor induces male sterility in the diamondback moth, Plutella xylostella, PEST MANAGEMENT SCIENCE, 2021, 通讯作者
（7） 5 '-Nucleotidase Plays a Key Role in Uric Acid Metabolism of Bombyx mori, CELLS, 2021, 通讯作者
（8） Genomic landscape and genetic manipulation of the black soldier fly Hermetia illucens, a natural waste recycler, CELL RESEARCH, 2020, 通讯作者
（9） Mutation of doublesex in Hyphantria cunea results in sex-specific sterility, PEST MANAGEMENT SCIENCE, 2020, 通讯作者
（10） Proboscipedia and Sex combs reduced are essential for embryonic labial palpus specification in Bombyx mori, Proboscipedia and Sex combs reduced are essential for embryonic labial palpus specification in Bombyx mori, JOURNAL OF INTEGRATIVE AGRICULTURE, 2020, 第 4 作者
（11） MicroRNA-2738 regulates gene expression in the sex determination pathway in Bombyx mori, MicroRNA-2738 regulates gene expression in the sex determination pathway in Bombyx mori, INSECT SCIENCE, 2020, 第 6 作者
（12） Gtsf1 is essential for proper female sex determination and transposon silencing in the silkworm, Bombyx mori, PLOS GENETICS, 2020, 通讯作者
（13） Mutation of Bdpaired induces embryo lethality in the oriental fruit fly, Bactrocera dorsalis, PEST MANAGEMENT SCIENCE, 2020, 通讯作者
（14） A single ortholog of teashirt and tiptop regulates larval pigmentation and adult appendage patterning in Bombyx mori, INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2020, 第 3 作者
（15） miR-34 regulates larval growth and wing morphogenesis by directly modulating ecdysone signalling and cuticle protein inBombyx mori, RNA BIOLOGY, 2020, 通讯作者
（16） Identification of a germline-expression promoter for genome editing in Bombyx mori, Identification of a germline-expression promoter for genome editing in Bombyx mori, INSECT SCIENCE, 2019, 通讯作者
（17） Draft genome of the cotton aphid Aphis gossypii, INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2019, 通讯作者
（18） Identification of a germline-expression promoter for genome editing in Bombyx mori, Identification of a germline-expression promoter for genome editing in Bombyx mori, 昆虫科学:英文版, 2019, 第 10 作者
（19） The Masc gene product controls masculinization in the black cutworm, Agrotis ipsilon, The Masc gene product controls masculinization in the black cutworm, Agrotis ipsilon, 昆虫科学:英文版, 2019, 第 7 作者
（20） Mutation of doublesex induces sex-specific sterility of the diamondback moth Plutella xylostella, INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2019, 通讯作者
（21） Fall webworm genomes yield insights into rapid adaptation of invasive species, NATURE ECOLOGY & EVOLUTION, 2019, 通讯作者
（22） Genome editing in insects:current status and challenges, Genome editing in insects:current status and challenges, 国家科学评论:英文版, 2019, 第 4 作者
（23） Bombyx mori histone methyltransferase BmAsh2 is essential for silkworm piRNA-mediated sex determination, PLOS GENETICS, 2018, 第 5 作者
（24） Identification of yellow gene family in Agrotis ipsilon and functional analysis of Aiyellow-y by CRISPR/Cas9, INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2018, 通讯作者
（25） Deletion of the Bombyx mori odorant receptor co-receptor (BmOrco) impairs olfactory sensitivity in silkworms, INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2017, 通讯作者
（26） Sexually dimorphic traits in the silkworm, Bombyx mori, are regulated by doublesex, INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2017, 通讯作者
（27） Bombyx mori P-element Somatic Inhibitor (BmPSI) Is a Key Auxiliary Factor for Silkworm Male Sex Determination, PLOS GENETICS, 2017, 通讯作者
（28） Transgenic CRISPR/Cas9-mediated viral gene targeting for antiviral therapy of Bombyx mori nucleopolyhedrovirus (BmNPV)., Journal of Virology., 2017, 通讯作者
（29） Genome Editing of Wnt-1, a Gene Associated with Segmentation, via CRISPR/Cas9 in the Pine Caterpillar Moth, Dendrolimus punctatus, FRONTIERS IN PHYSIOLOGY, 2017, 通讯作者
（30） CRISPR/Cas9 mediated knockout of the abdominal-A homeotic gene in the global pest, diamondback moth (Plutella xylostella), INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2016, 通讯作者
（31） Expansion of CRISPR targeting sites in Bombyx mori, INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2016, 通讯作者
（32） MiR-2 family targets awd and fng to regulate wing morphogenesis in Bombyx mori, RNA BIOLOGY, 2015, 通讯作者
（33） Transgenic characterization of two testis-specific promoters in the silkworm, Bombyx mori, INSECT MOLECULAR BIOLOGY, 2015, 
（34） Ectopic expression of ecdysone oxidase impairs tissue degeneration in Bombyx mori, PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2015, 通讯作者
（35） Enhancement of larval RNAi efficiency by over-expressing Argonaute2 gene in the silkworm, Bombyx mori, International Journal of Biological Sciences, 2015, 通讯作者
（36） Site-specific, TALENs-mediated transformation of Bombyx mori, INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2014, 第 10 作者
（37） MicroRNA Let-7 regulates molting and metamorphosis in the silkworm, Bombyx mori, INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2014, 通讯作者
（38） Transcription activator-like effector nuclease (TALEN)-mediated female-specific sterility in the silkworm, Bombyx mori, INSECT MOLECULAR BIOLOGY, 2014, 
（39） PDP1 regulates energy metabolism through food intake and insulin signaling pathway in the red flour beetle, Tribolium castaneum, Archive of Insect Biochemistry and Physiology, 2014, 通讯作者
（40） Functional characterization of the vitellogenin promoter in the silkworm, Bombyx mori, INSECT MOLECULAR BIOLOGY, 2014, 
（41） A transgene-based, female-specific lethality system for genetic sexing of the beneficial insect, Bombyx mori, Proceedings of the National Academy of Sciences USA, 2013, 通讯作者
（42） microRNA-281 suppresses ecdysone receptor B isoforms expression in Bombyx mori, Insect Molecular Biology and Biochemistry, 2013, 通讯作者
（43） Identification of miRNAs in Helicoverpa armigera and Spodoptera litura based on deep sequencing and homology analysis, International Journal of Biological Sciences, 2013, 通讯作者
（44） Mutation of a vitelline membrane protein, BmEP80, is responsible for the silkworm "Ming" lethal egg mutant, GENE, 2013, 第 9 作者
（45） The CRISPR/Cas System mediates efficient genome engineering in Bombyx mori, CELL RESEARCH, 2013, 通讯作者
（46） Fine mapping of a supernumerary proleg mutant (E-Cs-l) and comparative expression analysis of the abdominal-A gene in silkworm, Bombyx mori, INSECT MOLECULAR BIOLOGY, 2013, 
（47） Hindgut Innate Immunity and Regulation of Fecal Microbiota through Melanization in Insects, JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 第 7 作者
（48） A major facilitator superfamily protein participates in the reddish brown pigmentation in Bombyx mori, JOURNAL OF INSECT PHYSIOLOGY, 2012, 通讯作者
（49） Deletion of an N-acetyltransferase gene of silkworm confers the new black pattern in insects, Development, 2010, 通讯作者
（50） Silkworm (Bombyx mori) BmLid is a more prevalent histone lysine demethylase than its homologues in drosophila and mammals, Cell Research, 2010, 通讯作者
（51） A integrated genetic linkage map from three different parental combinations and its application, BMC Genomics, 2010, 通讯作者
（52） Proteomic analysis of silk gland programmed cell death during metamorphosis of the silkworm Bombyx mori, JOURNAL OF PROTEOME RESEARCH, 2007, 通讯作者
（53） Silencing a cotton bollworm p450 monooxygenase gene by plant-mediated rnai impairs larval tolerance of gossypol, NATURE BIOTECHNOLOGY, 2007, 第 7 作者
（54） Profile of the genes expressed in silkworm, Bombyx mori through serial analysis of gene expression (SAGE), Genomics, 2005, 通讯作者
（55） Simple Sequence Repeat-Based Consensus Linkage Map of the Silkworm Genome, Proceedings of the National Academy of Sciences USA, 2005, 通讯作者

   

（ 1 ） 基于性别调控和基因组编辑的雄性家蚕品系构建研究, 负责人, 国家任务, 2016-01--2020-12
（ 2 ） 鳞翅目害虫的遗传调控研究, 负责人, 国家任务, 2015-01--2019-12
（ 3 ） 利用基因组编辑技术构建复合型抗病毒的家蚕品系研究, 负责人, 国家任务, 2019-01--2023-12

（1）From sex determination to sex regulation   2015-11-15
（2）Sex determination and sex regulation in Lepidoptera insects   2015-08-15