结构为基础的新型疫苗及抗体工程改造

    基于结构的疫苗设计：通过对蛋白抗原结构的解析以及与抗体相互作用研究，分析抗原结构特征，设计结构完整有效疫苗。这种策略能够最大限度的保证抗原表位的空间结构，从而提高疫苗的免疫源性。

   抗体药物作用机制及抗体药物研发：抗体药物在治疗肿瘤、自身免疫性疾病、传染病等领域取得了突破性进展，在全球销售额前十位药物中，抗体药物占据六席，抗体药物正以前所未有的速度快速发展。本实验室研究内容之一就是利用抗体筛选平台及结构生物学平台研究抗体药物的作用机制，并进一步开发新的抗体药物。

   人源抗体筛选及动物来源抗体的人源化：利用噬菌体展示、酵母展示及人B细胞单细胞测序技术筛选重要传染病及肿瘤治疗性人源抗体。另外对鼠等动物来源抗体进行人源化改造。

   

071010-生物化学与分子生物学

抗体药物作用机制研究及治疗性抗体药物研发
基于蛋白质结构的新型疫苗设计及研发
结构为基础的新型疫苗设计、抗体筛选及作用机制研究

2001-09--2004-07   中国人民解放军军事医学科学院生物工程研究所   博士
1986-09--1989-07   南京农业大学农学系   硕士
1982-09--1986-07   安徽师范大学生物系   学士

   

2012-07~现在, 中国科学院微生物研究所, 研究员
2004-07~2012-07,中国科学院微生物研究所, 副研究员
1989-07~2001-08,安徽农业大学, 讲师 副教授

2021-12-21-今,Trends in Microbiology, 顾问
2021-02-19-今,Journal of Genetics and Genomics, 编委
2019-01-01-今,北京医学会医学病毒学分会, 委员
2018-12-29-今,Biosafety and Health, 编委
2018-07-01-今,《科学通报》, 编委
2018-04-13-今,中国生物工程学会抗体专业委员会（筹）, 主任委员
2017-11-01-今,中国工程学会精准医疗与伴随诊断专业会员会, 副主任委员

生物药物研究与开发
分子病毒学
免疫治疗
重大慢性传染病
微生物学实验技术

   

（1） 领雁银奖·振翅奖, 研究所（学校）, 2021
（2） 中国科学院微生物研究所所长奖教金特别奖, 特等奖, 研究所（学校）, 2021
（3） 中国科学院优秀导师奖, 院级, 2021
（4） 中国科学院优秀导师奖, 院级, 2020
（5） 抗击新冠肺炎疫情全国三八红旗集体, 国家级, 2020
（6） 全国抗击新冠肺炎疫情先进个人, , 国家级, 2020
（7） 全国创新争先奖, , 国家级, 2020
（8） “求是”杰出成就集体奖, , 其他, 2019
（9） 禽流感病毒感染人的生态与分子机制研究, 一等奖, 部委级, 2017
（10） 中国生命科学领域十大进展, 部委级, 2016
（11） 我国新现超强致病链球菌跨种传播致中毒性休克机制破解和侦检防, 二等奖, 国家级, 2014

   

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（1） 寨卡病毒与之寨卡病毒病-预防与治疗用抗体, 人民卫生出版社, 2019-05, 第 1 作者

   

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