基本信息
丁健 男 博导 上海药物研究所
电子邮件:suozhang@mail.shcnc.ac.cn
通信地址:科苑新村10号楼1005室
邮政编码:201203

招生信息

   
招生专业
100706-药理学
招生方向
肿瘤药理

教育背景

1986-10--1991-10 日本国立九州大学 获博士学位
1980-09--1983-08 中国医科大学 获硕士学位
1975-11--1978-09 江西医学院 学习
学历
-- 研究生
学位
-- 博士

工作经历

   
工作简历
2005-01--2012-01 新药研究国家重点实验室 主任/研究员
2001-01--2003-01 国家新药筛选中心 主任/研究员
1996-08--2004-11 中科院上海药物研究所 副所长/研究员
1994-02--今 中科院上海药物研究所 课题组组长/研究员
1992-02--1994-02 中科院上海药物研究所 博士后
1991-11--1992-01 日本国立九州大学 访问学者
1978-10--1986-09 江西医学院 教师
1969-09--1975-09 江西省崇仁县插队落户 知识青年
社会兼职
2012-01--今 Molecular Pharmacology,编委
2009-11--今 Journal of Biological Chemistry,编委
2007-05--今 中国药理学会肿瘤药理专业委员会,主任委员
2007-05--今 中国抗癌协会抗癌药物专业委员会,主任委员
2007-01--今 Journal of Ethnopharmacology,编委
2007-01--今 Cancer Biology & Therapy,编委
2007-01--今 中国药理协会,常务理事
2007-01--今 中国抗癌协会,常务理事
2007-01--今 中国药学会,常任理事
2007-01--今 European Journal of Pharmacology,编委
2006-01--今 Acta Pharmacologica Sinica,主编

专利与奖励

   
奖励信息
(1) 国家自然科学奖,二等奖,国家级,2013
(2) 上海市自然科学一等奖,一等奖,省级,2010
(3) 国家自然科学奖二等奖,二等奖,国家级,2009
(4) 上海市自然科学一等奖,一等奖,省级,2007
专利成果
[1] 胡有洪, 陈奕, 谢志铖, 丁健, 李欣, 方艳芬, 沈倩倩. 含2-芳杂环取代的脲类化合物、其制备方法和用途. CN115703738A, 2023-02-17.
[2] 胡有洪, 陈奕, 张卓, 方艳芬, 蒋婧升, 沈倩倩, 龙国璋, 丁健, 陈五红. 去唾液酸糖蛋白受体配体与细胞毒素的偶联物及其应用. 202310079838.3, 2023-01-17.
[3] 胡有洪, 耿美玉, 李大强, 沈爱军, 张卓, 李亚磊, 杨华杰, 刘红椿, 钟韩悦, 丁健. 含S构型的氨基苯甲酰胺基哒嗪酮类化合物、其制备方法、药物组合物及应用. CN114957132A, 2022-08-30.
[4] 胡有洪, 陈奕, 曾艳萍, 丁健, 肖剑. 一种蛋白降解剂及其制备方法和用途. 2022105722297, 2022-05-24.
[5] 丁健, 段文虎, 谢华, 耿美玉, 王彩霞, 詹正生, 高娜, 张阳. CSF1R激酶抑制剂及其用途. CN: CN114246864A, 2022-03-29.
[6] 王春河, 耿美玉, 谢作权, 王艳菲, 许慧, 陈艺丽, 黄承浩, 罗文新, 夏宁邵, 丁健. 一种靶向HER2和PD-1的双特异性抗体及其应用. CN: CN111995685B, 2022-03-08.
[7] 耿美玉, 孙广强, 王薪懿, 张靖, 冯腾, 丁健. 甘露糖醛酸寡糖治疗Th1主导相关疾病的用途. CN: CN113924100A, 2022-01-11.
[8] 耿美玉, 孙广强, 王薪懿, 张靖, 冯腾, 丁健. 用于识别阿尔茨海默病患者中的糖类药物敏感性患者的方法. CN: CN113891730A, 2022-01-04.
[9] 耿美玉, 孙广强, 王薪懿, 张靖, 冯腾, 丁健. 通过调节氨基酸水平治疗阿尔茨海默病的方法. CN: CN113891716A, 2022-01-04.
[10] 耿美玉, 孙广强, 王薪懿, 张靖, 冯腾, 丁健. 通过调节肠道微生物治疗阿尔茨海默病的方法. CN: CN113874039A, 2021-12-31.
[11] 耿美玉, 孙广强, 王薪懿, 张靖, 冯腾, 丁健. 通过抑制T细胞摄取氨基酸治疗阿尔茨海默病的方法. CN: CN113874038A, 2021-12-31.
[12] 张翱, 耿美玉, 艾菁, 王彩霞, 彭霞, 张阳, 丁健. 一种CSF-1R激酶抑制剂的用途. CN: CN113318110A, 2021-08-31.
[13] 张翱, 耿美玉, 宋子兰, 谢作权, 丁健, 张燕, 顾王婷, 王玺渊. 一类杂环取代的苯并咪唑二聚体或其药学上可接受的盐、组合物及其用途. CN: CN113248475A, 2021-08-13.
[14] 丁克, 丁健, 陆小云, 耿美玉, 李姗, 谢华, 陈灏, 童林江, 任小梅, 冯芳. 2-氨基嘧啶类化合物及其应用. CN: CN113166110A, 2021-07-23.
[15] 张翱, 耿美玉, 宋子兰, 谢作权, 丁健, 张燕, 顾王婷, 王玺渊. 一类苯并咪唑二聚体、其制备方法及用途. CN: CN113087668A, 2021-07-09.
[16] 周兵, 耿美玉, 高愚哲, 谢作权, 杨亚玺, 王玺渊, 张燕, 丁健. 一种杂环化合物及其用途. CN: CN112940004A, 2021-06-11.
[17] 段文虎, 耿美玉, 詹正生, 谢作权, 赵凯燕, 郭玉婷, 王玺渊, 张燕, 周晓倩, 丁健. 五元杂环氧代羧酸类化合物及其医药用途. CN: CN112724127A, 2021-04-30.
[18] 段文虎, 丁健, 陈运, 谢华, 张惠斌, 周金培. 一类IRAK4激酶抑制剂及其制备和应用. CN: CN112480101A, 2021-03-12.
[19] 段文虎, 耿美玉, 张贺峰, 丁健, 艾菁, 彭霞, 季寅淳. 具有Axl与c-Met激酶抑制活性的化合物及其制备和应用. CN: CN112457295A, 2021-03-09.
[20] 丁克, 耿美玉, 陈成斌, 丁健, 谈理, 艾菁, 张章, 彭霞, 任小梅, 季寅淳, 涂正超, 戴阳, 陆小云. 喹啉或喹唑啉类化合物及其应用. CN: CN112351971A, 2021-02-09.
[21] 丁克, 耿美玉, 陈成斌, 丁健, 谈理, 艾菁, 张章, 彭霞, 任小梅, 季寅淳, 段云鑫, 戴阳, 涂正超, 陆小云. 3-氨基吡唑类化合物及其应用. CN: CN112313213A, 2021-02-02.
[22] 柳红, 耿美玉, 周宇, 丁健, 方非非, 艾菁, 李建, 彭霞, 蒋华良, 季寅淳, 陈凯先. 一类并环吡唑啉酮甲酰胺类化合物及其制备方法、药物组合物和用途. CN: CN112236430A, 2021-01-15.
[23] 李洪林, 丁健, 徐玉芳, 谢华, 李倩男, 张弢, 赵振江. 喹唑啉类化合物作为EGFR三突变抑制剂及其应用. CN: CN112236422A, 2021-01-15.
[24] 胡有洪, 耿美玉, 陈菁菁, 沈爱军, 谢志铖, 刘红椿, 曾丽敏, 李亚磊, 彭润泽, 张敏敏, 张婕, 丁健. 一种吡咯并吡啶酮类化合物、其制备方法、其组合物和用途. CN: CN112094266A, 2020-12-18.
[25] 张翱, 丁健, 谢华, 宋子兰, 薛宇, 邢莉, 童林江, 耿美玉. 嘧啶并5,4-b吡呤化合物、其光学异构体、制备方法及用途. CN: CN111848634A, 2020-10-30.
[26] 李波, 谢华, 刘鹏, 童林江, 周云飞, 张勇, 徐志建, 施菊妹, 朱维良, 丁健. 芳基酮酰胺类化合物及其制备方法和用途. CN: CN111825605A, 2020-10-27.
[27] 夏林, 耿美玉, 叶艳, 丁健, 张琼, 沈爱军, 黄颖, 刘红椿, 杨浩然, 艾菁, 张敏敏. 具有BET抑制活性的化合物及其制备方法和用途. CN: CN111683932A, 2020-09-18.
[28] 胡有洪, 丁健, 唐炜, 谢华, 谢志铖, 童林江, 任文明, 高远卓. 邻氨基吡啶炔类化合物及其制备方法和用途. CN: CN111662227A, 2020-09-15.
[29] 杨春皓, 缪泽鸿, 陈旭星, 宦霞娟, 王玉勤, 谭村, 陈奕. 2-取代苯并咪唑-4-甲酰胺类化合物及制备方法和应用. CN: CN107922430B, 2020-09-04.
[30] 耿美玉, 丁健, 艾菁. 癌症患者根据脾酪氨酸激酶进行分层. CN: CN111521810A, 2020-08-11.
[31] 张翱, 耿美玉, 丁春勇, 谢作权, 丁健, 张燕, 沈安成, 王玺渊. 一类含氟取代的苯并噻吩类化合物及其药物组合物及应用. CN: CN111393405A, 2020-07-10.
[32] 段文虎, 丁健, 陈运, 谢华, 张惠斌, 周金培. 一类FLT3激酶抑制剂及其制备和应用. CN: CN111217816A, 2020-06-02.
[33] 丁克, 丁健, 申佳奕, 耿美玉, 陆小云, 谢华, 孙敏, 宗在伟. 嘧啶并吡啶酮或者吡啶并吡啶酮类化合物及其应用. CN: CN110914267A, 2020-03-24.
[34] 耿美玉, 丁健, 黄洵. EZH2异常相关癌症的治疗. CN: CN110856720A, 2020-03-03.
[35] 耿美玉, 辛现良, 张真庆, 丁健. 甘露糖醛二酸的组合物在治疗炎症中的应用. CN: CN110652525A, 2020-01-07.
[36] 耿美玉, 辛现良, 杜晓光, 张真庆, 丁健. 甘露糖醛二酸的组合物在治疗血管性痴呆症中的应用. CN: CN110652523A, 2020-01-07.
[37] 耿美玉, 张真庆, 晋迎申, 肖中平, 丁健. 褐藻胶寡糖二酸的组合物. CN: CN110652517A, 2020-01-07.
[38] 耿美玉, 辛现良, 杜晓光, 张真庆, 丁健. 甘露糖醛二酸的组合物在治疗帕金森氏症中的应用. CN: CN110652516A, 2020-01-07.
[39] 耿美玉, 辛现良, 张真庆, 丁健. 甘露糖醛二酸的组合物在治疗糖尿病中的应用. CN: CN110652526A, 2020-01-07.
[40] 耿美玉, 辛现良, 张真庆, 丁健. 甘露糖醛二酸的组合物在治疗疼痛中的应用. CN: CN110652524A, 2020-01-07.
[41] 胡有洪, 耿美玉, 任文明, 丁健, 官晓聪, 艾菁, 王浪, 彭霞, 刘杨, 戴阳, 曾丽敏. 含邻氨基杂芳环炔基的化合物及其制备方法和用途. CN: CN110582483A, 2019-12-17.
[42] 柳红, 耿美玉, 周宇, 丁健, 方非非, 艾菁, 李建, 彭霞, 蒋华良, 季寅淳, 陈凯先. 一类并环吡唑啉酮甲酰胺类化合物及其制备方法、药物组合物和用途. CN: CN110511218A, 2019-11-29.
[43] 赵玉军, 陈德恒, 郭德祥, 严子琴, 周飞龙, 耿美玉, 丁健, 沈爱军, 刘红椿, 张敏敏. 一种BRD4抑制剂及其制备和应用. CN: CN110506044A, 2019-11-26.
[44] 陈庆财, 丁健, 丁克, 金雪锋, 耿美玉, 谢华. 一种2-氨基嘧啶类化合物的药用组合物及其制备方法. CN: CN110446701A, 2019-11-12.
[45] 熊兵, 耿美玉, 郭祖浩, 黄洵, 沈竞康, 丁健, 杨红, 张竹青, 陈丹琦. 一类精氨酸甲基转移酶抑制剂及其药物组合物和用途. CN: CN110343095A, 2019-10-18.
[46] 丁克, 丁健, 李姗, 谢华, 陆小云, 耿美玉, 任小梅, 童林江. 2-氨基嘧啶类化合物及其应用. CN: CN110305161A, 2019-10-08.
[47] 张翱, 耿美玉, 宋子兰, 艾菁, 顾王婷, 刘博, 丁健. 一类芳基二氟苄基醚类化合物、制备方法及用途. CN: CN110240587A, 2019-09-17.
[48] 陈旭星, 耿美玉, 赵兆, 陈奕, 黄颖, 丁健, 张琼, 沈倩倩, 苏毅. 嘧啶并五元芳香杂环类化合物、其制备方法及用途. CN: CN110229157A, 2019-09-13.
[49] 陈旭星, 陈奕, 黄颖, 耿美玉, 张琼, 丁健, 姚虞财, 沈倩倩, 沈雁雁. 吲嗪类化合物、其制备方法及用途. CN: CN110229151A, 2019-09-13.
[50] 谭村, 张小飞, 杨春皓, 缪泽鸿, 宋姗姗, 宦霞娟, 陈奕, 丁健. 酞嗪酮类衍生物、其制备方法和用途. CN: CN110194762A, 2019-09-03.
[51] 张翱, 蒙凌华, 丁健, 陈树伦, 丁春勇, 郭伟. 含杂环侧链的噁二唑衍生物、合成方法及其应用. CN: CN110143955A, 2019-08-20.
[52] 耿美玉, 沈爱军, 刘红椿, 张敏敏, 丁健. 治疗肝癌的药物组合和方法. CN: CN110063956A, 2019-07-30.
[53] 段文虎, 耿美玉, 王蔚, 丁健, 艾菁, 许丹丹, 彭霞, 曹素芬, 季寅淳. 一种具有AXL抑制活性的化合物及其制备和应用. CN: CN110036014A, 2019-07-19.
[54] 南发俊, 丁健, 耿美玉, 陈奕, 胡有洪, 陈悦婷, 徐济民, 刘桦楠. EZH2抑制剂及其制备和抗肿瘤治疗中的应用. CN: CN110016014A, 2019-07-16.
[55] 张翱, 丁健, 谢华, 宋子兰, 薛宇, 童林江, 耿美玉. 嘧啶并5,4-b吲嗪或嘧啶并5,4-b吡呤化合物、其制备方法及用途. CN: CN109983016A, 2019-07-05.
[56] 李磊, 耿美玉, 黄颖, 丁健, 张琼, 黄敏, 唐帅, 沈宁, 陈奕. 具有ERK激酶抑制活性的化合物及其用途. CN: CN109863147A, 2019-06-07.
[57] 丁克, 寻秋菊, 丁健, 陆小云, 谢华, 张章, 耿美玉, 任小梅, 童林江. 嘧啶并嘧啶酮类化合物及其应用. CN: CN109836427A, 2019-06-04.
[58] 陈旭星, 耿美玉, 江磊, 陈奕, 曹建华, 蒋青云, 沈倩倩, 丁健, 姚虞财, 赵兆, 熊远芳. 吡啶并五元芳香环类化合物、其制备方法及用途. CN: CN109790160A, 2019-05-21.
[59] 南发俊, 李佳, 丁健, 耿美玉, 张仰明, 陈奕, 周宇波, 龚超骏, 苏明波, 高安慧. 一类芳基2,2’-串联双噻唑类化合物及其制备方法和用途. CN: CN109641888A, 2019-04-16.
[60] 段文虎, 耿美玉, 王玉明, 艾菁, 范珺, 戴阳, 丁健. 一种具有FGFR抑制活性的新型化合物及其制备和应用. CN: CN109328187A, 2019-02-12.
[61] 段文虎, 耿美玉, 王玉明, 艾菁, 范珺, 戴阳, 丁健. 一种具有FGFR抑制活性的新型化合物及其制备和应用. CN: CN109328187A, 2019-02-12.
[62] 杨玉社, 钮奥, 汪洋, 谢华, 丁健. 新型嘧啶并杂环类化合物及制备方法和用途. CN: CN109305967A, 2019-02-05.
[63] 胡有洪, 耿美玉, 段文文, 丁健, 万鹏辉, 沈爱军, 陆栋, 刘红椿, 魏爱环, 张敏敏, 曾丽敏, 曹靖晨. 一种哒嗪酮母核结构的组蛋白去乙酰化酶抑制剂及其制备方法和用途. CN: CN109280032A, 2019-01-29.
[64] 杨春皓, 缪泽鸿, 陈建阳, 宦霞娟, 丁健, 陈奕, 谭村, 贺茜. 吡咯1,2-b哒嗪类化合物或其可药用盐及它们的用途. CN: CN109232575A, 2019-01-18.
[65] 杨春皓, 缪泽鸿, 谭村, 宦霞娟, 丁健, 陈奕. 盐酸美呋哌瑞多晶型物及其制备方法与应用. CN: CN109134409A, 2019-01-04.
[66] 杨春皓, 蒙凌华, 向皞月, 李京, 王祥, 谭村, 贺茜, 丁健, 陈奕. 7-位取代吡咯并三嗪类化合物或其药学上可用的盐,及其制备方法和用途. CN: CN109111447A, 2019-01-01.
[67] 段文虎, 耿美玉, 詹正生, 艾菁, 丁健. 氘代SGX523及其用途. CN: CN108864101A, 2018-11-23.
[68] 李洪林, 丁健, 徐玉芳, 谢华, 赵振江, 陈海洋, 刁妍妍. 作为BTK抑制剂的杂环化合物及其应用. CN: CN108727382A, 2018-11-02.
[69] 李洪林, 丁健, 徐玉芳, 谢华, 赵振江, 陈海洋, 刁妍妍. 作为布鲁顿酪氨酸激酶抑制剂的嘧啶并杂环化合物及其应用. CN: CN108721298A, 2018-11-02.
[70] 赵玉军, 陈德恒, 郭德祥, 严子琴, 周飞龙, 耿美玉, 丁健, 沈爱军, 刘红椿, 张敏敏. 一种BRD4抑制剂及其制备和应用. CN: CN108727380A, 2018-11-02.
[71] 张翱, 耿美玉, 邢莉, 艾菁, 宋子兰, 彭霞, 顾王婷, 丁健. 一类取代的氨基六元氮杂环类化合物及其制备和用途. CN: CN108699030A, 2018-10-23.
[72] 沈竞康, 丁健, 耿美玉, 熊兵, 艾菁, 马宇驰, 戴阳. 五元杂环并吡嗪化合物、制备方法、中间体、组合和应用. CN: CN108570052A, 2018-09-25.
[73] 沈竞康, 丁健, 耿美玉, 熊兵, 艾菁, 马宇驰, 戴阳. 五元并六元杂环化合物、制备方法、中间体、组合和应用. CN: CN108570053A, 2018-09-25.
[74] 陈庆财, 丁健, 丁克, 金雪锋, 耿美玉, 谢华. 一种2-氨基嘧啶类化合物的药用组合物及其制备方法. CN: CN108498477A, 2018-09-07.
[75] 丁克, 耿美玉, 谈理, 丁健, 张章, 艾菁, 任小梅, 高冬林, 涂正超, 陆小云, 张冬梅. 取代喹诺酮类衍生物或其药学上可接受的盐或立体异构体及其药用组合物和应用. CN: CN108473434A, 2018-08-31.
[76] 胡有洪, 耿美玉, 任文明, 丁健, 官晓聪, 艾菁, 彭霞, 刘杨, 戴阳, 王浪, 曾丽敏. 含邻氨基杂芳环炔基的化合物及其制备方法和用途. CN: CN108456163A, 2018-08-28.
[77] 吕伟, 刘双喜, 陈奕, 张秋萌, 沈倩倩, 丁健. 伏立诺他和紫杉醇的共前药及其制备方法与应用. CN: CN108424405A, 2018-08-21.
[78] 张翱, 缪泽鸿, 王平原, 宋姗姗, 宋子兰, 宦霞娟, 樊州龙, 丁健. 一类取代三唑并哌嗪类PARP抑制剂及其制备方法和用途. CN: CN108290897A, 2018-07-17.
[79] 胡有洪, 陈笑艳, 丁健, 任文明, 钟大放, 陈奕, 谢华. 吲哚-1-碳酸酯类化合物、其制备方法和应用. CN: CN108250187A, 2018-07-06.
[80] 段文虎, 耿美玉, 王蔚, 丁健, 艾菁, 许丹丹, 彭霞, 曹素芬, 季寅淳. 一种具有Axl抑制活性的化合物及其制备和应用. CN: CN108250200A, 2018-07-06.
[81] 张翱, 丁健, 谢华, 宋子兰, 薛宇, 童林江, 耿美玉. 嘧啶并5,4-b吲嗪或嘧啶并5,4-b吡呤化合物、其制备方法及用途. CN: CN108101905A, 2018-06-01.
[82] 曹建华, 耿美玉, 黄敏, 江磊, 李磊, 唐帅, 冯加权, 杨晓彤, 郑红艳, 吴英雄, 任芳芳, 丁健. 具有ERK激酶抑制活性的化合物、其制备方法和用途. CN: CN107922405A, 2018-04-17.
[83] 杨春皓, 缪泽鸿, 陈旭星, 宦霞娟, 王玉勤, 谭村, 陈奕, 丁健. 2‑取代苯并咪唑‑4‑甲酰胺类化合物及制备方法和应用. CN: CN107922430A, 2018-04-17.
[84] 南发俊, 李佳, 丁健, 耿美玉, 张仰明, 陈奕, 周宇波, 龚超骏, 苏明波, 高安慧. 一类芳基2,2’‑串联双噻唑类化合物及其制备方法和用途. CN: CN107793375A, 2018-03-13.
[85] 朱维良, 蒙凌华, 李波, 王贺瑶, 徐志建, 王祥, 朱剑明, 郭彬彬, 王桂敏, 李钊, 丁健. 去氮嘌呤类化合物及其药物组合物、制备方法和用途. CN: CN107722013A, 2018-02-23.
[86] 江磊, 耿美玉, 郑乾刚, 黄敏, 万惠新, 唐帅, 付贤磊, 兰小晶, 曹建华, 丁健. 具有突变型异柠檬酸脱氢酶抑制活性的化合物、其制备方法及用途. CN: CN107556366A, 2018-01-09.
[87] 梅雪锋, 丁克, 丁健, 谢华, 陈成斌, 赵俊, 宋婷婷, 宗在伟, 孙敏. 一种2‑氨基嘧啶类化合物的多晶型形式. CN: CN107417626A, 2017-12-01.
[88] 江磊, 耿美玉, 郑乾刚, 黄敏, 万惠新, 唐帅, 付贤磊, 兰小晶, 曹建华, 刘斐斐, 丁健. 一种具有突变型IDH抑制活性的化合物、其制备方法及用途. CN: CN107216312A, 2017-09-29.
[89] 张翱, 耿美玉, 宋子兰, 艾青, 刘志清, 陈奕, 彭霞, 丁健. 一种2,4-二氨基嘧啶类衍生物、其制备方法及用途. CN: CN107216319A, 2017-09-29.
[90] 赵兴东, 丁健, 蒙凌华. 蛋白激酶抑制剂. CN: CN107207441A, 2017-09-26.
[91] 黄成钢, 李佳, 李志雄, 李静雅, 孙兆林, 潘国宇, 陈明苍, 田小亭, 崔仕超, 林云飞, 刘磊, 江磊, 丁健. 含小檗碱和知母皂苷的组合物及其应用. CN: CN107184590A, 2017-09-22.
[92] 李英霞, 丁健, 闫琪, 耿美玉, 谢华. 嘧啶类化合物. CN: CN107098887A, 2017-08-29.
[93] 张翱, 耿美玉, 邢莉, 艾菁, 宋子兰, 彭霞, 顾王婷, 丁健. 一类取代的氨基吡啶类化合物及其制备和用途. CN: CN107098884A, 2017-08-29.
[94] 张翱, 蒙凌华, 魏曼曼, 张希, 丁健. 一类取代喹唑啉-4-酮类化合物及其制备方法和医药用途. CN: CN106995438A, 2017-08-01.
[95] 曹建华, 耿美玉, 黄敏, 江磊, 李磊, 唐帅, 冯家权, 杨晓彤, 丁健. 具有ERK激酶抑制活性的化合物、其制备方法和用途. CN: CN106928216A, 2017-07-07.
[96] 张翱, 缪泽鸿, 王平原, 宦霞娟, 丁健. 一类取代三唑并哌嗪类PARP抑制剂及其制备方法和用途. CN: CN106749261A, 2017-05-31.
[97] 李英霞, 丁健, 肖强, 耿美玉, 刘建, 谢华. 5-(硫醚基)嘧啶类化合物及其药用组合物和应用. CN: CN106608868A, 2017-05-03.
[98] 黄成钢, 李佳, 李志雄, 李静雅, 孙兆林, 潘国宇, 陈明苍, 田小亭, 崔仕超, 林云飞, 刘磊, 江磊, 丁健. 含有螺甾烷化合物的组合物及其用途. CN: CN106551943A, 2017-04-05.
[99] 丁克, 耿美玉, 谈理, 丁健, 张章, 艾菁, 任小梅, 高冬林, 涂正超, 陆小云, 张冬梅. 取代喹诺酮类衍生物或其药学上可接受的盐或立体异构体及其药用组合物和应用. CN: CN106467541A, 2017-03-01.
[100] 丁克, 丁健, 陈成斌, 耿美玉, 任小梅, 谢华, 涂正超, 陈奕. 2‑氨基嘧啶类化合物及其药物组合物和应用. CN: CN106458930A, 2017-02-22.
[101] 段文虎, 耿美玉, 严伟, 丁健, 艾菁, 赵彬, 范珺, 彭霞, 陈奕. 吲唑类化合物的制备方法和用途. CN: CN106317023A, 2017-01-11.
[102] 曹建华. 一类具有激酶抑制活性的化合物、制备方法和用途. CN: CN106317055A, 2017-01-11.
[103] 段文虎, 耿美玉, 詹正生, 艾菁, 丁健. 氘代的3-(6-喹啉基)二氟甲基-6-(1-甲基)-4-吡唑基1,2,4三唑并4,3-b哒嗪及其应用. CN: CN106279176A, 2017-01-04.
[104] 柳红, 耿美玉, 朱未, 黄敏, 陈先杰, 刘红椿, 何玉龙, 李淳朴, 丁健, 蒋华良, 陈凯先. 苯并吡唑联吡啶类化合物、包含此类化合物的药物组合物及其用途. CN: CN106279101A, 2017-01-04.
[105] 刘磊, 程鹏, 耿美玉, 曹文杰, 江磊, 艾菁, 黄敏, 杨新颖, 查传涛, 曹建华, 陈春麟, 丁健. 一种新型激酶抑制剂的制备及其应用. CN: CN106279119A, 2017-01-04.
[106] 郭仕艳, 甘勇, 张翱, 缪泽鸿, 高丽, 丁健. SOMCL-9112固体分散体、其制备方法及包含其的SOMCL-9112固体制剂. CN: CN106265580A, 2017-01-04.
[107] 万惠新, 耿美玉, 程鹏, 黄敏, 江磊, 曹建华, 陈筑熙, 李磊, 唐帅, 苏毅, 曹文杰, 刘磊, 陈春麟, 丁健. 一类具有激酶抑制活性的化合物、制备方法和用途. 中国: CN106188038A, 2016.12.07.
[108] 万惠新, 耿美玉, 程鹏, 黄敏, 江磊, 曹建华, 陈筑熙, 李磊, 唐帅, 苏毅, 曹文杰, 刘磊, 陈春麟, 丁健. 一类具有激酶抑制活性的化合物、制备方法和用途. CN: CN106188038A, 2016-12-07.
[109] 段文虎, 耿美玉, 赵彬, 丁健, 艾菁, 范珺, 彭霞, 严伟, 陈奕. 吡唑并3,4-b吡啶类和吲唑类化合物的制备方法和用途. CN: CN106146493A, 2016-11-23.
[110] 李英霞, 耿美玉, 刘健, 丁健, 张伟, 艾菁. 吲唑类化合物及其制备方法和用途. CN: CN106032359A, 2016-10-19.
[111] 杨春皓, 缪泽鸿, 张小飞, 衣君玫, 贺茜, 宦霞娟, 宋姗姗, 王迎庆, 陈奕, 丁健. α-咔啉类化合物,其制备方法以及用途. CN: CN105820165A, 2016-08-03.
[112] 丁克, 丁健, 陈成斌, 耿美玉, 任小梅, 谢华, 涂正超, 陈奕. 2-氨基嘧啶类化合物及其药物组合物和应用. CN: CN105601573A, 2016-05-25.
[113] 张翱, 耿美玉, 宋子兰, 艾菁, 郭俊峰, 彭霞, 季寅淳, 丁健. 一类杂环取代的吲哚并萘酮衍生物、其制备方法、药物组合物及其用途. CN: CN105566307A, 2016-05-11.
[114] 耿美玉, 刘磊, 江磊, 黄敏, 查传涛, 艾菁, 王磊, 曹建华, 丁健. 作为FGFR激酶抑制剂的吲唑类化合物及其制备和应用. CN: CN105524048A, 2016-04-27.
[115] 丁健, 艾菁, 陈奕, 黄洵. 一种硫酸酯化聚古洛糖酸多糖或其可药用盐及其制备方法和用途. CN: CN105358582A, 2016-02-24.
[116] 张翱, 缪泽鸿, 王平原, 宦霞娟, 丁健. 一类氮芳基苯并噻唑类PARP抑制剂及其制备方法和用途. CN: CN105272936A, 2016-01-27.
[117] 江磊, 耿美玉, 丁健, 刘磊, 黄敏, 查传涛, 艾菁. 一种新型杂环化合物及其制备方法和作为激酶抑制剂的用途. CN: CN105218548A, 2016-01-06.
[118] 段文虎, 丁健, 吕永聪, 谢华. 萘酰胺类化合物、其制备方法和用途. CN: CN104860885A, 2015-08-26.
[119] 王为波, 耿美玉, 丁健, 赵兴东, 艾菁, 田强, 彭霞, 张卫鹏, 刘洪彬, 谭浩瀚, 陈岭. ALK激酶抑制剂. CN: CN104854101A, 2015-08-19.
[120] 段文虎, 丁健, 吕永聪, 谢华. 苯胺嘧啶类化合物、其制备方法和医药用途. CN: CN104829542A, 2015-08-12.
[121] 吕伟, 王磊, 陈奕, 丁健. 一类新型高喜树碱衍生物、制备方法和用途. CN: CN104530066A, 2015-04-22.
[122] 丁健, 艾菁, 陈奕, 黄洵. 一种硫酸酯化聚古洛糖酸多糖或其可药用盐及其制备方法和用途. CN: CN104277130A, 2015-01-14.
[123] 张倩, 丁健, 晋建文, 谢华, 董孟杰, 童林江, 刘振峰. 2-氟代喹唑啉环类化合物及其制备方法和药用用途. CN: CN104230826A, 2014-12-24.
[124] 张翱, 耿美玉, 宋子兰, 艾菁, 刘志清, 陈奕, 彭霞, 丁健. 2,4-二氨基嘧啶类化合物及其医药用途. CN: CN104230954A, 2014-12-24.
[125] 胡有洪, 耿美玉, 刘杨, 丁健, 艾菁. 一类炔基杂环类化合物及其应用. CN: CN104211639A, 2014-12-17.
[126] 张翱, 耿美玉, 宋子兰, 艾菁, 赵垠莹, 彭霞, 丁健. 杂环取代的吲哚并萘酮衍生物、其制备方法、药物组合物及其用途. CN: CN104211687A, 2014-12-17.
[127] 张翱, 耿美玉, 丁健, 宋子兰, 艾菁, 李晓刚, 彭霞. 杂环基取代的吲哚并萘酮衍生物及其医药用途. CN: CN104177342A, 2014-12-03.
[128] 张翱, 耿美玉, 丁健, 宋子兰, 艾菁, 李晓刚, 彭霞. 酰胺基取代的吲哚并萘酮衍生物及其医药用途. CN: CN104177332A, 2014-12-03.
[129] 李剑, 缪泽鸿, 丁健, 蒋华良, 刘云霞, 宦霞娟, 宋姗姗, 陈奕, 任国宾. 2,4-二氟-5-(酞嗪酮-1-甲基)-苯甲酰哌嗪类化合物及其用途. CN: CN104003940A, 2014-08-27.
[130] 郭跃伟, 丁健, 周振芳, 刘海利, 许承辉. 木果楝庚素及其制备方法和用途. CN: CN103864876A, 2014-06-18.
[131] 张翱, 缪泽鸿, 叶娜, 宦霞娟, 宋子兰, 陈川惠子, 陈奕, 丁健. 一类哒嗪酮类化合物及其制备方法和用途. CN: CN103833756A, 2014-06-04.
[132] 胡有洪, 耿美玉, 邢唯强, 丁健, 艾菁. 哒嗪酮类化合物、其制备方法、药物组合物及其用途. CN: CN103664895A, 2014-03-26.
[133] 张翱, 耿美玉, 刘志清, 丁健, 艾菁, 彭霞, 宋子兰, 张静, 纪寅淳. 苯氮卓类化合物及其制备方法和用途. CN: CN103664903A, 2014-03-26.
[134] 沈竞康, 丁健, 蒙凌华, 孟韬, 周华勇, 马兰萍, 胡定宇, 王昕, 王艺, 陈奕. 双环稠杂环化合物及其用途和药物组合物. CN: CN103626783A, 2014-03-12.
[135] 张翱, 缪泽鸿, 叶娜, 宦霞娟, 宋子兰, 陈川惠子, 陈奕, 丁健. 具有桥环结构的稠环哒嗪酮类化合物及其制备方法和用途. CN: CN103570730A, 2014-02-12.
[136] 张翱, 缪泽鸿, 叶娜, 宦霞娟, 宋子兰, 陈川惠子, 陈奕, 丁健. 哌嗪并三唑类化合物及其制备方法和用途. CN: CN103570725A, 2014-02-12.
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出版信息

   
发表论文
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[451] 卿晨, 张金生, 丁健. 新二萜醌类化合物salvicine体外抗肿瘤作用及其诱导凋亡机制的研究. 1999, 375-376, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CPFD&dbname=CPFD0914&filename=ZYTN199911001102&v=MTY3MDFWb2NQelRmWUxLeEY5ak5ybzlGWmVvUERoTkt1aGRobmo5OFRuanFxeGRFZU1PVUtyaWZaZVp2SGludFVMN0pK.
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[454] 袁胜涛, 肖东, 智强, 陆丽娟, 许承辉, 韩家娴, 杨蔚怡, 张家骝, 丁健. 血管形成抑制剂重组人内抑素抗肿瘤作用研究. 1999, 379-380, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CPFD&dbname=CPFD0914&filename=ZYTN199911001104&v=MTE3NDZqcXF4ZEVlTU9VS3JpZlplWnZIaW50VUw3SkpGc1JQelRmWUxLeEY5ak5ybzlGWmVvUENCTkt1aGRobmo5OFRu.
[455] 张金生, 丁健, 卿晨. 新二萜醌化合物杀尔威辛的体外细胞毒作用. ACTAPHARMACOLOGICASINICA[J]. 1999, 20(4): 297-, [456] 萧东, 丁健. 肿瘤血管生成抑制剂的研究现状及我国的发展战略探讨. 世界科技研究与发展[J]. 1999, 3-5, http://lib.cqvip.com/Qikan/Article/Detail?id=3870176.
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发表著作
(1) 高等药理学,Higher pharmacology,科学出版社,2013-05,第1作者

科研活动

   
科研项目
(1) 用于脑部肿瘤治疗的新型纳米药物研究,主持,国家级,2013-01--2016-12
(2) 免疫稳态失衡在炎癌转化的开关机制-免疫负性调控因子SIRPα 在免疫球蛋白受体pIgR 免疫背叛中的,主持,国家级,2013-01--2015-12
(3) 组蛋白甲基转移酶G9a在乳腺癌转移中的作用及机制研究?,主持,国家级,2013-01--2016-12
(4) 化学创新药物研发体系建设,参与,国家级,2012-01--2015-12
(5) 针对分子靶点的抗肿瘤药物发现及其机理研究,主持,国家级,2011-01--2013-12
(6) 基于蛋白质结构与功能的药物多靶标作用机制研究,参与,院级级,2011-01--2013-12
(7) 中国药物技术创新战略联盟,主持,部委级,2010-01--2012-12
(8) 1. 化学创新药物研发体系建设,主持,国家级,2009-06--2010-12
(9) 土槿皮乙酸对新生血管生成和微管抑制作用分子机制的深入研究,主持,国家级,2008-01--2011-12

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