070321-化学生物学
070303-有机化学
100705-微生物与生化药学

天然产物生物合成，化学生物学
微生物生理与生化，合成生物学
微生物药物

1994-09--1999-07   中国科学院上海有机化学研究所   硕博联读/博士
1990-09--1994-06   南开大学   本科/学士
1987-09--1990-06   山东省龙口市第一中学   高中

-- 研究生

-- 博士

   

2003-09~现在, 中国科学院上海有机化学研究所, 课题组长
2001-07~2003-08,美国威斯康辛大学药学院, 研究助理
2000-09~2001-06,美国加州大学戴维斯分校化学系, 博士后
1999-08~2000-08,中科院上海有机所, 课题组副组长/助研、副研

2014-06-15-今,沈阳药科大学兼职教授,

天然产物生物合成
核酸化学；天然产物生物合成
核酸与蛋白质；天然产物生物合成
核酸与蛋白质、天然产物生物合成
核酸与蛋白质化
核酸与蛋白质化学概论

   

[1] 唐功利, 张媚, 潘海学. 三欣卡辛的生物合成基因簇及其应用. CN: CN104911196B, 2020-04-28.

[2] 唐功利, 董雷, 侯现锋, 潘海学. 新型LL-D49194al类似物，及其制备方法和应用. ZL 201910156416.5, 2019-03-01.

[3] 唐功利, 胡煜, 张转, 潘海学. 阿克拉霉素类似物及其制法和用途. CN: CN108864221A, 2018-11-23.

[4] 唐功利, 姜浩, 潘海学, 赵娟, 李岩. 一种构建FK520高产工程菌株的方法和吸水链霉菌高产菌株. CN: CN107629994A, 2018-01-26.

[5] 唐功利, 孟松, 潘海学, 赵娟. 双环霉素生物合成中六个氧化酶的功能及其应用. ZL201711184703.4, 2017-11-23.

[6] 唐功利, 马宏敏, 周强, 张转. 越野他汀的生物合成基因簇及其应用. CN: CN103215282B, 2016-08-03.

[7] 唐功利, 李玮涛, 潘海学, 蹇晓红. 金核霉素的生物合成基因簇及其应用. CN: CN103540603B, 2015-10-28.

[8] 唐功利, 黄伟, 李燕, 张凤, 徐慧. 谷田霉素的生物合成基因簇. CN: CN102174531B, 2014-04-09.

[9] 唐功利, 王健博. 一种改造除虫链霉菌产生多拉菌素的方法. CN: CN102093997B, 2013-03-13.

[10] 唐功利, 张凤. FR901464的生物合成基因簇. CN: CN101818158B, 2013-03-13.

[11] 唐功利, 王健博. 利用调控蛋白基因提高阿维菌素的产量. CN: CN101724646B, 2012-07-18.

[12] 唐功利, 王健博. 利用初级糖代谢基因提高阿维菌素的产量. CN: CN101717778B, 2012-06-27.

[13] 唐功利, 刘文, 李磊. 番红霉素的生物合成基因簇. CN: CN101157929B, 2012-05-23.

   

[1] Ning Shao, Xueyang Ma, YingYing Zhang, Donghui Yang, Ming Ma, GongLi Tang. Dihydrofolate reductase-like protein inactivates hemiaminal pharmacophore for self-resistance in safracin biosynthesis. ACTA PHARMACEUTICA SINICA B[J]. 2023, 13(3): 1318-1325, http://dx.doi.org/10.1016/j.apsb.2022.10.005.
[2] He, JunBin, Wu, Lian, Wei, Wanqing, Meng, Song, Liu, ZhengTao, Wu, Xuan, Pan, HaiXue, Yang, Sheng, Liang, Yong, Zhou, Jiahai, Tang, GongLi. Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis. NATURE CATALYSIS. 2023, http://dx.doi.org/10.1038/s41929-023-00987-4.
[3] 王飞, 金文兵, 侯现锋, 潘海学, 唐功利. 金核霉素生物合成途径的体内研究和关键代谢物鉴定. 有机化学[J]. 2023, 43: 2561-2566, [4] Chen, Xiaorong, Pan, HaiXue, Tang, GongLi. Newly Discovered Mechanisms of Antibiotic Self-Resistance with Multiple Enzymes Acting at Different Locations and Stages. ANTIBIOTICS-BASEL[J]. 2023, 12(1): 35-, [5] Zhang, YingYing, Shao, Ning, Wen, WanHong, Tang, GongLi. A Cryptic Palmitoyl Chain Involved in Safracin Biosynthesis Facilitates Post-NRPS Modifications. ORGANIC LETTERS[J]. 2022, 24(1): 127-131, http://dx.doi.org/10.1021/acs.orglett.1c03741.
[6] Pei, ZengFei, Yang, MinJie, Zhang, Kai, Jian, XiaoHong, Tang, GongLi. Heterologous characterization of mechercharmycin A biosynthesis reveals alternative insights into post-translational modifications for RiPPs. CELL CHEMICAL BIOLOGY[J]. 2022, 29(4): 650-+, http://dx.doi.org/10.1016/j.chembiol.2021.08.005.
[7] Nie, QiuYue, Hu, Yu, Hou, XianFeng, Tang, GongLi. Biosynthesis of DNA-Alkylating Antitumor Natural Products. MOLECULESnull. 2022, 27(19): http://dx.doi.org/10.3390/molecules27196387.
[8] 唐功利. Heterologous characterization of mechercharmycin A biosynthesis reveals alternative insights into post-translational modifications for RiPPs.. Cell Chem. Biol.[J]. 2022, [9] Zou, ZiRuo, Zhang, Kai, Han, TingYan, Zhou, Qiang, Lin, Shuangjun, Hou, XianFeng, Tang, GongLi. Two-enzyme cascade catalyzed trideuteromethylative modification of natural products. TETRAHEDRON[J]. 2022, 129: http://dx.doi.org/10.1016/j.tet.2022.133137.
[10] Han, TingYan, Zhang, Kai, Tang, GongLi, Zhou, Qiang. Characterizing Post-PKS Modifications of 16-Demethyl-rifamycin Revealed Two Dehydrogenases Diverting the Aromatization Mode of Naphthalenic Ring in Ansamycin Biosynthesis. CHINESE JOURNAL OF CHEMISTRY[J]. 2022, 40(13): 1553-1558, http://dx.doi.org/10.1002/cjoc.202200098.
[11] Gao, YuHang, Nie, QiuYue, Hu, Yu, Lu, Xinhua, Xiang, Wensheng, Wang, Xiangjing, Tang, GongLi. Discovery of glycosylated naphthacemycins and elucidation of the glycosylation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2022, 622: 122-128, http://dx.doi.org/10.1016/j.bbrc.2022.06.095.
[12] Chen, Xiaorong, Bradley, Noah P, Lu, Wei, Wahl, Katherine L, Zhang, Mei, Yuan, Hua, Hou, XianFeng, Eichman, Brandt F, Tang, GongLi. Base excision repair system targeting DNA adducts of trioxacarcin/LL-D49194 antibiotics for self-resistance. NUCLEIC ACIDS RESEARCH[J]. 2022, 50(5): 2417-2430, http://dx.doi.org/10.1093/nar/gkac085.
[13] Hu, Yu, Zhou, Qiang, Zhang, Zhuan, Pan, HaiXue, Ilina, Yulia, MetsaKetela, Mikko, Igarashi, Yasuhiro, Tang, GongLi. Deciphering the Origin and Formation of Aminopyrrole Moiety in Kosinostatin Biosynthesis. CHINESE JOURNAL OF CHEMISTRY[J]. 2021, 39(12): 3329-3333, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7107335&detailType=1.
[14] 陈小蓉, 潘海学, 唐功利. 天然产物产生菌自抗性中DNA损伤修复的研究进展. 微生物学通报[J]. 2021, 48(7): 2454-2466, http://lib.cqvip.com/Qikan/Article/Detail?id=7105380941.
[15] Nie, QiuYue, Ji, ZhenYu, Hu, Yu, Tang, GongLi. Characterization of Highly Reductive Modification of Tetracycline D-Ring Reveals Enzymatic Conversion of Enone to Alkane. ACS CATALYSIS[J]. 2021, 11(14): 8399-8406, http://dx.doi.org/10.1021/acscatal.1c01226.
[16] Zhang, WenHe, Wang, Fei, Wang, YiLin, You, Song, Pan, HaiXue, Tang, GongLi. Identification and Characterization of Enzymes Catalyzing Early Steps in Miharamycin and Amipurimycin Biosynthesis. ORGANIC LETTERS[J]. 2021, 23(22): 8761-8765, http://dx.doi.org/10.1021/acs.orglett.1c03254.
[17] Zhou, Qiang, Peng, ShuYa, Zhang, Kai, Luo, GuangCai, Han, Li, He, QingLi, Tang, GongLi. A Flavin-Dependent Monooxygenase Mediates Divergent Oxidation of Rifamycin. ORGANIC LETTERS[J]. 2021, 23(6): 2342-2346, http://dx.doi.org/10.1021/acs.orglett.1c00485.
[18] WanHong Wen, Yue Zhang, YingYing Zhang, Qian Yu, ChuChu Jiang, ManCheng Tang, JinYue Pu, Lian Wu, YiLei Zhao, Ting Shi, Jiahai Zhou, GongLi Tang. Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics. NATURE COMMUNICATIONS[J]. 2021, 12: 7085-, [19] Yin, Yue, Shen, Yi, Meng, Song, Zhang, Mei, Pan, HaiXue, Tang, GongLi. Characterization of aMembrane-BoundO-AcetyltransferaseInvolved in Trioxacarcin Biosynthesis Offers Insights into Its Catalytic Mechanism. CHINESE JOURNAL OF CHEMISTRY[J]. 2020, 38(12): 1607-1611, http://lib.cqvip.com/Qikan/Article/Detail?id=7103704685.
[20] Wang, Fei, Zhang, WenHe, Zhao, Juan, Kang, WenJia, Wang, Shengyang, Yu, Biao, Pan, HaiXue, Tang, GongLi. Characterization of Miharamycin Biosynthesis Reveals a Hybrid NRPS-PKS to Synthesize High-Carbon Sugar from a Complex Nucleoside. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 142(13): 5996-6000, https://www.webofscience.com/wos/woscc/full-record/WOS:000526393700017.
[21] Jin, WenBing, Wu, Sheng, Xu, YiFan, Yuan, Hua, Tang, GongLi. Recent advances in HemN-like radical S-adenosyl-l-methionine enzyme-catalyzed reactions. NATURAL PRODUCT REPORTSnull. 2020, 37(1): 17-28, https://www.webofscience.com/wos/woscc/full-record/WOS:000509966800002.
[22] Hu, Yu, Zhang, Zhuan, Yin, Yue, Tang, GongLi. Directed Biosynthesis of Iso-aclacinomycins with Improved Anticancer Activity. ORGANIC LETTERS[J]. 2020, 22(1): 150-154, http://dx.doi.org/10.1021/acs.orglett.9b04069.
[23] Wang, Shengyang, Zhang, Qingju, Zhao, Yachen, Sun, Jiansong, Kang, Wenjia, Wang, Fei, Pan, Haixue, Tang, Gongli, Yu, Biao. The Miharamycins and Amipurimycin: their Structural Revision and the Total Synthesis of the Latter. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(31): 10558-10562, http://dx.doi.org/10.1002/anie.201905723.
[24] Dong, Lei, Shen, Yi, Hou, XianFeng, Li, WenJun, Tang, GongLi. Discovery of Druggability-Improved Analogues by Investigation of the LL-D49194 alpha 1 Biosynthetic Pathway. ORGANIC LETTERS[J]. 2019, 21(7): 2322-2325, https://www.webofscience.com/wos/woscc/full-record/WOS:000464247500083.
[25] Pan, HaiXue, Chen, Zhang, Zeng, Tianfang, Jin, WenBing, Geng, Yujie, Lin, GengMin, Zhao, Juan, Li, WeiTao, Xiong, Zijun, Huang, ShengXiong, Zhai, Xin, Liu, Hungwen, Tang, GongLi. Elucidation of the Herbicidin Tailoring Pathway Offers Insights into Its Structural Diversity. ORGANIC LETTERS[J]. 2019, 21(5): 1374-1378, https://www.webofscience.com/wos/woscc/full-record/WOS:000460491700028.
[26] Kang, WenJia, Pan, HaiXue, Wang, Shengyang, Yu, Biao, Hua, Huiming, Tang, GongLi. Identification of the Amipurimycin Gene Cluster Yields Insight into the Biosynthesis of C9 Sugar Nucleoside Antibiotics. ORGANIC LETTERS[J]. 2019, 21(9): 3148-3152, [27] Ji, ZhenYu, Nie, QiuYue, Yin, Yue, Zhang, Mei, Pan, HaiXue, Hou, XianFeng, Tang, GongLi. Activation and Characterization of Cryptic Gene Cluster: Two Series of Aromatic Polyketides Biosynthesized by Divergent Pathways. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(50): 18046-18054, https://www.webofscience.com/wos/woscc/full-record/WOS:000492069300001.
[28] Meng Song, Han Wei, Zhao Juan, Jian XiaoHong, Pan HaiXue, Tang GongLi. y A Six-Oxidase Cascade for Tandem C-H Bond Activation Revealed by Reconstitution of Bicyclomycin Biosynthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 57(3): 719-723, [29] Pei, ZengFei, Yang, MinJie, Li, Lei, Jian, XiaoHong, Yin, Yue, Li, Dehai, Pan, HaiXue, Lu, Yinhua, Jiang, Weihong, Tang, GongLi. Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system. ORGANICBIOMOLECULARCHEMISTRY[J]. 2018, 16(48): 9373-9376, https://www.webofscience.com/wos/woscc/full-record/WOS:000453230000008.
[30] Wang, Shengyang, Sun, Jiansong, Zhang, Qingju, Cao, Xin, Zhao, Yachen, Tang, Gongli, Yu, Biao. Amipurimycin: Total Synthesis of the Proposed Structures and Diastereoisomers. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 57(11): 2884-2888, https://www.webofscience.com/wos/woscc/full-record/WOS:000426490700021.
[31] Meng, Song, Tang, GongLi, Pan, HaiXue. Enzymatic Formation of Oxygen-Containing Heterocycles in Natural Product Biosynthesis. CHEMBIOCHEMnull. 2018, 19(19): 2002-2022, https://www.webofscience.com/wos/woscc/full-record/WOS:000446429400001.
[32] 唐功利. Directed production of aurantizolicin and new members based on YM-216391 biosynthetic system.. Org. Biomol. Chem.[J]. 2018, [33] Zhang, Yue, Wen, WanHong, Pu, JinYue, Tang, ManCheng, Zhang, Liwen, Peng, Chao, Xu, Yuquan, Tang, GongLi. Extracellularly oxidative activation and inactivation of matured prodrug for cryptic self-resistance in naphthyridinomycin biosynthesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 115(44): 11232-11237, https://www.webofscience.com/wos/woscc/full-record/WOS:000448713200049.
[34] Meng, Song, Han, Wei, Zhao, Juan, Jian, XiaoHong, Pan, HaiXue, Tang, GongLi. A Six-Oxidase Cascade for Tandem C-H Bond Activation Revealed by Reconstitution of Bicyclomycin Biosynthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 57(3): 719-723, https://www.webofscience.com/wos/woscc/full-record/WOS:000419594700017.
[35] 唐功利. Enzymology of anthraquinone--pyrone ring formation in complex aromatic polyketide biosynthesis.. Angew. Chem. Int. Ed.. 2018, [36] WenBing Jin, Sheng Wu, XiaoHong Jian, Hua Yuan, GongLi Tang. A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis. NATURE COMMUNICATIONS[J]. 2018, 9(1): https://doaj.org/article/363ff5321e1e41c99aac34d9167b5d26.
[37] Zhang, Zhuan, Gong, YuKang, Zhou, Qiang, Hu, Yu, Ma, HongMin, Chen, YongSheng, Igarashi, Yasuhiro, Pan, Lifeng, Tang, GongLi. Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2017, 114(7): 1554-1559, http://dx.doi.org/10.1073/pnas.1610097114.
[38] Wu, Sheng, Jiang, XiaoHong, Yuan, Hua, Jin, WenBing, Yin, Yue, Wang, LingYun, Zhao, Juan, Tang, GongLi. Unified Biosynthetic Origin of the Benzodipyrrole Subunits in CC-1065. ACS CHEMICAL BIOLOGY[J]. 2017, 12(6): 1603-1610, https://www.webofscience.com/wos/woscc/full-record/WOS:000403854000021.
[39] 唐功利. A FAD-linked oxidoreductase enables an extracellular deamination after saframycin A maturation.. Angew. Chem. Int. Ed.. 2017, [40] Zhuan Zhang, HaiXue Pan, GongLi Tang. New insights into bacterial type II polyketide biosynthesis. F1000RESEARCH. 2017, 6: http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=15&recid=&FileName=SJRX9AE4E4C38426AD5B6278B5E314C9421F&DbName=WWMERGEJLAST&DbCode=WWME&yx=&pr=&URLID=&bsm=.
[41] Hua Yuan, Jinru Zhang, Yujuan Cai, Sheng Wu, Kui Yang, H C Stephen Chan, Wei Huang, WenBing Jin, Yan Li, Yue Yin, Yasuhiro Igarashi, Shuguang Yuan, Jiahai Zhou, GongLi Tang. GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection. NATURE COMMUNICATIONS[J]. 2017, 8(1): 1-8, https://doaj.org/article/266a1355c538408382157a4388d51a1c.
[42] Tang, GongLi, Tang, ManCheng, Song, LiQiang, Zhang, Yue. Biosynthesis of Tetrahydroisoquinoline Antibiotics. CURRENT TOPICS IN MEDICINAL CHEMISTRYnull. 2016, 16(15): 1717-1726, http://dx.doi.org/10.2174/1568026616666151012112329.
[43] Wu LongFei, Meng Song, Tang GongLi. Ferrous iron and α-ketoglutarate-dependent dioxygenases in the biosynthesis of microbial natural products. BBA - PROTEINS AND PROTEOMICS[J]. 2016, 1864(5): 453-470, http://dx.doi.org/10.1016/j.bbapap.2016.01.012.
[44] 唐功利. Biosynthesis of trioxacarcin revealing a different starter unit and complex tailoring steps for type II polyketide synthas.. Chem. Sci.. 2015, [45] He, HaiYan, Yuan, Hua, Tang, ManCheng, Tang, GongLi. An Unusual Dehydratase Acting on Glycerate and a Ketoreducatse Stereoselectively Reducing alpha-Ketone in Polyketide Starter Unit Biosynthesis. ANGEWANDTECHEMIEINTERNATIONALEDITION[J]. 2014, 53(42): 11315-11319, https://www.webofscience.com/wos/woscc/full-record/WOS:000343751100038.
[46] Wu Longfei, He Haiyan, Pan Haixue, Han Li, Wang Renxiao, Tang Gongli. Characterization of QmnD3/QmnD4 for Double Bond Formation in Quartromicin Biosynthesis. ORG. LETT.[J]. 2014, 16(6): 1578-1581, http://ir.sioc.ac.cn/handle/331003/38940.
[47] He Haiyan, Tang Mancheng, Zhang Feng, Tang Gongli. Cis-Double Bond Formation by Thioesterase and Transfer by Ketosynthase in FR901464 Biosynthesis. J. AM. CHEM. SOC.[J]. 2014, 136(12): 4488-4491, http://ir.sioc.ac.cn/handle/331003/38939.
[48] Wang Jianbo, Zhang Feng, Pu Jinyue, Zhao Juan, Zhao Qunfei, Tang Gongli. Characterization of AvaR1, an autoregulator receptor that negatively controls avermectins production in a high avermectin-producing strain. BIOTECHNOL. LETT.[J]. 2014, 36(4): 813-819, http://ir.sioc.ac.cn/handle/331003/38936.
[49] Pan, HaiXue, Li, JiAn, Shao, Lei, Zhu, ChunBao, Chen, JunSheng, Tang, GongLi, Chen, DaiJie. Genetic manipulation revealing an unusual N-terminal region in a stand-alone non-ribosomal peptide synthetase involved in the biosynthesis of ramoplanins. BIOTECHNOLOGY LETTERS[J]. 2013, 35(1): 107-114, http://dx.doi.org/10.1007/s10529-012-1056-7.
[50] 唐功利. Unprecedented hybrid system for construction of pyrrolopyrrole moiety in kosinostatin biosynthesis.. Chem Biology. 2013, [51] Pu Jinyue, Peng Chao, Tang Mancheng, Zhang Yue, Guo Jianping, Song Liqiang, Hua Qiang, Tang Gongli. Naphthyridinomycin Biosynthesis Revealing the Use of Leader Peptide to Guide Nonribosomal Peptide Assembly. ORG. LETT.[J]. 2013, 15(14): 3674-3677, http://www.irgrid.ac.cn/handle/1471x/870653.
[52] 唐满成, 贺海燕, 张风, 唐功利. Baeyer-Villiger Oxidation of Acyl Carrier Protein-Tethered Thioester to Acyl Carrier Protein-Linked Thiocarbonate Catalyzed by a Monooxygenase Domain in FR901464 Biosynthesis. ACS CATAL.[J]. 2013, 3(3): 444-447, http://www.irgrid.ac.cn/handle/1471x/870682.
[53] Pan Haixue, Chen Zhouzhou, Li Jian, Zhu Chunbao, Tang Gongli, Chen Daijie. Production of ramoplanin analogues by genetic engineering of Actinoplanes sp.. BIOTECHNOL. LETT.[J]. 2013, 35(10): 1685-1692, http://www.irgrid.ac.cn/handle/1471x/870634.
[54] 唐功利. Self-resistance to antitumor antibiotic: a DNA glycosylase triggers the base excision repair system in yatakemycin biosynthesis.. 2012, [55] He Haiyan, Pan Haixue, Wu Longfei, Zhang Beibei, Chai Hanbo, Liu Wen, Tang Gongli. Quartromicin Biosynthesis: Two Alternative Polyketide Chains Produced by One Polyketide Synthase Assembly Line. CHEM. BIOL.[J]. 2012, 19(10): 1313-1323, http://dx.doi.org/10.1016/j.chembiol.2012.07.024.
[56] Jian, XiaoHong, Pan, HaiXue, Nin, TingTing, Shi, YuanYuan, Chen, YongSheng, Li, Yan, Zeng, XiaoWei, Xu, Jian, Tang, GongLi. Analysis of YM-216391 Biosynthetic Gene Cluster and Improvement of the Cyclopeptide Production in a Heterologous Host. ACS CHEMICAL BIOLOGY[J]. 2012, 7(4): 646-651, http://www.irgrid.ac.cn/handle/1471x/681928.
[57] Huang, Wei, Xu, Hui, Li, Yan, Zhang, Feng, Chen, XinYa, He, QingLi, Igarashi, Yasuhiro, Tang, GongLi. Characterization of Yatakemycin Gene Cluster Revealing a Radical S-Adenosylmethionine Dependent Methyltransferase and Highlighting Spirocyclopropane Biosynthesis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2012, 134(21): 8831-8840, http://www.irgrid.ac.cn/handle/1471x/681921.
[58] Peng, Chao, Pu, JinYue, Song, LiQiang, Jian, XiaoHong, Tang, ManCheng, Tang, GongLi. Hijacking a hydroxyethyl unit from a central metabolic ketose into a nonribosomal peptide assembly line. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2012, 109(22): 8540-8545, https://www.webofscience.com/wos/woscc/full-record/WOS:000304881700042.
[59] Tang Mancheng, Fu Chengyu, Tang Gongli. Characterization of SfmD as a Heme Peroxidase That Catalyzes the Regioselective Hydroxylation of 3-Methyltyrosine to 3-Hydroxy-5-methyltyrosine in Saframycin A Biosynthesis. J. BIOL. CHEM.[J]. 2012, 287(7): 5112-5121, http://dx.doi.org/10.1074/jbc.M111.306316.
[60] Peng Chao, Tang Yumin, Li Lei, Ding Wei, Deng Wei, Pu Jinyue, Liu Wen, Tang Gongli. In vivo investigation of the role of SfmO2 in saframycin A biosynthesis by structural characterization of the analogue saframycin O. SCI. CHINA-CHEM.[J]. 2012, 55(1): 90-97, http://lib.cqvip.com/Qikan/Article/Detail?id=40705761.
[61] Chen, YunLiang, Zhao, Juan, Liu, Wei, Gao, JuFang, Tao, LiMing, Pan, HaiXue, Tang, GongLi. Identification of phoslactomycin biosynthetic gene clusters from Streptomyces platensis SAM-0654 and characterization of PnR1 and PnR2 as positive transcriptional regulators. GENE[J]. 2012, 509(2): 195-200, http://dx.doi.org/10.1016/j.gene.2012.08.030.
[62] Wang Jianbo, Pan Haixue, Tang Gongli. Production of doramectin by rational engineering of the avermectin biosynthetic pathway. BIOORG. MED. CHEM. LETT.[J]. 2011, 21(11): 3320-3323, http://dx.doi.org/10.1016/j.bmcl.2011.04.008.
[63] Zhang, Feng, He, HaiYan, Tang, ManCheng, Tang, YuMin, Zhou, Qiang, Tang, GongLi. Cloning and Elucidation of the FR901464 Gene Cluster Revealing a Complex Acyltransferase-less Polyketide Synthase Using Glycerate as Starter Units. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2011, 133(8): 2452-2462, http://www.irgrid.ac.cn/handle/1471x/681894.
[64] He, QingLi, Jia, XinYing, Tang, ManCheng, Tian, ZhenHua, Tang, GongLi, Liu, Wen. Dissection of Two Acyl-Transfer Reactions Centered on Acyl-S-Carrier Protein Intermediates for Incorporating 5-Chloro-6-methyl-O-methylsalicyclic Acid into Chlorothricin. CHEMBIOCHEM[J]. 2009, 10(5): 813-819, http://dx.doi.org/10.1002/cbic.200800714.
[65] FU CHENGYU, Tang Mancheng, Peng Chao, Li Lei, HE YANLING, Liu Wen, Tang Gongli. Biosynthesis of 3-Hydroxy-5-Methyl-O-Methyltyrosine in the Saframycin/Safracin Biosynthetic Pathway. J. MICROBIOL. BIOTECHNOL.[J]. 2009, 19(5): 439-446, http://www.irgrid.ac.cn/handle/1471x/681885.
[66] Wen Liu. Characterization of the saframycin A gene cluster from Streptomyces lavendulae NRRL 11002 revealing a NRPS system for assembling the unusual tetrapeptidyl skeleton in an iterative manner. J. Bacteriol.. 2008, [67] He Qingli, Jiang Hui, Zhang Feng, Chen Haibao, Tang Gongli. Simultaneous identification of multiple receptors of natural product using an optimized cDNA phage display cloning. BIOORG. MED. CHEM. LETT.[J]. 2008, 18(14): 3995-3998, http://dx.doi.org/10.1016/j.bmcl.2008.06.006.
[68] 唐功利. Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from Streptomyces atroolivaceus S-140.. J. Biol. Chem.. 2007, [69] Tang, GL, Cheng, YQ, Shen, B. Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140. JOURNAL OF NATURAL PRODUCTS[J]. 2006, 69(3): 387-393, https://www.webofscience.com/wos/woscc/full-record/WOS:000236497400018.
[70] 唐功利. Characterization of the Chlorothricin Biosynthetic Gene Cluster as a model for Spirotetronate Antibiotic Biosynthesis.. Chem. Biol.. 2006, [71] Shao, Lei, Qu, XuDong, Jia, XinYing, Zhao, QunFei, Tian, ZhenHua, Wang, Min, Tang, GongLi, Liu, Wen. Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2006, 345(1): 133-139, https://www.webofscience.com/wos/woscc/full-record/WOS:000237877700019.
[72] 唐功利. The biosynthetic gene cluster of the antitumor antibiotic leinamycin from streptomycus atroolivaceus S-140 revealing unprecedented architectural complexity for a hybrid non-ribosomal peptide and polyketide synthetase.. Chm. Biol.. 2004, [73] Cheng, YQ, Tang, GL, Shen, B. Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2003, 100(6): 3149-3154, https://www.webofscience.com/wos/woscc/full-record/WOS:000181675200033.

   

（ 1 ） 两类高活性抗肿瘤天然产物靶蛋白的筛选及作用机制研究, 主持, 国家级, 2010-01--2012-12
（ 2 ） 复杂天然产物中Diels-Alder酶催化反应研究, 主持, 国家级, 2011-01--2013-12
（ 3 ） 农业生防微生物制剂的合成与作用机理及定向改造, 参与, 国家级, 2009-01--2013-12
（ 4 ） 具有重要生物活性的天然产物的化学合成, 参与, 国家级, 2010-01--2014-12
（ 5 ） 链霉菌源四氢异喹啉生物碱的生物合成与抗癌新药合成生物学研究, 主持, 国家级, 2014-01--2018-12
（ 6 ） 越野他汀生物合成与抗肿瘤蒽环抗生素组合生物合成研究, 主持, 国家级, 2014-01--2017-12
（ 7 ） 抗肿瘤多环天然产物的生物合成与调控研究, 参与, 国家级, 2017-01--2021-12
（ 8 ） 两类特殊大环天然产物的生物合成、途径再造与分子创新, 主持, 国家级, 2018-01--2020-12

已指导学生

瞿旭东  博士研究生  070303-有机化学  

贺庆利  博士研究生  070303-有机化学  

田振华  博士研究生  070303-有机化学  

马宏敏  博士研究生  070303-有机化学  

唐满成  博士研究生  070303-有机化学  

彭超  博士研究生  070303-有机化学  

黄伟  博士研究生  070303-有机化学  

王健博  博士研究生  070303-有机化学  

李玮涛  博士研究生  070303-有机化学  

蒲津越  博士研究生  070303-有机化学  

贺海燕  博士研究生  070303-有机化学  

张转  博士研究生  070303-有机化学  

宋立强  博士研究生  070303-有机化学  

张媚  博士研究生  070303-有机化学  

张玥  博士研究生  070303-有机化学  

殷乐  博士研究生  070303-有机化学  

吴龙飞  博士研究生  070303-有机化学  

季珍瑜  博士研究生  070303-有机化学  

裴增飞  博士研究生  070303-有机化学  

孟松  博士研究生  070303-有机化学  

现指导学生

董超  硕士研究生  0703Z1-化学生物学  

章盈盈  博士研究生  070303-有机化学  

胡煜  博士研究生  0703Z1-化学生物学  

杨敏杰  博士研究生  0703Z1-化学生物学  

刘正涛  硕士研究生  085238-生物工程  

温万红  博士研究生  070303-有机化学  

金文兵  博士研究生  0703Z1-化学生物学  

邵宁  硕士研究生  070303-有机化学  

徐一帆  硕士研究生  070303-有机化学  

张凯  硕士研究生  085238-生物工程  

聂秋玥  博士研究生  0703Z1-化学生物学