单分子生物物理
膜蛋白和细胞膜生物物理

   

德国魏尔茨堡大学 19950801--19981001 博士

德国魏尔茨堡大学 19950801--19981001  博士研究生
美国伊利诺伊大学 19981101--20010501  博士后

   

1967年出生，1989年华中理工大学（现华中科技大学）理学学士，1992年吉林大学理学硕士，1998年德国魏尔茨堡大学自然科学博士。1998年-2001年伊利诺伊大学芝加哥分校博士后。2000年获中科院“****”资助，2003年获国家“杰出青年”科学基金。2009年入选“新世纪百千万人才工程”国家级人选。现任中科院物理所研究员、所学术委员会委员、软物质物理重点实验室主任、SM4课题组组长。

新颖单分子研究技术的发展和应用；生物分子马达(解旋酶、核糖体等)的工作机理；膜蛋白的转运、插膜和跨膜机理。
每年招收研究生（硕博连读生或博士生）3名。欢迎各学科（物理、化学或生物）背景的青年学子报考。
http://sm4.iphy.ac.cn/

   

2003 国家杰出青年科学基金

[1] 黄星榞, 徐春华, 李明. 在小力下测算磁镊高度转换系数的方法及应用. CN: CN111721504B, 2022-02-18.

[2] 侯文清, 陆颖, 马东飞, 贺小龙, 李明. 观察活细胞细胞膜表面及附近生物大分子的荧光成像方法. CN: CN113008842A, 2021-06-22.

[3] 滕翠娟, 徐春华, 李明. 基于解旋酶检测DNA与蛋白质相互作用的方法. CN: CN110470844A, 2019-11-19.

[4] 李颖, 胡书新, 马丽, 刘仁威, 范苏娜, 李明. 荧光检测样品池及其制备方法. CN: CN105572046A, 2016-05-11.

[5] 翟永亮, 李明, 吴兰生. 横向磁镊装置. CN: CN104931419A, 2015-09-23.

[6] 胡书新, 翟永亮, 吴兰生, 李明. 一种胶体晶体测试装置. CN: CN102914621A, 2013-02-06.

[7] 翟永亮, 吴兰生, 李明, 胡书新. 一种胶体晶体测试装置. CN: CN102914622A, 2013-02-06.

[8] 翟永亮, 吴兰生, 李明, 胡书新, 李小龙. 一种多工位传动装置. CN: CN102874558A, 2013-01-16.

[9] 王爽, 翟永亮, 吴兰生, 李明. 成像磁镊装置及其与单分子荧光技术集成的系统和方法. CN: CN102749441A, 2012-10-24.

[10] 骆意勇, 吴兰生, 翟永亮, 李明. 实时观察胶体晶体内部缺陷的装置及方法. CN: CN101308101B, 2010-07-14.

[11] 李明, 孙博, 吴兰生, 翟永亮. 单分子操纵横向磁镊装置. CN: CN1869650A, 2006-11-29.

[12] 李明, 孙博, 吴兰生, 翟永亮. 单分子操纵横向磁镊装置. CN: CN1869650A, 2006-11-29.

   

[1] Yang, Chenguang, He, Xiaolong, Wang, Hao, Lin, Zhao, Hou, Wenqing, Lu, Ying, Hu, Shuxin, Li, Ming. Single-Molecule Monitoring of Membrane Association of the Necroptosis Executioner MLKL with Discernible Anchoring and Insertion Dynamics. NANO LETTERS[J]. 2023, 23(11): 4770-4777, http://dx.doi.org/10.1021/acs.nanolett.2c05062.
[2] Wang, YiZhou, Liu, Cuifang, Zhao, Jicheng, Yu, Juan, Luo, Anfeng, Xiao, Xue, Dou, ShuoXing, Ma, Lu, Wang, PengYe, Li, Ming, Li, Guohong, Yan, Jianbin, Chen, Ping, Li, Wei. H2A mono-ubiquitination differentiates FACT's functions in nucleosome assembly and disassembly. NUCLEIC ACIDS RESEARCH[J]. 2022, 50(2): 833-846, http://dx.doi.org/10.1093/nar/gkab1271.
[3] Fan, Qihui, Zheng, Yu, Wang, Xiaochen, Xie, Ruipei, Ding, Yu, Wang, Boyi, Yu, Xiaoyu, Lu, Ying, Liu, Liyu, Li, Yunliang, Li, Ming, Zhao, Yuanjin, Jiao, Yang, Ye, Fangfu. Dynamically Re-Organized Collagen Fiber Bundles Transmit Mechanical Signals and Induce Strongly Correlated Cell Migration and Self-Organization. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(21): 11858-11867, https://www.webofscience.com/wos/woscc/full-record/WOS:000629791300001.
[4] Hou, Wenqing, Ma, Dongfei, He, Xiaolong, Han, Weijing, Ma, Jianbing, Wang, Hao, Xu, Chunhua, Xie, Ruipei, Fan, Qihui, Ye, Fangfu, Hu, Shuxin, Li, Ming, Lu, Ying. Subnanometer-Precision Measurements of Transmembrane Motions of Biomolecules in Plasma Membranes Using Quenchers in Extracellular Environment. NANO LETTERS[J]. 2021, 21(1): 485-491, https://www.webofscience.com/wos/woscc/full-record/WOS:000611082000065.
[5] 贾棋, 樊秦凯, 侯文清, 杨晨光, 王利邦, 王浩, 徐春华, 李明, 陆颖. DNA双链退火压力对DNA聚合酶gp5链置换的调控. 物理学报[J]. 2021, 70(15): 326-333, http://lib.cqvip.com/Qikan/Article/Detail?id=7105271350.
[6] Lu, Ke, Liu, Cuifang, Liu, Yinuo, Luo, Anfeng, Chen, Jun, Lei, Zhichao, Kong, Jingwei, Xiao, Xue, Zhang, Shuming, Wang, YiZhou, Ma, Lu, Dou, ShuoXing, Wang, PengYe, Li, Ming, Li, Guohong, Li, Wei, Chen, Ping. Curaxin-Induced DNA Topology Alterations Trigger the Distinct Binding Response of CTCF and FACT at the Single-Molecule Level. BIOCHEMISTRY[J]. 2021, 60(7): 494-499, http://dx.doi.org/10.1021/acs.biochem.1c00014.
[7] 黄星榞, 隋明宇, 侯文清, 李明, 陆颖, 徐春华. RecA蛋白介导同源重组的步进式链交换. 物理学报[J]. 2020, 69(20): 344-351, http://lib.cqvip.com/Qikan/Article/Detail?id=7103122364.
[8] Huang, Xingyuan, Lu, Ying, Wang, Shuang, Sui, Mingyu, Li, Jinghua, Ma, Jianbing, Ma, Dongfei, Jia, Qi, Hu, Shuxin, Xu, Chunhua, Li, Ming. Mismatch sensing by nucleofilament deciphers mechanism of RecA-mediated homologous recombination. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 117(34): 20549-20554, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456136/.
[9] Huang XingYuan, Sui MingYu, Hou WenQing, Li Ming, Lu Ying, Xu ChunHua. Stepwise strand exchange during RecA-induced homologous recombination. ACTAPHYSICASINICA[J]. 2020, 69(20): https://www.webofscience.com/wos/woscc/full-record/WOS:000592460800036.
[10] Ma DongFei, Hou WenQing, Xu ChunHua, Zhao ChunYu, Ma JianBing, Huang XingYuan, Jia Qi, Ma Lu, Liu Cong, Li Ming, Lu Ying. Investigation of structure and dynamics of alpha-synuclein on membrane by quenchers-in-a-liposome fluorescence resonance energy transfer method. ACTA PHYSICA SINICA[J]. 2020, 69(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000527799000034.
[11] Qin, Zhenheng, Bin, Lulu, Hou, XiMiao, Zhang, Siqi, Zhang, Xia, Lu, Ying, Li, Ming, Modesti, Mauro, Xi, XuGuang, Sun, Bo. Human RPA activates BLM's bidirectional DNA unwinding from a nick. ELIFE[J]. 2020, 9: https://doaj.org/article/9ddd44bbe61043f6800b40aa02f180a5.
[12] 马东飞, 侯文清, 徐春华, 赵春雨, 马建兵, 黄星榞, 贾棋, 马璐, 刘聪, 李明, 陆颖. 脂质体包裹荧光受体方法研究α-突触核蛋白在磷脂膜上的结构和动态特征. 物理学报[J]. 2020, 69(3): 290-298, http://lib.cqvip.com/Qikan/Article/Detail?id=7100838041.
[13] Ma, JianBing, Chen, Ze, Xu, ChunHua, Huang, XingYuan, Jia, Qi, Zou, ZhenYu, Mi, ChenYang, Ma, DongFei, Lu, Ying, Zhang, HuiDong, Li, Ming. Dynamic structural insights into the molecular mechanism of DNA unwinding by the bacteriophage T7 helicase. NUCLEIC ACIDS RESEARCH[J]. 2020, 48(6): 3156-3164, http://dx.doi.org/10.1093/nar/gkaa057.
[14] Diao, Wenwen, Tong, Xuezhi, Yang, Cheng, Zhang, Fengrong, Bao, Chun, Chen, Hao, Liu, Liyu, Li, Ming, Ye, Fangfu, Fan, Qihui, Wang, Jiangfei, OuYang, ZhongCan. Behaviors of Glioblastoma Cells in in Vitro Microenvironments. SCIENTIFIC REPORTS[J]. 2019, 9(1): https://doaj.org/article/cf5dacf241dc4635b020e5bcbd5b928d.
[15] Nong, DaGuan, Li, Ming. An Improvement on the Combination of Magnetic Trap and Fluorescent Resonant Energy Transfer. CHINESE PHYSICS LETTERS[J]. 2019, 36(3): http://lib.cqvip.com/Qikan/Article/Detail?id=87767566504849574851485048.
[16] Ma, Li, Hu, Shuxin, He, Xiaolong, Yang, Na, Chen, Licui, Yang, Chenguang, Ye, Fangfu, Wei, Taotao, Li, Ming. Detection of tBid Oligomerization and Membrane Permeabilization by Graphene-Based Single-Molecule Surface-Induced Fluorescence Attenuation. NANO LETTERS[J]. 2019, 19(10): 6937-6944, [17] Ma, DongFei, Xu, ChunHua, Hou, WenQing, Zhao, ChunYu, Ma, JianBing, Huang, XingYuan, Jia, Qi, Ma, Lu, Diao, Jiajie, Liu, Cong, Li, Ming, Lu, Ying. Detecting Single-Molecule Dynamics on Lipid Membranes with Quenchers-in-a-Liposome FRET. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(17): 5577-5581, http://dx.doi.org/10.1002/anie.201813888.
[18] Li, Meijing, Xia, Xian, Tian, Yuanyuan, Jia, Qi, Liu, Xiaoyu, Lu, Ying, Li, Ming, Li, Xueming, Chen, Zhucheng. Mechanism of DNA translocation underlying chromatin remodelling by Snf2. NATURE[J]. 2019, 567(7748): 409-+, http://dx.doi.org/10.1038/s41586-019-1029-2.
[19] Zhang, Qian, Wen, Fengcai, Zhang, Siqi, Jin, Jiachuan, Bi, Lulu, Lu, Ying, Li, Ming, Xi, XuGuang, Huang, Xingxu, Shen, Bin, Sun, Bo. The post-PAM interaction of RNA-guided spCas9 with DNA dictates its target binding and dissociation. SCIENCE ADVANCES[J]. 2019, 5(11): [20] Lu, XiMing, Li, Hui, You, Jing, Li, Wei, Wang, PengYe, Li, Ming, Dou, ShuoXing, Xi, XuGuang. Folding Dynamics of Parallel and Antiparallel G-Triplexes under the Influence of Proximal DNA. JOURNAL OF PHYSICAL CHEMISTRY B[J]. 2018, 122(41): 9499-9506, https://www.webofscience.com/wos/woscc/full-record/WOS:000448087800008.
[21] Ma Li, He XiaoLong, Li Ming, Hu ShuXin. Fluorescent investigation on process of tBid inducing membrane permeabilization. ACTA PHYSICA SINICA[J]. 2018, 67(14): https://www.webofscience.com/wos/woscc/full-record/WOS:000443207500029.
[22] Huo, XinMei, Meng, Lifeng, Jiang, Tao, Li, Ming, Sun, FangZhen, Sun, Bo, Li, JianKe. Real-time observation of nucleoplasmin-mediated DNA decondensation and condensation reveals its specific functions as a chaperone. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS[J]. 2018, 1861(8): 743-751, http://dx.doi.org/10.1016/j.bbagrm.2018.07.002.
[23] Ma, JianBing, Jia, Qi, Xu, ChunHua, Li, JingHua, Huang, XingYuan, Ma, DongFei, Li, Ming, Xi, XuGuang, Lu, Ying. Asynchrony of Base-Pair Breaking and Nucleotide Releasing of Helicases in DNA Unwinding. JOURNAL OF PHYSICAL CHEMISTRY B[J]. 2018, 122(22): 5790-5796, [24] Xiao Xue, Dong Liping, Wang Yizhou, Wang Pengye, Li Ming, Li Guohong, Chen Ping, Li Wei. Dissection of structural dynamics of chromatin fibers by single-molecule magnetic tweezers. 生物物理学报：英文版[J]. 2018, 4(4): 222-232, http://lib.cqvip.com/Qikan/Article/Detail?id=676327040.
[25] Lu Yue, Ma JianBing, Teng CuiJuan, Lu Ying, Li Ming, Xu ChunHua. Binding process between E. coli SSB and ssDNA by single-molecule dynamics. ACTA PHYSICA SINICA[J]. 2018, 67(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000443194600024.
[26] 马建兵, 翟永亮, 农大官, 李菁华, 付航, 张兴华, 李明, 陆颖, 徐春华. 基于片层光照明的新型单分子横向磁镊. 物理学报[J]. 2018, 67(14): 148702-1, http://lib.cqvip.com/Qikan/Article/Detail?id=675734491.
[27] 马丽, 贺小龙, 李明, 胡书新. tBid蛋白引发磷脂膜透化过程的研究. 物理学报[J]. 2018, 67(14): 148703-1, http://lib.cqvip.com/Qikan/Article/Detail?id=675734492.
[28] Chen, Ping, Dong, Liping, Hu, Mingli, Wang, YiZhou, Xiao, Xue, Zhao, Zhongliang, Yan, Jie, Wang, PengYe, Reinberg, Danny, Li, Ming, Li, Wei, Li, Guohong. Functions of FACT in Breaking the Nucleosome and Maintaining Its Integrity at the Single-Nucleosome Level. MOLECULAR CELL[J]. 2018, 71(2): 284-+, http://dx.doi.org/10.1016/j.molcel.2018.06.020.
[29] Xue Xiao, Liping Dong, Yi-Zhou Wang, Peng-Ye Wang, Ming Li, Guohong Li, Ping Chen, Wei Li. Dissection of structural dynamics of chromatin fibers by single-molecule magnetic tweezers. 生物物理学报：英文版[J]. 2018, 4(4): 222-232, http://lib.cqvip.com/Qikan/Article/Detail?id=676327040.
[30] 陆越, 马建兵, 黄星榞, 肖雪, 李明, 陆颖, 徐春华. 单分子磁镊测量高亲和反应系数. 高等学校化学学报[J]. 2018, 39(6): 1228-1234, http://lib.cqvip.com/Qikan/Article/Detail?id=675402643.
[31] Teng CuiJuan, Lu Yue, Ma JianBing, Li Ming, Lu Ying, Xu ChunHua. Interaction between Sso7d and DNA studied by single-molecule technique. ACTA PHYSICA SINICA[J]. 2018, 67(14): https://www.webofscience.com/wos/woscc/full-record/WOS:000443207500026.
[32] Lu Yue, Ma Jianbing, Huang Xingyuan, Xiao Xue, Li Ming, Lu Ying, Xu Chunhua. Measuring the Reaction Rates of High Affinity Reactions by Single-molecule Magnetic Tweezers. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE[J]. 2018, 39(6): 1228-1234, https://www.webofscience.com/wos/woscc/full-record/WOS:000439940300018.
[33] Lu Yue, Ma JianBing, Teng CuiJuan, Lu Ying, Li Ming, Xu ChunHua. Binding process between E. coli SSB and ssDNA by single-molecule dynamics. ACTA PHYSICA SINICA[J]. 2018, 67(8): [34] Ma, Li, Li, Ying, Ma, Jianbing, Hu, Shuxin, Li, Ming. Watching Three-Dimensional Movements of Single Membrane Proteins in Lipid Bilayers. BIOCHEMISTRY[J]. 2018, 57(31): 4735-4740, [35] Ma JianBing, Zhai YongLiang, Nong DaGuan, Li JingHua, Fu Hang, Zhang XingHua, Li Ming, Lu Ying, Xu ChunHua. Single molecule transverse magnetic tweezers based on light sheet illumination. ACTA PHYSICA SINICA[J]. 2018, 67(14): https://www.webofscience.com/wos/woscc/full-record/WOS:000443207500028.
[36] Liu, Renwei, Fan, Suna, Xiao, Dongdong, Zhang, Jin, Liao, Mengzhou, Yu, Shansheng, Meng, Fanling, Liu, Baoli, Gu, Lin, Meng, Sheng, Zhang, Guangyu, Zheng, Weitao, Hu, Shuxin, Li, Ming. Free-Standing Single-Molecule Thick Crystals Consisting of Linear Long-Chain Polymers. NANO LETTERS[J]. 2017, 17(3): 1655-1659, [37] Zhao, ZhenYe, Xu, ChunHua, Shi, Jing, Li, JingHua, Ma, JianBing, Jia, Qi, Ma, DongFei, Li, Ming, Lu, Ying. Bloom's syndrome protein unfolding G-quadruplexes in two pathways. CHINESE PHYSICS B[J]. 2017, 26(8): [38] Ma, Li, Li, Ying, Li, Ming, Hu, Shuxin. Protein-membrane interactions investigated with surface-induced fluorescence attenuation. CHINESE PHYSICS B[J]. 2017, 26(12): 62-67, http://lib.cqvip.com/Qikan/Article/Detail?id=673835545.
[39] Fan, Qihui, Liu, Ruchuan, Jiao, Yang, Tian, Chunxiu, Farrell, James D, Diao, Wenwen, Wang, Xiaochen, Zhang, Fengrong, Yuan, Wei, Han, Haibo, Chen, Jinfeng, Yang, Yue, Zhang, Xixiang, Ye, Fangfu, Li, Ming, Ouyang, Zhongcan, Liu, Liyu. A novel 3-D bio-microfluidic system mimicking in vivo heterogeneous tumour microstructures reveals complex tumour-stroma interactions. LAB ON A CHIP[J]. 2017, 17(16): 2852-2860, http://dx.doi.org/10.1039/c7lc00191f.
[40] Wu, WenQiang, Hou, XiMiao, Zhang, Bo, Fosse, Philippe, Rene, Brigitte, Mauffret, Olivier, Li, Ming, Dou, ShuoXing, Xi, XuGuang. Single-molecule studies reveal reciprocating of WRN helicase core along ssDNA during DNA unwinding. SCIENTIFIC REPORTS[J]. 2017, 7: https://www.webofscience.com/wos/woscc/full-record/WOS:000395915600001.
[41] Lin, Wenxia, Ma, Jianbing, Nong, Daguan, Xu, Chunhua, Zhang, Bo, Li, Jinghua, Jia, Qi, Dou, Shuoxing, Ye, Fangfu, Xi, Xuguang, Lu, Ying, Li, Ming. Helicase Stepping Investigated with One-Nucleotide Resolution Fluorescence Resonance Energy Transfer. PHYSICAL REVIEW LETTERS[J]. 2017, 119(13): https://www.webofscience.com/wos/woscc/full-record/WOS:000411769700013.
[42] Lu XiMing, Li Hui, You Jing, Li Wei, Wang PengYe, Li Ming, Xi XuGuang, Dou ShuoXing. An optimization algorithm for single-molecule fluorescence resonance (smFRET) data processing. ACTA PHYSICA SINICA[J]. 2017, 66(11): https://www.webofscience.com/wos/woscc/full-record/WOS:000403091100038.
[43] 马丽, 李颖, 李明, 胡书新. Protein-membrane interactions investigated with surface-induced fluorescence attenuation. 中国物理B：英文版[J]. 2017, 26(12): 62-67, http://lib.cqvip.com/Qikan/Article/Detail?id=673835545.
[44] Ying Li, Zhenyu Qian, Li Ma, Shuxin Hu, Daguan Nong, Chunhua Xu, Fangfu Ye, Ying Lu, Guanghong Wei, Ming Li. Single-molecule visualization of dynamic transitions of pore-forming peptides among multiple transmembrane positions. NATURE COMMUNICATIONS[J]. 2016, 7(1): https://doaj.org/article/a28f4e82436648fabfc779dd0029fad1.
[45] Zhang YuWei, Yan Yan, Nong DaGuan, Xu ChunHua, Li Ming. Combination of magnetic tweezers with DNA hairpin as a potential approach to the study of RecA-mediated homologous recombination. ACTA PHYSICA SINICA[J]. 2016, 65(21): https://www.webofscience.com/wos/woscc/full-record/WOS:000389597200035.
[46] Li, Wei, Chen, Ping, Yu, Juan, Dong, Liping, Liang, Dan, Feng, Jianxun, Yan, Jie, Wang, PengYe, Li, Qing, Zhang, Zhiguo, Li, Ming, Li, Guohong. FACT Remodels the Tetranucleosomal Unit of Chromatin Fibers for Gene Transcription. MOLECULAR CELL[J]. 2016, 64(1): 120-133, http://dx.doi.org/10.1016/j.molcel.2016.08.024.
[47] Zhang, Bo, Wu, WenQiang, Liu, NaNv, Duan, XiaoLei, Li, Ming, Dou, ShuoXing, Hou, XiMiao, Xi, XuGuang. G-quadruplex and G-rich sequence stimulate Pif1p-catalyzed downstream duplex DNA unwinding through reducing waiting time at ss/dsDNA junction. NUCLEIC ACIDS RESEARCH[J]. 2016, 44(17): 8385-8394, https://www.webofscience.com/wos/woscc/full-record/WOS:000386158800035.
[48] Zhang YuWei, Yan Yan, Nong DaGuan, Xu ChunHua, Li Ming. Combination of magnetic tweezers with DNA hairpin as a potential approach to the study of RecA-mediated homologous recombination. ACTA PHYSICA SINICA[J]. 2016, 65(21): https://www.webofscience.com/wos/woscc/full-record/WOS:000389597200035.
[49] Chen, WeiFei, Dai, YangXue, Duan, XiaoLei, Liu, NaNv, Shi, Wei, Li, Na, Li, Ming, Dou, ShouXing, Dong, YuHui, Rety, Stephane, Xi, XuGuang. Crystal structures of the BsPif1 helicase reveal that a major movement of the 2B SH3 domain is required for DNA unwinding. NUCLEIC ACIDS RESEARCH[J]. 2016, 44(6): 2949-2961, http://ir.ihep.ac.cn/handle/311005/247875.
[50] Zhang, YuWei, Nong, DaGuan, Dou, ShuoXing, Li, Wei, Yan, Yan, Xi, XuGuang, Xu, ChunHua, Li, Ming. Iterative homology checking and non-uniform stepping during RecA-mediated strand exchange. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2016, 478(3): 1153-1157, https://www.webofscience.com/wos/woscc/full-record/WOS:000397715400022.
[51] Li, JingHua, Lin, WenXia, Zhang, Bo, Nong, DaGuan, Ju, HaiPeng, Ma, JianBing, Xu, ChunHua, Ye, FangFu, Xi, Xu Guang, Li, Ming, Lu, Ying, Dou, ShuoXing. Pif1 is a force-regulated helicase. NUCLEIC ACIDS RESEARCH[J]. 2016, 44(9): 4330-4339, https://www.webofscience.com/wos/woscc/full-record/WOS:000377472100039.
[52] Wu, WenQiang, Hou, XiMiao, Li, Ming, Dou, ShuoXing, Xi, XuGuang. BLM unfolds G-quadruplexes in different structural environments through different mechanisms. NUCLEIC ACIDS RESEARCH[J]. 2015, 43(9): 4614-4626, http://ir.iphy.ac.cn/handle/311004/60823.
[53] Tao Zhang, Shifeng Jin, Yuanxin Gu, Yao He, Ming Li, Yang Li, Haifu Fan. SFX analysis of non-biological polycrystalline samples. IUCRJ[J]. 2015, 2(3): 322-326, http://ir.iphy.ac.cn/handle/311004/60630.
[54] Li Wei, Wong WeiJuan, Lim CiJi, Ju HaiPeng, Ming, Li, Yan Jie, Wang PengYe. Catch-bond behavior of DNA condensate under tension. CHINESE PHYSICS B[J]. 2015, 24(12): http://ir.iphy.ac.cn/handle/311004/60404.
[55] Hou, XiMiao, Wu, WenQiang, Duan, XiaoLei, Liu, NaNv, Li, HaiHong, Fu, Jing, Dou, ShuoXing, Li, Ming, Xi, XuGuang. Molecular mechanism of G-quadruplex unwinding helicase: sequential and repetitive unfolding of G-quadruplex by Pif1 helicase. BIOCHEMICAL JOURNAL[J]. 2015, 466: 189-199, http://ir.iphy.ac.cn/handle/311004/60333.
[56] Li, Wei, Wong, Wei Juan, Lim, Ci Ji, Ju, HaiPeng, Li, Ming, Yan, Jie, Wang, PengYe. Complex kinetics of DNA condensation revealed through DNA twist tracing. PHYSICAL REVIEW E[J]. 2015, 92(2): http://ir.iphy.ac.cn/handle/311004/61251.
[57] Liu, NaNv, Duan, XiaoLei, Ai, Xia, Yang, YanTao, Li, Ming, Dou, ShuoXing, Rety, Stephane, Deprez, Eric, Xi, XuGuang. The Bacteroides sp. 3_1_23 Pif1 protein is a multifunctional helicase. NUCLEIC ACIDS RESEARCH[J]. 2015, 43(18): 8942-8954, http://ir.iphy.ac.cn/handle/311004/60825.
[58] Liu, Yuru, Xie, Ping, Wang, Pengye, Li, Ming, Li, Hui, Li, Wei, Dou, Shuoxing. A model for chromosome organization during the cell cycle in live E-coli. SCIENTIFIC REPORTS[J]. 2015, 5: http://ir.iphy.ac.cn/handle/311004/61409.
[59] Li Ying, Liu RenWei, Ma Li, Fan SuNa, Li Hui, Hu ShuXin, Li Ming. Redox-mediated reversible modulation of the photoluminescence of single quantum dots. CHINESE PHYSICS B[J]. 2015, 24(7): http://ir.iphy.ac.cn/handle/311004/60458.
[60] 李明. 超分辨显微，至极至美：2014年诺贝尔化学奖述评. 物理[J]. 2014, 43(12): 813-816, http://ir.iphy.ac.cn/handle/311004/59892.
[61] Li, XiaoLong, Hu, ShuXin, Sun, ZhiBin, Zhai, YongLiang, Wu, LanSheng, Huang, Zhen, Li, WeiNing, Yang, HanDong, Zhai, GuangJie, Li, Ming. A Compact Device for Colloidal Crystal Studies on Tiangong-1 Target Spacecraft. MICROGRAVITY SCIENCE AND TECHNOLOGY[J]. 2014, 25(6): 375-381, http://ir.iphy.ac.cn/handle/311004/59325.
[62] 胡书新, 李小龙, 孙志斌, 翟光杰, 李明. 空间胶体晶体生长结构变化的研究. 载人航天[J]. 2014, 20(3): 261-266, http://lib.cqvip.com/Qikan/Article/Detail?id=50304184.
[63] 郑海子, 农大官, 李明. Effect of Low-Pass Filtering in Force Calibration of Magnetic Tweezers. CHINESE PHYSICS LETTERS[J]. 2013, 30(11): 203-206, https://www.webofscience.com/wos/woscc/full-record/WOS:000329172900053.
[64] Chen, Ping, Zhao, Jicheng, Wang, Yan, Wang, Min, Long, Haizhen, Liang, Dan, Huang, Li, Wen, Zengqi, Li, Wei, Li, Xia, Feng, Hongli, Zhao, Haiyong, Zhu, Ping, Li, Ming, Wang, Qianfei, Li, Guohong. H3.3 actively marks enhancers and primes gene transcription via opening higher-ordered chromatin. GENES & DEVELOPMENT[J]. 2013, 27(19): 2109-2124, http://dx.doi.org/10.1101/gad.222174.113.
[65] Li, Wei, Hou, XiMiao, Wang, PengYe, Xi, XuGuang, Li, Ming. Direct Measurement of Sequential Folding Pathway and Energy Landscape of Human Telomeric G-quadruplex Structures. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2013, 135(17): 6423-6426, http://ir.iphy.ac.cn/handle/311004/56892.
[66] 郑海子, 农大官, 李明. Effect of Low-Pass Filtering in Force Calibration of Magnetic Tweezers. 2013, 30(11): 118702-, http://ir.iphy.ac.cn/handle/311004/57752.
[67] Li, Wei, Wang, PengYe, Yan, Jie, Li, Ming. Impact of DNA Twist Accumulation on Progressive Helical Wrapping of Torsionally Constrained DNA. PHYSICAL REVIEW LETTERS[J]. 2012, 109(21): http://ir.iphy.ac.cn/handle/311004/39626.
[68] Yuan, Bing, Hu, ShuXin, Lu, NaiYan, Xu, Fan, Zhou, Kun, Ma, YuQiang, Li, Ming. Electrical bistability in self-assembled hybrid multilayers of phospholipid and nanoparticles. NANOTECHNOLOGY[J]. 2011, 22(31): http://ir.iphy.ac.cn/handle/311004/36918.
[69] 李明. 用硬X射线自由电子激光解析复杂生物大分子的结构. 物理[J]. 2011, 40(4): 263-264, http://lib.cqvip.com/Qikan/Article/Detail?id=37436601.
[70] 侯锡苗, 张兴华, 魏孔吉, 季超, 窦硕星, 王渭池, 李明, 王鹏业. 用单分子技术研究抗癌药物顺铂对DNA结构的影响. 物理[J]. 2010, 108-112, http://lib.cqvip.com/Qikan/Article/Detail?id=33171667.
[71] Fu, Wenbo, Chen, Hu, Li, Ming, Yan, Jie. Kinetics of Single DNA Compaction by Hexaammine Cobalt Chloride. JOURNAL OF COMPUTATIONAL AND THEORETICAL NANOSCIENCE[J]. 2010, 7(1): 213-217, http://ir.iphy.ac.cn/handle/311004/40470.
[72] Pan, BingYi, Dou, ShuoXing, Yang, Ye, Xu, YaNan, Bugnard, Elisabeth, Ding, XiuYan, Zhang, Lingyun, Wang, PengYe, Li, Ming, Xi, Xu Guang. Mutual Inhibition of RecQ Molecules in DNA Unwinding. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2010, 285(21): 15884-15893, http://dx.doi.org/10.1074/jbc.M110.104299.
[73] 孙博, 魏孔吉, 李明. 用单分子磁镊研究解旋酶UvrD的工作机理. 生物物理学报[J]. 2009, 93-94, http://ir.iphy.ac.cn/handle/311004/44088.
[74] Hou, XiMiao, Zhang, XingHua, Wei, KongJi, Ji, Chao, Dou, ShuoXing, Wang, WeiChi, Li, Ming, Wang, PengYe. Cisplatin induces loop structures and condensation of single DNA molecules. NUCLEIC ACIDS RESEARCH[J]. 2009, 37(5): 1400-1410, http://ir.iphy.ac.cn/handle/311004/34741.
[75] Zhang, YuDong, Hu, ShuXin, Yuan, Bing, Hou, XiMiao, Lu, Ying, Li, Ming. Subnanometer-Thick PbS Film on Organic Substrate and Its Usage as Buffer for Homo- and Heteroepitaxial Overgrowth. LANGMUIR[J]. 2009, 25(10): 5609-5613, http://ir.iphy.ac.cn/handle/311004/53897.
[76] Luo, YiYong, Hu, ShuXin, Lu, Ying, Mai, ZhenHong, Li, Ming. Real time observation of partial dislocations in thin colloidal crystals. APPLIED PHYSICS LETTERS[J]. 2009, 95(17): http://dx.doi.org/10.1063/1.3253418.
[77] 张兴华, 肖彬, 侯锡苗, 徐春华, 王鹏业, 李明. 用单分子磁镊研究顺铂导致的DNA凝聚. 物理学报[J]. 2009, 4301-4306, http://lib.cqvip.com/Qikan/Article/Detail?id=30718227.
[78] Zhang XingHua, Xiao Bin, Hou XiMiao, Xu ChunHua, Wang PengYe, Li Ming. Study of cisplatin-induced DNA compaction using single molecule magnetic tweezers. ACTA PHYSICA SINICA[J]. 2009, 58(6): 4301-4306, http://dx.doi.org/10.7498/aps.58.4301.
[79] 陆颖, 胡书新, 麦振洪, 李明. 同步辐射X射线衍射研究短链DNA／磷脂多层膜的结构. 核技术[J]. 2009, 897-900, http://lib.cqvip.com/Qikan/Article/Detail?id=32368566.
[80] Wang, XiaoLing, Zhang, XingHua, Cao, Meiwen, Zheng, HaiZi, Xiao, Bin, Wang, Yilin, Li, Ming. Gemini Surfactant-Induced DNA Condensation into a Beadlike Structure. JOURNAL OF PHYSICAL CHEMISTRY B[J]. 2009, 113(8): 2328-2332, http://dx.doi.org/10.1021/jp8078887.
[81] Zhang XingHua, Hou XiMiao, Ji Chao, Li Ming, Dou ShuoXing, Wang PengYe. Spermidine-induced two-dimensional DNA condensations on mica surfaces: A different pathway from condensations in solution. CHINESE SCIENCE BULLETIN[J]. 2009, 54(14): 2425-2433, http://lib.cqvip.com/Qikan/Article/Detail?id=30866904.
[82] Li, Ming, Wen, Zhenchao, Fu, Jinxin, Fang, Xu, Dai, Yaomin, Liu, Rongjuan, Han, Xiufeng, Qiu, Xianggang. Composite metamaterials with dual-band magnetic resonances in the terahertz frequency regime. JOURNAL OF PHYSICS D-APPLIED PHYSICS[J]. 2009, 42(11): http://dx.doi.org/10.1088/0022-3727/42/11/115420.
[83] Li, X L, Lu, H B, Li, Ming, Mai, Zhenhong, Kim, Hyunjung, Jia, Q J. Characteristics of the low electron density surface layer on BaTiO3 thin films. APPLIED PHYSICS LETTERS[J]. 2008, 92(1): http://ir.ihep.ac.cn/handle/311005/240406.
[84] Ran ShiYong, Wang XiaoLing, Fu WenBo, Wang WeiChi, Li Ming. Single molecule DNA compaction by purified histones. CHINESE SCIENCE BULLETIN[J]. 2008, 53(6): 836-841, http://lib.cqvip.com/Qikan/Article/Detail?id=26743765.
[85] Chen, Xiaofang, Li, Congxin, Wang, Pengye, Li, Ming, Wang, Weichi. Dynamic simulation of the effect of calcium-release activated calcium channel on cytoplasmic Ca(2+) oscillation. BIOPHYSICAL CHEMISTRY[J]. 2008, 136(2-3): 87-95, http://dx.doi.org/10.1016/j.bpc.2008.04.010.
[86] MKamran, 戴耀民, 李明, 赵柏儒, 赵华英, 杨欢, 马继云, 方煦, 邱祥冈. La0.33Pr0.34Ca0.33MnO3薄膜的应变效应. 物理学报[J]. 2008, 57(11): 7168-7172, http://lib.cqvip.com/Qikan/Article/Detail?id=28662248.
[87] 王鹏业, 李明, 翁羽翔. 生物软物质研究的新进展. 物理[J]. 2008, 37(6): 441-448, http://lib.cqvip.com/Qikan/Article/Detail?id=27528380.
[88] Xing, LiLi, Yuan, Bing, Hu, ShuXin, Zhang, YuDong, Lu, Ying, Mai, ZhenHong, Li, Ming. Electrochemical synthesis of highly oriented layered zinc hydroxide with intercalated p-aminobenzoic acid. JOURNAL OF PHYSICAL CHEMISTRY C[J]. 2008, 112(10): 3800-3804, http://ir.iphy.ac.cn/handle/311004/37016.
[89] Wang XiaoLing, Zhang XingHua, Wei KongJi, Sun Bo, Li Ming. An improved single molecule manipulation apparatus and its applications. ACTA PHYSICA SINICA[J]. 2008, 57(6): 3905-3911, http://dx.doi.org/10.7498/aps.57.3905.
[90] RAN ShiYong WANG XiaoLing FU WenBo WANG WeiChi LI Ming. Single molecule DNA compaction by purified histones. 中国科学通报：英文版[J]. 2008, 53(6): 836-841, http://lib.cqvip.com/Qikan/Article/Detail?id=26743765.
[91] Li, X L, Lu, H B, Li, Ming, Mai, Zhenhong, Kim, Hyunjung. Temperature dependence surface structure of BaTiO3 thin films induced by ferroelectric phase transition. JOURNAL OF APPLIED PHYSICS[J]. 2008, 103(5): http://ir.iphy.ac.cn/handle/311004/44785.
[92] Sun, Bo, Wei, KongJi, Zhang, Bo, Zhang, XingHua, Dou, ShuoXing, Li, Ming, Xi, Xu Guang. Impediment of E. coli UvrD by DNA-destabilizing force reveals a strained-inchworm mechanism of DNA unwinding. EMBO JOURNAL[J]. 2008, 27(24): 3279-3287, http://ir.iphy.ac.cn/handle/311004/39636.
[93] Wang XiaoLing, Zhang XingHua, Wei KongJi, Sun Bo, Li Ming. An improved single molecule manipulation apparatus and its applications. ACTA PHYSICA SINICA[J]. 2008, 57(6): 3905-3911, http://ir.iphy.ac.cn/handle/311004/33653.
[94] 郭红莲, 王晓玲, 屈娥, 徐春华, 李明, 程丙英, 张道中. 双光镊研究DNA与SpoIIIE的作用动力学. 量子电子学报[J]. 2007, 24(1): 123-124, http://lib.cqvip.com/Qikan/Article/Detail?id=23727533.
[95] 冉诗勇, 王晓玲, 付文博, 王渭池, 李明. 纯化组蛋白引起的DNA凝聚. 科学通报[J]. 2007, 52(14): 1615-1619, http://lib.cqvip.com/Qikan/Article/Detail?id=25147876.
[96] 冉诗勇, 孙博, 李明. 单分子操纵与单分子生物物理. 物理[J]. 2007, 36(3): 228-235, http://lib.cqvip.com/Qikan/Article/Detail?id=23909453.
[97] Yuan, Bing, Xing, LiLi, Zhang, YuDong, Lu, Ying, Luo, YiYong, Mai, ZhenHong, Li, Ming. Penetration and saturation of lysozyme in phospholipid bilayers. JOURNAL OF PHYSICAL CHEMISTRY B[J]. 2007, 111(22): 6151-6155, http://ir.iphy.ac.cn/handle/311004/50649.
[98] Yuan, Bing, Xing, LiLi, Zhang, YuDong, Lu, Ying, Mai, ZhenHong, Li, Ming. Self-assembly of highly oriented lamellar nanoparticle-phospholipid nanocomposites on solid surfaces. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2007, 129(37): 11332-+, http://ir.iphy.ac.cn/handle/311004/52416.
[99] Jing HuaiYu, Li Ming, Mai ZhenHong. Potential controlled self-assembly of ZnO-surfactant hybrid multilayers on solid-liquid interface. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE[J]. 2006, 27(9): 1711-1715, http://ir.iphy.ac.cn/handle/311004/51185.
[100] Fu, WenBo, Wang, XiaoLing, Zhang, XingHua, Ran, ShiYong, Yan, Jie, Li, Ming. Compaction dynamics of single DNA molecules under tension. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2006, 128(47): 15040-15041, http://ir.iphy.ac.cn/handle/311004/34932.
[101] Li Ming, Mark L SCHLOSSMAN. X-RAY SCATTERING FROM LIQUID INTERFACES. 核技术（英文版）[J]. 2006, 17(6): 322-333, https://d.wanfangdata.com.cn/periodical/hjs-e200606002.
[102] 景怀宇, 李明, 麦振洪. 电位控制ZnO／表面活性剂复合多层膜在固／液界面上的自组装. 高等学校化学学报[J]. 2006, 27(9): 1711-1715, http://lib.cqvip.com/Qikan/Article/Detail?id=22714675.
[103] 胡书新, 李秀宏, 吴兰生, 贾全杰, 麦振洪, 李明. 固-液界面可聚合脂多层膜的X射线散射研究. 高能物理与核物理[J]. 2004, 27: A53-, http://ir.iphy.ac.cn/handle/311004/48458.
[104] 李秀宏, 谭智敏, 黄兰, 李晓龙, 麦振洪, 李明. 金属纳米颗粒-聚电解质多层膜的X射线反射率研究. 高等学校化学学报[J]. 2004, 25(7): 1314-1317, http://lib.cqvip.com/Qikan/Article/Detail?id=10006057.
[105] 洪新国, 都鲁超, 叶满萍, 翁羽翔, 李明. 宽带隙半导体TiO2纳米溶胶原位变温的X射线小角散射研究. 高能物理与核物理[J]. 2004, 27: A63-, http://ir.iphy.ac.cn/handle/311004/49264.
[106] 洪新国, 翁羽翔, 李明. 蛋白质溶液小角散射方法和天线膜蛋白LH2的低分辨形状研究. 高能物理与核物理[J]. 2004, 27: A57-, http://ir.iphy.ac.cn/handle/311004/47517.
[107] 赵永男, 陈向明, 李秀宏, 王勇, 王超英, 李明, 麦振洪. 微乳液体系中溶剂热合成Co纳米纤维. 高等学校化学学报[J]. 2003, 24(6): 986-988, http://lib.cqvip.com/Qikan/Article/Detail?id=7920431.
[108] Chang-Rong Su, Jia-Ming Li. The Optimum Metallic-bond Scheme: A Quantitative Analysis of Mass Spectra of Sodium Clusters. CHINESE PHY.LETTER[J]. 2001, 18: 1575-, http://ir.iphy.ac.cn/handle/311004/45373.
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2000  中科院****
2003  国家杰出青年基金
2006  基金委面上项目
2006  中科院知识创新重要方向性项目
2006  蛋白质研究重大计划子课题之蛋白质折叠
2008  基金委面上项目 

用单分子操纵技术研究并阐述生物分子马达UvrD解旋酶的工作机理；用电化学协同自组装方法制备一系列有机-无机复合多层膜。
研究工作的主要特点是物理学与生命科学和材料化学的交叉。用物理学思维方式思考生命科学和材料化学的基础问题，用先进的物理技术检验并实现新奇的想法。