071010-生物化学与分子生物学
071010-生物化学与分子生物学

生态毒理
分子毒理

1996-09--1999-07   南京大学   博士学位
1993-09--1996-07   厦门大学   硕士学位
1984-09--1988-07   安徽大学   学士学位

   

2005-04~现在, 中国科学院动物研究所, 研究员
2001-10~2005-04,美国康奈尔大学医学院, 博士后
2000-10~2001-10,美国得克萨斯州立大学, 博士后
1999-07~2000-10,同济大学, 博士后
1996-09~1999-07,南京大学, 博士学位
1993-09~1996-07,厦门大学, 硕士学位
1984-09~1988-07,安徽大学, 学士学位

   

（1） 朱丽月华奖教金, , 其他, 2012

   

（1） Perfluoropolyether carboxylic acids (novel alternatives to PFOA) impair zebrafish posterior swim bladder development via thyroid hormone disruption, Environment International, 2020, 通讯作者
（2） Associations of per-/polyfluoroalkyl substances with glucocorticoids and progestogens in newborns, Environment International, 2020, 通讯作者
（3） Analysis of emerging per- and polyfluoroalkyl substances: Progress and current issues, Trends in Analytical Chemistry, 2020, 通讯作者
（4） Comparative Hepatotoxicity of Novel PFOA Alternatives (Perfluoropolyether Carboxylic Acids) on Male Mice, Environ Sci Technol., 2019, 通讯作者
（5） Parental exposure to 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) induced transgenerational thyroid hormone disruption in zebrafish, Sci Total Environ, 2019, 通讯作者
（6） Chronic exposure to 6:2 chlorinated polyfluorinated ether sulfonate acid (F-53B) induced hepatotoxic effects in adult zebrafish and disrupted the PPAR signaling pathway in their offspring, Environ Pollut, 2019, 通讯作者
（7） Per- and polyfluoroalkyl substances (PFASs) in the blood of two colobine monkey species from China: Occurrence and exposure pathways, Sci Total Environ., 2019, 通讯作者
（8） Worldwide Distribution of Novel Perfluoroether Carboxylic and Sulfonic Acids in Surface Water, Environ Sci Technol, 2018, 通讯作者
（9） Corticosteroid-binding globulin, induced in testicular Leydig cells by perfluorooctanoic acid, promotes steroid hormone synthesis, Arch Toxicol, 2018, 第 4 作者
（10） Occurrence and Tissue Distribution of Novel Perfluoroether Carboxylic and Sulfonic Acids and Legacy Per/Polyfluoroalkyl Substances in Black-Spotted Frog (Pelophylax nigromaculatus)., Environ Sci Technol, 2018, 通讯作者
（11） 6:2 fluorotelomer sulfonamide alkylbetaine (6:2 FTAB), a novel perfluorooctane sulfonate alternative, induced developmental toxicity in zebrafish embryos., Aquat Toxicol., 2018, 通讯作者
（12） Nickel(ii) inhibits the oxidation of DNA 5-methylcytosine in mammalian somatic cells and embryonic stem cells., Metallomics, 2018, 第 3 作者
（13） Novel Chlorinated Polyfluorinated Ether Sulfonates and Legacy Per-/Polyfluoroalkyl Substances: Placental Transfer and Relationship with Serum Albumin and Glomerular Filtration Rate., Environ Sci Technol., 2017, 通讯作者
（14） High perfluorooctanoic acid exposure induces autophagy blockage and disturbs intracellular vesicle fusion in the liver., Archives of Toxicology, 2017, 通讯作者
（15） Perfluorooctanoic acid affects endocytosis involving clathrin light chain A and microRNA-133b-3p in mouse testes., Toxicol Appl Pharmacol., 2017, 通讯作者
（16） 6:2 Chlorinated polyfluorinated ether sulfonate, a PFOS alternative, induces embryotoxicity and disrupts cardiac development in zebrafish embryos., Aquatic Toxicology, 2017, 通讯作者
（17） Acot1 is a sensitive indicator for PPARα activation after perfluorooctanoic acid exposure in primary hepatocytes of Sprague-Dawley rats., Toxicol In Vitro, 2017, 第 10 作者
（18） RNA-sequencing analysis reveals the hepatotoxic mechanism of perfluoroalkyl alternatives, HFPO2 and HFPO4, following exposure in mice., J Appl Toxicol., 2017, 通讯作者
（19） Interaction of perfluoroalkyl acids with human liver fatty acid-binding protein, Archives of Toxicology, 2016, 通讯作者
（20） Comparative hepatotoxicity of 6:2 fluorotelomer carboxylic acid and 6:2 fluorotelomer sulfonic acid, two fluorinated alternatives to long-chain perfluoroalkyl acids, on adult male mice., Archives of Toxicology, 2016, 通讯作者
（21） Activation of peroxisome proliferator-activated receptor α ameliorates perfluorododecanoic acid-induced production of reactive oxygen species in rat liver., Archives of Toxicology, 2016, 通讯作者
（22） Perfluorooctanoic acid disrupts the blood-testis barrier and activates the TNFα/p38 MAPK signaling pathway in vivo and in vitro., Archives of Toxicology, 2016, 通讯作者
（23） High perfluorooctanoic acid exposure induces autophagy blockage and disturbs intracellular vesicle fusion in the liver., Archives of Toxicology, 2016, 通讯作者
（24） Zebrafish reproductive toxicity induced by chronic perfluorononanoate exposure, Aquatic Toxicology, 2016, 通讯作者
（25） Low dose perfluorooctanoate exposure promotes cell proliferation in a human non-tumor liver cell line., Journal of Hazard Materials, 2016, 通讯作者
（26） Associations of urinary 5-methyl-2’-deoxycytidine and 5-hydroxymethyl-2’-deoxycytidine with phthalate exposure and semen quality in 562 Chinese adult men, Environment International, 2016, 通讯作者
（27） Integrated proteomic and miRNA transcriptional analysis reveals the hepatotoxicity mechanism of PFNA exposure in mice, J Proteome Res, 2015, 通讯作者
（28） Interaction of perfluoroalkyl acids with human liver fatty acid-binding protein, Arch. Toxicol., 2015, 通讯作者
（29） Circulating microRNA profiles altered in mice after 28 d exposure to perfluorooctanoic acid, Toxicology Letters, 2014, 通讯作者
（30） Synergistic effects of perfluoroalkyl acids mixtures with J-shaped concentration-responses on viability of a human liver cell line., Chemosphere, 2014, 通讯作者
（31） Proteomic analysis of mouse testis reveals perfluorooctanoic acid-induced reproductive dysfunction via direct disturbance of testicular steroidogenic machinery, J. Proteome Res, 2014, 通讯作者
（32） Phosphoproteome analysis reveals an important role for glycogen synthase kinase-3 in perfluorododecanoic acid-induced rat liver toxicity, Toxicology Letters, 2013, 通讯作者
（33） Age- and gender-related accumulation of perfluoroalkyl substances in captive Chinese alligators (Alligator sinensis),  Environmental Pollution, 2013, 通讯作者
（34） Accumulation pattern of Dechlorane Plus and associated biological effects on rats after 90 d of exposure, Chemosphere, 2013, 通讯作者
（35） Distribution and fate of perfluoroalkyl substances in municipal wastewater treatment plants in economically developed areas of China, Environmental Pollution, 2013, 通讯作者
（36） Phosphoproteome analysis reveals an important role for glycogen synthase kinase-3 in perfluorododecanoic acid-induced rat liver toxicity, Toxicology Letters, 2013, 通讯作者
（37） Sex Differences in Transcriptional Expression of FABPs in Zebrafish Liver after Chronic Perfluorononanoic Acid Exposure, Environmental science technology, 2012, 通讯作者
（38） Association of Perfluorooctanoic Acid with HDL Cholesterol and Circulating miR-26b and miR-199-3p in Workers of a Fluorochemical Plant and Nearby Residents, Environmental science technology,, 2012, 通讯作者
（39） Proteomic analysis of male zebrafish livers chronically exposed to perfluorononanoic acid, Environment International, 2012, 通讯作者

   

（ 1 ） 血脂紊乱影响精子发生的生物标志物的鉴定和临床干预, 负责人, 国家任务, 2013-01--2017-12
（ 2 ） 野生动物体内全氟烷基化合物的来源、存在形态及毒性机制研究, 负责人, 国家任务, 2014-01--2018-12
（ 3 ） 全氟类化合物与人类肝脏型脂肪酸结合蛋白的相互作用及毒性机制研, 负责人, 国家任务, 2014-01--2017-12
（ 4 ） 典型污染物引发机体糖和脂肪代谢紊乱的机制（XDB14040200）, 负责人, 中国科学院计划, 2014-06--2019-06
（ 5 ） 基于系统性毒性研究指导全氟烷基化合物替代品设计与绿色合成, 负责人, 国家任务, 2018-01--2022-12
（ 6 ） 食品中典型持久性有机污染物健康危害与毒性机制, 负责人, 国家任务, 2017-01--2021-12
（ 7 ） 全氟烷基化合物替代品影响斑马鱼鱼鳔发育的分子机制研究, 负责人, 国家任务, 2019-01--2022-12
（ 8 ） 不孕不育人群环境与遗传致病因子鉴定及交互作用研究, 参与, 国家任务, 2018-12--2021-12
（ 9 ） 铬雾抑制剂的研究和产业化, 参与, 中国科学院计划, 2019-01--2020-12