General

Prof. Xinxia Cai
State Key Lab. of Transducer Technology
Institute of Electronics, Chinese Academy of Sciences
P.O. Box 2652, Beijing 100190, China
Phone: +86-10-58887193, Fax: +86-10-58887172
Email: xxcai@mail.ie.ac.cn

Research Areas

Major

Biosensors and Bioelectronics (080920), Microelectronics (080903)         

Research Areas:

1. Electrophysiological / neurotransmitter chemical microelectrode array with nanotechnology, neuron pattern recognition and intelligent algorithm.

2. Brain scientific instruments for high-throughput neuron information detection and multilevel control; Acupoint neural information detection and stimulation therapy.

3.  Immunosensors / aptamer sensors for cancer biomarkers  point-of-care-testing (POCT) etc.

Education

Ph.D. in Bioelectonics, Electronics & Electrical Engineering from Glasgow University, UK
M.Sc. in Microelectronics, Institute of Semiconductors, Chinese Academy of Sciences
B.Sc. in Microelectronics, Electrical Engineering Department, Beijing Institute of Technology

Experience

Dr. Xinxia Cai is a professor of biosensors at Institute of Electronics, Chinese Academy of Sciences, while she is a chief scientist of the national major scientific research project on nanoscience, a winner of national science fund for distinguished young scholars. In 1995, she held research position on biosensors at Tokyo Institute of Technology in Japan. She has published in excess of 160 journal and conference papers and has received 30 invention patents.          

Honors & Distinctions

The 2nd class prize of national technical invention award in 2013 (No.1)
The 2nd class prize for progress of science and technology in Beijing in 2012 (NO.1)
The national hundred, thousand and ten thousand talent project in 2014

Research Interests

Main Publications in Recent Years (*corresponding author):

1)       Yang Wang, Jinping Luo, Juntao Liu, Xinrong Li, Zhuang Kong, Hongyan Jin*, Xinxia Cai*, Electrochemical integrated paper-based immunosensor modified with multi-walled carbon nanotubes nanocomposites for point-of-care testing of 17β-estradiol. Biosensors and Bioelectronics, Volume 107, 1 June 2018, Pages 47-53

2)       Song Zhang, Yilin Song, Mixia Wang, Guihua Xiao, Fei Gao, Ziyue Li, Guoxian Tao, Ping Zhuang, Feng Yue*, Piu Chan*,Xinxia Cai*, Real-time simultaneous recording of electrophysiological activities and dopamine overflow in the deep brain nuclei of a non-human primate with Parkinson’s disease using nano-based microelectrode arrays, Microsystems & Nanoengineering (2018) 4, 17070; 17070; doi:10.1038/micronano.2017.70, www.nature.com/micronano

3)       Juntao Liu, Yan Fan, Zhuang Kong, Yang Wang, Jinping Luo, Shengwei Xu, Hongyan Jin*, Xinxia Cai*, Smart phone-based rapid quantitative detection of luteinizing hormone using gold immunochromatographic strip, Sensors and Actuators B: Chemical, Volume 259, 15 April 2018, Pages 1073-1081.

4)       Guihua Xiao, Yilin Song, Song Zhang, Lili Yang, Xinxia Cai*, A high-sensitive nano-modified biosensor for dynamic monitoring of glutamate and neural spike covariation from rat cortex to hippocampal sub-regions, Journal of Neuroscience Methods, Volume 291, 1 November 2017, Pages 122-130

5)       Xinyi Fan, Yilin Song, Yuanlin Ma, Song Zhang, Guihua Xiao, Lili Yang, Huiren Xu, Dai Zhang, Xinxia Cai*, In Situ Real-Time Monitoring of Glutamate and Electrophysiology from Cortex to Hippocampus in Mice Based on a Microelectrode Array, Sensors 2017, 17, 61; doi:10.3390/s17010061

6)       Xinyang Liu, Juntao Liu, Feng Duan, Rui Liu, Shuping Gai, Shengwei Xu, Jianhui Sun, Xinxia Cai*, Neuroscience Letters 653 (2017) 326–331. https://authors.elsevier.com/a/1VHs~15DX1HV4p

7)       Yan Fan, Juntao Liu, Yang Wang, Jinping Luo, Huiren Xu, Shengwei Xu, Xinxia Cai*, Biosensors and Bioelectronics, 2017,  95:60–66. https://authors.elsevier.com/a/1UtWK3PVtpZ0AF

8)       Song Zhang, Yilin Song, Mixia Wang, Zhiming Zhang, XinyiFan, Xianteng Song, Ping Zhuang, Feng Yue, Piu Chan*, Xinxia Cai*. A silicon based implantable microelectrode array for electrophysiological and dopamine recording from cortex to striatum in the non-human primate brain. Biosensors and Bioelectronics, 2016, 85:53-61.

9)       Yang Wang, HuirenXu, JinpingLuo, Juntao Liu, Li Wang, Yan Fan, Shi Yan, Yue Yang, Xinxia Cai*. A novel label-free microfluidic paper-based immunosensor for highly sensitive electrochemical detection of carcinoembryonic antigen. Biosensors and Bioelectronics, 2016, 83:319-326.

10)    Wenjing Wei, Yilin Song, Xinyi Fan, Song Zhang, Li Wang, Shengwei Xu, Mixia Wang, Xinxia Cai*. Simultaneous recording of brain extracellular glucose, spike and LFP in real time using an implantablemicroelectrode array with nano-materials. Nanotechnology, 2016, 27(11):114001.

11)    Huiren Xu, Yang Wang, Li Wang, Yilin Song, Jinping Luo, Xinxia Cai*. A label-free microelectrode array based on one-step synthesis of chitosan–multi-walled carbon nanotube–thionine for ultrasensitive detection of carcinoembryonic antigen. Nanomaterials, 2016, 6,132.

12)    Xinyang Liu, Juntao Liu, Shuping Gai, Kristina Meyer, Shengwei Xu, Xinxia Cai*. Time-frequency distribution properties of event-related potentials in mental fatigue induced by visual memory tasks. Neuro Report, 2016, 27(14):1031-1036.

13)    Wenjing Wei, Yilin Song, Li Wang, Song Zhang, Jinping Luo, Shengwei Xu, Xinxia Cai*, An implantable microelectrode array for simultaneous L-glutamate and electrophysiological recordings in vivo    Microsystems & Nanoengineering, 2015, 1, 15002, dio:10.1038/micronano.2015.2

14)    Li Wang, Huiren Xu, Jinping Luo, Chunxiu Liu, Shengwei Xu, Xinxia Cai*,   Highly Sensitive Detection of Quantal Dopamine Secretion from Pheochromocytoma Cells Using Neural Microelectrode Array Electrodeposited with Polypyrrole Graphene, ACS Applied materials & Interface, 2015, 7, 7619-7626

15)    Shuxue Qu, Juntao Liu, Jinping Luo, Bin Wang, Xinxia Cai*. A rapid and highly sensitive portable chemiluminescent immunosensor of carcinoembryonic antigen based on immunomagnetic separation in human serum, Analytica Chimica Acta, 2013, 766: 94-99.

16)    Huiren Xu, Li Wang, Jinping Luo,  Chunxiu Liu, Juntao Liu,  Song Zhang, Xinxia Cai*. Selective recognition of 5-Hydroxytryptamine and dopamine on multi-walled carbon nanotubes-chitosan hybrid film modified microelectrode array. Sensors, 2015, 15(1): 1008-1021.

17)    Quan Zhou, Shuping Gai, Nansen Lin, Jingjing Zhang, Lu Zhang, Renhuan Yu, Juntao Liu, Xinxia Cai*. Power spectral differences of electrophysiological signals detected at acupuncture points and non-acupuncture points. Acupunct Electrother Res., 2014, 39(2):169-181.

18)    Wenjing Wei, Yilin Song, Wentao Shi,Nansen Lin, Tingjun Jiang, Xinxia Cai*, A high sensitivityMEA probefor measuring real time rat brain glucose flux, Biosensors and Bioelectronics, 2014, 55, 66-71

19)    Li Wang, Tingjun Jiang, Yilin Song, Wentao Shi, Xinxia Cai*, Dopamine detection using a patchclamp system on a planar microeletrode array  electrodeposited by polypyrrole/graphene nanocomposites, Science China, 2014, 57, 1-5

20)    Chunxiu Liu, Yilin Song, Nansen Lin, Shuai Zhou, Mixia Wang, Xinxia Cai*,  Planar Microelectrode Chip for Synchronous Simulative Neurochemical and Neuroelectrial Monitoring, Journal of Nanoscience and Nanotechnology, 2013, 13(2), 736-740.

21)    Shuai Zhou, Chunxiu Liu, Yilin Song, Xinxia Cai*,  Highly Selective and Sensitive Determination of Dopamine Using Nafion Coated Microelectrode Arrays, Journal of Nanoscience and Nanotechnology, 2013, 13(2), 1598-1601

22)    Jinping Luo, Shuxue Qu, Juntao Liu, Bin Wang, Xinxia Cai*, Rapid detection of Cyfra 21-1 by optical-biosensing based on chemiluminescence immunoassay using bio-functionlized magnetic nanocomposites, Chinese Science Bulletin, 2013, 58(16), 1-3

23)    Wentao Shi, Chunxiu Liu, Yilin Song, Nansen Lin, Shuai Zhou, Xinxia Cai*, An ascorbic acid amperometric sensor using over-oxidized polypyrrole and palladium nanoparticles composites, Biosensors and Bioelectronics, 2012, 38, 100-106

24)    Yilin Song, Nansen Lin, Chunxiu Liu, Hong Jiang, Guogang Xing, Xinxia Cai*,  A novel dual mode microelectrode array for neuroelectrical and neurochemical recording in vitro, Biosensors and Bioelectronics, 2012, 38, 416-420.

25)    Jinping Luo, Weiwei Yue, Xiaohong Liu, Qing Tian, Xinxia Cai*, Bioluminescence-based biosensor for food contamination, Biosensors and Environmental Health, 2012,  Science Publishers, 18, 336-354