天然产物化学，有机分析

   

100800-中药学

天然药物化学
有机分析

1997-09--2000-02   浙江大学   博士
1994-09--1997-08   中国科学院成都生物研究所   硕士
1990-09--1994-08   西南师范大学   学士

   

2005-05~2005-09,美国杰克逊州立大学, 访问学者
2003-09~2004-10,法国巴黎自然历史博物馆, 博士后
2000-03~2001-02,日本国东丽医药研究所, 客座研究员
2000-03~现在, 中国科学院成都生物研究所, 助研、副研

2015-10-16-今,中国中西医结合学会基础理论专委会, 委员
2011-11-17-今,四川省质谱学会, 副理事长

   

[1] 廖循. 黑果枸杞在制备抗申请退行性疾病药物中的应用. 2022102404673.9, 2022-03-10.
[2] 廖循, 赵艳, 白小琳. 一种鸡蛋中氟虫腈及其代谢物的净化和检测方法. CN: CN111579673A, 2020-08-25.

   

[1] Yuan, Hao, Bai, XiaoLin, Hu, YiKao, Fan, WenQin, Ayeni, Emmanuel Ayodeji, Liao, Xun. Ligand fishing of monoamine oxidase B inhibitors from Platycodon grandiflorus (Jacq.) A.DC. roots by the enzyme functionalised magnetic nanoparticles. PHYTOCHEMICAL ANALYSIS[J]. 2023, 34(1): 67-75, [2] Liao, Xun, Bai, Xiaolin, Wang, Shuguan, Liggins, Christany, Pan, Li, Wang, Meiyuan, Tchounwou, Paul, Mao, Jinghe, Liu, YiMing. A novel one-pot fluorescence tagging and depyrimidination strategy for quantification of global DNA methylation. ANALYTICA CHIMICA ACTA[J]. 2023, 1239: http://dx.doi.org/10.1016/j.aca.2022.340636.
[3] Bai, XiaoLin, Luo, YingJie, Fan, WenQin, Zhang, YongMei, Liao, Xun. Neuroprotective Effects of Lycium Barbarum Fruit Extract on Pink1(B9)Drosophila Melanogaster Genetic Model of Parkinson's Disease. PLANT FOODS FOR HUMAN NUTRITION[J]. 2023, 78(1): 68-75, http://dx.doi.org/10.1007/s11130-022-01016-8.
[4] Wang MY, 廖循, Tchounwou PB, Liu YM. Coupling a droplet generator with conventional ESI–MS for quantitative analysis of small‑volume samples.. Analytical and Bioanalytical Chemistry[J]. 2022, [5] Ayeni, Emmanuel Ayodeji, Ma, Chao, Zhang, YongMei, Fan, WenQin, Liao, Xun. Chemical components and monoamine oxidase B inhibition activities from the tubers of Sauromatum giganteum (Engl.) Cusimano & Hett. NATURAL PRODUCT RESEARCH. 2022, [6] Zhao Y, Hu JJ, Bai XL, Liu HP, Qi XW, 廖循. Fast screening of tyrosinase inhibitors from traditional Chinese medicinal plants by ligand fshing in combination with in situ fuorescent assay. Analytical and Bioanalytical Chemistry[J]. 2022, [7] Hu, YiKao, Bai, XiaoLin, Yuan, Hao, Zhang, Yi, Ayeni, Emmanuel Ayodeji, Liao, Xun. Polyphenolic Glycosides from the Fruits Extract of Lycium ruthenicum Murr and Their Monoamine Oxidase B Inhibitory and Neuroprotective Activities. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2022, [8] Qi, XuWei, Liu, YiMing, Hu, YiKao, Yuan, Hao, Ayeni, Emmanuel Ayodeji, Liao, Xun. Ligand fishing based on tubular microchannel modified with monoamine oxidase B for screening of the enzyme's inhibitors from Crocus sativus and Edgeworthia gardneri. JOURNAL OF SEPARATION SCIENCE[J]. 2022, 45(13): 2394-2405, http://dx.doi.org/10.1002/jssc.202200057.
[9] Zhao, Yan, Yuan, Li, Bai, XiaoLin, Jiang, XinXin, Zhang, Yi, Fang, Qiong, Zhang, Qin, Liao, Xun. Tyrosinase covalently immobilized on carboxyl functionalized magnetic nanoparticles for fishing of the enzyme's ligands from Prunellae Spica. JOURNAL OF SEPARATION SCIENCE[J]. 2022, 45(18): 3635-3645, http://dx.doi.org/10.1002/jssc.202200303.
[10] Hu, YiKao, Liu, YiMing, Bai, XiaoLin, Ma, Chao, Liao, Xun. Screening of Monoamine Oxidase B Inhibitors from Fragaria nubicola by Ligand Fishing and Their Neuroprotective Effects. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2022, [11] Ayeni, Emmanuel Ayodeji, Gong, Yuzhou, Yuan, Hao, Hu, Yikao, Bai, Xiaolin, Liao, Xun. Medicinal Plants for Anti-neurodegenerative diseases in West Africa. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2022, 285: http://dx.doi.org/10.1016/j.jep.2021.114468.
[12] Zhao, Yan, Bai, XiaoLin, Liu, YiMing, Liao, Xun. Determination of fipronil and its metabolites in egg samples by UHPLC coupled with Q-Exactive high resolution mass spectrometry after magnetic solid-phase extraction. MICROCHEMICAL JOURNAL[J]. 2021, 169: http://dx.doi.org/10.1016/j.microc.2021.106540.
[13] Yuan, YunCong, Bai, XiaoLin, Liu, YiMing, Tang, XiaoYue, Yuan, Hao, Liao, Xun. Ligand fishing based on cell surface display of enzymes for inhibitor screening. ANALYTICA CHIMICA ACTA[J]. 2021, 1156: http://dx.doi.org/10.1016/j.aca.2021.338359.
[14] Tang, XiaoYue, Liu, YiMing, Bai, XiaoLin, Yuan, Hao, Hu, YiKao, Yu, XiaoPing, Liao, Xun. Turn-on fluorescent probe for dopamine detection in solutions and live cells based on in situ formation of aminosilane-functionalized carbon dots. ANALYTICA CHIMICA ACTA[J]. 2021, 1157: 338394-338394, http://dx.doi.org/10.1016/j.aca.2021.338394.
[15] Li, Xiangtang, Liao, Xun, Liu, YiMing. A microfluidic platform integrating paper adsorption-based sample clean-up and voltage-assisted liquid desorption electrospray ionization mass spectrometry for biological sample analysis. TALANTA[J]. 2020, 217: http://dx.doi.org/10.1016/j.talanta.2020.121106.
[16] Zhao, Yan, Yuan, YunCong, Bai, XiaoLin, Liu, YiMing, Wu, GuiFang, Yang, FaShu, Liao, Xun. Multi-mycotoxins analysis in liquid milk by UHPLC-Q-Exactive HRMS after magnetic solid-phase extraction based on PEGylated multi-walled carbon nanotubes. FOOD CHEMISTRY[J]. 2020, 305: http://dx.doi.org/10.1016/j.foodchem.2019.125429.
[17] Wan, Huida, Wang, Qi, Chen, Xiuting, Zeng, Qiufang, Shao, Yanjiao, Fang, Houqin, Liao, Xun, Li, HuSong, Liu, MingGang, Xu, TianLe, Diao, Miaomiao, Li, Dali, Meng, Bo, Tang, Bin, Zhang, Zhuohua, Liao, Lujian. WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death. AUTOPHAGY[J]. 2020, 16(3): 531-547, http://dx.doi.org/10.1080/15548627.2019.1630224.
[18] Wang, Tingting, Wang, Jingyu, Wang, Jie, Mao, Lin, Tang, Bin, Vanderklish, Peter W, Liao, Xun, Xiong, ZhiQi, Liao, Lujian. HAP1 is an in vivo UBE3A target that augments autophagy in a mouse model of Angelman syndrome. NEUROBIOLOGY OF DISEASE[J]. 2019, 132: http://dx.doi.org/10.1016/j.nbd.2019.104585.
[19] Jiang, Xiaolan, Yuan, Yuncong, Chen, Linbo, Liu, Yiming, Xiao, Mengwei, Hu, Yadong, Chun, Ze, Liao, Xun. Monoamine oxidase B immobilized on magnetic nanoparticles for screening of the enzyme's inhibitors from herbal extracts. MICROCHEMICAL JOURNAL[J]. 2019, 146: 1181-1189, http://dx.doi.org/10.1016/j.microc.2019.02.049.
[20] Wu, GuiFang, Jiang, XiaoLan, Gong, YuZhou, Hu, YaDong, Bai, XiaoLin, Liao, Xun. Ligand fishing of anti-neurodegenerative components from Lonicera japonica using magnetic nanoparticles immobilised with monoamine oxidase B. JOURNAL OF SEPARATION SCIENCE[J]. 2019, 42(6): 1289-1298, [21] Zhao, Yan, Bai, XiaoLin, Song, Tao, Zhang, GuoLin, Yuan, YunCong, Liu, YiMing, Liao, Xun. Determination of environmental estrogens and bisphenol A in water samples by ultra-high performance liquid chromatography coupled to Q-Exactive high resolution mass spectrometry after magnetic solid-phase extraction. MICROCHEMICAL JOURNAL[J]. 2019, 151: http://dx.doi.org/10.1016/j.microc.2019.104212.
[22] Xiao, MengWei, Bai, XiaoLin, Liu, YiMing, Yang, Li, Hu, YaDong, Liao, Xun. Rapid quantification of aloinA and B in aloe plants and aloe-containing beverages, and pharmaceutical preparations by microchip capillary electrophoresis with laser induced fluorescence detection. JOURNAL OF SEPARATION SCIENCE[J]. 2018, 41(19): https://www.webofscience.com/wos/woscc/full-record/WOS:000446667500013.
[23] Xiao, MengWei, Bai, XiaoLin, Liu, YiMing, Yang, Li, Liao, Xun. Simultaneous determination of trace Aflatoxin B-1 and Ochratoxin A by aptamer-based microchip capillary electrophoresis in food samples. JOURNAL OF CHROMATOGRAPHY A[J]. 2018, 1569: 222-228, http://dx.doi.org/10.1016/j.chroma.2018.07.051.
[24] Xun Liao. Analysis of neuronal phosphoproteome reveals PINK1 regulation of BAD function and cell death. Cell Death and Differentiation. Cell death and differentiation. 2018, [25] Zhao, Yan, Wan, LiHong, Bai, XiaoLin, Liu, YiMing, Zhang, FengPing, Liu, YaoMin, Liao, Xun. Quantification of mycotoxins in vegetable oil by UPLC-MS/MS after magnetic solid-phase extraction. FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT[J]. 2017, 34(7): 1201-1210, https://www.webofscience.com/wos/woscc/full-record/WOS:000407629800011.
[26] Xun Liao. Rapid determination of gizzerosine in fish meals using microchip capillary electrophoresis with laser induced fluorescence detecction. Food Additives and Contaminants A. 2017, [27] Wan, Hong, Zhang, Bo, Bai, XiaoLin, Zhao, Yan, Xiao, MengWei, Liao, Xun. Extraction of ochratoxin A in red wine with dopamine-coated magnetic multi-walled carbon nanotubes. JOURNAL OF SEPARATION SCIENCE[J]. 2017, 40(20): 4022-4031, https://www.webofscience.com/wos/woscc/full-record/WOS:000413567800012.
[28] Hu, JinJie, Bai, XiaoLin, Liu, YiMing, Liao, Xun. Functionalized carbon quantum dots with dopamine for tyrosinase activity analysis. ANALYTICA CHIMICA ACTA[J]. 2017, 995(2017): 99-105, http://dx.doi.org/10.1016/j.aca.2017.09.038.
[29] Zhang YongMei, Xu PeiLi, Zeng Qiong, Liu YiMing, Liao Xun, Hou MeiFang. Magnetism-assisted modification of screen printed electrode with magnetic multi-walled carbon nanotubes for electrochemical determination of dopamine. MATERIALS SCIENCE & ENGINEERING C[J]. 2017, 74: 62-69, http://dx.doi.org/10.1016/j.msec.2017.01.005.
[30] Qiong Zeng, Yi-Ming Liu, Yan-Wei Jia, Li-Hong Wan, Xun Liao. PEGylation of magnetic multi-walled carbon nanotubes for enhanced selectivity of dispersive solid phase extraction. MATERIALS SCIENCE & ENGINEERING C. 2017, 71: 186-194, http://dx.doi.org/10.1016/j.msec.2016.09.082.
[31] Wan, LiHong, Jiang, XiaoLan, Liu, YiMing, Hu, JinJie, Liang, Jian, Liao, Xun. Screening of lipase inhibitors from Scutellaria baicalensis extract using lipase immobilized on magnetic nanoparticles and study on the inhibitory mechanism. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2016, 408(9): 2275-2283, https://www.webofscience.com/wos/woscc/full-record/WOS:000372598600009.
[32] Jia, YanWei, Zeng, ZhongQiu, Shi, HaiLi, Liang, Jian, Liu, YiMing, Tang, YaXiong, Liao, Xun. Characterization of in vitro metabolites of irisflorentin by rat liver microsomes using high-performance liquid chromatography coupled with tandem mass spectrometry. BIOMEDICAL CHROMATOGRAPHY[J]. 2016, 30(9): 1363-1370, https://www.webofscience.com/wos/woscc/full-record/WOS:000380925400003.
[33] Li Yuan, Pei-Li Xu, Qiong Zeng, Yi-Ming Liu, Li-Sheng Ding, Xun Liao. Preparation of ds-DNA functionalized magnetic nanobaits for screening of bioactive compounds from medicinal plant. MATERIALS SCIENCE & ENGINEERING C. 2015, 56: 401-408, http://dx.doi.org/10.1016/j.msec.2015.06.050.
[34] Shi, HaiLi, Jia, YanWei, Peng, ShuLin, Liao, Xun, Ding, LiSheng, Liu, YiMing. Metabolic study of Angelica dahurica extracts using a reusable liver microsomal nanobioreactor by liquid chromatography-mass spectrometry. BIOMEDICAL CHROMATOGRAPHY[J]. 2015, 29(10): 1514-1521, http://210.75.237.14/handle/351003/27568.
[35] Xun Liao. Fast identi?cation of lipase inhibitors in oolong tea by using lipase functionalised Fe3O4 magnetic nanoparticles coupled with UPLC–MS/MS. Food Chemistry. 2015, [36] McCullum, Cassandra, Tchounwou, Paul, Ding, LiSheng, Liao, Xun, Liu, YiMing. Extraction of Aflatoxins from Liquid Foodstuff Samples with Polydopamine-Coated Superparamagnetic Nanoparticles for HPLC-MS/MS Analysis. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2014, 62(19): 4261-4267, http://210.75.237.14/handle/351003/26684.
[37] Zhu, YuanTing, Jia, YanWei, Liu, YiMing, Liang, Jian, Ding, LiSheng, Liao, Xun. Lipase Ligands in Nelumbo nucifera Leaves and Study of Their Binding Mechanism. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2014, 62(44): 10679-10686, http://210.75.237.14/handle/351003/26661.
[38] Shi, HaiLi, Peng, ShuLin, Sun, Jun, Liu, YiMing, Zhu, YuanTing, Qing, LinSen, Liao, Xun. Selective extraction of berberine from Cortex Phellodendri using polydopamine-coated magnetic nanoparticles. JOURNAL OF SEPARATION SCIENCE[J]. 2014, 37(6): 704-710, http://210.75.237.14/handle/351003/26694.
[39] Xun Liao. 5. Xiao-Qing Shan, Shu-Lin Peng, Hai-Li Shi, Xiao-Ling Wang,* Li-Sheng Ding, Xun Liao*. Panthogenins A and B, two novel norergostanol steroids from Dioscorea panthaica. Chinese Chemical Letters. 2014, [40] Yuan-Ting Zhu, Xiao-Yun Ren, Yi-Ming Liu, Ying Wei, Lin-Sen Qing, Xun Liao. Covalent immobilization of porcine pancreatic lipase on carboxyl-activated magnetic nanoparticles: Characterization and application for enzymatic inhibition assays. MATERIALS SCIENCE & ENGINEERING C. 2014, 38: 278-285, http://dx.doi.org/10.1016/j.msec.2014.02.011.
[41] LiSheng Ding. Rapid separation and characterisation of triacylglycerols in ostrichoil by ultra performance liquid chromatography coupled with quadrupole time-of-?ight mass spectrometry. Food Chemistry. 2013, [42] Xue, Ying, Xiong, Jing, Shi, HaiLi, Liu, YiMing, Qing, LinSen, Liao, Xun. In vitro metabolic study of Rhizoma coptidis extract using liver microsomes immobilized on magnetic nanoparticles. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2013, 405(27): 8807-8817, http://www.irgrid.ac.cn/handle/1471x/900531.
[43] Ren, XiaoYun, Xue, Ying, Liang, Jian, Ding, LiSheng, Liao, Xun. Selective extraction of flavonoids from Ginkgo biloba leaves using human serum albumin functionalized magnetic nanoparticles. CHINESE CHEMICAL LETTERS[J]. 2013, 24(12): 1099-1102, http://lib.cqvip.com/Qikan/Article/Detail?id=48218814.
[44] Xun Liao. Rapid magnetic solid-phase extraction for e selective determination of iso?avones in soymilk using baicalin-functionalized magnetic nanoparticles. Journal of Agricultural and Food Chemistry. 2013, [45] Qing, LinSen, Tang, Nan, Xue, Ying, Liang, Jian, Liu, YiMing, Liao, Xun. Identification of enzyme inhibitors using therapeutic target protein-magnetic nanoparticle conjugates. ANALYTICAL METHODS[J]. 2012, 4(6): 1612-1615, http://www.irgrid.ac.cn/handle/1471x/656387.
[46] Xun Liao. Identification of Flavonoid Glycosides in Rosa chinensis Flowers by LC-DAD-MSn in combination with 13C NMR. J. Chromatogr. A. 2012, [47] Xue, Ying, Xu, XueMin, Yan, JuFang, Deng, WenLong, Liao, Xun. Chemical constituents from Astilbe chinensis. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2011, 13(2): 188-191, http://www.irgrid.ac.cn/handle/1471x/517914.
[48] Qing, LinSen, Xue, Ying, Deng, WenLong, Liao, Xun, Xu, XueMin, Li, BoGang, Liu, YiMing. Ligand fishing with functionalized magnetic nanoparticles coupled with mass spectrometry for herbal medicine analysis. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2011, 399(3): 1223-1231, http://www.irgrid.ac.cn/handle/1471x/517906.
[49] Qing, LinSen, Xiong, Jing, Xue, Ying, Liu, YiMing, Guang, Bin, Ding, LiSheng, Liao, Xun. Using baicalin-functionalized magnetic nanoparticles for selectively extracting flavonoids from Rosa chinensis. JOURNAL OF SEPARATION SCIENCE[J]. 2011, 34(22): 3240-3245, http://www.irgrid.ac.cn/handle/1471x/517861.
[50] Qing, LinSen, Shan, XiaoQing, Xu, XueMin, Xue, Ying, Deng, WenLong, Li, BoGang, Wang, XiaoLing, Liao, Xun. Rapid probe and isolation of bioactive compounds from Dioscorea panthaica using human serum albumin functionalized magnetic nano-particles (HSA-MNPs)-based ligand fishing coupled with electrospray ionization mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY[J]. 2010, 24(22): 3335-3339, http://www.irgrid.ac.cn/handle/1471x/256645.
[51] Qing, LinSen, Xue, Ying, Zheng, Yi, Xiong, Jing, Liao, Xun, Ding, LiSheng, Li, BoGang, Liu, YiMing. Ligand fishing from Dioscorea nipponica extract using human serum albumin functionalized magnetic nanoparticles. JOURNAL OF CHROMATOGRAPHY A[J]. 2010, 1217(28): 4663-4668, http://dx.doi.org/10.1016/j.chroma.2010.05.009.
[52] Fu, Yu, Zhou, Yan, Liao, Xun, Bai, Bingru, Peng, Shulin, Ding, Lisheng. A New Alkaloid from Corydalis hendersonii. PLANTA MEDICA[J]. 2009, 75(5): 547-549, http://www.irgrid.ac.cn/handle/1471x/256536.
[53] Zeng QbrJia YWbrXu PLbrXiao MWbrLiu YMbrPeng SLbrLiao X. Quick and selective extraction of Z-ligustilide from Angelica sinensis using magnetic multiwalled carbon nanotubes. JOURNAL OF SEPARATION SCIENCE. 10.1002/jssc.201500862.

   

（ 1 ） 基于磁性纳米粒子的微粒体生物反应器用于中药代谢的研究, 主持, 国家级, 2011-01--2013-12
（ 2 ） 鸵鸟油的研究与开发, 主持, 研究所（学校）, 2010-03--2015-03
（ 3 ） 用荧光磁性纳米探针筛选中药中的小分子酶抑制剂, 主持, 国家级, 2012-01--2015-12
（ 4 ） 微流控芯片电泳在干细胞生物学中的应用, 主持, 部委级, 2015-01--2017-12
（ 5 ） 靶向帕金森病致病蛋白质的天然化合物建库及先导化合物筛选, 主持, 部委级, 2016-12--2018-06
（ 6 ） 表面展示技术用于药用植物中降糖活性成分的研究, 主持, 省级, 2017-03--2019-12
（ 7 ） 中药材品质评价与质量控制, 主持, 部委级, 2017-01--2018-12
（ 8 ） 秦巴山区到底中药材多元化种植示范及推广, 主持, 省级, 2017-01--2019-12
（ 9 ） 临床高通量基因侧学诊断试剂及其配套仪器的研发及产业化, 主持, 省级, 2017-11--2020-12
（ 10 ） 两种中药物质基础及质量控制研究, 主持, 院级, 2016-12--2020-12

（1）姜黄素对PINK1敲除果蝇帕金森症模型的保护作用   第十届全国有机化学学术会议   2017-12-19
（2）珊瑚菜内酯的体外代谢研究   第二届全国质谱分析学术报告会   2015-10-17

已指导学生

李丽梅  硕士研究生  071001-植物学  

官艳丽  硕士研究生  100701-药物化学  

薛莹  硕士研究生  077901-药物化学  

熊静  硕士研究生  077901-药物化学  

任晓云  硕士研究生  077901-药物化学  

祝元婷  硕士研究生  077901-药物化学  

薛莹  博士研究生  100701-药物化学  

贾颜维  硕士研究生  078001-药物化学  

万丽红  硕士研究生  085235-制药工程  

胡瑾洁  硕士研究生  078001-药物化学  

曾琼  硕士研究生  085235-制药工程  

蒋晓兰  硕士研究生  085235-制药工程  

吴桂芳  硕士研究生  085238-生物工程  

万虹  硕士研究生  078001-药物化学  

赵艳  博士研究生  100701-药物化学  

现指导学生

肖孟玮  博士研究生  100701-药物化学  

唐晓月  硕士研究生  085238-生物工程  

袁韫聪  博士研究生  100701-药物化学  

袁昊  硕士研究生  085238-生物工程  

龚宇舟  博士研究生  071002-动物学  

祁绪伟  硕士研究生  085238-生物工程  

胡义考  博士研究生  100701-药物化学