基本信息
袁伟成  男  博导  中国科学院成都有机化学研究所
电子邮件: yuanweicheng@126.com
通信地址: 成都市人民南路四段9号中科院成都有机化学研究所
邮政编码: 610041

研究领域

有机合成方法学研究
催化不对称合成

招生信息

有机合成
药物合成
招生专业
070303-有机化学
招生方向
有机合成方法学研究,催化不对称合成

教育背景

2001-09--2006-07   中科院成都有机化学研究所   有机化学专业,获博士学位
1994-09--1998-07   四川大学   四川大学化学系有机化学专业,获学士学位
出国学习工作
2006年8月-2007年9月,美国科罗拉多州立大学化学系,博士后
学历
-- 研究生
学位
-- 博士

工作经历

1998年8月-2001年8月,中国航天工业总公司第四研究院,助理工程师
2006年8月-2007年9月,美国科罗拉多州立大学化学系,博士后
2007年10月至今, 中国科学院成都有机化学研究所,研究员,博士生导师
2010年5月-2011年2月,手性药物国家工程研究中心,研发部经理
2011年3月至今, 手性药物国家工程研究中心副主任
2011年3月至今, 成都丽凯手性技术有限公司常务副总
奖励信息
1、中国科学院“西部之光”人才培养计划,2010年
2、四川省直机关工委优秀共产党员, 2010年
3、四川省学术与技术带头人后备人选,2011年
工作简历
2015-10~现在, 手性药物国家工程研究中心, 主任
2015-10~现在, 成都丽凯手性技术有限公司,手性药物国家工程研究中心, 董事长
2011-03~2011-07,成都丽凯手性技术有限公司,手性药物国家工程研究中心, 常务副总经理,研究中心副主任
2010-05~2011-02,成都丽凯手性技术有限公司,手性药物国家工程研究中心, 研发部经理
2007-10~2011-07,中国科学院成都有机化学研究所, 研究员,博士生导师
2006-08~2007-09,美国科罗拉多州立大学, 美国科罗拉多州立大学化学系,博士后
1998-08~2001-08,中国航天工业总公司第四研究院, 助理工程师
社会兼职
   

教授课程

   

指导学生

已指导学生

陈文兵  博士研究生  070303-有机化学  

孙宏伟  博士研究生  070303-有机化学  

刘雄利  博士研究生  070303-有机化学  

韩艳艳  博士研究生  070303-有机化学  

廖玉华  博士研究生  070303-有机化学  

李科  硕士研究生  070303-有机化学  

裴青蓝  博士研究生  070303-有机化学  

韩文勇  博士研究生  070303-有机化学  

崔宝东  博士研究生  070303-有机化学  

侯雪  博士研究生  070303-有机化学  

周鸣强  博士研究生  070303-有机化学  

左建  博士研究生  070303-有机化学  

梅青刚  博士研究生  070303-有机化学  

邓莉萍  硕士研究生  070303-有机化学  

白玫  博士研究生  070303-有机化学  

赵建强  博士研究生  070303-有机化学  

现指导学生

葛真真  博士研究生  070303-有机化学  

邢志奎  博士研究生  070303-有机化学  

游勇  博士研究生  070303-有机化学  

胡文飞  博士研究生  070303-有机化学  

陈剑锋  博士研究生  070303-有机化学  

卢文雅  硕士研究生  070303-有机化学  

袁书培   硕士研究生  070303-有机化学  

发表论文

发表论文
1. Wen-Bing Chen, Zhi-Jun Wu, Jing Hu, Lin-Feng Cun, Xiao-Mei Zhang, and Wei-Cheng Yuan*. Organocatalytic Direct Asymmetric Aldol Reactions of 3-Isothiocyanato Oxindoles to Ketones: Stereocontrolled Synthesis of Spirooxindoles Bearing Highly Congested Contiguous Tetrasubstituted Stereocenters. Org. Lett. 2011, accept.
2. Xiong-Li Liu, Zhi-Jun Wu, Xi-Lin Du, Xiao-Mei Zhang, and Wei-Cheng Yuan*. Amino-Indanol Catalyzed Asymmetric Michael Additions of Oxindoles to Protected 2-Amino-1-Nitroethenes for the Synthesis of 3,3’-Disubstituted Oxindoles Bearing α,β-Diamino Functionality. J. Org. Chem. 2011, accept.
3. Yu-Hua Liao, Xiong-Li Liu, Zhi-Jun Wu, Xi-Lin Du, Xiao-Mei Zhang, and Wei-Cheng Yuan*. Thiourea-Catalyzed Highly Diastereo- and Enantioselective Conjugate Additions of α-Substituted Cyanoacetates to Maleimides: Efficient Construction of Vicinal Quaternary-Tertiary Stereocenters. Adv. Synth. Catal. 2011, accept.
4. Hong-Wei Sun, Yu-Hua Liao, Zhi-Jun Wu, Hao-Yu Wang, Xiao-Mei Zhang, Wei-Cheng Yuan*. Enantioselective 1,6-Michael addition of anthrone to 3-methyl-4-nitro-5-alkenyl-isoxazoles catalyzed by bifunctional thiourea-tertiary amines. Tetrahedron, 2011, accept.
5. Xiong-Li Liu, Xiao-Mei Zhang, Wei-Cheng Yuan*. A simple and eco-friendly method for the aminomethylation of 3-substituted oxindoles via three-component Mannich reaction in aqueous media. Tetrahedron Letters 2011, 52, 903-906.
6. Yu-Hua Liao, Xiong-Li Liu, Zhi-Jun Wu, Lin-Feng Cun, Xiao-Mei Zhang and Wei-Cheng Yuan*. Highly Diastereo- and Enantioselective Michael Additions of 3-Substituted Oxindoles to Maleimides Catalyzed by Chiral Bifunctional Thiourea-tertiary amine. Org. Lett., 2010, 12, 2896-2899.
7. Wen-Bing Chen, Zhi-Jun Wu, Qing-Lan Pei, Lin-Feng Cun, Xiao-Mei Zhang, and Wei-Cheng Yuan*. Highly Enantioselective Construction of Spiro[4H-pyran-3,3’-oxindoles] Through Domino Knoevenagel/Michael/Cyclization Sequence Catalyzed by Cupreine. Org. Lett., 2010, 12, 3132-3135.
8. Xiong-Li Liu, Yu-Hua Liao, Zhi-Jun Wu, Lin-Feng Cun, Xiao-Mei Zhang, and Wei-Cheng Yuan*. Direct Catalytic Asymmetric Aldol Reaction of 3-Substituted Oxindoles with Paraformaldehyde by Chiral Bifunctional Thiourea. J. Org. Chem. 2010, 75, 4872-4875.
9. Yu-Hua Liao, Wen-Bing Chen, Zhi-Jun Wu, Xi-Lin Du, Lin-Feng Cun, Xiao-Mei Zhang and Wei-Cheng Yuan*. Organocatalytic Asymmetric Michael Addition of Pyrazolin-5-ones to Nitroolefins with Bifunctional Thiourea: Stereocontrolled Construction of Contiguous Quaternary and Tertiary Stereocenters. Adv. Synth. Catal. 2010, 352, 827-832.
10. Wen-Bing Chen, Xi-Lin Du, Lin-Feng Cun, Xiao-Mei Zhang and Wei-Cheng Yuan*. Highly enantioselective aldol reaction of acetaldehyde and isatins only with 4-hydroxydiarylprolinol as catalyst: concise stereoselective synthesis of (R)-convolutamydines B and E, (−)-donaxaridine and (R)-chimonamidine. Tetrahedron 2010, 66, 1441-1446.
11. Yan-Yan Han, Zhi-Jun Wu, Xiao-Mei Zhang and Wei-Cheng Yuan*. An efficient synthesis of 3-(indol-3-yl)quinoxalin-2-ones with TfOH-catalyzed Friedel-Crafts type coupling reaction in air. Tetrahedron Letters 2010, 51, 2023-2028.
12. Hui Zhang, Lin-Feng Cun, Xiao-Mei Zhang, Wei-Cheng Yuan*. Chiral Phosphoric Acid Catalyzed Diastereo- and Enantioselective 1,4-Conjugate Addition of β-Ketoesters to Nitroolefins. Letters in Organic Chemistry, 2010, 7, 219-225.
13. Yu-Hua Liao, Hui Zhang, Zhi-Jun Wu, Lin-Feng Cun, Xiao-Mei Zhang, and Wei-Cheng Yuan*. Enantioselective Michael addition of anthrone to nitroalkenes catalyzed by bifunctional thiourea-tertiary amines. Tetrahedron: Asymmetry 2009, 20, 2397-2402.
14. Wen-Bing Chen, Yu-Hua Liao, Xi-Lin Du, Xiao-Mei Zhang, and Wei-Cheng Yuan*. Catalyst-free aldol condensation of ketones and isatins under mild reaction conditions in DMF with molecular sieves 4 Å as additive. Green Chem., 2009, 11, 1465-1476.
15. Wei-Cheng Yuan*, Lin-Feng Cun, Ai-Qiao Mi, Yao-Zhong Jiang and Liu-Zhu Gong. A class of readily available optically pure 7,7’-disubstituted BINAPs for asymmetric catalysis. Tetrahedron 2009, 65, 4130-4141.

专利与奖励

   
奖励信息
(1) 四川省第十三届青年科技奖, 省级, 2015
(2) 成都人才计划, 市地级, 2014
(3) 国家工程研究中心先进个人, 国家级, 2012
(4) 四川省"****"人才, 其他, 2012
(5) 中科院朱李月华优秀教师奖, 院级, 2011
(6) 四川省直机关工委优秀共产党员, 院级, 2010
专利成果
( 1 ) 一种四氢呋喃-2-甲酸工业化消旋工艺, 发明, 2016, 第 1 作者, 专利号: 201610000558.9
( 2 ) 一种高光学纯度乙酰基四氢呋喃的工业化制备方法, 发明, 2016, 第 1 作者, 专利号: 201610000556.X
( 3 ) 一种高光学纯度1-[(2S)-四氢-2-呋喃基]乙酮的工业化制备方法, 发明, 2016, 第 1 作者, 专利号: 201610000557.4
( 4 ) 一种合成环丙贝特的新方法, 发明, 2015, 第 1 作者, 专利号: 201510711121.1
( 5 ) 一种采用对香豆酸制备降血脂药环丙贝特的方法, 发明, 2015, 第 1 作者, 专利号: 201510711339.7
( 6 ) 一种制备脲类化合物的新方法, 发明, 2015, 第 1 作者, 专利号: 201510018993.X
( 7 ) 一种喹啉酮类衍生物及其制备方法, 发明, 2015, 第 1 作者, 专利号: 201510019003.4
( 8 ) 氮杂二苯并环辛炔盐酸盐类化合物及其制备方法, 发明, 2015, 第 1 作者, 专利号: 201510018994.4
( 9 ) 一种氟氯西林钠一水合物的合成方法., 发明, 2015, 第 1 作者, 专利号: 201510380228.
( 10 ) 一种高光学纯度盐酸坦索罗辛的制备方法, 发明, 2015, 第 1 作者, 专利号: 201510380212.1
( 11 ) 一种L-苯丙氨酸不对称转换制备D-苯丙氨酸的方法., 发明, 2015, 第 1 作者, 专利号: 201510380183.9
( 12 ) 一种2-(2-乙氧基苯氧基)溴代乙烷的工业化制备方法, 发明, 2015, 第 1 作者, 专利号: 201510380235.2
( 13 ) 一种2-(2-甲氧基乙氧基)乙醛缩二醇的制备方法, 发明, 2015, 第 1 作者, 专利号: 201510380237.1
( 14 ) 一种合成氧化呋咱化合物的新方法, 发明, 2014, 第 1 作者, 专利号: 201410338114.7
( 15 ) 3,3’-二取代的3-吡咯氧化吲哚化合物及其不对称合成方法., 发明, 2016, 第 1 作者, 专利号: 201410338206.5;

出版信息

   
发表论文
(1) Arylacetyl Phosphonates as Michael Donors for the Asymmetric Michael Reaction to Construct alpha-Substituted Chiral Carboxylic Esters, Tetrahedron, 2016, 通讯作者
(2) A Neber approach for the synthesis of spiro-fused 2H-azirine-pyrazolone, Org. Biomol. Chem, 2016, 通讯作者
(3) Organocatalytic asymmetric Henry reaction of 1H-pyrrole-2,3-diones with bifunctional amine-thiourea catalysts bearing multiple hydrogen-bond donors., Beilstein J. Org. Chem., 2016, 通讯作者
(4) Organocatalytic Asymmetric Michael/Cyclization Cascade Reactions of 3-Hydroxyoxindoles/3-Aminooxindoles with α,β-Unsaturated Acyl Phosphonates for the Construction of Spirocyclic Oxindole-γ-lactones/lactams., J. Org. Chem, 2015, 通讯作者
(5) Zn-Catalyzed Diastereo- and Enantioselective ascade Reaction of 3-Isothiocyanato Oxindoles and 3-Nitroindoles: Stereocontrolled Syntheses of Polycyclic Spirooxindoles., Org. Lett., 2015, 通讯作者
(6) α-Isothiocyanato Amides, Esters and Phosphonates: New Platforms in Catalytic Asymmetric Synthesis., Adv. Synth. Catal., 2015, 通讯作者
(7) Enantioselective Synthesis of 3,3-Disubstituted Oxindoles Bearing two Heteroatoms at the C3 Position by Organocatalyzed Sulfenylation and Selenenylation of 3-Pyrrolyl-oxindoles., J. Org. Chem., 2015, 通讯作者
(8) Diastereo- and Enantioselective Direct Vinylogous Michale Addition of γ-Substituted Butenolides to 2‑Enoylpyridines Catalyzed by Chiral Bifunctional Amine-Squaramides. ., Chem. Commun, 2015, 通讯作者
(9) Asymmetric Michael/Cyclization Cascade Reaction of 3-Isothiocyanato Oxindoles and 3-Nitroindoles with Amino-Thiocarbamate Catalysts: Enantioselective Synthesis of Polycyclic Spirooxindoles., Org. Lett., 2015, 通讯作者
(10) Organocatalytic Asymmetric Michael/Friedel-Crafts Cascade Reaction of 3-Pyrrolyl-oxindoles and α,β-Unsaturated Aldehydes for the Construction of Chiral Spiro[5,6-dihydropyrido[1,2-a]pyrrole-3,3'-oxindoles]., J. Org. Chem., 2015, 通讯作者
(11) DMAP-catalyzed Diels-Alder reaction of 3-hydroxy-2-pyrone and methyleneindolinones for the synthesis of spirocyclic oxindoles., Tetrahedron, 2015, 通讯作者
(12) Organocatalytic asymmetric Michael addition of 3-substituted oxindoles to α,β-unsaturated acyl phosphonates for the synthesis of 3,3'-disubstituted oxindoles with chiral squaramides. ., Org. Biomol. Chem, 2015, 通讯作者
(13) Organocatalytic asymmetric Michael addition of 3-substituted oxindoles to α,β-unsaturated acyl phosphonates for the synthesis of 3,3'-disubstituted oxindoles with chiral squaramides., Org. Biomol. Chem., 2015, 通讯作者
(14) Synthesis of furoxan derivatives: DABCO-mediated cascade sulfonylation/cyclization reaction of α-nitro-ketoximes and sulfonyl chlorides., Tetrahedron, 2015, 通讯作者
(15) Quinine-catalyzed asymmetric domino Mannich-cyclization reactions of 3-isothiocyanato oxindoles with imines for the synthesis of spirocyclic oxindoles., Tetrahedron, 2015, 通讯作者
(16) Preparation of 3-Sulfonylated 3,3-Disubstituted Oxindoles by the Addition of Sulfinate Salts to 3-Halooxindoles., J. Org. Chem., 2015, 通讯作者
(17) 3-Pyrrolyl-oxindoles as efficient nucleophiles for organocatalytic asymmetric synthesis of structurally diverse 3,3'-disubstituted oxindole derivatives., Chem. Commun., 2015, 通讯作者
(18) A convenient method for synthesis of polyfunctional dihydropyrrole spiro-fused oxindole-2-ones via an organocatalytic tandem Michael/cyclization sequence., Tetrahedron Lett., 2014, 通讯作者
(19) Highly regioselective synthesis of 3-alkylthio-2-oxindoles via DABCO-catalyzed allylic a-substitution of MoritaeBayliseHillman carbonates of isatins with various thiols,, Tetrahedron, 2014, 通讯作者
(20) Organocatalytic asymmetric double Michael reaction of Nazarov reagents with alkylidene azlactones for the construction of spiro-fused cyclohexanone/5-oxazolone system., Tetrahedron, 2014, 通讯作者
(21) A facile synthesis of 3-hydroxy-3-(trifluoromethyl)-1H-pyrrol-2(3H)-ones with Brønsted acid-catalyzed condensation-cyclization reactions of β-enamino esters and ethyl trifluoropyruvate., Tetrahedron, 2014, 通讯作者
(22) Tandem Michael Addition-Ring Transformation Reactions of 3-Hydroxyoxindoles/3-Aminooxindoles with Olefinic Azlactones: Direct Access to Structurally Diverse Spirocyclic Oxindoles., J. Org. Chem., 2014, 通讯作者
(23) Quinine-catalyzed asymmetric domino Michael-cyclization reaction for the synthesis of spirocyclic oxindoles bearing two spiro quaternary centers and three consecutive stereocenters., Tetrahedron, 2014, 通讯作者
(24) Enantioselective Synthesis of Quaternary 3‑Aminooxindoles via Organocatalytic Asymmetric Michael Addition of 3‑Monosubstituted 3‑Aminooxindoles to Nitroolefins, J. Org. Chem., 2013, 通讯作者
(25) Asymmetric Synthesis of β-Hydroxy-α-Amino Phosphonic Acid Derivatives via Organocatalytic Direct Aldol Reaction of α-Isothiocyanato Phosphonates with Aldehydes., J. Org. Chem., 2013, 通讯作者
(26) A Chiral Ruthenium-Monophosphine Catalyst for Asymmetric Addition of Arylboronic Acids to Aryl Aldehydes., J. Org. Chem., 2013, 通讯作者
(27) Highly efficient synthesis of spiro[oxazolidine-2-thione-oxindoles] with 3-isothiocyanato oxindoles and aldehydes via an organocatalytic cascade aldol-cyclization reaction., Tetrahedron, 2013, 通讯作者
(28) Organocatalytic diastereo- and enantioselective sulfa-Michael addition to α,β-disubstituted nitroalkenes., Tetrahedron, 2013, 通讯作者
(29) Lewis Acid Catalyzed Formation of 3-Amino-3-Carboxy-Tetrahydroquinoline Derivatives via Tandem 1,5-Hydride Transfer/Cyclization Process., Tetrahedron, 2013, 通讯作者
(30) 3-Isothiocyanato Oxindoles Serving as Powerful and Versatile Precursors to Structurally Diverse Dispirocyclic Thiopyrrolidineoxindoles via Cascade Michael/Cyclization Process Using Amino-Thiocarbamate Catalysts., Chem. Eur. J., 2013, 通讯作者
(31) Highly Efficient and Stereocontrolled Construction of 3,3'-Pyrrolidonyl Spirooxindoles via Organocatalytic Domino Michael/Cyclization Reaction., Org. Lett., 2013, 通讯作者
(32) Enantioselective Petasis reaction among salicylaldehydes, amines, and organoboronic acids catalyzed by BINOL., Tetrahedron, 2013, 通讯作者
(33) Organocatalyzed Enantioselective Decarboxylative Stereoablation Reaction for the Construction of 3,3′-Disubstituted Oxindoles Using β‑Ketoacids and 3‑Halooxindoles., J. Org. Chem., 2012, 通讯作者
(34) Organocatalyzed Enantioselective Decarboxylative Stereoablation Reaction for the Construction of 3,3′-Disubstituted Oxindoles Using β‑Ketoacids and 3‑Halooxindoles., J. Org. Chem., 2012, 通讯作者
(35) Organocatalytic Enantioselective Stereoablative Hydroxylation of 3-Halooxindoles: An Effective Method for the Construction of Enantioenriched 3-Substituted-3-Hydroxy-2-Oxindoles., Chem. Eur. J., 2012, 通讯作者
(36) Organocatalytic Asymmetric Conjugate Addition of 3-Monosubstituted Oxindoles to (E)-1,4-Diaryl-2-buten-1,4-diones: a Strategy for the Indirect Enantioselective Furanylation and Pyrrolylation of 3-Alkyloxindoles., Chem. Eur. J., 2012, 通讯作者
(37) Enantioselective Organocatalytic Three-Component Petasis Reaction among Salicylaldehydes, Amines and Organoboronic Acids., Org. Lett., 2012, 通讯作者
(38) Highly Efficient and Stereoselective Construction of Dispiro-[oxazolidine-2-thione]bisoxindoles and Dispiro [imidazolidine-2-thione]bisoxindoles., Org. Lett., 2012, 通讯作者
(39) Catalytic Asymmetric 1,6-Michael Addition of Arylthiols to 3-methyl-4-nitro-5-alkenyl-isoxazoles with Bifunctional Catalysts, J. Org. Chem, 2011, 通讯作者
(40) Organocatalytic Direct Asymmetric Aldol Reactions of 3-Isothiocyanato Oxindoles to Ketones: Stereocontrolled Synthesis of Spirooxindoles Bearing Highly Congested Contiguous Tetrasubstituted Stereocenters, Org. Lett, 2011, 通讯作者
(41) Amino-Indanol Catalyzed Asymmetric Michael Additions of Oxindoles to Protected 2-Amino-1-Nitroethenes for the Synthesis of 3,3’-Disubstituted Oxindoles Bearing α,β-Diamino Functionality, J. Org. Chem, 2011, 通讯作者
(42) Thiourea-Catalyzed Highly Diastereo- and Enantioselective Conjugate Additions of α-Substituted Cyanoacetates to Maleimides: Efficient Construction of Vicinal Quaternary-Tertiary Stereocenters, Adv. Synth. Catal, 2011, 通讯作者
(43) Enantioselective 1,6-Michael addition of anthrone to 3-methyl-4-nitro-5-alkenyl-isoxazoles catalyzed by bifunctional thiourea-tertiary amines, Tetrahedron, 2011, 通讯作者
(44) A simple and eco-friendly method for the aminomethylation of 3-substituted oxindoles via three-component Mannich reaction in aqueous media, Tetrahedron Letters, 2011, 通讯作者
(45) Highly Diastereo- and Enantioselective Michael Additions of 3-Substituted Oxindoles to Maleimides Catalyzed by Chiral Bifunctional Thiourea-tertiary amine, Org. Lett, 2010, 通讯作者
(46) Highly Enantioselective Construction of Spiro[4H-pyran-3,3’-oxindoles] Through Domino Knoevenagel/Michael/Cyclization Sequence Catalyzed by Cupreine, Org. Lett., 2010, 通讯作者
(47) Direct Catalytic Asymmetric Aldol Reaction of 3-Substituted Oxindoles with Paraformaldehyde by Chiral Bifunctional Thiourea, J. Org. Chem, 2010, 通讯作者
(48) Organocatalytic Asymmetric Michael Addition of Pyrazolin-5-ones to Nitroolefins with Bifunctional Thiourea: Stereocontrolled Construction of Contiguous Quaternary and Tertiary Stereocenters, Adv. Synth. Catal, 2010, 通讯作者
发表著作
Organocatalyzed Asymmetric Reaction Using α-Isothiocyanato Compounds, InTechOpen, 2016-06, 第 1 作者

科研活动

   
科研项目
( 1 ) 新型双手性双钒金属催化剂与不对称氧化偶联反应, 主持, 国家级, 2009-01--2011-12
( 2 ) 手性催化的重要科学基础, 参与, 国家级, 2010-01--2012-12
( 3 ) 多种含手性螺环结构氧化吲哚类化合物的催化不对称合成研究, 主持, 省级, 2011-01--2013-12
( 4 ) 抗艾滋病药依非韦伦(Efavirenz)的不对称合成新工艺开发, 主持, 部委级, 2010-01--2012-12
( 5 ) 手性Lewis Acids催化的分子内串联1,5-氢迁移/环合反应及其在构建结构多样性手性含氮杂环化合物中的应用, 主持, 国家级, 2014-01--2017-12
( 6 ) 基于α-卤代腙的不对称环化反应在构建含多氮杂环手性化合物中的应, 主持, 国家级, 2016-01--2019-12
参与会议
(1)3-NCS氧化吲哚参与的不对称反应研究   2015年西部有机化学论坛   2015-11-07

合作情况

   
项目协作单位