071009-细胞生物学
0710J6-再生医学

肝脏疾病的分子病理机制

1998-09--2003-08   中国科学院上海生命科学院上海细胞研究所   博士
1992-09--1997-08   中国科学技术大学生物系   学士

   

2008-09~2011-07,中国科学院上海生命科学院上海生物化学和细胞研究所, 研究员
2004-08~2008-08,奥地利维也纳Institute of Molecular Pathology (IMP), 博士后
1998-09~2003-08,中国科学院上海生命科学院上海细胞研究所, 博士
1992-09~1997-08,中国科学技术大学生物系, 学士

2012-07-01-2017-07-01,Journal of Biological Chemistry, 编委
2009-01-01-2016-08-31,中国细胞生物学学报编委,

   

（ 1 ） Hepatocyte-like cells and uses thereof, 2016, 第 1 作者, 专利号: 13883748

（ 2 ） Human hepatocyte-like cells and uses thereof, 2015, 第 1 作者, 专利号: 特願2015-556390

（ 3 ） Human hepatocyte-like cells and uses thereof, 2014, 第 1 作者, 专利号: PCT/CN2014/071898

（ 4 ） 一种新的制备肝实质细胞的方法, 2013, 第 1 作者, 专利号: zl201010531420.4

（ 5 ） miRNA-27b在抗肿瘤耐药中的应用, 2013, 第 1 作者, 专利号: 201310368487.4

（ 6 ） 一种新的制备肝实质细胞的方法, 2013, 第 1 作者, 专利号: 201310050796.7

（ 7 ） Hepatocyte-like cells and uses thereof , 2011, 第 1 作者, 专利号: PCT/CN2011/001857

   

（1） A Pharmacogenomic Landscape in Human Liver Cancers, Cancer Cell, 2019, 通讯作者
（2） Modeling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes., Nature Cell Biology, 2019, 通讯作者
（3） A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling, Cell Stem Cell., 2019, 通讯作者
（4） Arid1a regulates response to anti-angiogenic therapy in advanced hepatocellular carcinoma., J Hepatol., 2018, 通讯作者
（5） Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening., Cell Research., 2017, 通讯作者
（6） Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor., Stem Cell Reports., 2017, 通讯作者
（7） High-throughput screening for Survivin and Borealin interaction inhibitors in hepatocellular carcinoma., Biochemical and Biophysical Research Communications., 2017, 通讯作者
（8） Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes., Cell Research, 2016, 通讯作者
（9） Hepatocellular carcinoma repression by TNFa-mediated synergistic lethal effect of mitosis defect-induced senescence and cell death sensitization, Hepatology, 2016, 通讯作者
（10） Hepatocellular carcinoma cell lines retain the genomic and transcriptomic landscapes of primary human cancers, Scientific reports, 2016, 通讯作者
（11） Efficient liver repopulation of transplanted hepatocyte prevents cirrhosis in a rat model of hereditary tyrosinemia type I., Scientific Reports, 2016, 通讯作者
（12） Hepatic Loss of Borealin Impairs Postnatal Liver Development, Regeneration, and Hepatocarcinogenesis., J Biol Chem, 2016, 通讯作者
（13） DUSP16 ablation arrests the cell cycle and induces cellular senescence, The FEBS journal, 2015, 通讯作者
（14） miR-27b synergizes with anticancer drugs via p53 activation and CYP1B1 suppression, Cell Research, 2015, 通讯作者
（15） Direct reprogramming of human fibroblasts to functional and expandable hepatocytes, Cell stem cell, 2014, 通讯作者
（16） Cell fate conversion: direct induction of hepatocyte-like cells from fibroblasts, Journal of cellular biochemistry, 2013, 通讯作者
（17） Hepatic loss of survivin impairs postnatal liver development and promotes expansion of hepatic progenitor cells in mice, Hepatology, 2013, 通讯作者
（18）  p38alpha controls erythroblast enucleation and Rb signaling in stress erythropoiesis, Cell research, 2012, 通讯作者
（19） Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin, Nature cell biology, 2012, 通讯作者
（20）  Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors,  Nature, 2011, 通讯作者
（21） Mitogen-activated protein kinases in hepatocellular carcinoma development, Semin Cancer Biol. , 2010, 通讯作者
（22） Hepatoblast-like progenitor cells derived from embryonic stem cells can repopulate livers of mice, Gastroenterology, 2010, 通讯作者
（23） of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation, Journal of Clinical Investigation , 2008, 第 1 作者
（24） Antagonistic control of cell fates by JNK and p38-MAPK signaling, Cell Death Differentiation , 2008, 第 3 作者
（25） p38alpha: a suppressor of cell proiferation and tumorigenesis, Cell Cycle , 2007, 第 1 作者
（26） p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway, Nature Genetics , 2007, 第 1 作者
（27） Identification of Alternatively Spliced mRNA Isoforms Associated with Cancers by Genome-wide ESTs Alignment, Oncogene , 2004, 第 1 作者

   

（ 1 ） 肝脏再生过程细胞可塑性的分子调控机制研究, 负责人, 国家任务, 2017-01--2021-12
（ 2 ） 肝脏损伤再生过程巨噬细胞对肝细胞重编程的作用和调控, 负责人, 国家任务, 2020-01--2024-12