基本信息
时玉舫  男  博导  苏州大学
电子邮件: yufangshi@sibs.ac.cn
通信地址: 上海岳阳路320号新生命科学大楼1113室
邮政编码:

招生信息

   
招生专业
071009-细胞生物学
招生方向
1不同T细胞群体的AICD过程;
2骨髓间质干细胞的免疫抑制
3肿瘤免疫

教育背景

1988-09--1992-09   加拿大阿尔伯塔大学   博士
1985-09--1988-08   加拿大阿尔伯塔大学   硕士
1977-09--1982-07   山东农业大学   学士

工作经历

   
工作简历
2014-07~现在, 中国科学院上海生命科学研究院, 研究员
2008-06~2014-06,中国科学院上海生命科学研究院, 所长/研究员
2003-07~2008-05,美国新泽西医科和牙科大学-罗伯特•伍德•约翰逊医学院, 终身教授
2001-08~2008-05,美国新泽西癌症研究所, 研究员
2001-08~2003-06,美国新泽西医科和牙科大学- 罗伯特•伍德•约翰逊医学院, 终身副教授
1999-07~2001-08,美国乔治华盛顿大学, 终身副教授
1999-07~2001-08,美国红十字协会Holland医学生物研究所, Scientist II 终身副教授
1999-07~2001-08,美国乔治•华盛顿大学, 助理教授
1996-07~1999-07,美国乔治•华盛顿大学, 助理教授
1995-02~1999-06,美国红十字协会Holland医学生物研究所, Scientist I 助理教授
1992-09~1995-02,加拿大多伦多大学, 博士后
1988-09~1992-09,加拿大阿尔伯塔大学, 博士
1986-09~1989-05,加拿大阿尔伯塔大学, 助教
1985-09~1988-08,加拿大阿尔伯塔大学, 硕士
1982-01~1985-09,山东农业大学, 助教
1977-09~1982-07,山东农业大学, 学士
社会兼职
2011-01-01-今,Stem Cells Translational Medicine, Member of Editorial Board
2010-01-01-今,Cell Death and Disease, Editor-in-Chief
2010-01-01-今,Cell &Biosciences, Associate Editor
2009-01-01-今,American Journal of Translational Research, Member of Editorial Board
2009-01-01-今,Journal of Biomedicine and Biotechnology, Member of Editorial Board
2009-01-01-今,Stem Cell Research and Therapy, Member of Editorial Board
2008-01-01-今,Oncogene, Receiving Editor
2008-01-01-今,Journal of Biological Chemistry, Member of Editorial Board
2008-01-01-今,Journal of Molecular Cell Biology, Member of Editorial board
2004-01-01-今,Cellular and Molecular Immunology, Member of Editorial Board
1999-01-01-今,Journal of Immunology, Associate Editor
1996-01-01-今,Cell Research, Editorial Board, Regional Editor, Associate Editor-in Chief and Editor

教授课程

免疫生物学

专利与奖励

   
奖励信息
(1) ****, 部委级, 2012
(2) 中组部****, 国家级, 2008
专利成果
( 1 ) IL-17在提高间充质干细胞免疫功能中的应用, 2014, 第 1 作者, 专利号: PCT/CN2015/077862

( 2 ) 间充质干细胞在预防或治疗应激反应导致的免疫力下降中的应用, 2013, 第 1 作者, 专利号: PCT/CN2014/076511

出版信息

   
发表论文
(1) Downregulation of CXCL12 in Mesenchymal Stromal Cells by TGFβ Promotes Breast Cancer Metastasis., Oncogene, 2016, 通讯作者
(2) TNFα-activated Mesenchymal Stromal Cells Promote Breast Cancer Metastasis through Recruiting CXCR2+ Neutrophils., Oncogene, 2016, 通讯作者
(3) SHP1 Regulates Bone Mass by Directing Mesenchymal Stem Cell Differentiation., Cell Reports, 2016, 通讯作者
(4) Tumour cell-derived exosomes endow mesenchymal stromal cells with tumour-promotion capabilities., Oncogene, 2016, 通讯作者
(5) Type I Interferons Exert Anti-tumor Effect via Reversing Immunosuppression Mediated by Mesenchymal Stromal Cells., Oncogene, 2016, 通讯作者
(6) Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?, Cell Death and Differentiation, 2016, 通讯作者
(7) Local proliferation initiates macrophage accumulation in adipose tissue during obesity., Cell Death and Diseases, 2016, 通讯作者
(8) P53 functional abnormality in mesenchymal stem cells promotes osteosarcoma development., Cell Death and Diseases, 2016, 通讯作者
(9) Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages, Cell Death and Differentiation, 2016, 通讯作者
(10) CD11b Regulates Obesity-Induced Insulin Resistance via Limiting Alternative Activation and Proliferation of Adipose Tissue Macrophages., Proceedings of the National Academy of Sciences, 2015, 通讯作者
(11) Rethinking regeneration: empowerment of stem cells by inflammation., Cell Death and Differentiation, 2015, 第 1 作者
(12) The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation., J Mol Cell Biol., 2015, 通讯作者
(13) Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity., Oncogene, 2015, 通讯作者
(14) Mesenchymal stem cells and adaptive immune responses., Immunology Letter, 2015, 通讯作者
(15) Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications., Nature Immunology, 2014, 通讯作者
(16) The 1000th publication features protection of normal cells during chemotherapy: a land mark for Cell Death & Disease., Cell Death and Diseases, 2014, 通讯作者
(17) Interleukin-17 enhances immunosuppression by mesenchymal stem cells., Cell Death and Differentiation, 2014, 通讯作者
(18) Immunobiology of mesenchymal stem cells., Cell Death and Differentiation, 2014, 通讯作者
(19) Chronic restraint stress decreases the repair potential from mesenchymal stem cells on liver injury by inhibiting TGF-β1 generation., Cell Death and Diseases, 2014, 通讯作者
(20) Mesenchymal stem cells prevent restraint stress-induced lymphocyte depletion via interleukin-4., Brain, Behavior and Immunity., 2014, 通讯作者
(21) The interaction between mesenchymal stem cells and steroids during inflammation., Cell Death and Diseases, 2014, 通讯作者
(22) Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment., Cancer Research, 2014, 通讯作者
(23) TGF-β Promotes Immune Responses in the Presence of Mesenchymal Stem Cells., Journal of Immunology, 2014, 通讯作者
(24) Tumor resident mesenchymal stromal cells endow naïve stromal cells with tumor-promoting properties., Oncogene, 2014, 通讯作者
(25) p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation., Oncogene, 2014, 通讯作者
(26) Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species., Cell Death and Differentiation, 2014, 通讯作者
(27) An Osteopontin-Integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells., Stem cells, 2014, 通讯作者
(28) Interferon-α-secreting mesenchymal stem cells exert potent antitumor effect in vivo., Oncogene, 2014, 通讯作者
(29) A novel subset of helper T cells promotes immune responses by secreting GM-CSF., Cell Death and Differentiation, 2013, 通讯作者
(30) Curative effect of hepatic portal venous administration of autologous bone marrow in AIDS patients with decompensated liver cirrhosis., Cell Death and Diseases, 2013, 通讯作者
(31) MiR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2., Journal of Biological Chemistry, 2013, 通讯作者
(32) One cell, multiple roles: contribution of mesenchymal stem cells to tumor development in tumor microenvironment., Cell & Bioscience, 2013, 通讯作者
(33) Reprogramming cancer cells: back to the future., Oncogene, 2013, 第 2 作者
(34) CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα., Cell Stem Cell, 2012, 通讯作者
(35) A two-hit model of autoimmunity: lymphopenia and unresponsiveness to TGF-β signaling., Cellular & Molecular Immunology, 2012, 通讯作者
(36) Mesenchymal stem cells: a double-edged sword in regulating immune responses., Cell Death and Differentiation, 2012, 通讯作者
(37) How mesenchymal stem cells interact with tissue immune responses., Trends in Immunology, 2012, 通讯作者
(38) How mesenchymal stem cells interact with tissue immune responses., Trends in Immunology, 2012, 通讯作者
(39) How mesenchymal stem cells interact with tissue immune responses., Trends in Immunology, 2012, 通讯作者
(40) Stem Cells Deployed for Bone Repair Hijacked by T Cells., Cell Stem Cell, 2012, 通讯作者
(41) Stem Cells Deployed for Bone Repair Hijacked by T Cells., Cell Stem Cell, 2012, 通讯作者
(42) Concise review: mesenchymal stem cells and rranslational medicine: emerging issues., Stem Cells Transl Med., 2012, 通讯作者
(43) Adhesion molecules: key players in mesenchymal stem cell-mediated immunosuppression., Cell Adhesion & Migration, 2011, 通讯作者
(44) The putative cannabinoid receptor GPR55 promotes cancer cell proliferation., Oncogene, 2011, 通讯作者
(45) Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair., Cell Research, 2010, 通讯作者
(46) Inflammatory Cytokine-Induced Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 in Mesenchymal Stem Cells Are Critical for Immunosuppression., Journal of Immunology, 2010, 通讯作者
(47) Brief report: IFN-γ induces expansion of Lin-Sca-1+C-Kit+ Cells., Stem Cells, 2010, 通讯作者
(48) Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation., Journal of Experimental Medicine, 2009, 通讯作者
(49) Species Variation in the Mechanisms of Mesenchymal Stem Cell-Mediated Immunosuppression., Stem Cells, 2009, 通讯作者
(50) A Sino-British frontier workshop of cancer biology., Cell Death and Differentiation, 2009, 通讯作者
(51) C/EBPβ Mdiates the Synergistic Upregulation of Gene Expression by IFN-γ and TNF-α in Bone Marrow-Derived Mesenchymal Stem Cells., Stem Cells, 2009, 通讯作者
(52) Natural killer cells go inside: entosis versus cannibalism., Cell Research, 2009, 通讯作者
(53) Bone marrow stromal cells induce apoptosis of lymphoma cells in the presence of IFNgamma and TNF by producing nitric oxide., Biochem Biophys Res Commun., 2008, 通讯作者
(54) Apoptotic cells induce immunosuppression through dendritic cells: critical roles of IFN-gamma and nitric oxide., Journal of Immunology, 2008, 通讯作者
(55) New Hope for Cancer Treatment: exploring the distinction betweennormal adult stem cells and cancer stem cells., Pharmacology and Therapeutics, 2008, 通讯作者
(56) Th17 Cells Undergo Fas-mediated Activation-induced Cell Independent of IFN-γ., Journal of Immunology, 2008, 通讯作者
(57) Chloramphenicol induces abnormal cell differentiation and inhibits apoptosis in activated T cells: possible links to leukemogenesis., Cancer Research, 2008, 通讯作者
(58) Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide., Cell Stem Cell, 2008, 通讯作者

科研活动

   
科研项目
( 1 ) 基于间充质干细胞的肿瘤免疫反应调控机制和对抗新策略, 负责人, 国家任务, 2014-01--2018-12
( 2 ) 干细胞治疗帕金森氏病:从基础研究到动物模型, 负责人, 中国科学院计划, 2013-01--2016-09