基本信息
杨运桂  男  博导  中国科学院北京基因组研究所(国家生物信息中心)
电子邮件: ygyang@big.ac.cn
通信地址: 北京市朝阳区北辰西路1号104楼
邮政编码: 100101

研究领域

RNA表观遗传学特征、调控和功能。研发RNA化学修饰高通量测序和分析技术,系统研究RNA甲基化及其修饰酶,阐明其功能及遗传性状(表型)和组织器官再生机制,揭示其与疾病关联及干预​。


招生信息

生化、分子、细胞、基因组学、生物信息学、计算等


招生专业
071010-生物化学与分子生物学
071022-基因组学
071021-生物信息学
招生方向
RNA甲基化表观转录调控
疾病基因组学网络
网络计算

教育背景

1995-07--2000-07   中科院上海药物所及上海生物工程研究中心   博士
1991-09--1995-09   复旦大学   学士

教授课程

分子遗传学和表观遗传学
健康数据与基因组技术
生物化学与分子生物学实验
入学教育与交流
表观遗传学
染色体结构与基因组稳定性
英文生物论文写作
干细胞研究进展系列讲座
基因组科学与信息

出版信息

   
发表论文
[1] Tingfu Du, Chunchun Gao, Shuaiyao Lu, Qianlan Liu, Yun Yang, Wenhai Yu, Wenjie Li, Yong Qiao Sun, Cong Tang, Junbin Wang, Jiahong Gao, Yong Zhang, Fangyu Luo, Ying Yang, YunGui Yang, Xiaozhong Peng. Differential Transcriptomic Landscapes of SARS-CoV-2 Variants in Multiple Organs from Infected Rhesus Macaques. GENOMICS, PROTEOMICS & BIOINFORMATICS[J]. 2023, http://dx.doi.org/10.1016/j.gpb.2023.06.002.
[2] Heng Jian, Shi Boyang, Zhou Jia-yi, Zhang Yifan, Ma Dongyuan, Yang Yun-Gui, Liu Feng. Cpeb1b-mediated cytoplasmic polyadenylation of shha mRNA modulates zebrafish definitive hematopoiesis. Proc Natl Acad Sci U S A.[J]. 2023, 120(7): [3] Cui, Guanshen, Dong, Kangning, Zhou, JiaYi, Li, Shang, Wu, Ying, Han, Qinghua, Yao, Bofei, Shen, Qunlun, Zhao, YongLiang, Yang, Ying, Cai, Jun, Zhang, Shihua, Yang, YunGui. Spatiotemporal transcriptomic atlas reveals the dynamic characteristics and key regulators of planarian regeneration. NATURE COMMUNICATIONS[J]. 2023, 14(1): http://dx.doi.org/10.1038/s41467-023-39016-0.
[4] []. HALL: a comprehensive database for human aging and longevity studies. Nucleic Acids Research[J]. 2023, [5] Wang, Yueqin, Wei, Jingyao, Feng, Luyao, Li, Ouwen, Huang, Lan, Zhou, Shaoxuan, Xu, Yingjie, An, Ke, Zhang, Yu, Chen, Ruiying, He, Lulu, Wang, Qiming, Wang, Han, Du, Yue, Liu, Ruijuan, Huang, Chunmin, Zhang, Xiaojian, Yang, Yungui, Kan, Quancheng, Tian, Xin. Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer. MOLECULAR CANCER[J]. 2023, 22(1): http://dx.doi.org/10.1186/s12943-023-01780-4.
[6] Emerging Roles of RNA Methylation in Development. Accounts of chemical research[J]. 2023, https://pubs.acs.org/doi/full/10.1021/acs.accounts.3c00448.
[7] Jiaming Li, Muzhao Xiong, XiangHong Fu, Yanling Fan, Chen Dong, Xiaoyan Sun, Fang Zheng, SiWei Wang, Lixiao Liu, Ming Xu, Cui Wang, Jiale Ping, Shanshan Che, Qiaoran Wang, Kuan Yang, Yuesheng Zuo, Xiaoyong Lu, Zikai Zheng, Tian Lan, Si Wang, Shuai Ma, Shuhui Sun, Bin Zhang, ChenShui Chen, KeYun Cheng, Jinlin Ye, Jing Qu, Yongbiao Xue, YunGui Yang, Feng Zhang, Weiqi Zhang, GuangHui Liu. Determining a multimodal aging clock in a cohort of Chinese women. MED[J]. 2023, 4(11): 825-848.e13, http://dx.doi.org/10.1016/j.medj.2023.06.010.
[8] Shi, Yong, Guo, Yanjie, Zhou, Jiayi, Cui, Guanshen, Cheng, JungChien, Wu, Ying, Zhao, YongLiang, Fang, Lanlan, Han, Xiao, Yang, YunGui, Sun, Yingpu. A spatiotemporal gene expression and cell atlases of the developing rat ovary. CELL PROLIFERATION. 2023, http://dx.doi.org/10.1111/cpr.13516.
[9] Wen-Lan Yang, Weinan Qiu, Ting Zhang, Kai Xu, Zi-Juan Gu, Yu Zhou, Heng-Ji Xu, Zhong-Zhou Yang, Bin Shen, Yong-Liang Zhao, Qi Zhou, Ying Yang, Wei Li, Peng-Yuan Yang, Yun-Gui Yang. Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis. NATURE COMMUNICATIONS[J]. 2023, 14(1): 1-16, http://dx.doi.org/10.1038/s41467-023-36595-w.
[10] Huan Yao, Chun-Chun Gao, Danru Zhang, Jiawei Xu, Gege Song, Xiu Fan, Dao-Bo Liang, Yu-Sheng Chen, Qian Li, Yanjie Guo, Yu-Ting Cai, Lulu Hu, Yong-Liang Zhao, Ying-Pu Sun, Ying Yang, Jianyong Han, Yun-Gui Yang. scm 6 A-seq reveals single-cell landscapes of the dynamic m 6 A during oocyte maturation and early embryonic development. NATURE COMMUNICATIONS[J]. 2023, 14(1): 1-16, http://dx.doi.org/10.1038/s41467-023-35958-7.
[11] LinFang Ju, HengJi Xu, YunGui Yang, Ying Yang. Omics Views of Mechanisms for Cell Fate Determination in Early Mammalian Development. GENOMICS, PROTEOMICS & BIOINFORMATICS[J]. 2023, http://dx.doi.org/10.1016/j.gpb.2023.03.001.
[12] Cui, Guanshen, Zhou, JiaYi, Ge, XinYang, Sun, BaoFa, Song, GeGe, Wang, Xing, Wang, XiuZhi, Zhang, Rui, Wang, HaiLin, Jing, Qing, Koziol, Magdalena J, Zhao, YongLiang, Zeng, An, Zhang, WeiQi, Han, DaLi, Yang, YunGui, Yang, Ying. m(6)A promotes planarian regeneration. CELL PROLIFERATION[J]. 2023, 56(5): http://dx.doi.org/10.1111/cpr.13481.
[13] Wang Xiuzhi, Wang Mengke, Dai Xinyuan, Han Xiao, Zhou Yu, Lai Weiyi, Zhang Liyuan, Yang Ying, Chen Yusheng, Wang Hailin, Zhao Yong-Liang, Shen Bin, Zhang Yuhan, Huang Ying, Yang Yun-Gui. RNA 5-methylcytosine regulates YBX2-dependent liquid-liquid phase separation. Fundamental Research[J]. 2022, 2: 48-55, [14] Yao Huan, Yang Ying, Yang Yun-Gui. scDART-Seq: Mapping m6A at single cell level. Molecular Cell[J]. 2022, 82(4): 713-715, [15] Shi, Boyang, Heng, Jian, Zhou, JiaYi, Yang, Ying, Zhang, WanYing, Koziol, Magdalena J, Zhao, YongLiang, Li, Pilong, Liu, Feng, Yang, YunGui. Phase separation of Ddx3xb helicase regulates maternal-to-zygotic transition in zebrafish. CELL RESEARCH[J]. 2022, 32(8): 715-728, http://dx.doi.org/10.1038/s41422-022-00655-5.
[16] Ge, XinYang, Han, Xiao, Zhao, YongLiang, Cui, GuanShen, Yang, YunGui. An insight into planarian regeneration. CELL PROLIFERATIONnull. 2022, 55(9): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000822622800001.
[17] Gao, ChunChun, Li, Man, Deng, Wei, Ma, ChunHui, Chen, YuSheng, Sun, YongQiao, Du, Tingfu, Liu, QianLan, Li, WenJie, Zhang, Bing, Sun, Lihong, Liu, SiMeng, Li, Fengli, Qi, Feifei, Qu, Yajin, Ge, Xinyang, Liu, Jiangning, Wang, Peng, Niu, Yamei, Liang, Zhiyong, Zhao, YongLiang, Huang, Bo, Peng, XiaoZhong, Yang, Ying, Qin, Chuan, Tong, WeiMin, Yang, YunGui. Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques. PROTEIN & CELL[J]. 2022, 13(12): 920-939, http://lib.cqvip.com/Qikan/Article/Detail?id=7108920222.
[18] Xu, Yangfan, He, Xiaoyu, Wang, Shanzheng, Sun, Baofa, Jia, Ruobing, Chai, Peiwei, Li, Fang, Yang, Ying, Ge, Shengfang, Jia, Renbing, Yang, YunGui, Fan, Xianqun. The m(6)A reading protein YTHDF3 potentiates tumorigenicity of cancer stem-like cells in ocular melanoma through facilitating CTNNB1 translation. ONCOGENE[J]. 2022, 41(9): 1281-1297, http://dx.doi.org/10.1038/s41388-021-02146-0.
[19] Shi Boyang, Heng jian, Liu Feng, Yang Yun-Gui. Phase separation of Ddx3xb helicase regulates maternal-to-zygotic transition in zebrafish. Cell Res[J]. 2022, 32(8): 715-728, [20] Chen, YuSheng, Lu, Shuaiyao, Zhang, Bing, Du, Tingfu, Li, WenJie, Lei, Meng, Zhou, Yanan, Zhang, Yong, Liu, Penghui, Sun, YongQiao, Zhao, YongLiang, Yang, Ying, Peng, Xiaozhong, Yang, YunGui. Comprehensive analysis of RNA-seq and whole genome sequencing data reveals no evidence for SARS-CoV-2 integrating into host genome. PROTEIN & CELLnull. 2022, 13(5): 379-385, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7254561&detailType=1.
[21] Xiao Han, Jia Guo, Mengke Wang, Nan Zhang, Jie Ren, Ying Yang, Xu Chi, Yusheng Chen, Huan Yao, YongLiang Zhao, YunGui Yang, Yingpu Sun, Jiawei Xu. Dynamic DNA 5-hydroxylmethylcytosine and RNA 5-methycytosine Reprogramming During Early Human Development. GENOMICS, PROTEOMICS & BIOINFORMATICS[J]. 2022, http://dx.doi.org/10.1016/j.gpb.2022.05.005.
[22] Chen, YuSheng, Yang, WenLan, Zhao, YongLiang, Yang, YunGui. Dynamic transcriptomic m(5)C and its regulatory role in RNA processing. WILEY INTERDISCIPLINARY REVIEWS-RNAnull. 2021, 12(4): http://dx.doi.org/10.1002/wrna.1639.
[23] Mu, Haiyuan, Zhang, Ting, Yang, Ying, Zhang, Danru, Gao, Jie, Li, Junhong, Yue, Liang, Gao, Dengfeng, Shi, Bingbo, Han, Yue, Zhong, Liang, Chen, Xinze, Wang, ZhenBo, Lin, Zhen, Tong, MingHan, Sun, QingYuan, Yang, YunGui, Han, Jianyong. METTL3-mediated mRNA N-6-methyladenosine is required for oocyte and follicle development in mice. CELL DEATH & DISEASE[J]. 2021, 12(11): http://dx.doi.org/10.1038/s41419-021-04272-9.
[24] Wu, Gongwei, Suo, Caixia, Yang, Ying, Shen, Shengqi, Sun, Linchong, Li, ShiTing, Zhou, Yingli, Yang, Dongdong, Wang, Yan, Cai, Yongping, Wang, Nana, Zhang, Huafeng, Yang, YunGui, Cao, Jie, Gao, Ping. MYC promotes cancer progression by modulating m(6)A modifications to suppress target gene translation. EMBO REPORTS[J]. 2021, 22(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000606482600001.
[25] Li, Yaqian, Zhang, QingYang, Sun, BaoFa, Ma, Yidi, Zhang, Ye, Wang, Min, Ma, Congcong, Shi, Honghui, Sun, Zhijing, Chen, Juan, Yang, YunGui, Zhu, Lan. Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse. NATURE COMMUNICATIONS[J]. 2021, 12(1): https://doaj.org/article/4b0a3ef279214a6ab382df23c46f0f76.
[26] Zhang, Ting, Yang, Ying, Xiang, Zichun, Gao, ChunChun, Wang, Wenjing, Wang, Conghui, Xiao, Xia, Wang, Xing, Qiu, WeiNan, Li, WenJie, Ren, Lili, Li, Mingkun, Zhao, YongLiang, Chen, YuSheng, Wang, Jianwei, Yang, YunGui. N-6-methyladenosine regulates RNA abundance of SARS-CoV-2. CELL DISCOVERYnull. 2021, 7(1): https://doaj.org/article/ff9505871ecf4f7284bcec184d22b832.
[27] Shi, Boyang, Zhang, Jinsong, Heng, Jian, Gong, Jing, Zhang, Ting, Li, Pan, Sun, BaoFa, Yang, Ying, Zhang, Ning, Zhao, YongLiang, Wang, HaiLin, Liu, Feng, Zhang, Qiangfeng Cliff, Yang, YunGui. RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function. GENOME BIOLOGY[J]. 2020, 21(1): http://dx.doi.org/10.1186/s13059-020-02022-2.
[28] Han, Xiao, Liu, Hanchen, Zhang, Zezhong, Yang, Wenlan, Wu, Chunyan, Liu, Xueying, Zhang, Fang, Sun, Baofa, Zhao, Yongliang, Jiang, Guibin, Yang, YunGui, Ding, Wenjun. Epitranscriptomic 5-Methylcytosine Profile in PM2.5-induced Mouse Pulmonary Fibrosis. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2020, 18(1): 41-51, http://lib.cqvip.com/Qikan/Article/Detail?id=00002HUHLL7G7JP0MPDO8JP1MFR.
[29] Wu, Rong, Li, Ang, Sun, Baofa, Sun, JianGuang, Zhang, Jinhua, Zhang, Ting, Chen, Yusheng, Xiao, Yujie, Gao, Yuhao, Zhang, Qingyang, Ma, Jun, Yang, Xin, Liao, Yajin, Lai, WeiYi, Qi, Xiaolong, Wang, Shukun, Shu, Yousheng, Wang, HaiLin, Wang, Fengchao, Yang, YunGui, Yuan, Zengqiang. A novel m(6)A reader Prrc2a controls oligodendroglial specification and myelination. CELL RESEARCH[J]. 2019, 29(1): 23-41, http://lib.cqvip.com/Qikan/Article/Detail?id=6100265646.
[30] Malbec, Lionel, Zhang, Ting, Chen, YuSheng, Zhang, Ying, Sun, BaoFa, Shi, BoYang, Zhao, YongLiang, Yang, Ying, Yang, YunGui. Dynamic methylome of internal mRNA N-7-methylguanosine and its regulatory role in translation. CELL RESEARCH[J]. 2019, 29(11): 927-941, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889513/.
[31] Chen, Xin, Li, Ang, Sun, BaoFa, Yang, Ying, Han, YaNan, Yuan, Xun, Chen, RiXin, Wei, WenSu, Liu, Yanchao, Gao, ChunChun, Chen, YuSheng, Zhang, Mengmeng, Ma, XiaoDan, Liu, ZhuoWei, Luo, JunHang, Lyu, Cong, Wang, HaiLin, Ma, Jinbiao, Zhao, YongLiang, Zhou, FangJian, Huang, Ying, Xie, Dan, Yang, YunGui. 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs. NATURE CELL BIOLOGY[J]. 2019, 21(8): 978-+, http://dx.doi.org/10.1038/s41556-019-0361-y.
[32] Peng, Shiming, Xiao, Wen, Ju, Dapeng, Sun, Baofa, Hou, Nannan, Liu, Qianlan, Wang, Yanli, Zhao, Haijiao, Gao, Chunchun, Zhang, Song, Cao, Ran, Li, Pengfei, Huang, Huanwei, Ma, Yongfen, Wang, Yankai, Lai, Weiyi, Ma, Zhixiong, Zhang, Wei, Huang, Song, Wang, Hailin, Zhang, Zhiyuan, Zhao, Liping, Cai, Tao, Zhao, YongLiang, Wang, Fengchao, Nie, Yongzhan, Zhi, Gang, Yang, YunGui, Zhang, Eric Erquan, Huang, Niu. Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. SCIENCE TRANSLATIONAL MEDICINE[J]. 2019, 11(488): [33] Yang, Xin, Liu, QianLan, Xu, Wei, Zhang, YiChang, Yang, Ying, Ju, LinFang, Chen, Jing, Chen, YuSheng, Li, Kuan, Ren, Jie, Sun, Qianwen, Yang, YunGui. m(6)A promotes R-loop formation to facilitate transcription termination. CELL RESEARCH[J]. 2019, 29(12): 1035-1038, http://lib.cqvip.com/Qikan/Article/Detail?id=7101065630.
[34] Jia, Ruobing, Chai, Peiwei, Wang, Shanzheng, Sun, Baofa, Xu, Yangfan, Yang, Ying, Ge, Shengfang, Jia, Renbing, Yang, YunGui, Fan, Xianqun. m(6)A modification suppresses ocular melanoma through modulating HINT2 mRNA translation. MOLECULAR CANCER[J]. 2019, 18(1): http://dx.doi.org/10.1186/s12943-019-1088-x.
[35] Peng, Junya, Sun, BaoFa, Chen, ChuanYuan, Zhou, JiaYi, Chen, YuSheng, Chen, Hao, Liu, Lulu, Huang, Dan, Jiang, Jialin, Cui, GuanShen, Yang, Ying, Wang, Wenze, Guo, Dan, Dai, Menghua, Guo, Junchao, Zhang, Taiping, Liao, Quan, Liu, Yi, Zhao, YongLiang, Han, DaLi, Zhao, Yupei, Yang, YunGui, Wu, Wenming. Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma. CELL RESEARCH[J]. 2019, 29(9): 725-738, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6567338&detailType=1.
[36] Yang, Ying, Hsu, Phillip J, Chen, YuSheng, Yang, YunGui. Dynamic transcriptomic m(6)A decoration: writers, erasers, readers and functions in RNA metabolism. CELL RESEARCH[J]. 2018, 28(6): 616-624, http://lib.cqvip.com/Qikan/Article/Detail?id=675655256.
[37] Zeyu Zhang, Meng Wang, Dongfang Xie, Zenghui Huang, Lisha Zhang, Ying Yang, Dongxue Ma, Wenguang Li, Qi Zhou, YunGui Yang, XiuJie Wang. METTL3-mediated N^6-methyladenosine mRNA modification enhances long-term memory consolidation. 细胞研究:英文版[J]. 2018, 28(11): 1050-1061, http://lib.cqvip.com/Qikan/Article/Detail?id=676884685.
[38] Wang, ChenXin, Cui, GuanShen, Liu, XiuYing, Xu, Kai, Wang, Meng, Zhang, XinXin, Jiang, LiYuan, Li, Ang, Yan, Ying, Lai, WeiYi, Sun, BaoFa, Jiang, GuiBin, Wang, HaiLin, Tong, WeiMin, Li, Wei, Wang, XiuJie, Yang, YunGui, Zhou, Qi. METTL3-mediated m6A modification is required for cerebellar development. PLOS BIOLOGY[J]. 2018, 16(6): https://doaj.org/article/ac22537f22f14d259073b36f082d0530.
[39] Yang, Xin, Yang, Ying, Sun, BaoFa, Chen, YuSheng, Xu, JiaWei, Lai, WeiYi, Li, Ang, Wang, Xing, Bhattarai, Devi Prasad, Xiao, Wen, Sun, HuiYing, Zhu, Qin, Ma, HaiLi, Adhikari, Samir, Sun, Min, Hao, YaJuan, Zhang, Bing, Huang, ChunMin, Huang, Niu, Jiang, GuiBin, Zhao, YongLiang, Wang, HaiLin, Sun, YingPu, Yang, YunGui. 5-methylcytosine promotes mRNA export-NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. CELLRESEARCH[J]. 2017, 27(5): 606-625, http://ir.rcees.ac.cn/handle/311016/39231.
[40] Xu, Kai, Yang, Ying, Feng, GuiHai, Sun, BaoFa, Chen, JunQing, Li, YuFei, Chen, YuSheng, Zhang, XinXin, Wang, ChenXin, Jiang, LiYuan, Liu, Chao, Zhang, ZeYu, Wang, XiuJie, Zhou, Qi, Yang, YunGui, Li, Wei. Mettl3-mediated m(6)A regulates spermatogonial differentiation and meiosis initiation. CELL RESEARCH[J]. 2017, 27(9): 1100-1114, https://www.webofscience.com/wos/woscc/full-record/WOS:000408916300006.
[41] Zhang, Chunxia, Chen, Yusheng, Sun, Baofa, Wang, Lu, Yang, Ying, Ma, Dongyuan, Lv, Junhua, Heng, Jian, Ding, Yanyan, Xue, Yuanyuan, Lu, Xinyan, Xiao, Wen, Yang, YunGui, Liu, Feng. m(6)A modulates haematopoietic stem and progenitor cell specification. NATURE[J]. 2017, 549(7671): 273-+, http://dx.doi.org/10.1038/nature23883.
[42] Li, Ang, Chen, YuSheng, Ping, XiaoLi, Yang, Xin, Xiao, Wen, Yang, Ying, Sun, HuiYing, Zhu, Qin, Baidya, Poonam, Wang, Xing, Bhattarai, Devi Prasad, Zhao, YongLiang, Sun, BaoFa, Yang, YunGui. Cytoplasmic m(6)A reader YTHDF3 promotes mRNA translation. CELL RESEARCH[J]. 2017, 27(3): 444-447, https://www.webofscience.com/wos/woscc/full-record/WOS:000396265500013.
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[44] Mi, Shuangli, Klungland, Arne, Yang, YunGui. Base-excision repair and beyond -A short summary attributed to scientific achievements of Tomas Lindahl, Nobel Prize Laureate in Chemistry 2015. SCIENCE CHINA-LIFE SCIENCES[J]. 2016, 59(1): 89-92, https://www.webofscience.com/wos/woscc/full-record/WOS:000371281300013.
[45] Yang, YunGui, Qi, Yijun. RNA-directed repair of DNA double-strand breaks. DNA REPAIR[J]. 2015, 32: 82-85, http://dx.doi.org/10.1016/j.dnarep.2015.04.017.
[46] Tangliang Li, Yue Shi, Pei Wang, Luis Miguel Guachalla, Baofa Sun, Tjard Joerss, YuSheng Chen, Marco Groth, Anja Krueger, Matthias Platzer, YunGui Yang, Karl Lenhard Rudolph, ZhaoQi Wang. Smg6/Est1 licenses embryonic stem cell differentiation via nonsense‐mediated mRNA decay. THE EMBO JOURNAL. 2015, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJWD15061500000115&DbName=SJWDLAST&DbCode=SJWD&yx=&pr=&URLID=&bsm=.
[47] Arne Klungland, YunGui Yang. Endogenous DNA Damage and Repair Enzymes. GENOMICS, PROTEOMICS & BIOINFORMATICS. 2015, 14(3): 122-125, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936663/.
[48] Ying YANG, Baofa SUN, Wen XIAO, Xin YANG, HuiYing SUN, YongLiang ZHAO, YunGui YANG. Dynamic m6A modification and its emerging regulatory role in mRNA splicing. SCIENCE BULLETIN[J]. 2015, 60(1): 21-32, http://dx.doi.org/10.1007/s11434-014-0695-6.
[49] Zhao, Xu, Yang, Ying, Sun, BaoFa, Shi, Yue, Yang, Xin, Xiao, Wen, Hao, YaJuan, Ping, XiaoLi, Chen, YuSheng, Wang, WenJia, Jin, KangXuan, Wang, Xing, Huang, ChunMin, Fu, Yu, Ge, XiaoMeng, Song, ShuHui, Jeong, Hyun Seok, Yanagisawa, Hiroyuki, Niu, Yamei, Jia, GuiFang, Wu, Wei, Tong, WeiMin, Okamoto, Akimitsu, He, Chuan, Danielsen, Jannie M Rendtlew, Wang, XiuJie, Yang, YunGui. FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. CELL RESEARCH[J]. 2014, 24(12): 1403-1419, https://www.webofscience.com/wos/woscc/full-record/WOS:000345894800006.
[50] Gao, Min, Wei, Wei, Li, MingMing, Wu, YongSheng, Ba, Zhaoqing, Jin, KangXuan, Li, MiaoMiao, Liao, YouQi, Adhikari, Samir, Chong, Zechen, Zhang, Ting, Guo, CaiXia, Tang, Tieshan, Zhu, BingTao, Xu, XingZhi, Mailand, Niels, Yang, YunGui, Qi, Yijun, Danielsen, Jannie M Rendtlew. Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination. CELL RESEARCH[J]. 2014, 24(5): 532-541, https://www.webofscience.com/wos/woscc/full-record/WOS:000335914700003.
[51] Ping, XiaoLi, Sun, BaoFa, Wang, Lu, Xiao, Wen, Yang, Xin, Wang, WenJia, Adhikari, Samir, Shi, Yue, Lv, Ying, Chen, YuSheng, Zhao, Xu, Li, Ang, Yang, Ying, Dahal, Ujwal, Lou, XiaoMin, Liu, Xi, Huang, Jun, Yuan, WeiPing, Zhu, XiaoFan, Cheng, Tao, Zhao, YongLiang, Wang, Xinquan, Danielsen, Jannie M Rendtlew, Liu, Feng, Yang, YunGui. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. CELL RESEARCH[J]. 2014, 24(2): 177-189, https://www.webofscience.com/wos/woscc/full-record/WOS:000331216400007.
[52] Tapias, Alicia, Zhou, ZhongWei, Shi, Yue, Chong, Zechen, Wang, Pei, Groth, Marco, Platzer, Matthias, Huttner, Wieland, Herceg, Zdenko, Yang, YunGui, Wang, ZhaoQi. Trrap-Dependent Histone Acetylation Specifically Regulates Cell-Cycle Gene Transcription to Control Neural Progenitor Fate Decisions. CELL STEM CELL[J]. 2014, 14(5): 632-643, http://dx.doi.org/10.1016/j.stem.2014.04.001.
[53] Zhao, Xu, Yang, Ying, Sun, BaoFa, Zhao, YongLiang, Yang, YunGui. FTO and Obesity: Mechanisms of Association. CURRENT DIABETES REPORTS[J]. 2014, 14(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000334449100005.
[54] Niu, YaMei, Zhao, Xu, Wu, YongSheng, Li MingMing, Wang, XiuJie, Yang, YunGui. N6-methyl-adenosine (m6A) in RNA: an old modification with a novel epigenetic function. GENOMICS, PROTEOMICS & BIOINFORMATICS[J]. 2013, 11(1): 8-17, http://dx.doi.org/10.1016/j.gpb.2012.12.002.
[55] Zheng, Guanqun, Dahl, John Arne, Niu, Yamei, Fu, Ye, Klungland, Arne, Yang, YunGui, He, Chuan. Sprouts of RNA epigenetics The discovery of mammalian RNA demethylases. RNA BIOLOGYnull. 2013, 10(6): 915-918, https://www.webofscience.com/wos/woscc/full-record/WOS:000327574000003.
[56] Yin, Ruichuan, Mao, ShiQing, Zhao, Bailin, Chong, Zechen, Yang, Ying, Zhao, Chao, Zhang, Dapeng, Huang, Hua, Gao, Juan, Li, Zheng, Jiao, Yan, Li, Cuiping, Liu, Shengquan, Wu, Danni, Gu, Weikuan, Yang, YunGui, Xu, GuoLiang, Wang, Hailin. Ascorbic Acid Enhances Tet-Mediated 5-Methylcytosine Oxidation and Promotes DNA Demethylation in Mammals. JOURNALOFTHEAMERICANCHEMICALSOCIETY[J]. 2013, 135(28): 10396-10403, http://dx.doi.org/10.1021/ja4028346.
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指导学生

已指导学生

黄春敏  硕士研究生  071010-生物化学与分子生物学  

徐倩  硕士研究生  071010-生物化学与分子生物学  

周东平  硕士研究生  071022-基因组学  

王文岭  硕士研究生  071022-基因组学  

高敏  博士研究生  071022-基因组学  

廖友琦  硕士研究生  071010-生物化学与分子生物学  

李明明  博士研究生  071010-生物化学与分子生物学  

赵旭  博士研究生  071010-生物化学与分子生物学  

金康宣  硕士研究生  071022-基因组学  

杨莹  博士研究生  071022-基因组学  

史悦  博士研究生  071022-基因组学  

吕英  硕士研究生  071010-生物化学与分子生物学  

肖文  博士研究生  071010-生物化学与分子生物学  

平晓丽  博士研究生  071010-生物化学与分子生物学  

李苗苗  硕士研究生  071010-生物化学与分子生物学  

马海丽  硕士研究生  071010-生物化学与分子生物学  

郝亚娟  博士研究生  071010-生物化学与分子生物学  

王文佳  硕士研究生  071010-生物化学与分子生物学  

祝芹  硕士研究生  071010-生物化学与分子生物学  

杨鑫  博士研究生  0710Z1-基因组学  

孙慧颖  硕士研究生  0710Z1-基因组学  

王兴  硕士研究生  071010-生物化学与分子生物学  

于佳丽  硕士研究生  071010-生物化学与分子生物学  

闫克强  硕士研究生  071010-生物化学与分子生物学  

韩亚男  硕士研究生  0710J3-生物信息学  

现指导学生

陈宇晟  博士研究生  071010-生物化学与分子生物学  

李昂  博士研究生  071010-生物化学与分子生物学  

时博阳  博士研究生  071010-生物化学与分子生物学  

张益畅  硕士研究生  0710J3-生物信息学  

鞠林芳  硕士研究生  071010-生物化学与分子生物学  

葛新阳  硕士研究生  071010-生物化学与分子生物学  

韩悦  博士研究生  0710Z1-基因组学  

张清杨  博士研究生  071010-生物化学与分子生物学  

李若琳  硕士研究生  071010-生物化学与分子生物学  

周佳熠  博士研究生  0710Z1-基因组学  

梁承志  硕士研究生  071010-生物化学与分子生物学  

姚欢  博士研究生  0710Z1-基因组学  

刘倩兰  博士研究生  0710Z1-基因组学  

杨文兰  博士研究生  071010-生物化学与分子生物学  

陈静  硕士研究生  085238-生物工程  

工作经历

2008-11--至今 中科院北京基因组研究所研究员,博士生导师

2005-11--2008-11 英国癌症研究署,博士后,导师:Tomas Lindhal教授/英国皇家科学院院士、2015诺贝尔化学奖得主

2000-09--2005-11 法国世界卫生组织国际癌症研究署,博士后/Staff Scientist,导师:汪兆琦教授/欧洲科学院院士

承担科研项目情况

1、中以NSFC-ISF合作研究项目,解析神经发育疾病基因MeCP2和LIS1相互作用的分子机制,3161101005,2017/01-2019/12,在研,主持;

2、国家“杰出青年”科学基金,基因表达调控与表观遗传学,31625016,2017/01-2022/12,在研,主持;

3、国家重点研发计划精准医学研究重点专项,表观基因组学检测技术研发与临床应用,2016YFC0900300,2016/07-2018/12,在研,主持;

4、国家自然科学基金重点项目,RNA m6A修饰甲基转移酶复合物及其表观调控因子鉴定和作用机制研究,2015/01-2019/12,在研,主持;

5、国家自然科学基金面上项目,RNA表观遗传新机制调控DNA双链断裂修复分子机理研究,2014/01-2017/12,在研,主持;

6、国家自然科学基金重大研究计划(集成项目),DNA与RNA甲基化表观修饰对单倍体干细胞多能性与发育能力影响的机制研究,2014/01-2018/12,在研,参加;

7、科技部 973,中国人前列腺癌的表观遗传特征及调控机制,2012/01-2016/09,已结题,骨干;

8、科技部 973,组蛋白甲基化对肺癌发生发展的作用及其机制,2011/01-2015/12,已结题,主持;

9、国家自然科学基金面上项目,ALKBH4加双氧酶介导的细胞分裂重要功能因子去甲基化机制研究,2011/01-2013/12,已结题,主持;

10、国家自然科学基金面上项目,DNA损伤检验点和DNA双链断裂修复途径的相互协调维持基因组稳定性的分子机理的研究,2009/01-2011/12,已结题,主持;

11、中科院“****”人才项目,科研启动经费,2008/11-2013/12,已结题,主持。

获奖及荣誉


2012 获中国科学院大学-BHPB 导师科研奖

2013 获中国科学院青年科学家国际合作奖

2013 获中国科学院朱李月华优秀教师奖

2014 中国科学院“****”终期评估优秀获得者

2015中国科学院特聘研究员

2016国家“杰出青年”科学基金获得者

2016 科技部创新人才推进计划-中青年科技创新领军人才

2017中组部国家“万人计划”科技创新领军人才

2017 Sanofi-Cell Research优秀研究文章奖

2017年度中国生命科学领域十大进展

2018中国科学院优秀导师奖

2018第三届中国科协优秀科技论文





项目组情况

课题组于2008年11月成立,系统研究表观转录组调控与RNA甲基化功能机理,在拓展RNA甲基化表观转录组调控的前沿新领域合作研究中,取得了系列原创性发现,包括鉴定人源RNA m6A的修饰甲基转移酶复合物 METTL3/METTL14/WTAPm6A去甲基化酶ALKBH5/FTO Nat Chem Biol, 2011; Mol Cell, 2013; Cell Res, 2014a),揭示非编码miRNA介导的m6A甲基化位点形成的选择性机制(Cell Stem Cell,2015)及其m6A修饰的外显子被保留现象(Cell Res, 2014b)等。发现了m6A的识别因子(readerYTHDC1的的两个互作蛋白是mRNA剪接因子SRSF3SRSF10 Mol Cell2016RNA Biol, 2016)。揭示m5C调控mRNA出核的重要功能以及YTHDF3YTHDF1在翻译过程中的协同调控作用机制(Cell Res, 2017a, 2017b);,发现m6A通过YTHDF2介导notch1a mRNA的稳定性,维持内皮和造血细胞基因表达平衡,进而调控造血干细胞的命运决定(Nature, 2017;被评为2017中国生命科学十大研究进展);阐明了m6A调控脑发育和记忆作用机制(PLos Biol, 2018; Cell Res, 2018a,b)。对m6A的甲基转移酶、结合蛋白和去甲基化酶的生物学功能,及m6A在可变剪接等RNA代谢过程的调控作用进行了系统综述(Cell Res, 2018c)。