基本信息
肖庚富  男  博导  中国科学院武汉病毒研究所
电子邮件: xiaogf@wh.iov.cn
通信地址: 湖北省武汉市武昌区小洪山中区44号
邮政编码: 430071

招生信息

   
招生专业
071010-生物化学与分子生物学
071005-微生物学
招生方向
病毒生物化学
病毒学

教育背景

1995-09--武汉大学   理学博士
1989-09--同济医科大学   医学硕士
1984-09--同济医科大学   医学学士

工作经历

   
工作简历
1995-09~现在, 武汉大学, 理学博士
1989-09~现在, 同济医科大学, 医学硕士
1984-09~现在, 同济医科大学, 医学学士
社会兼职
2020-12-25-今,湖北江夏实验室, 主任
2018-05-08-今,国家重点研发计划“蛋白质机器”重点专项总体专家组, 成员

教授课程

分子病毒学

专利与奖励

   
奖励信息
(1) 国务院政府特殊津贴, 一等奖, 国家级, 2018
专利成果
( 1 ) 一类氰基化合物、其制备方法及用途, 2022, 第 9 作者, 专利号: PCT/CN2022/122384

( 2 ) 一类黄芩素衍生物、其制备方法和用途, 2022, 第 3 作者, 专利号: PCT/CN2022/117692

( 3 ) 一种表达荧光素酶基因的淋巴脉络丛脑膜炎病毒及其构建方法和应用, 2022, 第 2 作者, 专利号: CN114231562A

( 4 ) 杨梅素和二氢杨梅素磷酸酯类化合物在防治新冠肺炎药物中的应用, 2022, 第 6 作者, 专利号: PCT/CN2022/078851

( 5 ) 核苷类似物或含有核苷类似物的组合制剂在抗病毒中的应用, 2022, 第 2 作者, 专利号: CN114096543A

( 6 ) 抗新型冠状病毒的药物, 2022, 第 6 作者, 专利号: CN113940933A

( 7 ) 一类酰胺类化合物、制备方法及其应用, 2021, 第 9 作者, 专利号: CN202111615267.8

( 8 ) 贝尼地平在制备预防和/或治疗布尼亚病毒感染性疾病药物中的应用, 2021, 第 3 作者, 专利号: CN110237074B

( 9 ) 抗新型冠状病毒的抗体及其制备方法和应用, 2021, 第 4 作者, 专利号: CN113388027A

( 10 ) 五味子提取物的新应用, 2021, 第 3 作者, 专利号: CN113304200A

( 11 ) 黄芩主要成分黄芩素、黄芩苷及其组合物在抗冠状病毒中的应用, 2021, 第 3 作者, 专利号: CN113244211A

( 12 ) 双黄连制剂在抗病毒感染中的应用, 2021, 第 8 作者, 专利号: CN113197886A

( 13 ) 4-氨基二苯甲酮的应用, 2021, 第 3 作者, 专利号: CN113143897A

( 14 ) 曲美替尼在制备抗沙粒病毒的抗病毒制剂中的应用, 2021, 第 4 作者, 专利号: CN112957361A

( 15 ) 一种组合物在制备预防和/或治疗发热伴血小板减少综合征病毒的药物中的应用, 2021, 第 5 作者, 专利号: CN110279693B

( 16 ) 苯甲酸雌二醇或其药物可接受盐在制备抗冠状病毒的药物中的应用, 2021, 第 6 作者, 专利号: CN112516149A

( 17 ) 伊曲康唑或其药物可接受盐在制备抗冠状病毒的药物中的应用, 2021, 第 6 作者, 专利号: CN112516144A

( 18 ) 钙离子通道抑制剂的新应用, 2020, 第 2 作者, 专利号: CN110743015B

( 19 ) 针对新型冠状病毒的亚单位疫苗及应用, 2020, 第 2 作者, 专利号: CN111533809A

( 20 ) 一种新型的呼吸道合胞病毒疫苗抗原的制备方法及其用途, 2019, 第 1 作者, 专利号: CN110229219A

( 21 ) 一种针对胡宁病毒的中和抗体、其制备方法及其应用, 2019, 第 3 作者, 专利号: CN110204613A

( 22 ) 佛手柑素和/或蔓荆子黄素的应用和应用其的产品, 2019, 第 2 作者, 专利号: CN109864988A

( 23 ) 一种化合物及其在抗沙粒病毒感染中的应用, 2019, 第 3 作者, 专利号: CN109503528A

( 24 ) 地高辛在制备治疗哺乳动物黄病毒科病毒感染的药物中的应用, 2018, 第 2 作者, 专利号: CN108619164A

( 25 ) 乌本苷在制备治疗哺乳动物黄病毒科病毒感染的药物中的应用, 2018, 第 2 作者, 专利号: CN108498528A

( 26 ) 一种抑制病毒感染的多肽及其基因、药物及应用, 2017, 第 5 作者, 专利号: CN106854236A

( 27 ) 马尼地平在制备治疗黄病毒科病毒感染药物中的应用, 2017, 第 5 作者, 专利号: CN106727574A

( 28 ) 拉西地平在制备治疗沙粒病毒感染的药物中的应用, 2017, 第 5 作者, 专利号: CN106511343A

( 29 ) 穿梭质粒载体及其构建方法和应用, 2014, 第 1 作者, 专利号: CN104087610A

( 30 ) 一种抗间皮素的纳米抗体及其编码基因和该纳米抗体的用途, 2014, 第 2 作者, 专利号: CN103819559A

( 31 ) 呼吸道合胞病毒F蛋白与Fc的融合蛋白及其用途, 2013, 第 1 作者, 专利号: CN103204943A

( 32 ) 重组1型单纯疱疹病毒及制备方法和应用, 2006, 第 4 作者, 专利号: CN1844376A

( 33 ) 抑制SARS冠状病毒的多肽药物及其衍生物和其应用, 2005, 第 4 作者, 专利号: CN1223605C

( 34 ) 重组1型单纯疱疹病毒及其制备方法和应用, 2005, 第 3 作者, 专利号: CN1570091A

( 35 ) 一种控制艾滋病性传播的栓剂, 2002, 第 1 作者, 专利号: CN1357331A

( 36 ) 缺失调亡抑制基因病毒的构建及在肿瘤基因治疗中的应用, 1999, 第 2 作者, 专利号: CN1230595A

( 37 ) 发光蛋白基因载体的构建与发光基因免疫诊断试剂, 1998, 第 9 作者, 专利号: CN1175639A

出版信息

   
发表论文
(1) Synthesis of maleimide-braced peptide macrocycles and their potential anti-SARS-CoV-2 mechanisms, CHEMICAL COMMUNICATIONS, 2023, 通讯作者
(2) Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2, CELL DISCOVERY, 2023, 第 10 作者
(3) High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors, PROTEIN & CELL, 2023, 通讯作者
(4) CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity, CELL DISCOVERY, 2022, 第 24 作者
(5) Screening and identification of Lassa virus endonuclease-targeting inhibitors from a fragment-based drug discovery library, ANTIVIRAL RESEARCH, 2022, 通讯作者
(6) Target-Based Virtual Screening and LC/MS-Guided Isolation Procedure for Identifying Phloroglucinol-Terpenoid Inhibitors of SARS-CoV-2, JOURNAL OF NATURAL PRODUCTS, 2022, 第 9 作者
(7) Screening of Botanical Drugs against SARS-CoV-2 Entry Reveals Novel Therapeutic Agents to Treat COVID-19, VIRUSES, 2022, 第 10 作者
(8) Bergamottin, a bioactive component of bergamot, inhibits SARS-CoV-2 infection in golden Syrian hamsters, ANTIVIRAL RESEARCH, 2022, 第11作者
(9) Visualizing lymphocytic choriomeningitis virus infection in cells and living mice, ISCIENCE, 2022, 第 9 作者
(10) Ebola virus VP35 hijacks the PKA-CREB1 pathway for replication and pathogenesis by AKIP1 association, NATURE COMMUNICATIONS, 2022, 通讯作者
(11) Screening and Identification of Lassa Virus Entry Inhibitors from a Fragment-Based Drug Discovery Library, VIRUSES-BASEL, 2022, 第 8 作者
(12) Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2022, 第 10 作者
(13) Effect of genomic variations in severe fever with thrombocytopenia syndrome virus on the disease lethality, EMERGING MICROBES & INFECTIONS, 2022, 第 18 作者
(14) Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease, NATURE COMMUNICATIONS, 2021, 第 15 作者
(15) Design and development of an oral remdesivir derivative W116 against SARS-CoV-2, Design and development of an oral remdesivir derivative W116 against SARS-CoV-2, 细胞研究:英文版, 2021, 第 10 作者
(16) Effects of N-Linked Glycan on Lassa Virus Envelope Glycoprotein Cleavage,Infectivity,and Immune Response, Effects of N-Linked Glycan on Lassa Virus Envelope Glycoprotein Cleavage, Infectivity, and Immune Response, VIROLOGICA SINICA, 2021, 第 6 作者
(17) Characterizing the Lassa Virus Envelope Glycoprotein Membrane Proximal External Region for Its Role in Fusogenicity, Characterizing the Lassa Virus Envelope Glycoprotein Membrane Proximal External Region for Its Role in Fusogenicity, VIROLOGICA SINICA, 2021, 通讯作者
(18) High-Throughput Screening of an FDA-Approved Drug Library Identifies Inhibitors against Arenaviruses and SARS-CoV-2, ACS INFECTIOUS DISEASES, 2021, 通讯作者
(19) Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2, CELL RESEARCH, 2021, 第 10 作者
(20) RNAi screening reveals requirement for PDGFRβ in JEV infection., Antimicrob Agents Chemother, 2021, 通讯作者
(21) RBD-homodimer, a COVID-19 subunit vaccine candidate, elicits immunogenicity and protection in rodents and nonhuman primates, CELL DISCOVERY, 2021, 通讯作者
(22) Drug Repurposing of Itraconazole and Estradiol Benzoate against COVID-19 by Blocking SARS-CoV-2 Spike Protein-Mediated Membrane Fusion, ADVANCED THERAPEUTICS, 2021, 通讯作者
(23) Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2021, 第 15 作者
(24) RNA Interference Screening Reveals Requirement for Platelet-Derived Growth Factor Receptor Beta in Japanese Encephalitis Virus Infection, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021, 通讯作者
(25) Screening of Botanical Drugs against Lassa Virus Entry, JOURNAL OF VIROLOGY, 2021, 第 7 作者
(26) High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors, High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors, PROTEIN & CELL, 2021, 第 22 作者
(27) Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension (vol 6, 96, 2020), CELL DISCOVERY, 2021, 第 16 作者
(28) Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein, Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 通讯作者
(29) 一种可能起源于蝙蝠的新型冠状病毒有关的肺炎暴发, A pneumonia outbreak associated with a new coronavirus of probable bat origin, Nature, 2020, 第 23 作者
(30) Share Immunoglobulin fragment F(ab')2 against RBD potently neutralizes SARS-CoV-2 in vitro, Antiviral Res, 2020, 通讯作者
(31) Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes, EMERGING MICROBES & INFECTIONS, 2020, 第 8 作者
(32) Absorbed plant MIR2911 in honeysuckle decoction inhibits SARS-CoV-2 replication and accelerates the negative conversion of infected patients, CELL DISCOVERY, 2020, 第 7 作者
(33) 关于新型冠状病毒命名的思考与建议, Consideration and Suggestion for Naming the Novel Coronavirus, 中国科技术语, 2020, 第 10 作者
(34) Development of horse neutralizing immunoglobulin and immunoglobulin fragments against Junin virus, ANTIVIRAL RESEARCH, 2020, 通讯作者
(35) Development of horse neutralizing immunoglobulin and immunoglobulin fragments against Junín virus., Antiviral Res., 2020, 通讯作者
(36) Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients, Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients, ACTA PHARMACOLOGICA SINICA, 2020, 第 16 作者
(37) Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus 2019-nCoV in vitro, Cell Research, 2020, 
(38) Decreased HD-MIR2911 absorption in human subjects with the SIDT1 polymorphism fails to inhibit SARS-CoV-2 replication, CELL DISCOVERY, 2020, 第 6 作者
(39) Inhibition of Na+/K+ ATPase blocks Zika virus infection in mice, COMMUNICATIONS BIOLOGY, 2020, 第 7 作者
(40) Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease, SCIENCE, 2020, 第 21 作者
(41) Immunoglobulin fragment F(ab’) 2 against RBD potently neutralizes SARS-CoV-2 in vitro, ANTIVIRAL RESEARCH, 2020, 通讯作者
(42) Structure of M-pro from SARS-CoV-2 and discovery of its inhibitors, NATURE, 2020, 第 26 作者
(43) Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2 In Vitro, Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2 In Vitro, VIROLOGICA SINICA, 2020, 通讯作者
(44) Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension, CELL DISCOVERY, 2020, 通讯作者
(45) Lipid-Specific Labeling of Enveloped Viruses with Quantum Dots for Single-Virus Tracking, MBIO, 2020, 通讯作者
(46) A Comparative Quantitative Proteomic Analysis of HCMV-Infected Cells Highlights pUL138 as a Multifunctional Protein, MOLECULES, 2020, 第 3 作者
(47) Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2, Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2, PROTEIN & CELL, 2020, 第 22 作者
(48) Inhibition of Na + + ATPase blocks Zika virus infection in mice, COMMUNICATIONS BIOLOGY, 2020, 第 7 作者
(49) Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur, Nature Structural & Molecular Biology, 2020, 
(50) SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation, CELL REPORTS, 2020, 第 9 作者
(51) Screening of Natural Extracts for Inhibitors against Japanese Encephalitis Virus Infection, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2020, 通讯作者
(52) Comprehensive Interactome Analysis Reveals that STT3B Is Required for N-Glycosylation of Lassa Virus Glycoprotein, JOURNAL OF VIROLOGY, 2019, 通讯作者
(53) Screening of Natural Extracts for Inhibitors against Japanese Encephalitis Virus Infection., Antimicrobial Agents and Chemotherapy, 2019, 
(54) Quantitative Proteomic Analysis Reveals Unfolded-Protein Response Involved in Severe Fever with Thrombocytopenia Syndrome Virus Infection, JOURNAL OF VIROLOGY, 2019, 第 6 作者
(55) Structure-activity relationship optimization for lassa virus fusion inhibitors targeting the transmembrane domain of GP2, PROTEIN & CELL, 2019, 第 10 作者
(56) Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality, CELL RESEARCH, 2019, 第 19 作者
(57) Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality, Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality, 细胞研究:英文版, 2019, 第 19 作者
(58) A novel RSV F-Fc fusion protein vaccine reduces lung injury induced by respiratory syncytial virus infection, ANTIVIRAL RESEARCH, 2019, 通讯作者
(59) Structure-activity relationship optimization for lassa virus fusion inhibitors targeting the transmembrane domain of GP2, Structure-activity relationship optimization for lassa virus fusion inhibitors targeting the transmembrane domain of GP2, 蛋白质与细胞:英文版, 2019, 第 9 作者
(60) A Subcellular Quantitative Proteomic Analysis of Herpes Simplex Virus Type 1-Infected HEK 293T Cells, MOLECULES, 2019, 通讯作者
(61) Phylogenomic analysis unravels evolution of yellow fever virus within hosts, PLOS NEGLECTED TROPICAL DISEASES, 2018, 第 19 作者
(62) Novel neutralizing monoclonal antibodies against Junin virus, ANTIVIRAL RESEARCH, 2018, 通讯作者
(63) Fungal mannosylation enhances human papillomavirus 16 E7 therapeutic immunity against TC-1 tumors., ONCOLOGY REPORTS, 2018, 通讯作者
(64) Uncovering the rab5-independent autophagic trafficking of influenza a virus by quantum-dot-based single-virus tracking, SMALL, 2018, 第 6 作者
(65) Screening and Identification of Lassa Virus Entry Inhibitors from an FDA-Approved Drug Library, JOURNAL OF VIROLOGY, 2018, 第 9 作者
(66) Construction and rescue of a functional synthetic baculovirus, ACS SYNTHETIC BIOLOGY, 2017, 第 3 作者
(67) Antiviral activity of peptide inhibitors derived from the protein E stem against Japanese encephalitis and Zika viruses, ANTIVIRAL RESEARCH, 2017, 第 8 作者
(68) Quantitative Proteomic Analysis of Mosquito C6/36 Cells Reveals Host Proteins Involved in Zika Virus Infection, JOURNAL OF VIROLOGY, 2017, 通讯作者
(69) Screening of FDA-Approved Drugs for Inhibitors of Japanese Encephalitis Virus Infection, JOURNAL OF VIROLOGY, 2017, 第 6 作者
(70) Global quantitative proteomic analysis profiles host protein expression in response to sendai virus infection, PROTEOMICS, 2017, 第 7 作者
(71) Japanese encephalitis virus counteracts BST2 restriction via its envelope protein E, VIROLOGY, 2017, 第 10 作者
(72) Assembly of long DNA sequences using a new synthetic Escherichia coli-yeast shuttle vector., VIROLOGICA SINICA, 2016, 通讯作者
(73) Structure-function relationship of the mammarenavirus envelope glycoprotein, VIROLOGICA SINICA, 2016, 第 5 作者
(74) Roles of methionine oxidation in E200K prion protein misfolding: Implications for the mechanism of pathogenesis in E200K linked familial Creutzfeldt–Jakob disease, BBA - PROTEINS AND PROTEOMICS, 2016, 第 3 作者
(75) Roles of methionine oxidation in E200K prion protein misfolding Implications for the mechanism of pathogenesis in E200K linked familial Creutzfeldt-Jakob disease, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2016, 第 3 作者
(76) DC-SIGN as an attachment factor mediates Japanese encephalitis virus infection of human dendritic cells via interaction with a single high-mannose residue of viral E glycoprotein, VIROLOGY, 2016, 其他(合作组作者)
(77) The ubiquitin-proteasome system is essential for the productive entry of Japanese encephalitis virus, VIROLOGY, 2016, 通讯作者
(78) Isolation and characterization of Zika virus imported to China using C6/36 mosquito cells, VIROLOGICASINICA, 2016, 第 9 作者
(79) Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus, JOURNAL OF VIROLOGY, 2016, 通讯作者
(80) Subcellular quantitative proteomic analysis reveals host proteins involved in human cytomegalovirus infection, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2015, 第 9 作者
(81) Subcellular quantitative proteomic analysis reveals host proteins involved in human cytomegalovirus infection., BIOCHIMICA ET BIOPHYSICA ACTA, 2015, 第 9 作者
(82) Enhancement of immune response to a hepatitis C virus E2 DNA vaccine by an immunoglobulin Fc fusion tag, JOURNAL OF MEDICAL VIROLOGY, 2015, 第 7 作者
(83) Structure-based mutational analysis of several sites in the E protein: implications for understanding the entry mechanism of Japanese encephalitis virus., JOURNAL OF VIROLOGY, 2015, 通讯作者
(84) Characterization of the fusion core in zebrafish endogenous retroviral envelope protein, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 第 4 作者
(85) Methionine oxidation accelerates the aggregation and enhances the neurotoxicity of the D178N variant of the human prion protein, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2014, 通讯作者
(86) Peptide inhibitor of Japanese encephalitis virus infection targeting envelope protein domain III., ANTIVIRAL RESEARCH, 2014, 通讯作者
(87) Methionine oxidation accelerates the aggregation and enhances the neurotoxicity of the D178N variant of the human prion protein., BIOCHIMICA ET BIOPHYSICA ACTA, 2014, 第 7 作者
(88) Real-time quantitative PCR assay for rapid detection of murine virus contamination in bioproducts, Real-time quantitative PCR assay for rapid detection of murine virus contamination in bioproducts, 中国病毒学(英文版), 2014, 
(89) IGF-1-Induced Enhancement of PRNP Expression Depends on the Negative Regulation of Transcription Factor FOXO3a, PLOS ONE, 2013, 第 5 作者
(90) Comprehensive Study of the Interaction Between a Potential Antiprion Cationic Porphyrin and Human Prion Protein at Different pH by Using Multiple Spectroscopic Methods, JOURNAL OF PHARMACEUTICAL SCIENCES, 2013, 第 6 作者
(91) Metal-enhanced fluorescence of nano-core–shell structure used for sensitive detection of prion protein with a dual-aptamer strategy, ANALYTICA CHIMICA ACTA, 2013, 第 8 作者
(92) Japanese Encephalitis Virus Activates Autophagy as a Viral Immune Evasion Strategy, PLOS ONE, 2013, 第 9 作者
(93) Modulation of the Cellular Distribution of Human Cytomegalovirus Helicase by Cellular Factor Snapin, JOURNAL OF VIROLOGY, 2013, 第 7 作者
(94) Conformational conversion of prion protein in prion diseases., ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2013, 通讯作者
(95) Identification of host proteins involved in Japanese encephalitis virus infection by quantitative proteomics analysis., JOURNAL OF PROTEOME RESEARCH, 2013, 第 4 作者
(96) RNase P-Associated External Guide Sequence Effectively Reduces the Expression of Human CC-Chemokine Receptor 5 and Inhibits the Infection of Human Immunodeficiency Virus 1, BIOMED RESEARCH INTERNATIONAL, 2013, 第 7 作者
(97) 致死性家族性失眠症死亡1例, 法医学杂志, 2012, 第 7 作者
(98) PrPC interacts with potassium channel tetramerization domain containing 1 (KCTD1) protein through the PrP(51-136) region containing octapeptide repeats., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 通讯作者
(99) Effectively and Efficiently Dissecting the Infection of Influenza Virus by Quantum-Dot-Based Single-Particle Tracking, ACS NANO, 2012, 第 7 作者
(100) A Hsp40 Chaperone Protein Interacts with and Modulates the Cellular Distribution of the Primase Protein of Human Cytomegalovirus, PUBLIC LIBRARY OF SCIENCE, 2012, 第 9 作者
(101) Expression, purification, and secondary structure characterization of recombinant KCTD1, BIOCHEMISTRY-MOSCOW, 2012, 第 8 作者
(102) Gold nanoparticles as a label-free probe for the detection of amyloidogenic protein., TALANTA, 2012, 第 4 作者
(103) Label-Free Detection of Prion Protein with Its DNA Aptamer through the Formation of T-Hg2+-T Configuration, JOURNAL OF PHYSICAL CHEMISTRY B, 2012, 第 3 作者
(104) 中国人群XPD-751位点基因多态性与肝细胞癌易感性的Meta分析, A Meta-Analysis of the Relationship between XPD-751 Polymorphism and Susceptibility to Hepatocellular Carcinoma in Chinese Population, 医学分子生物学杂志, 2012, 第 2 作者
(105) Clathrin-mediated endocytosis in living host cells visualized through quantum dot labeling of infectious hematopoietic necrosis virus., JOURNAL OF VIROLOGY, 2011, 通讯作者
(106) Bioluminescence in-vivo imaging technology and its application in the study of viral infection--a review, Wei Sheng Wu Xue Bao, 2011, 通讯作者
(107) Blocking peptides against hbv: pres1 protein selected from a phage display library, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 通讯作者
(108) Total Chemical Synthesis,Assembly of Human Torque Teno Virus Genome, Total Chemical Synthesis,Assembly of Human Torque Teno Virus Genome, 中国病毒学:英文版, 2011, 
(109) Reticulon 3 attenuates the clearance of cytosolic prion aggregates by inhibiting autophagy, AUTOPHAGY, 2011, 通讯作者
(110) Human cytomegalovirus primase UL70 specifically interacts with cellular factor Snapin., JOURNAL OF VIROLOGY, 2011, 第 7 作者
(111) 活体生物发光成像技术及其在病毒感染研究中的应用, Bioluminescence in-vivo imaging technology and its application in the study of viral infection-A review, 微生物学报, 2011, 第 3 作者
(112) Total chemical synthesis, assembly of human torque teno virus genome, VIROLOGICA SINICA,, 2011, 第 2 作者
(113) Fibril Formation of the Rabbit/Human/Bovine Prion Proteins, BIOPHYSICAL JOURNAL, 2011, 
(114) Copper (II) promotes the formation of soluble neurotoxic PrP oligomers in acidic environment., JOURNAL OF CELLULAR BIOCHEMISTRY, 2010, 通讯作者
(115) Calnexin inhibits thermal aggregation and neurotoxicity of prion protein, JOURNAL OF CELLULAR BIOCHEMISTRY, 2010, 通讯作者
(116) Unique Structural Characteristics of the Rabbit Prion Protein, JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 第 7 作者
(117) A new method for the detection of the H5 influenza virus by magnetic beads capturing quantum dot fluorescent signals, BIOTECHNOLOGY LETTERS, 2010, 通讯作者
(118) Real-time visualization of prion transport in single live cells using quantum dots., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 第 10 作者
(119) PEG-interspersed nitrilotriacetic acid-functionalized quantum dots for site-specific labeling of prion proteins expressed on cell surfaces, BIOMATERIALS, 2010, 通讯作者
(120) Macromolecular crowding converts the human recombinant prpc to the soluble neurotoxic beta-oligomers, FASEB JOURNAL, 2010, 通讯作者
(121) Enhancement of keratinolytic activity of a thermophilic subtilase by improving its autolysis resistance and thermostability under reducing conditions, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2010, 第 4 作者
(122) Macromolecular crowding converts the human recombinant PrPC to the soluble neurotoxic beta-oligomers., FASEB JOURNAL : OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY, 2010, 第 9 作者
(123) 传染性造血组织坏死症病毒囊膜蛋白在原核细胞中的表达, Expression of Full Length Glycoprotein Gene of Infectious Hematopoietic Necrosis Virus (IHNV) in Escherichia coli, 华中农业大学学报, 2009, 第 5 作者
(124) 牛朊蛋白理化性质分析及其多克隆抗体的制备, Physico-Chemical Property and Polyclonal Antibody Production of Bovine Prion Protein, 武汉大学学报:医学版, 2009, 第 3 作者
(125) Aptamer-mediated turn-on fluorescence assay for prion protein based on guanine quenched fluophor, TALANTA, 2009, 第 6 作者
(126) Ni2+-NTA功能化量子点用于识别细胞表面的朊蛋白, 分析化学, 2009, 第 5 作者
(127) Robust prediction of mutation-induced protein stability change by property encoding of amino acids, PROTEIN ENGINEERING DESIGN & SELECTION, 2009, 通讯作者
(128) H5N1亚型禽流感病毒核蛋白NP的原核表达及抗体制备, Prokaryotic expression of NP protein of influenza A virus H5N1 and preparation of polyclonal antibody, 中国人兽共患病学报, 2008, 第 3 作者
(129) PrPC interacts with tetraspanin-7 through bovine PrP154-182 containing alpha-helix 1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 通讯作者
(130) 家族性致死性失眠症临床及相关特征(附1例报道), Characteristics of familial fatal insonmia (a case report), 卒中与神经疾病, 2007, 第 5 作者
(131) An efficient RNA‐cleaving DNA enzyme can specifically target the 5′‐untranslated region of severe acute respiratory syndrome associated coronavirus (SARS‐CoV), JOURNAL OF GENE MEDICINE, 2007, 第 6 作者
(132) Syncytin-A mediates the formation of syncytiotrophoblast involved in mouse placental development, CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2007, 通讯作者
(133) 分子内二硫键对HERV囊膜蛋白融合核心结构的影响, Influence of Intramolecular Disulfide Bond on Fusion Core Structure of Envelope Protein of HERV, 中国病毒学, 2006, 第 7 作者
(134) 人巨细胞病毒UL131A,UL130,UL128基因在先天感染患儿临床株中的变异, Genetic Variability of Human Cytomegalovirus UL131A,UL130,UL128 Genes in Strains from Congenitally Infected Infants, 武汉大学学报. 理学版, 2006, 第 4 作者
(135) 环孢菌素A的研究进展及应用, The Research Advances and Applications of CyclosporineA, 生物技术通报, 2006, 第 2 作者
(136) 致死性家族性失眠症一例临床及基因特征, Fatal familial insomnia: clinical characteristics and genetic description, 中华神经科杂志, 2005, 第 6 作者
(137) 重组可溶性人TRAIL抑制肿瘤细胞增殖, Antitumor Activity of Recombinant Soluble Human TRAIL, 武汉大学学报:理学版, 2005, 第 4 作者
(138) 一氧化氮介导的肿瘤治疗研究进展, Research Advances on Tumor Therapy via Nitric Oxide, 癌症:英文版, 2004, 第 1 作者
(139) 一氧化氮介导的肿瘤治疗研究进展, 癌症:英文版, 2004, 第 3 作者
(140) 臭氧水对SARS病毒的灭活效果观察, Examination of the efficacy of ozone solution disinfectant in inactivating sars virus, 中国消毒学杂志, 2004, 第 3 作者
(141) 人朊病毒蛋白及其突变体的溶剂可及性和模拟分析, Solvent Accessibility and Computer Modeling Analysis on the Native and the Mutants of human prion Protein, 中国病毒学, 2004, 第 6 作者
(142) PrP^c与蛋白质X结合位点可及性的初步探讨, Preliminary Studies on the Accessibility of Amino Acid Residue Sites of PrP~C to Bind Protein X, 氨基酸和生物资源, 2003, 第 1 作者
(143) SARS—CoV感染Vero E6细胞诱导细胞凋亡, SARS-CoV Infection Induces Apoptosis of Vero E6, 中国病毒学, 2003, 第 5 作者
(144) 人类免疫缺陷病毒—1进入细胞的分子机制及相关药物的研究, Molecular Mechanism of The Entry of HIV-1 into Cells and The Related Drug Research, 生物化学与生物物理进展, 2003, 第 2 作者
(145) 平菇多糖清除O2^—及对红细胞膜自由基氧化的影响, Effects of Pleurotus ostreatus Polysaccharide on Eliminating Super O_2~- and Peroxidation of Free Radical of Erythrocyte Membrane, 氨基酸和生物资源, 2002, 第 5 作者
(146) 一种快速简便的CaCl2质粒转化方法, 生物化学与生物物理进展, 2000, 第 2 作者
(147) 利用重组病毒选择性杀死肿瘤和病毒, 肿瘤, 1999, 第 3 作者
(148) 携带p53基因的重组腺病毒的构建及对肿瘤细胞抑制的研究, 生物工程学报, 1999, 第 1 作者
(149) 癌胚抗原启动子驱动tk基因在人肺腺癌细胞中的靶向表达, 武汉大学学报:自然科学版, 1999, 第 3 作者
(150) 新基因bak研究进展简评, 科学通报, 1999, 第 1 作者
(151) 杆状病毒介导对哺乳动物细胞的基因转移, 中国科学:C辑, 1998, 第 2 作者
(152) 病毒在基因水平上的起源与进化, 病毒学报, 1997, 第 1 作者
(153) Deletion of the first glycosylation site promotes Lassa virus glycoprotein-mediated membrane fusion, VIROLOGICA SINICA, 第 8 作者
发表著作
( 1 ) 基因工程, Gene engineering, 科学出版社, 2004-04, 第 2 作者

科研活动

   
科研项目
( 1 ) 病毒侵染过程的时空诠释, 负责人, 国家任务, 2011-01--2015-12
( 2 ) 重要病毒的入侵抑制, 负责人, 国家任务, 2010-01--2014-08
( 3 ) 朊病毒转录调控机制, 负责人, 国家任务, 2012-01--2015-12
( 4 ) 朊病毒导致神经疾病机制, 负责人, 国家任务, 2011-01--2013-12
( 5 ) 重要新发突发病毒宿主适应与 损伤机制研究, 负责人, 国家任务, 2016-06--2019-06
( 6 ) **病毒**糖基化位点改造提高抗原和抗体活性(国防), 负责人, 中国科学院计划, 2015-10--2017-10
( 7 ) 烈性病毒抗血清制备, 负责人, 中国科学院计划, 2016-01--2018-12
( 8 ) **应急免疫快速评价技术(非公开), 负责人, 国家任务, 2016-07--2019-06
( 9 ) 2019-nCoV的保护性抗体、疫苗研发和药物筛选与评价研究, 负责人, 国家任务, 2020-02--2020-12
( 10 ) 湖北省新型肺炎应急科技攻关项目, 负责人, 地方任务, 2020-02--2021-12
( 11 ) 非公开, 负责人, 中国科学院计划, 2019-01--2020-12
( 12 ) 广谱抗冠状病毒小分子抑制剂的鉴定、优化及作用机制研究, 负责人, 国家任务, 2023-01--2026-12
( 13 ) 口服核苷类抗新冠病毒候选新药VV116的临床研究, 负责人, 国家任务, 2021-11--2026-12
( 14 ) 核苷类似物或含有核苷类似物的组合制剂在抗病毒中的应用, 负责人, 境内委托项目, 2020-12--2025-12