采用化学生物学的原理与方法，发现调控干扰素激活的JAK/STAT信号通路，雌激素的生物合成和代谢，RNAi信号通路和蛋白质泛素降解信号通路的天然产物化学小分子，研究其构效关系，以活性小分子为探针研究其作用机制，以期发现新的信号调控机制以及具有诊疗作用的药物前体；

　　探索新型蛋白质标记体系，实时动态的研究细胞膜受体在天然配体和化学小分子作用下的变化，以发现细胞膜受体的新的作用机制； 

　　以骨质疏松为模型，研究中药治疗骨质疏松的物质基础和作用机制。 

   

100701-药物化学
100706-药理学

干扰素、雌激素生物合成和microRNA途径的化学生物学研究
干扰素、雌激素生物合成和microRNA途径的化学生物学研究

2000-09--2005-09   中国科学院遗传与发育生物学研究所   博士（硕博连读）
1996-09--2000-07   河南师范大学   学士

   

2014-01~现在, 中国科学院成都生物研究所, 研究员
2008-03~2013-12,中国科学院成都生物研究所, 副研究员
2005-10~2008-02,University of California San Francisco, 博士后

2018-02-22-2022-02-22,中国人民政治协商会议成都市第十五届委员会, 常务委员
2016-01-01-今,成都市九三学社高新区委员会第二支社, 主委
2013-01-01-2014-12-31,中国科学院青年创新促进会成都分会, 会长
2011-06-01-2014-06-01,中国科学院青年创新促进会, 理事

化学生物学

   

（1） 中国科学院院长特别奖, 特等奖, 院级, 2004
（2） 中国科学院地奥奖一等奖, 一等奖, 院级, 2004
（3） 中科院遗传发育所“研究生优秀论, 一等奖, 研究所（学校）, 2004

[1] 王飞, 张国林, 李晟, 周宗元, 艾曼纽·莫福蒂, 付乃洁, 黎玥佳. 一种抗肿瘤的联合用药物. CN: CN109453164B, 2021-08-06.

[2] 焦威, 向玲, 邵华武, 王飞, 张中辉. 一类千金子二萜衍生物及其应用. CN: CN113200950A, 2021-08-03.

[3] 肖伟烈, 王飞, 李一明, 周宗元, 曹碧云, 李晓莉, 张芮菡, 张兴杰. 含氮联芳环类化合物、制备方法和应用. CN: CN113087693A, 2021-07-09.

[4] 王飞, 阿皮恰德苏克萨穆然, 张国林, 康佳娜旺克阿将, 林源, 沈晓飞. 二芳基庚烷类化合物. CN: CN106831383B, 2021-03-30.

[5] 肖伟烈, 王飞, 普德兵, 杜宝文, 张芮菡, 史楠, 高俊博, 张兴杰. 一类异海松烷型二萜衍生物，其药物组合物及其用途. CN: CN108530281B, 2021-02-02.

[6] 王飞, 阿皮恰德苏克萨穆然, 张国林, 提帕万初普阿焦布, 林源, 沈晓飞. 二芳基庚烷类化合物的用途. CN: CN106806361B, 2020-03-06.

[7] 王飞, 阿彼察·苏萨朗, 张国林",null,"卢晓霞. 姜黄素衍生物的用途. CN: CN110327315A, 2019-10-15.

[8] 张国林, 王飞, 卢晓霞, 闻永举, 周宗元. 一种苄胺酰类衍生物及其在制备抗炎药物中的用途. CN: CN109879772A, 2019-06-14.

[9] 王飞, 卢晓霞, 张国林, 王涛, 彭婷. 一种miRNA生物合成抑制剂. CN: CN109810071A, 2019-05-28.

[10] 王飞, 张国林, 李晟, 周宗元, 艾曼纽·莫夫蒂, 付乃洁. 一种IDO1抑制剂及其应用. CN: CN109485615A, 2019-03-19.

[11] 肖伟烈, 王飞, 张兴杰, 杜宝文, 张芮菡. 甲氧基-7-木犀草素及其制备方法和用途. 中国: CN108383821A, 2018-08-10.

[12] 王飞, 张国林, 王淳, 彭勇, 蒲文臣, 邓腾, 强喆, 李娇. SHP2抑制剂在制备抗肿瘤的药物中的用途. 中国: CN108113984A, 2018-06-05.

[13] 王飞, 张国林, 奥汝丸.汪嘎纳. 6‑羟基‑3‑O‑甲基山奈酚6‑O‑吡喃葡萄糖苷的新用途. 中国: CN107714711A, 2018-02-23.

[14] 王飞, 张国林, 何玉娇, 张华. 一种苯基恶唑类化合物在制备治疗癌症的药中的应用. 中国: CN104306373A, 2015-01-28.

[15] 王飞, 张国林, 何玉娇, 张华. 苯基恶唑类化合物及在制备治疗癌症的药中的应用. 中国: CN104230836A, 2014-12-24.

[16] 张国林, 王飞, 淳泽, 林源. 菲及二氢菲类化合物及其应用. 中国: CN103408612A, 2013-11-27.

[17] 王飞, 章从恩, 陈前锋, 张国林. 一种特女贞苷的制备方法. 中国: CN102372754A, 2012-03-14.

[18] 王飞, 邰正福, 杨莉娟, 张国林. 一种抗病毒的组合药物. 中国: CN102343083A, 2012-02-08.

   

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[16] 席芮颖, 付乃洁, 李润择, 张国林, 王飞. 氯氰碘柳胺钠通过抑制蛋白酪氨酸磷酸酶SHP2诱导RAS突变型肺癌细胞衰老和死亡. 应用与环境生物学报[J]. 2021, 28: 365-371, https://t.cnki.net/kcms/detail?v=3uoqIhG8C46NmWw7YpEsKHTPvOGrUOOqX1coEOzL8AFqhlmu-o6sXjzYJdv148CfTKvdryZMFAk5AWFaMJpGIVQ9Jw4CizvT.
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[46] Ebokaiwe, Azubuike P, Ijomone, Omamuyovwi M, Osawe, Sharon O, Chukwu, Chukwuma J, Ejike, Chukwunonso E C C, Zhang, Guolin, Wang, Fei. Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus. REDOX REPORT[J]. 2018, 23(1): 194-205, https://doaj.org/article/6099c37be82d488e84ed627cf01bc5e3.
[47] Gong, Guidong, Cao, Yuan, Wang, Fei, Zhao, Gang. Planar Chiral Ferrocene Cyclopalladated Derivatives Induce Caspase-Dependent Apoptosis and Antimetastasis in Cancer Cells. ORGANOMETALLICS[J]. 2018, 37(7): 1103-1113, https://www.webofscience.com/wos/woscc/full-record/WOS:000429886300003.
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[49] Fu Li, BaoWen Du, DanFeng Lu, WenXuan Wu, Kanjana Wongkrajang, Lun Wang, WenChen Pu, ChangLu Liu, HanWei Liu, MingKui Wang, Fei Wang. Flavonoid glycosides isolated from Epimedium brevicornum and their estrogen biosynthesis-promoting effects. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/cdbf79c242b5456e9d71bb62e04b9411.
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（ 1 ） 女贞子抗高原反应的研究, 主持, 部委级, 2013-01--2015-12
（ 2 ） 蛋白激酶A介导的磷酸化调控芳香化酶降解机制的化学生物学研究, 主持, 国家级, 2014-01--2017-12
（ 3 ） 基于共轭聚合物纳米粒子的蛋白质-蛋白质相互作用药物筛选新方法的研究及其应用, 主持, 部委级, 2014-01--2016-12
（ 4 ） 青年研究员人才支持项目, 主持, 市地级, 2013-01--2017-12
（ 5 ） 四川省杰出青年学术技术带头人计划, 主持, 省级, 2014-01--2016-12
（ 6 ） α7尼古丁乙酰胆碱受体激动剂治疗类风湿性关节炎的研究, 主持, 省级, 2016-03--2019-06
（ 7 ） 治疗老年性疾病的天然产物药物发现研究, 参与, 国家级, 2015-10--2018-09
（ 8 ） 苯基噁唑类化合物通过TRBP调控microRNA生物合成抑制肝癌转移的化学生物学研究, 主持, 国家级, 2017-01--2020-12
（ 9 ） 二苯庚烷类化合物作为α7尼古丁乙酰胆碱受体激动剂治疗心律失常的研究, 主持, 部委级, 2016-09--2018-09
（ 10 ） 基于天然产物的老年性疾病候选药物研究, 参与, 国家级, 2019-01--2021-12
（ 11 ） 黄烷酮类小分子靶向蛋白酪氨酸磷酸酶SHP2调控RAS信号通路抑制肺癌的化学生物学研究, 主持, 国家级, 2020-01--2023-12

已指导学生

郭加加  硕士研究生  077901-药物化学  

邓腾  硕士研究生  078001-药物化学  

李晟  硕士研究生  085238-生物工程  

彭辉盼  硕士研究生  105500-药学  

盛钰雯  硕士研究生  085238-生物工程  

史楠  硕士研究生  077804-病理学与病理生理学  

现指导学生

史小可  硕士研究生  100104-病理学与病理生理学  

周宗元  博士研究生  100706-药理学  

李润择  硕士研究生  077804-病理学与病理生理学  

曹东怡  博士研究生  100701-药物化学  

靳钰洁  硕士研究生  078006-药理学  

盛钰雯  博士研究生  100706-药理学