基本信息
王勇  男  博导  中国科学院分子植物科学卓越创新中心
电子邮件: yongwang@cemps.ac.cn
通信地址: 上海市枫林路300号
邮政编码: 200032

招生信息

   
招生专业
071005-微生物学
招生方向
合成生物学

教育背景

2001-09--2004-08   华东理工大学生物工程学院   博士

教授课程

代谢工程与合成生物学

专利与奖励

1.      王勇,王国栋,刘海利,拟南芥三烯甲素及其制备,申请号:201710178601.5

2.      王勇,孙雨伟卓,李建华,新 UDP-糖基及其用,申201710758391.7

3.      王勇,郝玉有,一种阵列式高通量分离培养微生物装置,中国专利,ZL 201210548502.9

4.      王勇,郝玉有,用于发酵的棉籽蛋白及其制备方法和应用,中国专利,CN 103215310 B

5.      王勇,汪建峰,熊智强,异源合成广霍香醇的方法和微生物,中国专利,申请号:2014103093474.4

6.      王勇, 熊智强, 李诗渊, 汪建峰. 高效合成萜类化合物的重组大肠杆菌底盘细胞及其制法和应用, 中国专利, 申请号: 201310501221.2

7.      王勇, 熊智强, 宋书杰, 刘巧霞,汪建峰. 一种提高大肠杆菌异源合成聚酮类化合物的方法和用途, 中国专利, 申请号: 201410338738.9.

8.      王勇, 熊智强, 李诗渊, 汪建峰. 利用微生物生产甜菊糖苷类化合物的方法, 申请号:201310460493.2PCT专利, 国际申请号: PCT/CN2013/084618.

9.      王勇, 熊智强, 汪建峰, 李诗渊, 刘巧霞. 一种新的贝壳烯酸-13α-羟化酶、其编码基因及其应用, 申请号:201410105875.8PCT专利, 申请号:PCT/CN2015/074344

10.   Blaine Pfeifer, Yong Wang, Genetically modified E. Coli Strains Overexpressing Genes Involved in Non-mevalonate 1-deoxy-D- xylulose-5-phosphate Synthetic Pathway and Uses Thereof’, US Patent Filed 4/2009, Application # 12/420,482.


专利成果
[1] 王勇, 许建林, 刘海利, 刘志凤. 具有脂肪酶抑制活性的酰基他定类化合物、其制备方法及应用. CN: CN114075256A, 2022-02-22.

[2] 王勇, 许建林, 刘海利, 刘志凤. 具有糖苷酶抑制活性的酰基他定类化合物的应用. CN: CN114073708A, 2022-02-22.

[3] 王勇, 吕华军, 张英, 邵洁, 刘海利. 阿魏酸生产工程菌、其建立方法及其应用. CN: CN114075524A, 2022-02-22.

[4] Wang, Yong, Lv, Huajun, Zhang, Ying, Shao, Jie, Liu, Haili. Engineering Bacteria for Ferulic Acid Production, Preparation Method and Use Thereof. CN: US20220049235(A1), 2022-02-17.

[5] 王勇, 孙雨伟, 陈卓. 新型黄酮羟基化酶、合成黄酮碳苷类化合物的微生物及其应用. CN: CN113322288A, 2021-08-31.

[6] 王勇, 孙雨伟, 陈卓, 张前, 张英, 刘海利, 李建华. 双功能碳苷糖基转移酶及其应用. CN: CN113265433A, 2021-08-17.

[7] 王勇, 孙雨伟, 陈卓, 张前, 张英, 刘海利, 李建华. 新型碳苷糖基转移酶及其应用. CN: CN113136373A, 2021-07-20.

[8] 王勇, 李建华, 王凯博. 用于生产5α-羟基紫杉二烯的融合蛋白及其用途. CN: CN112574968A, 2021-03-30.

[9] 王勇, 孙雨伟, 刘志凤, 陈卓, 李建华, 刘海利, 吕华军. 糖基转移酶UGT76G1突变体的制备及其应用. CN: CN112553175A, 2021-03-26.

[10] 王勇, 陈卓, 孙雨伟. 黄酮碳苷单体化合物的应用. CN: CN112206227A, 2021-01-12.

[11] 王勇, 陈卓, 孙雨伟. 黄酮碳苷单体化合物的应用. CN: CN112168815A, 2021-01-05.

[12] 王勇, 刘志凤, 孙雨伟, 吕华军, 张鹏, 李建戌, 刘海利, 李建华, 陈卓. 糖基转移酶、突变体及其应用. CN: CN110462033A, 2019-11-15.

[13] 王勇, 熊智强, 宋书杰, 刘巧霞, 汪建峰. 一种提高大肠杆菌异源合成聚酮类化合物的方法和用途. CN: CN106191155A, 2016-12-07.

出版信息

   
发表论文
[1] Zhang, YaQun, Wang, ZiLong, Chen, Zhuo, Jin, ZhengTong, Hasan, Aobulikasimu, Wang, HaiDong, Sun, YuWei, Qiao, Xue, Wang, Yong, Ye, Min. A highly selective 2 ''-O-glycosyltransferase from Ziziphus jujuba and De novo biosynthesis of isovitexin 2 ''-O-glucoside. CHEMICAL COMMUNICATIONS[J]. 2022, 58(15): 2472-2475, http://dx.doi.org/10.1039/d1cc06949g.
[2] Sun, Yuwei, Chen, Zhuo, Wang, Guangyi, Lv, Huajun, Mao, Yaping, Ma, Ke, Wang, Yong. De novo production of versatile oxidized kaurene diterpenes in Escherichia coli. METABOLIC ENGINEERING[J]. 2022, 73: 201-213, http://dx.doi.org/10.1016/j.ymben.2022.08.001.
[3] Jianlin Xu, Zhifeng Liu, Zhanguang Feng, Yuhong Ren, Haili Liu, Yong Wang. Rapid Mining of Novel α -Glucosidase and Lipase Inhibitors from Streptomyces sp. HO1518 Using UPLC-QTOF-MS/MS. MARINEDRUGS[J]. 2022, 20(189): https://doaj.org/article/e80a960187084ea3ba92af48df6187ac.
[4] Liu Zhifeng, Xu Jianlin, Feng Zhanguang, Wang Yong. Multi-strategy engineering unusual sugar TDP-L-mycarose biosynthesis to improve the production of 3-O-α-mycarosylerythronolide B in Escherichia coli. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY[J]. 2022, 7(2): 756-764, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7258757&detailType=1.
[5] Liu, Zhifeng, Xu, Jianlin, Liu, Haili, Wang, Yong. Engineered EryF hydroxylase improving heterologous polyketide erythronolide B production in Escherichia coli. MICROBIAL BIOTECHNOLOGY[J]. 2022, 15(5): 1598-1609, http://dx.doi.org/10.1111/1751-7915.14000.
[6] Chenfei Tian, Yixin Zhang, Jianhua Li, Yong Wang. Benchmarking Intrinsic Promoters and Terminators for Plant Synthetic Biology Research. BIODESIGN RESEARCH[J]. 2022, https://doaj.org/article/ed2af7764fb0403798a71673f0c55ca9.
[7] Ji, Dongni, Li, Jianhua, Ren, Yuhong, Wang, Yong. Rational engineering in Escherichia coli for high-titer production of baicalein based on genome-scale target identification. BIOTECHNOLOGY AND BIOENGINEERING[J]. 2022, 119(7): 1916-1925, http://dx.doi.org/10.1002/bit.28087.
[8] Mutanda, Ishmael, Li, Jianhua, Xu, Fanglin, Wang, Yong. Recent Advances in Metabolic Engineering, Protein Engineering, and Transcriptome-Guided Insights Toward Synthetic Production of Taxol. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY[J]. 2021, 9: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892896/.
[9] Xu, Jianlin, Chen, Yuchan, Liu, Zhaoming, Li, Saini, Wang, Yong, Ren, Yuhong, Liu, Hongxin, Zhang, Weimin. Lithocarpins E-G, Potent Anti-Tumor Tenellone-Macrolides from the Deep-Sea Fungus Phomopsis lithocarpus FS508. CHINESE JOURNAL OF CHEMISTRY[J]. 2021, 39(5): 1104-1112, http://dx.doi.org/10.1002/cjoc.202000621.
[10] Gaohua Yang, Sen Hong, Pengjie Yang, Yuwei Sun, Yong Wang, Peng Zhang, Weihong Jiang, Yang Gu. Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria. NATURE COMMUNICATIONS[J]. 2021, 12(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862272/.
[11] Ji, Dongni, Li, Jianhua, Xu, Fanglin, Ren, Yuhong, Wang, Yong. Improve the Biosynthesis of Baicalein and Scutellarein via Manufacturing Self-Assembly Enzyme Reactor In Vivo. ACS SYNTHETIC BIOLOGY[J]. 2021, 10(5): 1087-1094, http://dx.doi.org/10.1021/acssynbio.0c00606.
[12] Shao, Jie, Sun, Yuwei, Liu, Haili, Wang, Yong. Pathway elucidation and engineering of plant-derived diterpenoids. CURRENT OPINION IN BIOTECHNOLOGYnull. 2021, 69: 10-16, http://dx.doi.org/10.1016/j.copbio.2020.08.007.
[13] Sun, Yuwei, Chen, Zhuo, Yang, Jingya, Mutanda, Ishmael, Li, Shiyi, Zhang, Qian, Zhang, Ying, Zhang, Yulian, Wang, Yong. Pathway-specific enzymes from bamboo and crop leaves biosynthesize anti-nociceptive C-glycosylated flavones. COMMUNICATIONS BIOLOGY[J]. 2020, 3(1): https://doaj.org/article/85b35d70626e405c8aae9477c2fa4149.
[14] 田晨菲, 李建华, 王勇. 植物合成生物学调控元件的研究进展. 植物生理学报[J]. 2020, 56(11): 2261-2274, http://lib.cqvip.com/Qikan/Article/Detail?id=7103796493.
[15] Xu, JianLin, Liu, HaiLi, Liu, ZhiFeng, Ren, YuHong, Wang, Yong. Acylated Aminooligosaccharides from the Yellow Sea Streptomyces sp. HO1518 as Both alpha-Glucosidase and Lipase Inhibitors. MARINE DRUGS[J]. 2020, 18(11): http://dx.doi.org/10.3390/md18110576.
[16] NaiQian Dong, Yuwei Sun, Tao Guo, ChuanLin Shi, YiMin Zhang, Yi Kan, YouHuang Xiang, Hai Zhang, YiBing Yang, YaChao Li, HuaiYu Zhao, HongXiao Yu, ZiQi Lu, Yong Wang, WangWei Ye, JunXiang Shan, HongXuan Lin. UDP-glucosyltransferase regulates grain size and abiotic stress tolerance associated with metabolic flux redirection in rice. NATURE COMMUNICATIONS[J]. 2020, 11(1): https://doaj.org/article/bda2dec5eedc4bc8b66d15ebf60672e8.
[17] Li, Jianhua, Tian, Chenfei, Xia, Yuhui, Mutanda, Ishmael, Wang, Kaibo, Wang, Yong. Production of plant-specific flavones baicalein and scutellarein in an engineered E-coli from available phenylalanine and tyrosine. METABOLIC ENGINEERING[J]. 2019, 52: 124-133, http://dx.doi.org/10.1016/j.ymben.2018.11.008.
[18] Jianhua Li, Ishmael Mutanda, Kaibo Wang, Lei Yang, Jiawei Wang, Yong Wang. Chloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes biosynthesis in Nicotiana benthamiana. NATURE COMMUNICATIONS[J]. 2019, 10(1): http://dx.doi.org/10.1038/s41467-019-12879-y.
[19] Yuwei Sun, Zhuo Chen, Jianxu Li, Jianhua Li, Huajun LV, Jingya Yang, Weiwei Li, Dingan Xie, Zhiqiang Xiong, Peng Zhang, Yong Wang. Diterpenoid UDP-Glycosyltransferases from Chinese Sweet Tea and Ashitaba Complete the Biosynthesis of Rubusoside. 分子植物:英文版[J]. 2018, 11(10): 1308-1311, http://lib.cqvip.com/Qikan/Article/Detail?id=676885988.
[20] Li, Weichao, Zhou, Yiqing, You, Wenjing, Yang, Mengquan, Ma, Yanrong, Wang, Mingli, Wang, Yong, Yuan, Shuguang, Xiao, Youli. Development of Photoaffinity Probe for the Discovery of Steviol Glycosides Biosynthesis Pathway in Stevia rebuadiana and Rapid Substrate Screening. ACS CHEMICAL BIOLOGY[J]. 2018, 13(8): 1944-1949, https://www.webofscience.com/wos/woscc/full-record/WOS:000442452300005.
[21] Sun, Yuwei, Chen, Zhuo, Li, Jianxu, Li, Jianhua, Lv, Huajun, Yang, Jingya, Li, Weiwei, Xie, Dingan, Xiong, Zhiqiang, Zhang, Peng, Wang, Yong. Diterpenoid UDP-Glycosyltransferases from Chinese Sweet Tea and Ashitaba Complete the Biosynthesis of Rubusoside. MOLECULAR PLANT[J]. 2018, 11(10): 1308-1311, http://lib.cqvip.com/Qikan/Article/Detail?id=676885988.
[22] Liu, HaiLi, E, HengChao, Xie, DingAn, Cheng, WenBo, Tao, WanQi, Wang, Yong. Acylated Aminooligosaccharides with Inhibitory Effects against -Amylase from Streptomyces sp HO1518. MARINE DRUGS[J]. 2018, 16(11): https://www.webofscience.com/wos/woscc/full-record/WOS:000451159500006.
[23] Shao Jie, Chen QingWen, Lv HuaJun, He Juan, Liu ZhiFeng, Lu YanNa, Liu HaiLi, Wang GuoDong, Wang Yong. (+)-Thalianatriene and (−)-Retigeranin B Catalyzed by Sesterterpene Synthases from Arabidopsis thaliana. ORGANIC LETTERS[J]. 2017, [24] Wang Yong. Enhanced production of avermectin by deletion of type III PKSs biosynthetic cluster rpp in Streptomyces avermitilis. Lett Appl Microbiol. 2016, [25] Li, Jianhua, Meng, Hailin, Wang, Yong. Synbiological systems for complex natural products biosynthesis. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY[J]. 2016, 1(4): 221-229, http://lib.cqvip.com/Qikan/Article/Detail?id=7103844682.
[26] Wang, Jianfeng, Li, Shiyuan, Xiong, Zhiqiang, Wang, Yong. Pathway mining-based integration of critical enzyme parts for de novo biosynthesis of steviolglycosides sweetener in Escherichia coli. CELL RESEARCH[J]. 2016, 26(2): 258-261, http://dx.doi.org/10.1038/cr.2015.111.
[27] Wang Yong. Construction of polyketide overproducing E. coli strains via synthetic antisense RNAs based on in silico fluxome analysis and comparative transcriptome analysis.. Biotechnol J. 2016, [28] Yang, Jingya, Xiong, ZhiQiang, Song, ShuJie, Wang, JianFeng, Lv, HuaJun, Wang, Yong. Improving heterologous polyketide production in Escherichia coli by transporter engineering. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2015, 99(20): 8691-8700, http://dx.doi.org/10.1007/s00253-015-6718-7.
[29] Xiong, ZhiQiang, Yang, YingYing, Liu, QiaoXia, Sun, CuiCui, Jin, Yu, Wang, Yong. Endophytes in the plant Huperzia serrata: fungal diversity and discovery of a new pentapeptide. ARCHIVES OF MICROBIOLOGY[J]. 2015, 197(3): 411-418, http://dx.doi.org/10.1007/s00203-014-1072-1.
[30] Wang, Jianfeng, Xiong, Zhiqiang, Li, Shiyuan, Wang, Yong. Exploiting exogenous MEP pathway genes to improve the downstream isoprenoid pathway effects and enhance isoprenoid production in Escherichia coli. PROCESS BIOCHEMISTRY[J]. 2015, 50(1): 24-32, http://dx.doi.org/10.1016/j.procbio.2014.10.022.
[31] Wang, Jianfeng, Xiong, Zhiqiang, Yang, Yingying, Zhao, Na, Wang, Yong. Significant expression of a Chinese scorpion peptide, BmK1, in Escherichia coli through promoter engineering and gene dosage strategy. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY[J]. 2014, 61(4): 466-473, https://www.webofscience.com/wos/woscc/full-record/WOS:000341021300014.
[32] Sun, Zhiqiang, Meng, Hailin, Li, Jing, Wang, Jianfeng, Li, Qian, Wang, Yong, Zhang, Yansheng. Identification of Novel Knockout Targets for Improving Terpenoids Biosynthesis in Saccharomyces cerevisiae. PLOS ONE[J]. 2014, 9(11): http://www.irgrid.ac.cn/handle/1471x/1812327.
[33] Wang, JianFeng, Xiong, ZhiQiang, Li, ShiYuan, Wang, Yong. Enhancing isoprenoid production through systematically assembling and modulating efflux pumps in Escherichia coli. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2013, 97(18): 8057-8067, http://dx.doi.org/10.1007/s00253-013-5062-z.
[34] Wang Yong. In silico analysis and experimental improvement of the terpenoid precursor supply pathways for taxadiene heterologous biosynthesis in Escherichia coli.. Biotechnology and Bioprocess Engineering.. 2011, [35] 陈菲菲, 王勇, 王以光, 赫卫清. 海洋微生物来源的天然产物开发研究进展. 应用与环境生物学报[J]. 2011, 17(2): 287-294, http://lib.cqvip.com/Qikan/Article/Detail?id=37685026.
[36] Wang Yong. Distribution and diversity of glycosylated natural product genes in marine bacteria genomes.. Applied Microbiology and Biotechnology.. 2011, [37] Wang Yong. In silico improvement of heterologous biosynthesis of erythromycin precursor 6-deoxyerythronilide B in Escherichia coli. Biotechnology and Bioprocess Engineering. 2011, [38] Ajikumar, Parayil Kumaran, Xiao, WenHai, Tyo, Keith E J, Wang, Yong, Simeon, Fritz, Leonard, Effendi, Mucha, Oliver, Phon, Too Heng, Pfeifer, Blaine, Stephanopoulos, Gregory. Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli. SCIENCE[J]. 2010, 330(6000): 70-74, https://www.webofscience.com/wos/woscc/full-record/WOS:000282334500035.
[39] Zhang, Haoran, Wang, Yong, Wu, Jiequn, Skalina, Karin, Pfeifer, Blaine A. Complete Biosynthesis of Erythromycin A and Designed Analogs Using E. coli as a Heterologous Host. CHEMISTRY & BIOLOGY[J]. 2010, 17(11): 1232-1240, http://dx.doi.org/10.1016/j.chembiol.2010.09.013.
[40] Hu, Hui, Qian, Jiangchao, Chu, Ju, Wang, Yong, Zhuang, Yingping, Zhang, Siliang. DNA shuffling of methionine adenosyltransferase gene leads to improved S-adenosyl-L-methionine production in Pichia pastoris. JOURNALOFBIOTECHNOLOGY[J]. 2009, 141(3-4): 97-103, http://dx.doi.org/10.1016/j.jbiotec.2009.03.006.
[41] Wang, Yong, Chu, Ju, Zhuang, Yingping, Wang, Yonghong, Xia, Jianye, Zhang, Siliang. Industrial bioprocess control and optimization in the context of systems biotechnology. BIOTECHNOLOGY ADVANCES[J]. 2009, 27(6): 989-995, http://dx.doi.org/10.1016/j.biotechadv.2009.05.022.
[42] Wang Yong. Regulation of meilingmycin in Streptomyces nanchangensis: effect of ammonium ion.. 2009, [43] Wang Yong. Probing the heterologous metabolism supporting 6-deoxyerythronolide B biosynthesis in E. coli.. Microbial Biotechnol.. 2009, [44] Wang, Yong, Pfeifer, Blaine A. 6-Deoxyerythronolide B production through chromosomal localization of the deoxyerythronolide B synthase genes in E. coli. METABOLIC ENGINEERING[J]. 2008, 10(1): 33-38, http://dx.doi.org/10.1016/j.ymben.2007.09.002.
[45] Yuwei Sun, Jie Shao, Haili Liu, Hua Wang, Guangyi Wang, Jianhua Li, Yaping Mao, Zhuo Chen, Ke Ma, Lin Xu, Yong Wang. A chromosome-level genome of Isodon rubescens reveals that tandem-duplicated CYP706V oxidase genes control oridonin biosynthesis in shoot apex. MOLECULAR PLANT. http://dx.doi.org/10.1016/j.molp.2022.12.007.

科研活动

   
科研项目
( 1 ) 紫杉醇等萜类化合物的异源合成, 主持, 国家级, 2012-01--2016-12
( 2 ) 新型甜菊糖苷类化合物的合成生物学设计与构建, 主持, 省级, 2014-09--2017-08
( 3 ) 高值生物基化学品关键技术研发及示范, 主持, 部委级, 2016-01--2017-12
( 4 ) 甜菊糖的合成生物制造研究, 主持, 院级, 2015-10--2017-10
( 5 ) 天然产物糖基化修饰的底盘设计及适配, 主持, 国家级, 2017-01--2020-12
参与会议
(1)Biosynthesis of Complex Natural Products in Engineered Escherichia coli   亚洲生物技术大会   YONG WANG   2011-05-11

指导学生

已指导学生

吕华军  博士研究生  071005-微生物学  

现指导学生

鄂恒超  博士研究生  071005-微生物学  

夏裕会  硕士研究生  071005-微生物学  

陈卓  硕士研究生  071005-微生物学  

刘志凤  博士研究生  071005-微生物学  

邵洁  博士研究生  071005-微生物学