071011-生物物理学
100706-药理学
100701-药物化学

激酶抑制剂的系统开发，肿瘤的抗药性机理
生物活性的小分子化合物的化学合成
生物功能化合物的设计和动物体内代谢的研究

2004-08--2006-08   Vanderbilt University/美国   访问博士研究生
2002-01--2006-12   Texas A&M University/美国   博士学位
2001-08--2001-12   Brandeis University/美国   博士研究生
1997-09--2001-06   南开大学   学士学位

   

2011-02~2012-02,Dana Farber Cancer Institute/HMS, Research Scientist
2007-11~2011-01,Dana Farber Cancer Institute/HMS, Research Fellow
2006-09~2007-10,Harvard Medical School, Postdoc fellow
2004-08~2006-08,Vanderbilt University/美国, 访问博士研究生
2002-01~2006-12,Texas A&M University/美国, 博士学位
2001-08~2001-12,Brandeis University/美国, 博士研究生
1997-09~2001-06,南开大学, 学士学位

   

（ 1 ） Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof, 2014, 第 3 作者, 专利号: WO/2014/063054 A1

（ 2 ） Host targeted irreversible inhibitors of dengue virus and other biodefense viruses, 2013, 第 3 作者, 专利号: WO 2013154778 A1

（ 3 ） soluble mTOR complexes and modulators thereof, 2010, 第 5 作者, 专利号: WO20100044885

   

（1） Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies, Leukemia, 2014, 通讯作者
（2） Exploration of Type II Binding Mode a Privileged Approach for Kinase Inhibitor Focused Drug Discovery, ACS Chem Biol, 2014, 通讯作者
（3） Interleukin-6 secretion by astrocytes is dynamically regulated by PI3K-mTOR-calcium signaling, PloS One, 2014, 通讯作者
（4） Discovery of a Potent, Covalent BTK Inhibitor for B-Cell Lymphoma, ACS Chem Biol, 2014, 通讯作者
（5） Combined inhibition of mTORC1 and mTORC2 signaling pathways is a promising therapeutic option in inhibiting pheochromocytoma tumor growth: in vitro and in vivo studies in female athymic nude mice, Endocrinology, 2013, 通讯作者
（6） Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR., Cancer Res., 2013, 第 1 作者
（7） Selective Akt inhibitors synergize with tyrosine kinase inhibitors and effectively override stroma-associated cytoprotection of mutant FLT3-positive AML cells., PLoS One, 2013, 第 1 作者
（8） Developing irreversible inhibitors of the protein kinase cysteinome., Chem Biol, 2013, 第 1 作者
（9） Discovery of a Selective Irreversible BMX Inhibitor for Prostate Cancer., ACS Chem Biol. , 2013, 通讯作者
（10） Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a target in LKB1 Mutant Lung Cancer., Cancer Discov., 2013, 通讯作者
（11） The influence of hypoxia on CML trafficking through modulation of CXCR4 and E-cadherin expression., Leukemia, 2013, 通讯作者
（12） Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor, ACS Chem Biol, 2013, 通讯作者
（13） Chaperones as thermodynamic sensors of drug::target interactions in living cells, Nature Biotechnology, 2013, 通讯作者
（14） A simple, highly visual in vivo screen for anaplastic lymphoma kinase inhibitors., ACS Chem Biol, 2012, 通讯作者
（15） Kinase inhibitors targeting angiogenesis as anti-cancer therapies, Current Angiogenesis, 2012, 通讯作者
（16） Development of ATP-competitive mTOR inhibitors., Methods Mol Biol, 2012, 第 1 作者
（17） Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics, J Biol Chem, 2012, 第 1 作者
（18） Natural products as kinase inhibitors., Nat Prod Rep, 2012, 通讯作者
（19） Systematic identification of genomic markers of drug sensitivity in cancer cells., Nature, 2012, 通讯作者
（20） Selective ATP-Competitive Inhibitors of TOR Suppress Rapamycin-Insensitive Function of TORC2 in Saccharomyces cerevisiae, ACS Chem Biol. , 2012, 第 1 作者
（21） Functional Characterization of an Isoform-Selective Inhibitor of PI3K-p110β as a Potential Anticancer Agent., Cancer Discovery, 2012, 第 1 作者
（22） Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors, and JAK inhibitors., Leukemia, 2012, 第 1 作者
（23） The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma., Cancer Cell, 2012, 通讯作者
（24） Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability., Bioorg Med Chem Lett., 2011, 第 1 作者
（25） Systemic inhibition of the mammalian target of rapamycin (mTOR) pathway reduces neuropathic pain in mice., Pain, 2011, 通讯作者
（26） The controversial links among calorie restriction, SIRT1, and resveratrol., Free Radic Biol Med, 2011, 通讯作者
（27） Anti-HCV drugs in the pipeline., Curr Opin Virol., 2011, 第 4 作者
（28） Characterization of a selective inhibitor of the Parkinsons disease kinase LRRK2, Nat Chem Biol, 2011, 通讯作者
（29） Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer., J Med Chem., 2011, 第 1 作者
（30） Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer., J Med Chem., 2010, 第 1 作者
（31） mTOR Mediated Anti-Cancer Drug Discovery., Drug Discov Today Ther Strateg. , 2009, 第 1 作者
（32） Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors., Bioorg Med Chem Lett. , 2009, 通讯作者
（33） FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML., Drug Resist Updat., 2009, 第 3 作者
（34） An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1., J Biol Chem., 2009, 第 4 作者
（35） Synthesis and evaluation of the cytotoxicity of apoptolidinones A and D., J Org Chem., 2008, 第 4 作者
（36） Studies on the Synthesis of Apoptolidin: Progress on the Stereocontrolled Assembly of the Pseudo Aglycone of Apoptolidin, E. J. Org. Chem, 2006, 第 2 作者
（37） Development of an End-Game Strategy Towards Apoptolidin: a Sequential Suzuki Coupling Approach, Tetrahedron , 2005, 第 2 作者
（38） Total synthesis of apoptolidinone., Angew Chem Int Ed Engl, 2004, 第 2 作者

（ 1 ） mTOR : Methods and Protocols: Development of ATP-competitive mTOR inhibitors, mTOR : Methods and Protocols: Development of ATP-competitive mTOR inhibitors, Humana Press, 2012-05, 第 1 作者
（ 2 ） The Emerging Mechanism of Limited Therapeutic Efficacy of Rapamycin for Cancer, The Emerging Mechanism of Limited Therapeutic Efficacy of Rapamycin for Cancer, Nova Science Publishers, 2012-06, 第 5 作者
（ 3 ） Applications of fluorescent molecular probes in cell biology, Applications of fluorescent molecular probes in cell biology, Nova Science Publishers, 2013-09, 第 5 作者

   

（1）Rational Design, Synthesis and Characterization of Synthetic Kinase Inhibitors ---A Chemical Biology Link Between Synthetic Materials and Life Science    qingsong Liu   2011-07-01
（2）Discovery and optimization of potent and selective benzonaphthyridinone analogs as dual mTOR/ATR small molecular inhibitors for treatment of cancer   Qingsong Liu, Danny Zhou, Bunsho Shiotani, Nathanael S. Gray, Stephen J. Elledge, Lee Zou   2011-04-02
（3）2. Discovery of Torin1 as a highly potent, selective Mammalian Target of Rapamycin (mTOR) inhibitor for the treatment of cancer    Qingsong Liu, Jae Won Chang, Jinhua Wang, Seong A. Kang , Carson C. Thoreen , Andrew Markhard, Wooyoung Hur , Jianming Zhang , Taebo Sim, David M. Sabatini , Nathanael S. Gray   2010-11-02
（4）Synthesis of pseudoapoptolidinone and structural corroboration of apoptolidin.   Wu, Bin; Jin, Bohan; Qu, Tao; Liu, Qingsong; Sulikowski, Gary A   2003-03-27