基本信息
高召兵  男  博导  中国科学院上海药物研究所
电子邮件: zbgao@simm.ac.cn
通信地址: 上海市海科路501号2515室
邮政编码:

招生信息

   
招生专业
100706-药理学
招生方向
神经系统疾病离子通道药物研发
新型离子通道发现和靶标确证
疼病毒离子通道

教育背景

2006-10--2010-03   约翰霍普金斯大学医学院   博士后
2003-09--2006-06   中科院上海药物所   博士研究生

工作经历

   
工作简历
2013-10~现在, 中科院上海药物研究所, 研究员
2010-04~现在, 中科院上海药物所, 副研究员
2006-10~2010-03,约翰霍普金斯大学医学院, 博士后
2003-09~2006-06,中科院上海药物所, 博士研究生
社会兼职
2021-07-01-今,上海市神经科学会, 理事
2020-07-01-今,中国药理学会, 理事
2020-04-30-今,中国抗癫痫协会药物治疗专业委员会, 委员

教授课程

复旦大学药学院药理精品课程

专利与奖励

   
奖励信息
(1) 美国心脏学会博士后Fellowship, , 其他, 2007
专利成果
( 1 ) 酰胺类化合物及其制备方法和用途, 2022, 第 1 作者, 专利号: 202210267217.3

( 2 ) 具有抗癫痫活性的化合物及其在制备抗癫痫药物中的应用, 2022, 第 2 作者, 专利号: CN113968837A

( 3 ) 血根碱在制备TRPA1通道激动剂中的应用, 2021, 第 1 作者, 专利号: CN113545316A

( 4 ) 一类苯磺酰胺取代的衍生物,其制法及其用途, 2020, 第 2 作者, 专利号: CN111285825A

( 5 ) 一类KCNQ钾通道激动剂、其制备方法和用途, 2018, 第 3 作者, 专利号: CN105017085B

( 6 ) 苯溴马隆在制备电压门控钾离子通道KCNQ激动剂中的应用, 2016, 第 1 作者, 专利号: CN105853405A

( 7 ) 天然抗癫痫活性化合物及其在药物制剂中的用途, 2016, 第 7 作者, 专利号: CN105503988A

( 8 ) 一类新型的KCNQ钾通道激动剂、其制备方法和用途, 2015, 第 3 作者, 专利号: CN105017085A

( 9 ) 1,3-取代脲或硫脲化合物、其制备方法、药物组合物和应用, 2014, 第 4 作者, 专利号: CN103709097A

( 10 ) 六氯酚在制备电压门控钾离子通道激动剂中的应用, 2014, 第 2 作者, 专利号: CN103565783A

( 11 ) N,N'-二取代哌嗪类衍生物及其制备方法、药物组合物和用途, 2007, 第 6 作者, 专利号: CN101007794A

出版信息

   
发表论文
(1) Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2, CELL DISCOVERY, 2023, 第 20 作者
(2) Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2, CELL DISCOVERY, 2023, 通讯作者
(3) Why is the SARS-CoV-2 Omicron variant milder?, Why is the SARS-CoV-2 Omicron variant milder?, 创新(英文), 2022, 第 9 作者
(4) Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates, Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates, ACTA PHARMACOLOGICA SINICA, 2022, 通讯作者
(5) SCN8A epileptic encephalopathy mutations display a gain-of-function phenotype and divergent sensitivity to antiepileptic drugs, ACTA PHARMACOLOGICA SINICA, 2022, 通讯作者
(6) Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution, ADVANCED SCIENCE, 2021, 第 9 作者
(7) SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, CELL RESEARCH, 2021, 通讯作者
(8) Sanguinarine is an agonist of TRPA1 channel, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021, 通讯作者
(9) An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy, NATURE BIOMEDICAL ENGINEERING, 2021, 其他(合作组作者)
(10) Discovery of HN37 as a Potent and Chemically Stable Antiepileptic Drug Candidate, JOURNAL OF MEDICINAL CHEMISTRY, 2021, 通讯作者
(11) Identification of 2-substituted pyrrolo1,2-bpyridazine derivatives as new PARP-1 inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 第 5 作者
(12) CCT128930 is a novel and potent antagonist of TRPM7 channel, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021, 通讯作者
(13) Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core, Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core, ACTA PHARMACOLOGICA SINICA, 2020, 通讯作者
(14) Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels, Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels, ACTA PHARMACOLOGICA SINICA, 2020, 通讯作者
(15) Inhibitory effects of lappaconitine on the neuronal isoforms of voltage-gated sodium channels, inhibitoryeffectsoflappaconitineontheneuronalisoformsofvoltagegatedsodiumchannels, ACTA PHARMACOLOGICA SINICA, 2019, 通讯作者
(16) Selective activation of TWIK-related acid-sensitive K+ 3 subunit-containing channels is analgesic in rodent models, SCIENCE TRANSLATIONAL MEDICINE, 2019, 第 25 作者
(17) A Small-Molecule Compound Selectively Activates K2P Channel TASK-3 by Acting at Two Distant Clusters of Residues, MOLECULAR PHARMACOLOGY, 2019, 通讯作者
(18) Discovery of Novel Retigabine Derivatives as Potent KCNQ4 and KCNQ5 Channel Agonists with Improved Specificity, ACS MEDICINAL CHEMISTRY LETTERS, 2019, 通讯作者
(19) 靶向TRPA1通道治疗有机磷导致的神经损伤, 中国药理学与毒理学杂志, 2018, 第 1 作者
(20) A Statistical Thermodynamic Model for Ligands Interacting With Ion Channels: Theoretical Model and Experimental Validation of the KCNQ2 Channel, FRONTIERS IN PHARMACOLOGY, 2018, 通讯作者
(21) The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 第 8 作者
(22) Succinate-acetate permease from Citrobacter koseri is an anion channel that unidirectionally translocates acetate, CELL RESEARCH, 2018, 通讯作者
(23) Succinate-acetate permease from Citrobacter koseri is an anion channel that unidirectionally translocates acetate, Succinate-acetate permease from Citrobacter koseri is an anion channel that unidirectionally translocates acetate, 细胞研究:英文版, 2018, 第 13 作者
(24) Enhancing inactivation rather than reducing activation of Nav1.7 channels by a clinically effective analgesic CNV1014802, ACTA PHARMACOLOGICA SINICA, 2018, 通讯作者
(25) CNV1014802 Rescues the Paroxysmal Extreme Pain Disorders Nav1.7 Mutants by Restoring Impaired Inactivation, BIOPHYSICAL JOURNAL, 2017, 第 3 作者
(26) Label-free brainwide visualization of senile plaque using cryo-micro-optical sectioning tomography, OPTICS LETTERS, 2017, 第 6 作者
(27) Grafting Voltage Sensing Sensitivity and Pharmacology in Potassium Channels, BIOPHYSICAL JOURNAL, 2017, 第 6 作者
(28) The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: modifications at C12 and C7, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 第 6 作者
(29) Two novel C18-diterpenoid alkaloids, sinomontadine with an unprecedented seven-membered ring A and chloride-containing sinomontanine N from Aconitum sinomontanum, TETRAHEDRON LETTERS, 2017, 第 4 作者
(30) Discovery of NAV1.7 Modulators from Marketed Drugs using High throuthput Automated Electrophysiological System Ionworks Barracuda, BIOPHYSICAL JOURNAL, 2017, 第 4 作者
(31) TRPA1 channel mediates organophosphate-induced delayed neuropathy, CELL DISCOVERY, 2017, 通讯作者
(32) Voltage- to Ligand-Gated Switch in Voltage-Gated Potassium Channels, BIOPHYSICAL JOURNAL, 2017, 第 3 作者
(33) MLKL forms cation channels, CELL RESEARCH, 2016, 通讯作者
(34) Identification and Evaluation of Antiepileptic Activity of C-21 Steroidal Glycosides from the Roots of Cynanchum wilfordii, JOURNAL OF NATURAL PRODUCTS, 2016, 通讯作者
(35) Ion channels research in the post-genomic era, Ion channels research in the post-genomic era, ACTA PHARMACOLOGICA SINICA, 2016, 第 2 作者
(36) Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy, JOURNAL OF MEDICINAL CHEMISTRY, 2016, 第 10 作者
(37) Computer-Aided Drug Discovery and Design Targeting Ion Channels, CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2016, 通讯作者
(38) Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp-based high-throughput screening techniques, ACTA PHARMACOLOGICA SINICA, 2016, 第 6 作者
(39) Grafting voltage and pharmacological sensitivity in potassium channels, CELL RESEARCH, 2016, 
(40) Canonical transient receptor potential 4 and its small molecule modulators, SCIENCE CHINA-LIFE SCIENCES, 2015, 第 2 作者
(41) P-Retigabine: An N-Propargyled Retigabine with Improved Brain Distribution and Enhanced Antiepileptic Activity, MOLECULAR PHARMACOLOGY, 2015, 通讯作者
(42) Activation of peripheral KCNQ channels relieves gout pain, PAIN, 2015, 通讯作者
(43) P-Retigabine: a N-propargyled retigabine with improved brain distribution and enhanced antiepileptic activity, Molecular Pharm., 2014, 通讯作者
(44) Development of Mechanostimulated Patch-Clamp System for Cellular Physiological Study, IEEE-ASME TRANSACTIONS ON MECHATRONICS, 2014, 第 5 作者
(45) Bimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation, PF, 2014, 第 10 作者
(46) Bimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation., PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2014, 第 10 作者
(47) Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopentabpyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 其他(合作组作者)
(48) 电压门控钾离子通道小分子调控新机制, 2014, 第 7 作者
(49) The Human Ether-A-Go-Go-Related Gene Activator NS1643 Enhances Epilepsy-Associated KCNQ Channels, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2014, 通讯作者
(50) An Activator Binding Site in the Gating Charge Pathway of KCNQ2 Channel, BIOPHYSICAL JOURNAL, 2014, 第 4 作者
(51) Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 第 5 作者
(52) Discovery of a retigabine derivative that inhibits KCNQ2 potassium channels, ACTA PHARMACOLOGICA SINICA, 2013, 第 6 作者
(53) Dynamic PIP 2 interactions with voltage sensor elements contribute to KCNQ2 channel gating, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 第 6 作者
(54) PIP2 alters pharmacological selectivity for epilepsy-causing KCNQ channels, 2013, 第 5 作者
(55) kcnq1钾离子通道及其小分子调节剂, 中国新药与临床杂志, 2013, 第 3 作者
(56) Natural product vindoline stimulates insulin secretion and efficiently ameliorates glucose homeostasis in diabetic murine models, JOURNAL OF ETHNOPHARMACOLOGY, 2013, 第 10 作者
(57) The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands, CELL RESEARCH, 2013, 第 8 作者
(58) Further SAR studies on 3,5-diamino-7-trifluoromethylquinolines as highly potent tyrosine kinase c-Met inhibitors: efforts to correct hERG inhibition, MEDCHEMCOMM, 2012, 通讯作者
(59) Kv1.2 potassium channel inhibitors from Chukrasia tabularis, ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, 第 5 作者
(60) Chukrasones A and B: Potential Kv1.2 Potassium Channel Blockers with New Skeletons from Chukrasia tabularis, ORGANIC LETTERS, 2012, 第 4 作者
(61) A Theoretical Model for Calculating Voltage Sensitivity of Ion Channels andthe Application on Kv1.2 Potassium Channel, BIOPHYSICAL JOURNAL, 2012, 第 2 作者
(62) Comparison of the effects of DC031050, a class III antiarrhythmic agent, on hERG channel and three neuronal potassium channels, ACTA PHARMACOLOGICA SINICA, 2012, 第 9 作者
(63) Hexachlorophene Is a Potent KCNQ1/KCNE1 Potassium Channel Activator Which Rescues LQTs Mutants, PLOSONE, 2012, 第 7 作者
(64) Characteristics and molecular basis of celecoxib modulation on K(v)7 potassium channels., BRITISH JOURNAL OF PHARMACOLOGY, 2011, 
(65) Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules, ACTA PHARMACOLOGICA SINICA, 2011, 通讯作者
(66) Isoform-specific prolongation of Kv7 (KCNQ) potassium channel opening mediated by new molecular determinants for drug-channel interactions., THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 第 1 作者
(67) Effects of Na+, K+, and Ca2+ on the Structures of Anionic Lipid Bilayers and Biological Implication, JOURNAL OF PHYSICAL CHEMISTRY B, 2010, 第 3 作者
(68) Electrophysiological characterization of a novel Kv channel blocker N,No-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl ) ]bis(4-methyl ) -benzenesulfonamide found in virtual screening, Acta Pharmacol Sin., 2008, 第 1 作者
(69) Desensitization of Chemical Activation by Auxiliary Subunits: CONVERGENCE OF MOLECULAR DETERMINANTS CRITICAL FOR AUGMENTING KCNQ1 POTASSIUM CHANNELS, JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 第 1 作者
(70) Electrophysiological characterization of a novel Kv channel blocker N,N '-oxybis(2,1-ethanediyloxy-2,1-ethanediyl)bis(4-methyl)-benzenesulfonamide found in virtual screening, ACTA PHARMACOLOGICA SINICA, 2008, 第 1 作者
(71) Chlorahololides C-F: a new class of potent and selective potassium channel blockers from Chloranthus holostegius, TETRAHEDRON, 2008, 第 2 作者
(72) Discovering potassium channel blockers from synthetic compound database by using structure-based virtual screening in conjunction with electrophysiological assay, JOURNAL OF MEDICINAL CHEMISTRY, 2007, 第 2 作者
(73) 紫杉醇PLGA微球制备及荷Hep-2喉癌裸鼠体内疗效评估, Preparation of paclitaxel loaded PLGA microspheres and its efficacy in Hep-2 laryngeal sqnamous cell carcinoma-bearing nude mice, 复旦学报医学版, 2007, 第 3 作者
(74) Chlorahololides A and B, two potent and selective blockers of the potassium channel isolated from Chloranthus holostegius, ORGANIC LETTERS, 2007, 第 2 作者
(75) Inhibition of excitatory synaptic transmission by trans-resveratrol in rat hippocampus, BRAIN RESEARCH, 2006, 第 1 作者
(76) 紫杉醇plga微球制备及体外性质评估, 中国新药杂志, 2006, 第 3 作者
(77) 紫杉醇PLGA微球制备及工艺优化, Preparation of paclitaxel loaded poly(lactic-co-glycolic acid) microspheres and optimization of formulation, 中国医院药学杂志, 2006, 第 3 作者

科研活动

   
科研项目
( 1 ) KCNQ钾离子通道成药性功能确证及其新型激动剂设计, 负责人, 国家任务, 2010-01--2013-12
( 2 ) 利用纳米操作机器人研究膜脂构成对细胞机械特性及钾通道反应性的影响, 负责人, 研究所自主部署, 2011-01--2011-12
( 3 ) KCNQ钾离子通道作为治疗难治性癫痫靶点的验证及候选活性化合物研发, 负责人, 地方任务, 2013-01--2016-12
( 4 ) 离子通道与膜转运蛋白的的结构和新生物功能研究, 参与, 国家任务, 2012-01--2017-12
( 5 ) 新型抗癫痫药物先导化合物 CF312 的结构优化及候选药物的发现, 负责人, 国家任务, 2013-01--2016-12
( 6 ) 以钾离子通道为靶点的神经系统疾病药物研发, 参与, 国家任务, 2014-01--2016-12
( 7 ) 靶向离子通道电压感受区治疗神经兴奋性升高疾病, 负责人, 国家任务, 2013-01--2016-12
( 8 ) 靶向离子通道电压感受区治疗神经兴奋性升高疾病, 负责人, 国家任务, 2014-10--2017-09
( 9 ) 抗癫痫候选新药HN37的临床前开发, 负责人, 研究所自主部署, 2015-08--2016-12
( 10 ) 膜蛋白配体发现和新的生物学功能研究, 负责人, 国家任务, 2013-01--2017-08
( 11 ) 基于钠钙通道阻滞剂JX11057的新型抗癫痫候选药物发现, 负责人, 地方任务, 2015-10--2018-09
( 12 ) 难治性癫痫候选新药HN37个性化特征的临床前研究, 负责人, 中国科学院计划, 2016-01--2018-12
( 13 ) KCNQ4通道作为新型内脏痛治疗靶点的研究, 负责人, 国家任务, 2018-01--2021-12
( 14 ) 离子通道毒 性关键技术, 负责人, 中国科学院计划, 2018-01--2020-09
( 15 ) 离子通道药 理学, 负责人, 国家任务, 2019-01--2023-12
( 16 ) 抗癫痫候选 新药派恩加 滨的 I 期 临床研究, 负责人, 地方任务, 2019-04--2022-03
( 17 ) 包膜蛋白E作为抗冠状病毒广谱靶点的可行性研究及候选药物发现, 负责人, 国家任务, 2022-01--2025-12
参与会议
(1)Grafting voltage sensitivity in potassium channels   第61届生物物理年会   2017-02-12
(2)Activation of Peripheral KCNQ Channels Relieves Gout Pain   亚洲疼痛年会   2015-11-10
(3)Development of antiepilepsy drug candidates targeting ion channels.   中以神经科学研讨会   2015-04-06
(4)PIP2 alters pharmacological selectivity for epilepsy-causing KCNQ channels by dynamically interacting with voltage sensor elements   Pingzheng Zhou    2014-08-02
(5)PIP2 alters pharmacological selectivity of epilepsy-causing KCNQ channels   Pingzheng Zhou   2014-03-13
(6)The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands   Ping Li   2013-07-02
(7)PIP2 alters pharmacological selectivity for epilepsy-causing KCNQ channels   Pingzheng Zhou   2013-06-02
(8)Molecular structural basis of TRPA1 channel rectification   第九届全国钙信号和细胞功能研讨会   Xia Wan    2012-07-16
(9)Chemical activation of voltage-gated potassium channels   中国神经科学会第九届全国学术会议   Zhaobing Gao, Min Li   2011-07-29
(10)Chemical activation of voltage-gated potassium channels   Zhaobing Gao, Min Li   2011-07-24