071010-生物化学与分子生物学
100102-免疫学

抗感染免疫应答，病毒免疫逃逸

2007-09--2010-06   武汉大学   博士
2004-08--2006-06   美国科罗拉多大学医学院   硕士
2000-09--2004-06   北京大学   学士

   

2018-10~现在, 中科院武汉病毒所, 所长
2015-12~2018-10,中科院武汉病毒所, 副所长
2014-12~2015-12,中科院武汉病毒所, 所长助理
2014-07~2015-06,武昌区卫生和计划生育委员会（挂职）, 副主任
2012-03~现在, 中科院武汉病毒所, 研究员
2010-11~2012-02,武汉大学生命科学学院, 副教授
2006-08~2010-10,武汉大学生命科学学院, 讲师

2019-12-01-今,中国青年科技工作者协会, 副理事长
2019-12-01-今,武汉市青年联合会（第十四届）, 副主席
2018-12-01-今,武汉微生物学会, 理事长
2017-05-31-今,湖北省青年联合会, 副秘书长
2014-10-31-2017-05-31,武汉市青年联合会, 委员
2014-07-01-2015-06-30,武昌区卫生和计划生育委员会, 副主任
2013-12-01-今,湖北省妇女联合会执行委员会,
2013-01-01-今,中国免疫学会青年工作委员会, 副主任委员

现代生物学进展
免疫学

   

（1） 国家万人计划中青年科技创新领军人才, , 国家级, 2019
（2） 第十二届中国科学院杰出青年, 院级, 2017
（3） 享受政府特殊津贴专家, 国家级, 2016
（4） 国家自然科学奖, 二等奖, 国家级, 2015
（5） 国家百千万人才工程“有突出贡献中年青年专家”, 国家级, 2015
（6） 湖北省青年五四奖章, 省级, 2015
（7） 湖北省青年五四奖章, 省级, 2015
（8） 教育部自然科学奖, 一等奖, 部委级, 2015
（9） 国家杰出青年科学基金, 国家级, 2014
（10） 中组部万人计划首批青年拔尖人才, , 部委级, 2013
（11） 武汉市优秀科技工作者, , 市地级, 2013
（12） 武汉市青年科技奖, , 市地级, 2012
（13） 武汉大学“珞珈青年学者”, , 研究所（学校）, 2012
（14） 中国免疫学青年学者奖, , 其他, 2010
（15） 武汉大学青年教师教学竞赛二等奖, , 研究所（学校）, 2010
（16） 武汉大学学生工作先进个人, , 研究所（学校）, 2008

[1] 王延轶, 付辉, 冉勇, 朱海, 石正旺, 袁克湖, 张克山, 林季敏, 马涛, 易俊伟, 杨年松, 严义勇. 编码非洲猪瘟病毒抗原的DNA序列、由其编码的抗原的组合物及其在免疫学检测中的应用. CN: CN110093356B, 2021-07-20.

   

[1] Li, YuHui, Peng, JiangLing, Xu, ZhiSheng, Xiong, MeiGuang, Wu, HuangNing, Wang, SuYun, Li, Dan, Zhu, GuoQiang, Ran, Yong, Wang, YanYi. African Swine Fever Virus Cysteine Protease pS273R Inhibits Type I Interferon Signaling by Mediating STAT2 Degradation. JOURNAL OF VIROLOGY. 2023, http://dx.doi.org/10.1128/jvi.01942-22.
[2] Luo, WeiWei, Tong, Zhen, Cao, Pan, Wang, FuBing, Liu, Ying, Zheng, ZhouQin, Wang, SuYun, Li, Shu, Wang, YanYi. Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes. NATURE COMMUNICATIONS[J]. 2022, 13(1): http://dx.doi.org/10.1038/s41467-022-32401-1.
[3] Yong Ran, Dan Li, MeiGuang Xiong, HuaNan Liu, Tao Feng, ZhengWang Shi, YuHui Li, HuangNing Wu, SuYun Wang, HaiXue Zheng, YanYi Wang. African swine fever virus I267L acts as an important virulence factor by inhibiting RNA polymerase III-RIG-I-mediated innate immunity. PLOS PATHOGENS[J]. 2022, 18(1): [4] ZhouQin Zheng, YuZhi Fu, SuYun Wang, ZhiSheng Xu, HongMei Zou, YanYi Wang. Herpes simplex virus protein UL56 inhibits cGAS-Mediated DNA sensing to evade antiviral immunity. CELL INSIGHT[J]. 2022, 1(2): 100014-, [5] Wang, DongPeng, Zhang, HongYan, Liao, BoWei, Tong, Zhen, Xu, ZhiSheng, Wang, YanYi, Yang, Yan. SRP54 Negatively Regulates IFN-Beta Production and Antiviral Response by Targeting RIG-I and MDA5. VIROLOGICA SINICA[J]. 2021, 36(2): 231-240, http://lib.cqvip.com/Qikan/Article/Detail?id=7104879080.
[6] BoWei Liao, HongYan Zhang, WenTian Du, Yong Ran, YanYi Wang, ZhiSheng Xu. FAM177A1 Inhibits IL-1β–Induced Signaling by Impairing TRAF6–Ubc13 Association. JOURNAL OF IMMUNOLOGY[J]. 2021, [7] Fu, YuZhi, Wang, SuYun, Zheng, ZhouQin, Huang, Yi, Li, WeiWei, Xu, ZhiSheng, Wang, YanYi. SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2021, 18(3): 613-620, http://dx.doi.org/10.1038/s41423-020-00571-x.
[8] Lian, DongSheng, Chen, XiangYuan, Zeng, HuaSong, Wang, YanYi. Capillary electrophoresis based on nucleic acid analysis for diagnosing inherited diseases. CLINICAL CHEMISTRY AND LABORATORY MEDICINEnull. 2021, 59(2): 249-266, http://dx.doi.org/10.1515/cclm-2020-0186.
[9] Zhang, Wei, Du, RongHui, Li, Bei, Zheng, XiaoShuang, Yang, XingLou, Hu, Ben, Wang, YanYi, Xiao, GengFu, Yan, Bing, Shi, ZhengLi, Zhou, Peng. Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. EMERGING MICROBES & INFECTIONS[J]. 2020, 9(1): 386-389, http://dx.doi.org/10.1080/22221751.2020.1729071.
[10] Shan, Chao, Yao, YanFeng, Yang, XingLou, Zhou, YiWu, Gao, Ge, Peng, Yun, Yang, Lian, Hu, Xue, Xiong, Jin, Jiang, RenDi, Zhang, HuaJun, Gao, XiaoXiao, Peng, Cheng, Min, Juan, Chen, Ying, Si, HaoRui, Wu, Jia, Zhou, Peng, Wang, YanYi, Wei, HongPing, Pang, Wei, Hu, ZhengFei, Lv, LongBao, Zheng, YongTang, Shi, ZhengLi, Yuan, ZhiMing. Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques. CELL RESEARCH[J]. 2020, 30(8): 670-677, http://lib.cqvip.com/Qikan/Article/Detail?id=7102918057.
[11] 王延轶. SRP54NegativelyRegulatesIFN-BetaProductionandAntiviralResponsebyTargetingRIG-IandMDA5. VirologicaSinica. 2020, [12] 王延轶. Human Cytomegalovirus Protein UL94 Targets MITA to Evade Antiviral Immune Response.. Journal of Virology. 2020, [13] Yang, Qi, Tang, Jielin, Xu, Chonghui, Zhao, He, Zhou, Yuan, Wang, Yanyi, Yang, Min, Chen, Xinwen, Chen, Jizheng. Histone deacetylase 4 inhibits NF-kappa B activation by facilitating I kappa B alpha sumoylation. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2020, 12(12): 933-945, https://www.webofscience.com/wos/woscc/full-record/WOS:000634891000004.
[14] Xiong, MeiGuang, Xu, ZhiSheng, Li, YuHui, Wang, SuYun, Wang, YanYi, Ran, Yong. RNF152 positively regulates TLR/IL-1R signaling by enhancing MyD88 oligomerization. EMBO REPORTS[J]. 2020, 21(3): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054668/.
[15] Fu, YuZhi, Wang, SuYun, Zheng, ZhouQin, Huang, Yi, Li, WeiWei, Xu, ZhiSheng, Wang, YanYi. SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response. CELLULAR & MOLECULAR IMMUNOLOGY. 2020, 1-8, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588591/.
[16] Zou, HongMei, Huang, ZheFu, Yang, Yan, Luo, WeiWei, Wang, SuYun, Luo, MinHua, Fu, YuZhi, Wang, YanYi. Human Cytomegalovirus Protein UL94 Targets MITA to Evade the Antiviral Immune Response. JOURNAL OF VIROLOGY[J]. 2020, 94(12): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307088/.
[17] HongYan Zhang, BoWei Liao, ZhiSheng Xu, Yong Ran, DongPeng Wang, Yan Yang, WeiWei Luo, YanYi Wang. USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA.. PLOS PATHOGENS[J]. 2020, 16(1): https://doaj.org/article/ac1cfb79f25f49b1ac96310bc67d87ed.
[18] Zhi-Sheng Xu, Ting Shu, Liang Kang, Di Wu, Xing Zhou, Bo-Wei Liao, Xiu-Lian Sun, Xi Zhou, Yan-Yi Wang. Temporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients. Signal Transduction and Targeted Therapy. 2020, https://www.nature.com/articles/s41392-020-0211-1.
[19] Li, WeiWei, Nie, Ying, Yang, Yan, Ran, Yong, Luo, WeiWei, Xiong, MeiGuang, Wang, SuYun, Xu, ZhiSheng, Wang, YanYi. Ubiquitination of TLR3 by TRIM3 signals its ESCRT-mediated trafficking to the endolysosomes for innate antiviral response. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 117(38): 23707-23716, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519224/.
[20] YuZhi Fu, SuYun Wang, ZhiSheng Xu, YanYi Wang, ZhouQin Zheng. SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication. CELL DISCOVERY. 202, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA202107079638260ZK.
[21] Ran, Yong, Xiong, Meiguang, Xu, Zhisheng, Luo, Weiwei, Wang, Suyun, Wang, YanYi. YIPF5 Is Essential for Innate Immunity to DNA Virus and Facilitates COPII-Dependent STING Trafficking. JOURNAL OF IMMUNOLOGY[J]. 2019, 203(6): 1560-1570, https://www.webofscience.com/wos/woscc/full-record/WOS:000484842100015.
[22] Yang, Qi, Tang, Jielin, Pei, Rongjuan, Gao, XiaoXiao, Guo, Jing, Xu, Chonghui, Wang, Yun, Wang, Qian, Wu, Chunchen, Zhou, Yuan, Hu, Xue, Zhao, He, Wang, Yanyi, Chen, Xinwen, Chen, Jizheng. Host HDAC4 regulates the antiviral response by inhibiting the phosphorylation of IRF3. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2019, 11(2): 158-169, http://lib.cqvip.com/Qikan/Article/Detail?id=7001603102.
[23] Xu, ZhiSheng, Zhang, HongXia, Li, WeiWei, Ran, Yong, Liu, TianTian, Xiong, MeiGuang, Li, QingLan, Wang, SuYun, Wu, Min, Shu, HongBing, Xia, Huimin, Wang, YanYi. FAM64A positively regulates STAT3 activity to promote Th17 differentiation and colitis-associated carcinogenesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 116(21): 10447-10452, https://www.webofscience.com/wos/woscc/full-record/WOS:000468403400046.
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[26] 王延轶. Human Cytomegalovirus DNA Polymerase 1 Subunit UL44 Antagonizes Antiviral Immune Responses by Suppressing IRF3- and NF-B-mediated transcription.. J. Virol.. 2019, [27] Fu, YuZhi, Su, Shan, Zou, HongMei, Guo, Yi, Wang, SuYun, Li, Shu, Luo, MinHua, Wang, YanYi. Human Cytomegalovirus DNA Polymerase Subunit UL44 Antagonizes Antiviral Immune Responses by Suppressing IRF3-and NF-kappa B-Mediated Transcription. JOURNAL OF VIROLOGY[J]. 2019, 93(11): http://dx.doi.org/10.1128/JVI.00181-19.
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（1） 抗病毒天然免疫, Antiviral Innate Immunity, 科学出版社, 2009-09, 第 3 作者

   

（ 1 ） WWP2 调节TLR3 信号转导的机制, 主持, 国家级, 2012-01--2015-12
（ 2 ） 丙型肝炎病毒感染及防治的基础研究, 参与, 国家级, 2009-01--2013-12
（ 3 ） 抑郁症的蛋白质组学和多肽组学研究, 参与, 国家级, 2009-01--2013-12
（ 4 ） 动物病毒－宿主相互作用机制的研究, 主持, 国家级, 2014-01--2018-12
（ 5 ） 抗病毒天然免疫信号转导, 主持, 国家级, 2013-01--2015-12
（ 6 ） 病毒与宿主相互作用的分子机理, 主持, 国家级, 2014-01--2016-12
（ 7 ） 慢性丙型病毒性肝炎免疫逃逸与免疫病理研究, 主持, 国家级, 2015-01--2019-12
（ 8 ） 细胞抗病毒反应的分子机制, 主持, 国家级, 2015-01--2019-12
（ 9 ） DNA病毒与宿主天然免疫相互作用的分子机制, 主持, 部委级, 2016-08--2020-12
（ 10 ） 病毒与宿主相互作用的分子机理, 参与, 国家级, 2017-01--2019-12
（ 11 ） 病毒与宿主天然免疫的相互作用机制, 主持, 部委级, 2018-01--2022-12
（ 12 ） 非洲猪瘟病毒免疫应答与疫苗策略研究, 参与, 部委级, 2019-01--2021-12

（1）TRIM8 modulate TNF-alpha and IL-1beta triggered NF-kappaB activation by tarteting TAK1 for K63-linked polyubiquitination   中国免疫学会青年工作委员会2013年学术年会   2013-01-20
（2）TRIM8 modulates NF-κB activation pathways triggered by proinflammatory cytokines   第九届海峡两岸细胞生物学学术研讨会   2012-09-23
（3）WWP2 negatively regulates TLR3-mediated innate immune responses by targeting TRIF for ubiquitination and degradation   第四届“细胞结构与功能的信号基础研讨会”长白山会议   2012-08-10
（4）DDB1 is a cellular substrate of NS3/4A protease and required for HCV replication   2011-10-15
（5）WDR5在VISA信号复合物组装及细胞抗病毒反应中的作用机制   中国免疫学会第六次全国会员代表大会暨第七届学术会议    王延轶   2010-10-22

已指导学生

刘丽丽  硕士研究生  071010-生物化学与分子生物学  

潘召义  硕士研究生  085238-生物工程  

聂映  博士研究生  071010-生物化学与分子生物学  

章红艳  博士研究生  100102-免疫学  

黄哲夫  博士研究生  100102-免疫学  

现指导学生

李伟伟  博士研究生  071010-生物化学与分子生物学  

邹红梅  博士研究生  100102-免疫学  

王东鹏  博士研究生  071010-生物化学与分子生物学  

廖博威  博士研究生  071010-生物化学与分子生物学  

熊梅光  博士研究生  071010-生物化学与分子生物学  

郑周沁  博士研究生  100102-免疫学  

童珍  博士研究生  100102-免疫学  

李宇辉  硕士研究生  071010-生物化学与分子生物学  

邹家鹏  硕士研究生  071010-生物化学与分子生物学  

杜文恬  硕士研究生  071005-微生物学