基本信息

李琳琳  女  博导 硕导  中国科学院大学
电子邮件: lilinlin@ucas.ac.cn
通信地址: 北京市怀柔区雁栖经济开发区杨雁东一路8号院
邮政编码:

研究领域

自供能生物材料与生物电子器件的研发及在生物医学领域的应用,主要包括

1. 组织/细胞调控及再生医学

2. 可植入/可穿戴生物医学传感

3. 恶性肿瘤等疾病的治疗

招生信息

课题组的研究方向为多学科交叉研究,包括功能性纳米生物材料和生物电子器件在疾病治疗,组织再生,生物传感等领域的应用。


课题组招生要求:

1. 生物、电子、化学、材料、医药学等相关专业

2. 在校期间有过科研经历

3. 踏实肯干,善于沟通


详见课题组网页https://www.x-mol.com/groups/lilinlin


导师简介:李琳琳,北京纳米能源与系统研究所纳米能源与生物传感课题组负责人。曾获国家级人才计划青年项目支持,中科院卢嘉锡青年人才奖,中科院青年创新促进会会员,中国科学院大学领雁金奖(引航奖)2019-2021年连续入选美国斯坦福大学发布的全球前2%顶尖科学家” 年度科学影响力排行榜。作为项目负责人主持国家自然科学基金,北京市自然科学基金,横向课题等10余项项目。作为研究骨干参与10余项国家重点研发计划、863、中科院先导、自然科学基金等项目。发表学术论文160余篇,论文共被引用1.3万余次,H-index54Web of Science)。其中在Adv. Mater.J. Am. Chem. Soc.ACS NanoNano TodayNano EnergySci. Bull.等期刊发表通讯/第一作者论文100余篇(影响因子10以上的通讯/第一作者论文50余篇)。授权和申请国家发明专利16项,撰写英文专著3章。

课题组招收直博生、博士生和硕士生。

指导的研究生多人次获得博士后创新人才计划,国家奖学金、北京市三好学生、中科院奖学金、研究所卓越奖学金等。


招生专业
0703J1-纳米科学与技术
071011-生物物理学
招生方向
纳米生物材料
纳米生物学

工作经历

   
社会兼职
2023-05-01-今,中国生物医学工程学会纳米医学与工程分会, 委员
2023-04-01-今,《Exploration》, 副主编
2021-01-01-今,Chinese Journal of Analytical Chemistry, 副主编
2019-01-01-今,北京生物医学工程学会, 理事

教授课程

微纳生物电子学与自驱动传感器

专利与奖励

   
奖励信息
(1) 中国科学院大学年度优秀个人, 研究所(学校), 2022
(2) 北京纳米能源与系统研究所优秀职工, 研究所(学校), 2022
(3) 北京纳米能源与系统研究所优秀共产党员, 研究所(学校), 2022
(4) 中国科学院大学“领雁金奖(引航奖), 一等奖, 研究所(学校), 2021
(5) 中国科学院大学优秀共产党员, 研究所(学校), 2021
(6) 国家万人计划青年拔尖人才, , 国家级, 2020
(7) 中科院卢嘉锡青年人才奖, , 院级, 2014
(8) 北京市科学技术奖, 三等奖, 省级, 2012

出版信息

   
发表论文
(1) Piezoelectric Nanotopography Induced Neuron-Like Differentiation of Stem Cells, ADVANCED FUNCTIONAL MATERIALS, 2019, 通讯作者
(2) Piezoelectric-Effect-Enhanced Full-Spectrum Photoelectrocatalysis in p-n Heterojunction, ADVANCED FUNCTIONAL MATERIALS, 2019, 通讯作者
(3) Transparent and stretchable triboelectric nanogenerator for self-powered tactile sensing, NANO ENERGY, 2019, 通讯作者
(4) Self-Assembled Copper Amino Acid Nanoparticles for in Situ Glutathione "AND" H2O2 Sequentially Triggered Chemodynamic Therapy, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 通讯作者
(5) Regulation of Ca2+ Signaling for Drug-Resistant Breast Cancer Therapy with Mesoporous Silica Nanocapsules Encapsulated Doxorubicin/siRNA Cocktail, ACS Nano, 2019, 通讯作者
(6) Self-Powered Intracellular Drug Delivery by a Biomechanical Energy-Driven Triboelectric Nanogenerator, ADVANCED MATERIALS, 2019, 通讯作者
(7) Photothermally tunable biodegradation of implantable triboelectric nanogenerators for tissue repairing, NANO ENERGY, 2018, 通讯作者
(8) Nanostructured molybdenum disulfide biointerface for adhesion and osteogenic differentiation of mesenchymal stem cells, APPLIED MATERIALS TODAY, 2018, 通讯作者
(9) Killing two birds with one stone: To eliminate the toxicity and enhance the photocatalytic property of CdS nanobelts by assembling ultrafine TiO2 nanowires on them, SOLAR ENERGY MATERIALS AND SOLAR CELLS, 2018, 通讯作者
(10) Heterostructured nanorod array with piezophototronic and plasmonic effect for photodynamic bacteria killing and wound healing, NANO ENERGY, 2018, 通讯作者
(11) Piezoelectric Polyacrylonitrile Nanofiber Film-Based Dual-Function Self-Powered Flexible Sensor, ACS APPLIED MATERIALS & INTERFACES, 2018, 通讯作者
(12) Structural effect of Fe3O4 nanoparticles on peroxidase-like activity for cancer therapy, COLLOIDS AND SURFACES B-BIOINTERFACES, 2017, 通讯作者
(13) One-step synthesis of ultrathin nanobelts-assembled urchin-like anatase TiO2 nanostructures for highly efficient photocatalysis, CRYSTENGCOMM, 2017, 通讯作者
(14) Hierarchical Porous Carbon with Ordered Striaight Micro-Channels Templated by Continuous Filament Glass Fiber Array for High Performance Supercapacitor., J. Mater. Chem. A, 2017, 通讯作者
(15) Nanostructured molybdenum disulfide film for promoting neural stem cell neuronal differentiation: towards nerve tissue-engineered 3D scaffold., Advanced Biosystems, 2017, 通讯作者
(16) Biodegradable inorganic nanoparticles: an opportunity for improved cancer therapy?, NANOMEDICINE, 2017, 通讯作者
(17) High-performance wearable supercapacitors fabricated with surface activated continuous filament graphite fibers, JOURNAL OF POWER SOURCES, 2017, 通讯作者
(18) TiO2 nanorod array as highly affinitive nano-bio interface of microfluidic device for efficient capture of circulating tumor cells, Nano Research, 2016, 
(19) Microenvironment-Driven Bioelimination of Magnetoplasmonic Nanoassemblies and Their Multimodal Imaging-Guided Tumor Photothermal Therapy, ACS NANO, 2016, 通讯作者
(20) Rutile nanorod/anatase nanowire junction array as both sensor and power supplier for high performance wireless UV photodetector., Small, 2016, 通讯作者
(21) Application of bacterial magnetic nanoparticles in nanobiotechnology., J. Nanosci. Nanotechnol., 2016, 通讯作者
(22) Size Effect of Mesoporous and Hollow Silica Nanoparticles on Solid Tumor Targeting and Penetration, JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2016, 通讯作者
(23) Self-powered electrical stimulation for enhancing neural differentiation of MSCs on graphene-PEDOT hybrid microfibers., ACS Nano, 2016, 通讯作者
(24) High-yield preparation of robust gold nanoshells on silica nanorattles with good biocompatibility., Sci. Bull., 2016, 通讯作者
(25) Multifunctional Carbon-Silica Nanocapsules with Gold Core for Synergistic Photothermal and Chemo-Cancer Therapy under the Guidance of Bimodal Imaging, ADVANCED FUNCTIONAL MATERIALS, 2016, 通讯作者
(26) Bacterial magnetic nanoparticles for photothermal therapy of cancer under the guidance of MR imaging, Biomaterials, 2016, 通讯作者
(27) Biosynthesis of fluorescent gold nanoclusters for in vitro and in vivo tumor imaging, OPTICS COMMUNICATIONS, 2015, 通讯作者
(28) Biodistribution, excretion, and toxicity of mesoporous silica nanoparticles after oral administration depend on their shape, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2015, 通讯作者
(29) Fluorescence switching method for cascade detection of salicylaldehyde and zinc(II) ion using protein protected gold nanoclusters, BIOSENSORS AND BIOELECTRONICS, 2015, 第 5 作者
(30) Multifuntional silica-based nanocomposites for cancer nanotheranostics., J. Biomed. Nanotechnol., 2014, 第 1 作者
(31) Overcoming Multidrug Resistance with Mesoporous Silica Nanorods as Nanocarrier of Doxorubicin, JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2012, 第 1 作者
(32) The shape effect of PEGylated mesoporous silica nanoparticles on cellular uptake pathway in Hela cells, MICROPOROUS AND MESOPOROUS MATERIALS, 2012, 第 2 作者
(33) Doxorubicin loaded silica nanorattle actively homing to tumor with improved anti-tumor effect, Nanoscale, 2012, 
(34) Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery, ADVANCED MATERIALS, 2012, 第 2 作者
(35) Fabrication of PLGA coated silica nanorattle for controlling the drug release behavior, Fabrication of PLGA coated silica nanorattle for controlling the drug release behavior, 中国科学通报:英文版, 2012, 
(36) The Shape Effect of Mesoporous Silica Nanoparticles on Biodistribution, Clearance, and Biocompatibility in Vivo, ACS NANO, 2011, 第 2 作者
(37) Silica Nanorattle-Doxorubicin-Anchored Mesenchymal Stem Cells for Tumor-Tropic Therapy, ACS NANO, 2011, 第 1 作者
(38) Single and repeated dose toxicity of mesoporous hollow silica nanoparticles in intravenously exposed mice, BIOMATERIALS, 2011, 第 2 作者
(39) In Vivo Delivery of Silica Nanorattle Encapsulated Docetaxel for Liver Cancer Therapy with Low Toxicity and High Efficacy, ACS NANO, 2010, 第 1 作者
(40) Facile and Scalable Synthesis of Tailored Silica "Nanorattle" Structures, ADVANCED MATERIALS, 2009, 第 2 作者
(41) Preparation and characterization of quantum dots coated magnetic hollow spheres for magnetic fluorescent multimodal imaging and drug delivery, JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2009, 第 1 作者
发表著作
(1) Multifunctional Mesoporous/Hollow Silica for Cancer Nanotheranostics, Advances in Nanotheranostics II, Springer Verlag, 2015-09, 第 2 作者
(2) Gold Nanoparticles and Their Bioapplications, John Wiley and Sons Ltd., 2018-03, 第 3 作者
(3) Hybrid Nanocapsules for Imaging-Guided Synergistic Theranostics, Elsevier, 2019-03, 第 3 作者

科研活动

   
科研项目
( 1 ) 间充质干细胞携带药物控释纳米颗粒靶向治疗脑胶质瘤的原理研究, 负责人, 国家任务, 2010-01--2012-12
( 2 ) 诊疗一体化多级纳米超分子组装体的构建及提高肿瘤靶向输送的研究, 负责人, 国家任务, 2015-01--2018-12
( 3 ) 间充质干细胞靶向协同纳米金壳夹心二氧化硅增敏热化疗治疗恶性肿瘤的研究, 负责人, 国家任务, 2013-01--2016-12
( 4 ) 磁性荧光夹心二氧化硅复合颗粒药物靶向输送联合MRI影像/荧光双重影像治疗恶性肿瘤的研究, 负责人, 研究所自主部署, 2013-07--2015-06
( 5 ) 青年促进会, 负责人, 中国科学院计划, 2015-01--2018-12
( 6 ) 具有纳米结构和压电性能的生物支架调控干细胞神经分化用于神经缺损修复, 负责人, 地方任务, 2017-01--2019-12
( 7 ) 具有化学动力学和钙信号调控协同效应的纳米药物构建及抗肿瘤研究, 负责人, 国家任务, 2020-01--2022-12
( 8 ) 万人计划青年拔尖人才计划, 负责人, 国家任务, 2020-01--2023-12
参与会议
(1)Size Effect of Mesoporous and Hollow Silica nanoparticles on Tumor Targeting and Penetration   2014-04-13
(2) Different Mesoporous Silica Drug Delivery System and their Biological Effect.   Linlin Li   2010-06-21