基本信息
魏刚  男  博导  中国科学院上海营养与健康研究所
电子邮件: weigang@picb.ac.cn
通信地址: 岳阳路320号
邮政编码:

招生信息

   
招生专业
0710Z2-计算生物学
086000-生物与医药
招生方向
计算生物学-发育和疾病的表观遗传调控
生物与医药-发育和疾病的表观遗传调控

教育背景

2000-09--2005-07   北京大学   博士
1996-09--2000-07   北京大学   学士

工作经历

   
工作简历
2012-01~现在, 中科院上海生命科学研究院计算生物学研究所, 研究员
2005-09~2011-12,美国国立健康研究院, 博士后研究助理
2000-09~2005-07,北京大学, 博士
1996-09~2000-07,北京大学, 学士

出版信息

   
发表论文
(1) PfSET2 Is Involved in Genome Organization of Var Gene Family in Plasmodium falciparum, MICROBIOLOGY SPECTRUM, 2023, 通讯作者
(2) The CTCF/LncRNA-PACERR complex recruits E1A binding protein p300 to induce pro-tumour macrophages in pancreatic ductal adenocarcinoma via directly regulating PTGS2 expression, CLINICAL AND TRANSLATIONAL MEDICINE, 2022, 通讯作者
(3) Reorganization of 3D chromatin architecture in doxorubicin-resistant breast cancer cells, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 通讯作者
(4) Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging, DEVELOPMENTAL CELL, 2022, 第 18 作者
(5) Global changes in chromatin accessibility and transcription in growth hormone-secreting pituitary adenoma, ENDOCRINE, 2022, 通讯作者
(6) Pre-existing chromatin accessibility of switchable repressive compartment delineates cell plasticity, Pre-existing chromatin accessibility of switchable repressive compartment delineates cell plasticity, NATIONAL SCIENCE REVIEW, 2022, 通讯作者
(7) Integrated Chromatin Accessibility and Transcriptome Landscapes of Doxorubicin-Resistant Breast Cancer Cells, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 通讯作者
(8) The Architectural Factor HMGB1 Is Involved in Genome Organization in the Human Malaria Parasite Plasmodium falciparum, MBIO, 2021, 通讯作者
(9) Coordinated regulation of infection-related morphogenesis by the KMT2-Cre1-Hyd4 regulatory pathway to facilitate fungal infection, SCIENCE ADVANCES, 2020, 通讯作者
(10) Membrane-bound TNF mediates microtubule-targeting chemotherapeutics-induced cancer cytolysis via juxtacrine inter-cancer-cell death signaling, CELL DEATH AND DIFFERENTIATION, 2020, 第 9 作者
(11) The Nuclear Matrix Protein SAFB Cooperates with Major Satellite RNAs to Stabilize Heterochromatin Architecture Partially through Phase Separation, MOLECULAR CELL, 2020, 第11作者
(12) Rrp6 Regulates Heterochromatic Gene Silencing via ncRNA RUF6 Decay in Malaria Parasites, MBIO, 2020, 第 16 作者
(13) Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies, Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies, CELL RESEARCH, 2020, 第 23 作者
(14) SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation, NATURE COMMUNICATIONS, 2020, 第 10 作者
(15) Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase, SCIENCE, 2020, 其他(合作组作者)
(16) Enhanced PAPSS2/VCAN sulfation axis is essential for Snail-mediated breast cancer cell migration and metastasis, CELL DEATH AND DIFFERENTIATION, 2019, 通讯作者
(17) Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses, NATURE COMMUNICATIONS, 2019, 第 26 作者
(18) SMYD2 Drives Mesendodermal Differentiation of Human Embryonic Stem Cells Through Mediating the Transcriptional Activation of Key Mesendodermal Genes, STEM CELLS, 2019, 通讯作者
(19) MiR-17-5p enhances pancreatic cancer proliferation by altering cell cycle profiles via disruption of RBL2/E2F4-repressing complexes, CANCER LETTERS, 2018, 第 7 作者
(20) Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome., PROTEIN & CELL, 2018, 第 5 作者
(21) Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription, ELIFE,6,(2017-10-12), 2017, 第 2 作者
(22) Deletion of Macrophage Mineralocorticoid Receptor Protects Hepatic Steatosis and Insulin Resistance Through ER/HGF/Met Pathway, DIABETES, 2017, 其他(合作组作者)
(23) SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing, NUCLEIC ACIDS RESEARCH, 2017, 第 9 作者
(24) Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor, STEM CELL REPORTS, 2017, 通讯作者
(25) Epigenomic analysis in a cell-based model reveals the roles of H3K9me3 in breast cancer transformation, EPIGENOMICS, 2017, 通讯作者
(26) Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening, CELL RESEARCH, 2017, 通讯作者
(27) USP21 prevents the generation of T-helper-1-like Treg cells, NATURE COMMUNICATIONS, 2016, 第 10 作者
(28) A positive role for polycomb in transcriptional regulation via H4K20me1, CELL RESEARCH, 2016, 通讯作者
(29) Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model, CLINICAL EPIGENETICS, 2016, 通讯作者
(30) GFRα2 prompts cell growth and chemoresistance through down-regulating tumor suppressor gene PTEN via Mir-17-5p in pancreatic cancer, CANCER LETTERS, 2016, 其他(合作组作者)
(31) Retinoid signaling controls spermatogonial differentiation by regulating expression of replication-dependent core histone genes, DEVELOPMENT, 2016, 第 4 作者
(32) Foxp1/2/4 regulate endochondral ossification as a suppresser complex, DEVELOPMENTAL BIOLOGY, 2015, 第11作者
(33) Stage-Dependent and Locus-Specific Role of Histone Demethylase Jumonji D3 (JMJD3) in the Embryonic Stages of Lung Development, PLOSGENETICS, 2014, 第 5 作者
(34) Critical role of histone demethylase Jmjd3 in the regulation of CD4 + T cell differentiation, NATURE COMMUNICATIONS, 2014, 第 8 作者
(35) Comparison of REST Cistromes across Human Cell Types Reveals Common and Context-Specific Functions, PLOS COMPUTATIONAL BIOLOGY, 2014, 第 4 作者
(36) Reconstruction of the Gene Regulatory Network Involved in the Sonic Hedgehog Pathway with a Potential Role in Early Development of the Mouse Brain, PLOS COMPUTATIONAL BIOLOGY, 2014, 第 5 作者
(37) PARP-1 regulates expression of TGF-β receptors in T cells, BLOOD, 2013, 第 9 作者
(38) Understanding human diseases with high-throughput quantitative measurement and analysis of molecular signatures, SCIENCE CHINA-LIFE SCIENCES, 2013, 第 2 作者
(39) The Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses, IMMUNITY, 2012, 第 4 作者
(40) c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells, CELL, 2012, 第 3 作者
(41) Genome-Wide Mapping of Nucleosome Occupancy, Histone Modifications, and Gene Expression Using Next-Generation Sequencing Technology, NUCLEOSOMES, HISTONES & CHROMATIN, PT B, 2012, 第 1 作者
(42) Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization, CELL RESEARCH, 2012, 第 2 作者
(43) Chapter Thirteen - Genome-Wide Mapping of Nucleosome Occupancy, Histone Modifications, and Gene Expression Using Next-Generation Sequencing Technology, METHODSINENZYMOLOGY, 2012, 第 1 作者
(44) Genome-wide Analyses of Transcription Factor GATA3-Mediated Gene Regulation in Distinct T Cell Types, IMMUNITY, 2011, 第 1 作者
(45) Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2011, 第 2 作者
(46) GATA3 controls Foxp3(+) regulatory T cell fate during inflammation in mice, JOURNAL OF CLINICAL INVESTIGATION, 2011, 第 13 作者
(47) Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq, CELL RESEARCH, 2010, 第 3 作者
(48) The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma, IMMUNITY, 2010, 第 3 作者
(49) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 第 2 作者
(50) Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103(+) inducible regulatory T cells, JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 第 3 作者
(51) H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions, NATURE GENETICS, 2009, 第 3 作者
(52) Detection of single nucleotide variations in expressed exons of the human genome using RNA-Seq, NUCLEIC ACIDS RESEARCH, 2009, 第 2 作者
(53) Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4 + T Cells, IMMUNITY, 2009, 第 1 作者
(54) Dynamic Regulation of Nucleosome Positioning in the Human Genome, CELL, 2008, 第 7 作者
(55) High-Resolution Profiling of Histone Methylations in the Human Genome, CELL, 2007, 第 7 作者
(56) Genome-wide prediction of conserved and nonconserved enhancers by histone acetylation patterns, GENOME RESEARCH, 2007, 第 2 作者
(57) The chromatin remodeler Chd4 maintains embryonic stem cell identity by controlling pluripotency- and differentiation-associated genes, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 第 6 作者

科研活动

   
科研项目
( 1 ) Th2 细胞分化过程中染色质长距离相互作用的调控功能, 负责人, 国家任务, 2013-01--2016-12
( 2 ) 干细胞衰老的细胞分子机理及转化应用研究, 参与, 国家任务, 2015-05--2019-08
( 3 ) 细胞转分化过程中染色质高级结构的动态变化及其调控机制, 负责人, 国家任务, 2018-01--2021-12
( 4 ) 非编码RNA介导的染色质高级结构动态变化对骨骼肌细胞谱系命运决定的调控功能及分子机制(中胚层), 参与, 国家任务, 2016-07--2020-12