基本信息
尹文艳 女 博导 中国科学院高能物理研究所
电子邮件: yinwy@ihep.ac.cn
通信地址: 北京市石景山区玉泉路19号乙
邮政编码:100049
研究领域
(1)智能纳米材料的设计与肿瘤诊疗和抗菌研究;
(2)智能纳米酶的设计与原位生物催化活性提高;
(3)纳米材料的表界面生物效应与体内安全性研究;
(2)智能纳米酶的设计与原位生物催化活性提高;
(3)纳米材料的表界面生物效应与体内安全性研究;
招生信息
(1)专业背景/知识(符合其中之一)的博士研究生和硕士研究生:无机化学、材料化学、生物、医学。
(2)要求:身心健康、积极上进、具有团队合作精神
招生专业
070301-无机化学
招生方向
智能纳米材料的构建与肿瘤诊疗和抗菌研究纳米酶的构建和生物体内原位催化活性的提高纳米材料的表界面生物效应与体内安全性研究
教育背景
2008-08--2009-09 美国Delaware大学 访问学者2006-09--2010-01 北京理工大学 博士
学位
工作经历
2010年-至今:中国科学院高能物理研究所 多学科研究中心,助理研究员、副研究员、研究员
专利与奖励
奖励信息
(1) Wiley威立中国开放科学2022年度作者国际学术奖, , 专项, 2023(2) 中国科学院高能物理研究所优秀青年人才基金奖, 研究所(学校), 2015(3) T-more 创新奖, 一等奖, 其他, 2009
专利成果
( 1 ) 一种高催化活性钼基纳米酶及其制备方法和应用, 发明专利, 2022, 第 1 作者, 专利号: CN113952984A( 2 ) 一种无机纳米MoS x /γ-MnS复合材料及其制备方法和应用, 发明专利, 2021, 第 1 作者, 专利号: CN113750235A( 3 ) 一种放疗防护剂及其制备方法和应用, 发明专利, 2021, 第 1 作者, 专利号: CN113230269A( 4 ) 一种二硫化钼/二氧化铪的复合纳米材料、其制备方法及用途, 专利授权, 2020, 第 1 作者, 专利号: CN109010828B( 5 ) 一种层状纳米硫化物及其制备方法和应用, 发明专利, 2019, 第 1 作者, 专利号: CN109574077A( 6 ) 纳米硫化钼抗菌材料及其合成方法、应用, 发明专利, 2016, 第 1 作者, 专利号: CN105948124A( 7 ) 单层MoS 2 纳米片、制备方法以及纳米药物载体, 发明专利, 2014, 第 1 作者, 专利号: CN103705928A( 8 ) 上转换NaYF 4 空心纳米球及其制备方法、应用, 发明专利, 2014, 第 1 作者, 专利号: CN103571492A
出版信息
发表论文
(1) Harnessing Hafnium-Based Nanomaterials for Cancer Diagnosis and Therapy, 2023, 通讯作者(2) Coordination-Driven Self-Assembly Strategy-Activated Cu Single-Atom Nanozymes for Catalytic Tumor-Specific Therapy, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2023, 通讯作者(3) H 2 S-releasing adhesive hydrogel as oral radioprotectant for gastrointestinal tract radioprotection, 2023, 通讯作者(4) Molybdenum-based antimicrobial nanomaterials: A comprehensive review, Nano Today, 2023, 通讯作者(5) Neurotoxicity study of lead-based perovskite nanoparticles, NANO TODAY, 2023, 通讯作者(6) Intercalation-Activated Layered MoO3 Nanobelts as Biodegradable Nanozymes for Tumor-Specific Photo-Enhanced Catalytic Therapy, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 通讯作者(7) Ag-Activated Metal-Organic Framework with Peroxidase-like Activity Synergistic Ag+ Release for Safe Bacterial Eradication and Wound Healing, NANOMATERIALS, 2022, 通讯作者(8) A Copper Peroxide Fenton Nanoagent-Hydrogel as an In Situ pH- Responsive Wound Dressing for Effectively Trapping and Eliminating Bacteria, ACS Appl. Bio Mater., 2022, 通讯作者(9) Biodegradable MoOx@MB incorporated hydrogel as light-activated dressing for rapid and safe bacteria eradication and wound healing, RSC ADVANCES, 2022, 通讯作者(10) The age of bioinspired molybdenum‐involved nanozymes: Synthesis, catalytic mechanisms, and biomedical applications, VIEW, 2021, 通讯作者(11) An overview of the use of nanozymes in antibacterial applications, CHEMICALENGINEERINGJOURNAL, 2021, 通讯作者(12) Mn^(2+)-doped ZrO_(2)@PDA nanocomposite for multimodal imaging-guided chemo-photothermal combination therapy, Mn2+-doped ZrO2@PDA nanocomposite for multimodal imaging-guided chemo-photothermal combination therapy, CHINESE CHEMICAL LETTERS, 2021, 通讯作者(13) Bi3+-Doped BaYF5:Yb,Er Upconversion Nanoparticles with Enhanced Luminescence and Application Case for X-ray Computed Tomography Imaging, INORGANIC CHEMISTRY, 2020, 通讯作者(14) A two-step gas/liquid strategy for the production of N-doped defect-rich transition metal dichalcogenide nanosheets and their antibacterial applications, NANOSCALE, 2020, 通讯作者(15) Liquid-Phase Exfoliation and Functionalization of MoS2 Nanosheets for Effective Antibacterial Application, CHEMBIOCHEM, 2020, 通讯作者(16) Stimuli-Responsive Small-on-Large Nanoradiosensitizer for Enhanced Tumor Penetration and Radiotherapy Sensitization, ACS NANO, 2020, 通讯作者(17) A Bi2S3@mSiO(2)@Ag nanocomposite for enhanced CT visualization and antibacterial response in the gastrointestinal tract, JOURNAL OF MATERIALS CHEMISTRY B, 2020, 通讯作者(18) Two-dimensional nanomaterials beyond graphene for antibacterial applications: current progress and future perspectives, THERANOSTICS, 2020, 通讯作者(19) Glucose-responsive cascaded nanocatalytic reactor with self-modulation of the tumor microenvironment for enhanced chemo-catalytic therapy, MATERIALS HORIZONS, 2020, 通讯作者(20) Translocation, biotransformation-related degradation, and toxicity assessment of polyvinylpyrrolidone-modified 2h-phase nano-mos2, NANOSCALE, 2019, 通讯作者(21) Biodegradable MoOx nanoparticles with efficient near-infrared photothermal and photodynamic synergetic cancer therapy at the second biological window, NANOSCALE, 2018, 第 1 作者(22) Synthesis of Surface-Modification-Oriented Nanosized Molybdenum Disulfide with High Peroxidase-Like Catalytic Activity for H2O2 and Cholesterol Detection, CHEMISTRY-A EUROPEAN JOURNAL, 2018, 通讯作者(23) A Size-Reducible Nanodrug with an Aggregation-Enhanced Photodynamic Effect for Deep Chemo-Photodynamic Therapy, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 通讯作者(24) Peroxidase-like activity of mos2 nanoflakes with different modifications and their application for h2o2 and glucose detection, JOURNAL OF MATERIALS CHEMISTRY B, 2018, 通讯作者(25) Functionalized MoS2 Nanovehicle with Near-Infrared Laser-Mediated Nitric Oxide Release and Photothermal Activities for Advanced Bacteria-Infected Wound Therapy, SMALL, 2018, 通讯作者(26) Intelligent mos2 nanotheranostic for targeted and enzyme-/ph-/nir-responsive drug delivery to overcome cancer chemotherapy resistance guided by pet imaging, ACS APPLIED MATERIALS & INTERFACES, 2018, 通讯作者(27) Biodistribution, excretion, and toxicity of polyethyleneimine modified NaYF 4: Yb, Er upconversion nanoparticles in mice via different administration routes, NANOSCALE, 2017, 通讯作者(28) One-pot synthesis of mose2 hetero-dimensional hybrid self-assembled by nanodots and nanosheets for electrocatalytic hydrogen evolution and photothermal therapy, NANO RESEARCH, 2017, 通讯作者(29) Mos2-nanosheet-assisted coordination of metal ions with porphyrin for rapid detection and removal of cadmium ions in aqueous media, ACS APPLIED MATERIALS & INTERFACES, 2017, 通讯作者(30) Mesoporous Bamboo Charcoal Nanoparticles as a New Near-Infrared Responsive Drug Carrier for Imaging-Guided Chemotherapy/Photothermal Synergistic Therapy of Tumor, ADVANCED HEALTHCARE MATERIALS, 2016, 通讯作者(31) Functionalized Nano-MoS2 with Peroxidase Catalytic and Near-Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications, ACS NANO, 2016, 通讯作者(32) One-pot synthesis of PEGylated plasmonic MoO3-x hollow nanospheres for photoacoustic imaging guided chemo-photothermal combinational therapy of cancer, BIOMATERIALS, 2016, 通讯作者(33) Fluorescent supramolecular micelles for imaging-guided cancer therapy, NANOSCALE, 2016, 通讯作者(34) Synthesis of PVP-functionalized ultra-small MoS2 nanoparticles with intrinsic peroxidase-like activity for H2O2 and glucose detection, RSC ADVANCES, 2016, 通讯作者(35) Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging, THERANOSTICS, 2015, 通讯作者(36) Phytotoxicity, Translocation, and Biotransformation of NaYF4 Upconversion Nanoparticles in a Soybean Plant, SMALL, 2015, 通讯作者(37) WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells, NANOSCALE, 2014, 通讯作者(38) High-Throughput Synthesis of Single-Layer MoS2 Nanosheets as a Near-Infrared Photothermal-Triggered Drug Delivery for Effective Cancer Therapy, ACS NANO, 2014, 第 1 作者(39) Design of multifunctional alkali ion doped CaF2 upconversion nanoparticles for simultaneous bioimaging and therapy, DALTON TRANSACTIONS, 2014, 通讯作者(40) One-Pot Template-Free Synthesis of NaYF4 Upconversion Hollow Nanospheres for Bioimaging and Drug Delivery, CHEMISTRY-AN ASIAN JOURNAL, 2014, 通讯作者(41) Enhanced Red Emission from GdF3:Yb3+,Er3+ Upconversion Nanocrystals by Li+ Doping and Their Application for Bioimaging, CHEMISTRY-A EUROPEAN JOURNAL, 2012, 第 1 作者(42) Lanthanide-doped GdVO4 upconversion nanophosphors with tunable emissions and their applications for biomedical imaging, JOURNAL OF MATERIALS CHEMISTRY, 2012, 第 1 作者(43) Controlling Novel Red-Light Emissions by Doping In2O3 Nano/Microstructures with Interstitial Nitrogen., J. Phys. Chem. C, 2012, 第 1 作者(44) Vertically Well-Aligned In2O3 Cone-Like Nanowire Arrays Grown on Indium Substrates, EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2011, 第 1 作者
科研活动
科研项目
( 1 ) 医用及工业应用纳米材料在复杂生物体系中的释放、迁移与转化过程, 负责人, 国家任务, 2016-06--2021-05( 2 ) 钆基多功能荧光上转换纳米材料的可控合成及在生物医学领域的应用研究, 负责人, 国家任务, 2012-01--2014-12( 3 ) 硫化钼纳米片的制备、功能化修饰及其时空可控的多效抗肿瘤诊疗研究, 负责人, 国家任务, 2018-01--2021-12( 4 ) 功能纳米硫化钼设计制备及其在生物体系中的代谢过程研究, 负责人, 国家任务, 2020-01--2021-12( 5 ) 基底支撑响应型解组装Hf基辐射-催化纳米体系的构建及对肿瘤的高渗透放射增敏治疗, 负责人, 国家任务, 2022-01--2025-12( 6 ) 新型多功能层状纳米硫化钼的构建及对乳腺耐药肿瘤的成像引导靶向诊疗, 负责人, 地方任务, 2018-01--2020-12( 7 ) 新型功能硫化钼基高效纳米放疗增敏剂的研制及CT成像导航的肿瘤诊疗一体化研究, 负责人, 地方任务, 2020-01--2022-12( 8 ) 医用可降解钼基纳米抗菌敷料的研制, 负责人, 地方任务, 2021-01--2023-05( 9 ) 纳米材料穿越生物屏障机制与效应调控方法, 负责人, 国家任务, 2021-12--2026-12( 10 ) 多功能纳米复合材料的设计及对乳腺肿瘤干细胞的靶向诊疗研究, 负责人, 中国科学院计划, 2020-01--2022-12( 11 ) 新型纳米药物的体内过程及安全性研究, 参与, 国家任务, 2012-01--2016-12( 12 ) Hf基纳米放疗增敏剂, 负责人, 其他任务, 2021-01--2022-06
参与会议
(1)Molybdenum-Based Nanomaterials: Enzyme-Like Catalytic Property and Bioapplications 第四届国际纳米材料电子会议 (IOCN 2023) 2023-05-15(2)智能钼基纳米材料的构建和生物医学应用 国家纳米科学中心 第22期纳米青年科学论坛 2023-04-19(3)配位驱动自组装策略激活的Cu单原子纳米酶 第二届中国纳米酶大会 2023-04-07(4)Design of Surface Modification-Related MoS2 Nanomedicine for Biomedical Application 第3届纳米药物国际会议 2018-10-15
指导学生
已指导学生
周如意 博士研究生 0703Z2-生物无机化学