0710Z2-计算生物学
086000-生物与医药

计算生物学-皮肤基因组学；人类表型组学
生物与医药-皮肤基因组学；人类表型组学

2003-09--2009-02   伦敦大学   博士
2002-09--2003-09   杜勒姆大学   硕士
1998-09--2002-06   复旦大学   学士

   

2012-10~现在, 中国科学院上海生命科学研究院, 研究员
2009-02~2012-05,哈佛大学, 博士后研究员
2009-02~2012-05,美国博德研究所, 兼职研究助理
2003-09~2009-02,伦敦大学, 博士
2002-09~2003-09,杜勒姆大学, 硕士
1998-09~2002-06,复旦大学, 学士

2017-06-01-今,第七届上海人类学学会, 副会长
2016-01-01-今,Ann Hum Genet, 副主编

   

（1） NAFLD-related gene polymorphisms and all-cause and cause-specific mortality in an Asian population: the Shanghai Changfeng Study, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2022, 第 19 作者
（2） Genetic evidence for facial variation being a composite phenotype of cranial variation and facial soft tissue thickness, JOURNAL OF GENETICS AND GENOMICS, 2022, 第 13 作者
（3） Genetic variants underlying differences in facial morphology in East Asian and European populations, NATURE GENETICS, 2022, 通讯作者
（4） From musk to body odor: Decoding olfaction through genetic variation, PLOS GENETICS, 2022, 通讯作者
（5） Limb development genes underlie variation in human fingerprint patterns, CELL, 2022, 通讯作者
（6） A Genome-Wide Scan on Individual Typology Angle Found Variants at SLC24A2 Associated with Skin Color Variation in Chinese Populations, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022, 通讯作者
（7） A Genome-Wide Association Study Finds Variants at 2p21 Associated with Self-Reported Sensitive Skin in the Han Chinese population, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022, 第 7 作者
（8） Genetically predicted body composition in relation to cardiometabolic traits: a Mendelian randomization study, EUROPEANJOURNALOFEPIDEMIOLOGY, 2021, 通讯作者
（9） A genome-wide association study of facial morphology identifies novel genetic loci in Han Chinese, A genome-wide association study of facial morphology identifies novel genetic loci in Han Chinese, JOURNAL OF GENETICS AND GENOMICS, 2021, 通讯作者
（10） Dissecting dynamics and differences of selective pressures in the evolution of human pigmentation, BIOLOGY OPEN, 2021, 第 2 作者
（11） A custom-designed panel sequencing study in 201 Chinese patients with craniosynostosis revealed novel variants and distinct mutation spectra, A custom-designed panel sequencing study in 201 Chinese patients with craniosynostosis revealed novel variants and distinct mutation spectra, JOURNAL OF GENETICS AND GENOMICS, 2021, 通讯作者
（12） Insights into contribution of genetic variants towards the susceptibility of MAFLD revealed by the NMR-based lipoprotein profiling, JOURNAL OF HEPATOLOGY, 2021, 第 3 作者
（13） Type 2 Diabetes Is Causally Associated With Reduced Serum Osteocalcin: A Genomewide Association and Mendelian Randomization Study, JOURNALOFBONEANDMINERALRESEARCH, 2021, 通讯作者
（14） Analysis of factors influencing patch test reactions: Results from a large- population-based study in Chinese, JOURNAL OF COSMETIC DERMATOLOGY, 2021, 通讯作者
（15） Identification of factors associated with minimal erythema dose variations in a large‐scale population study of 22146 subjects, JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2020, 
（16） A cell-type deconvolution meta-analysis of whole blood EWAS reveals lineage-specific smoking-associated DNA methylation changes, NATURE COMMUNICATIONS, 2020, 通讯作者
（17） Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population, JOURNAL OF DERMATOLOGICAL SCIENCE, 2019, 通讯作者
（18） Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction, Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction, 遗传学报：英文版, 2018, 第 15 作者
（19） Towards broadening Forensic DNA Phenotyping beyond pigmentation: Improving the prediction of head hair shape from DNA, FORENSIC SCIENCE INTERNATIONAL-GENETICS, 2018, 第 30 作者
（20） CETP (Cholesteryl Ester Transfer Protein) Concentration A Genome-Wide Association Study Followed by Mendelian Randomization on Coronary Artery Disease, CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2018, 
（21） Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans, PLOS GENETICS, 2018, 通讯作者
（22） Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction, JOURNAL OF GENETICS AND GENOMICS, 2018, 通讯作者
（23） Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair, HUMAN MOLECULAR GENETICS, 2018, 第 29 作者
（24） A Genome-Wide Association Study of Basal Transepidermal Water Loss Finds that Variantsat 9q34.3 Are Associated with SkinBarrier Function, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2017, 通讯作者
（25） Genetic History of Xinjiang's Uyghurs Suggests Bronze Age Multiple-Way Contacts in Eurasia, MOLECULAR BIOLOGY AND EVOLUTION, 2017, 通讯作者
（26） Indoor PM2.5 exposure affects skin aging manifestation in a Chinese population, SCIENTIFIC REPORTS, 2017, 通讯作者
（27） Genetic variants associated with skin aging in the Chinese Han population, JOURNAL OF DERMATOLOGICAL SCIENCE, 2017, 通讯作者
（28） Multiethnic GWAS Reveals Polygenic Architecture of Earlobe Attachment, AMERICAN JOURNAL OF HUMAN GENETICS, 2017, 通讯作者
（29） Large-scale genome-wide scans do not support petaloid toenail as a Mendelian trait, JOURNAL OF GENETICS AND GENOMICS, 2016, 通讯作者
（30） EDARV370A associated facial characteristics in Uyghur population revealing further pleiotropic effects, HUMAN GENETICS, 2016, 第 17 作者
（31） Ancestry variation and footprints of natural selection along the genome in Latin American populations, SCIENTIFIC REPORTS, 2016, 通讯作者
（32） Traffic-Related Air Pollution Contributes to Development of Facial Lentigines: Further Epidemiological Evidence from Caucasians and Asians, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2016, 通讯作者
（33） Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations, HUMAN GENETICS, 2016, 通讯作者
（34） Epidemiological evidence that indoor air pollution from cooking with solid fuels accelerates skin aging in Chinese women, JOURNAL OF DERMATOLOGICAL SCIENCE, 2015, 第 16 作者
（35） Characteristics of dental morphology in the Xinjiang Uyghurs and correlation with the EDARV370A variant, SCIENCE CHINA-LIFE SCIENCES, 2014, 通讯作者
（36） Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant, CELL, 2013, 第 2 作者
（37） The adaptive variant EDARV370A is associated with straight hair in East Asians, HUMAN GENETICS, 2013, 第 6 作者
（38） Genetic Divergence Disclosing a Rapid Prehistorical Dispersion of Native Americans in Central and South America, PLOS ONE, 2012, 第 4 作者
（39） Exploring Population Admixture Dynamics via Empirical and Simulated Genome-wide Distribution of Ancestral Chromosomal Segments, AMERICAN JOURNAL OF HUMAN GENETICS, 2012, 第 2 作者
（40） X-Chromosomal Genetic Diversity and Linkage Disequilibrium Patterns in Amerindians and Non-Amerindian Populations, AMERICAN JOURNAL OF HUMAN BIOLOGY, 2011, 第 2 作者

   

（ 1 ） EDA通路基因影响东亚人群形态特征的微进化机制研究, 负责人, 国家任务, 2014-01--2016-12
（ 2 ） 东亚人群的适应性进化, 负责人, 国家任务, 2014-01--2016-12
（ 3 ） 国家中央组织部“****”计划, 负责人, 国家任务, 2014-01--2016-12
（ 4 ） 亚欧人群色素相关表型的进化与多基因作用机制, 负责人, 国家任务, 2017-01--2019-12
（ 5 ） 家犬表型组的量化研究及整合解析, 负责人, 中国科学院计划, 2017-01--2019-06
（ 6 ） 表型组数据库的构建和遗传分析研究 16JC1400504 2016/7/1 2019/6/30 240, 负责人, 地方任务, 2016-07--2019-06
（ 7 ） 国际人类表型组计划（一期）-人类表型组数据的有效挖掘及分析方法构建, 负责人, 地方任务, 2017-01--2021-12
（ 8 ） 多维生命组学数据智能整合分析, 负责人, 国家任务, 2018-07--2020-12
（ 9 ） 体质表型组队列多组学参比数据的采集, 负责人, 中国科学院计划, 2020-01--2024-12