071009-细胞生物学

蛋白折叠与聚集
神经退行性疾病的致病机理
蛋白质原子结构与功能研究

2002-09--2008-06   北京大学   博士学位
1998-09--2002-06   吉林大学   学士学位

   

2013-09~现在, 上海有机化学研究所, 研究员
2008-09~2013-07,美国加州大学洛杉矶分校, 博士后
2002-09~2008-06,北京大学, 博士学位
1998-09~2002-06,吉林大学, 学士学位

蛋白质导论

   

（ 1 ） α-突触核蛋白C末端作为抗帕金森病药物的重要靶点, 2021, 第 1 作者, 专利号: 202110657784.5

（ 2 ） 筛选和表征具有相分离能力蛋白的方法., 2019, 第 1 作者, 专利号: 201911106032 .9

（ 3 ） 一种蛋白质微小晶体冷冻样品的制备及结构解析的方法, 2018, 第 1 作者, 专利号: 201810081566 .X

   

（1） Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease, Nat Chem Biol, 2021, 通讯作者
（2） The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3, Proc Natl Acad Sci U S A, 2021, 通讯作者
（3） A novel partially-open state of SHP2 points to a "multiple gear" regulation mechanism, J Biol Chem, 2021, 通讯作者
（4） Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation, Cell, 2020, 通讯作者
（5） Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation, Nat Struct Mol Biol, 2020, 通讯作者
（6） Parkinson's disease-related phosphorylation at Tyr39 rearranges alpha-synuclein amyloid fibril structure revealed by cryo-EM, Proc Natl Acad Sci U S A, 2020, 通讯作者
（7） Parkinson's disease associated mutation E46K of alpha-synuclein triggers the formation of a distinct fibril structure, Nat Commun, 2020, 通讯作者
（8） The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure., Nat Commun, 2020, 通讯作者
（9） Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly, Nat Commun, 2020, 通讯作者
（10） Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles, Proc Natl Acad Sci U S A, 2020, 通讯作者
（11） Cryo-EM structure of full-length alpha-synuclein amyloid fibril with Parkinson's disease familial A53T mutation, Cell Res, 2020, 通讯作者
（12） Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases, Sci China Life Sci, 2020, 通讯作者
（13） Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation, Mol Cell, 2020, 通讯作者
（14） Cryo-EM structure of an amyloid fibril formed by full-length human prion protein, Nat Struct Mol Biol, 2020, 通讯作者
（15） Structural basis of the interplay between alpha-synuclein and Tau in regulating pathological amyloid aggregation, J Biol Chem, 2020, 通讯作者
（16） Nicotinamide mononucleotide adenylyltransferase uses its NAD(+) substrate-binding site to chaperone phosphorylated Tau, Elife, 2020, 通讯作者
（17） Structural Diversity of Amyloid Fibrils and Advances in Their Structure Determination, Biochemistry, 2020, 通讯作者
（18） Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly, Nat Commun, 2019, 通讯作者
（19） Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells, Nat Commun, 2019, 通讯作者
（20） Programming Conventional Electron Microscopes for Solving Ultrahigh-Resolution Structures of Small and Macro-Molecules, Anal Chem, 2019, 通讯作者
（21） Exploiting mammalian low-complexity domains for liquid-liquid phase separation–driven underwater adhesive coatings, Sci Adv, 2019, 通讯作者
（22） Modular genetic design of multi-domain functional amyloids: insights into self-assembly and functional properties, Chem Sci, 2019, 通讯作者
（23） Fibril Self-Assembly of Amyloid-Spider Silk Block Polypeptides, Biomacro-molecules, 2019, 通讯作者
（24） New insights of poly(ADP- ribosylation) in neurodegenerative diseases: A focus on protein phaseseparation and pathologic aggregation, Biochem Pharmacol, 2019, 通讯作者
（25） Detecting single molecule dynamics on lipid membranes with quenchers-in-a-liposome FRET, Angew Chem Int Ed Engl, 2019, 通讯作者
（26） PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins, Cell Res, 2019, 通讯作者
（27） Heat shock protein 104 (HSP104) chaperones soluble Tau via a mechanism distinct from its disaggregase activity, J Biol Chem, 2019, 通讯作者
（28） Better Together: A Hybrid Amyloid Signals Necroptosis, Cell, 2018, 通讯作者
（29） Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation, Nat Struct Mol Biol, 2018, 通讯作者
（30） Amyloid fibril structure of alpha-synuclein determined by cryo-electron microscopy, Cell Res, 2018, 通讯作者
（31） In-Cell NMR Study of Tau and MARK2 Phosphorylated Tau, Int J Mol Sci, 2018, 通讯作者
（32） Mechanistic insights into the switch of alphaB-crystallin chaperone activity and self-multimerization, J Biol Chem, 2018, 通讯作者
（33） Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment, J Med Chem, 2017, 通讯作者
（34） N-Terminal Acetylation Preserves alpha-Synuclein from Oligomerization by Blocking Intermolecular Hydrogen Bonds, ACS Chem Neurosci, 2017, 通讯作者
（35） Diverse Supramolecular Nanofiber Networks Assembled by Functional Low-Complexity Domains, ACS Nano, 2017, 通讯作者
（36） A Structural View of alphaB-crystallin Assembly and Amyloid Aggregation, Protein Pept Lett, 2017, 通讯作者
（37） Versatile Structures of alpha-Synuclein, Front Mol Neurosci, 2016, 通讯作者
（38） Precise and Reversible Protein-Microtubule-Like Structure with Helicity Driven by Dual Supramolecular Interactions, J Am Chem Soc, 2016, 通讯作者
（39） Tunable assembly of amyloid-forming prptides into nanosheets as a retrovirus carrier, Proc Natl Acad Sci U S A, 2015, 通讯作者
（40） Structure-based design of functional amyloid materials, J Am Chem Soc, 2014, 通讯作者
（41） Structure-based design of functional amyloid materials, J Am Chem Soc, 2014, 通讯作者
（42） Structure-based design of functional amyloid materials, J Am Chem Soc, 2014, 通讯作者
（43） Antiparalle triple-strand architecture for prefibrillar Abeta42 oligomer, J Biol Chem, 2014, 第 1 作者
（44） Designed amyloid fibers as materials for selective carbon dioxide capture, Proc Natl Acad Sci U S A, 2014, 通讯作者
（45） The structured core domain of aB-crystallin can prevent amyloid fibrillation and associated toxicity. , Proc. Natl. Acad.Sci. USA, 2014, 第 2 作者
（46） Structure-baseddiscovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta, Elife, 2013, 第 1 作者
（47） Out-of-register β-sheets suggest a pathway to toxicamyloid aggregations., Proc. Nat. Acad. Sci. USA.,, 2012, 第 1 作者
（48） Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity. , Nature Chemistry, 2012, 第 1 作者
（49） Toxic fibrillar oligomers of amyloid-β have cross-β structure, Proc. Nat. Acad. Sci. USA, 2012, 第 1 作者
（50） Atomic view of a toxic amyloid small oligomer, Science, 2012, 第 2 作者
（51） Characteristics of amyloid-related oligomers revealed by crystal structures of macrocyclic β-sheet mimics., J. Am. Chem. Soc, 2011, 第 1 作者
（52） β2-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages., Nat. Struct. Mol. Biol., , 2011, 第 1 作者

   

（ 1 ） 青年****, 负责人, 国家任务, 2014-10--2017-09
（ 2 ） 蛋白质超微晶体结构研究方法的建立及其在人类重要蛋白结构研究中的应用, 负责人, 国家任务, 2015-01--2017-12
（ 3 ） 热休克蛋白解聚致病淀粉样纤维的结构与分子机理研究, 负责人, 国家任务, 2015-01--2018-12
（ 4 ） 神经退行性疾病中 细胞死亡机理和干预的研究, 参与, 国家任务, 2016-08--2021-07
（ 5 ） 《alpha-突触核蛋白在突触前的保护机制研究》, 负责人, 国家任务, 2020-11--2023-11
（ 6 ） 《蛋白相分离的紊乱与神经退行性疾病》, 负责人, 地方任务, 2020-10--2023-09
（ 7 ） 《细胞程序死亡过程中重要蛋白质复合体的动态调控机制与结构生物学基础》, 负责人, 地方任务, 2018-12--2021-11
（ 8 ） 帕金森病关键蛋白病理聚集的分子机制与化学干预研究, 负责人, 中国科学院计划, 2023-01--2025-12
（ 9 ） 神经系统疾病致病机理的研究和干预, 参与, 国家任务, 2022-06--2026-12