General

Prof. Liu is a Professor in Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, the Director of CAS Key Laboratory for Quantitative Engineering Biology, the Director of Shenzhen Institute of Synthetic Biology (iSynBio), the Chief Scientist of Shenzhen Synthetic Biology Core Facility, the Deputy Director of Synthetic Biology Specialized Committee in Chinese Society of Bioengineering, and the Chairman of Shenzhen Synthetic Biology Association. He also serves as an Editorial Advisory Board member of journals ACS Synthetic Biology and Quantitative Biology. Liu obtained a Ph.D. in Biochemistry from the University of Hong Kong, and postdoctoral training in MCB, Harvard University.where he worked on RNAs roles in chromosome organization. He also is the recipients of several prestigious awards, e.g. VCANBIO Award for Biosciences and Medicine, "Li Ka Shing Award", "Hong Kong Young Scientist Award", He was awarded the National Science Fund for Distinguished Young Scholars.

Research Areas

Synthetic Quantitative Microbiology

SynBio Tumor Therapy

Directed Evolution System

Chromosome Biology


Education

Ph.D. (Biochemistry): The University of Hong Kong, China, 2006-2011

Supervisor: Dr. Jian-Dong Huang (jdhuang@hku.hk)

M.Sc. B.Sc. (Biochemistry and Molecular Biology): Xiamen University, China, 1998-2005

Supervisor: Prof. Zongze Shao (shaozz@163.com)


Publications



Papers

1. Zhiguang Chang#, Yue Shen#, Qi Lang#, Hai Zheng,  Taku. Tokuyasu, Shuqiang Huang, Chenli Liu*. (2019) Microfluidic synchronizer using a synthetic nanoparticle-capped bacterium. ACS Synthetic Biology. DOI: 10.1021/acssynbio.9b00058

2. Jinming Cui#, Guoqin Mai, zuowei wang, Quan Liu, Yan Zhou, Yingfei Ma*, Chenli Liu*. (2019) Metagenomic insights into a cellulose-rich niche reveal microbial cooperation in cellulose degradation. Frontiers in Microbiology , 10 (618) : 1-12 doi:10.3389/fmicb.2019.00618 

3. He Lia, Xia-qing Shi, Mingji Huang, Xiao Chena, Minfeng Xiao, Chenli Liu, Hugues Chaté, Hepeng Zhang*. (2018) Data-driven quantitative modeling of bacterial active nematics. PNAS, 116(3): 777-785 doi.org/10.1073/pnas.1812570116 

4. 崔金明#, 张炳照, 马迎飞, 傅雄飞, 王猛, 刘陈立*. (2018) 合成生物学研究的工程化平台. 中国科学院院刊, 33 (11) : 1249-1257.  

5. 崔金明#, 王力为, 常志广, 臧中盛, 刘陈立*. (2018) 合成生物学的医学应用研究进展. 中国科学院院刊, 33 (11) : 1218-1226. 

6. Ling Chen#, Shengjian Yuan, Liu Quan, Guoqing Mai, Jinfang Yang, Deng Deng, Bingzhao Zhang, Chenli Liu, Yingfei Ma*. (2018) In vitro design and evaluation of phage cocktails against Aeromonas salmonicida. Frontiers in Microbiology. 9: 1476 . doi: 10.3389/fmicb.2018.01476. 

7. Yingfei Ma*, Xiaoyan You, Guoqin Mai, Taku Tokuyasu and Chenli Liu*. (2018) A human gut phage catalog correlates the gut phageome with type 2 diabetes. Microbiome, 6: 24. doi:10.1186/s40168-018-0410-y. 

8. Arieh Zaritsky*, Avinoam Rabinovitch, Chenli Liu, Conrad L. Woldringh c. (2017) Does the eclipse limit bacterial nucleoid complexity and cell width? Synthetic and Systems Biotechnology. 2, 267-275. doi: 10.1016/j.synbio.2017.11.004. eCollection 2017 Dec. Review. 

9. Yang Bai#, Meng Gao, Lingling Wen, Caiyun He, Yuan Chen, Chenli Liu, Xiongfei Fu*, Shuqiang Huang*. (2017) Applications of Microfluidics in Quantitative Biology. Biotechnology Journal. doi: 10.1002/biot.201700170. [Epub ahead of print] Review. 

10. Jinming Cui#, Minfeng Xiao#, Mingzhu Liu, Zuowei Wang, Furong Liu, Hailin Meng, Honggang Zhang, Jinfang Yang, Deng Deng, Huang, Shuqiang Huang, Yingfei Ma*, Chenli Liu*. (2017) Coupling metagenomics with cultivation to select host-specific probiotic micro-organisms for subtropical aquaculture. Journal of Applied Microbiology 123, 1274-1285. doi: 10.1111/jam.13555 

11. Hailin Meng, Yingfei Ma, Guoqin Mai, Yong Wang* and Chenli Liu*. (2017) Construction of precise support vector machine based models for predicting promoter strength. Quantitative Biology 5, 90-98. doi: 10.1007/s40484-017-0096-3.  

12. Lizhong Liu#, Yang Bai, Hai Zheng, Xiongfei Fu*, Chenli Liu*. (2017) Fundamental aspects of synthetic biology. Chinese journal of biotechnology 33, 315-323. doi: 10.13345/j.cjb.160477-en  

13. Chenli Liu#, Claudia Danilowicz, Nancy Kleckner* and Mara Prentiss. (2017) Single molecule identification of homology-dependent interactions between long ssRNA and dsDNA. Nucleic Acids Research 45, 894-901. doi: 10.1093/nar/gkw758  

14. Hai Zheng#, Po-Yi Ho, Meiling Jiang, Bin Tang, Weirong Liu, Dengjin Li, Xuefeng Yu, Nancy E. Kleckner, Ariel Amir*, and Chenli Liu*. (2016) Interrogating the Escherichia coli cell cycle by cell dimension perturbations. PNAS , 15000-15005. doi: 10.1073/pnas.1617932114. 

15. Bingzhao Zhang#, Wangsheng Lai and Chenli Liu*. (2015) Methodology and Philosophy of Synthetic Biology. SCIENTIA SINICA Vitae (Chinese), 45. doi: 10.1360/N052015-00045. 

16. Minfeng Xiao#, Bingzhao Zhang and Chenli Liu.* (2015) Synthetic Biology in Studying the Origin of Life, Evolution, and Structure-Function Relation. SCIENTIA SINICA Vitae (Chinese), 45. doi: 10.1360/N052015-00046. 

17. Yue Zhuo# and Chenli Liu* (2015) Outline of Bacterial Cancer Therapy. Journal of Integration Technology, 4 (4) : 83-89. 

18. Honggang Zhang#, Xinzhi Li, Bingzhao Zhang and Chenli Liu* (2015) Draft Genome Sequence of Acinetobacter sp. Strain YZS-X1-1, a Denitrifying Bacterium Isolated from Freshwater Pond Sludge in China. Genome Announcements 3. doi: 10.1128/genomeA.01579-14. 

19. Xiongfei Fu#, Leihan Tang, Chenli Liu, Jiandong Huang, Terence Hwa, Lenz P. (2012) Stripe formation in bacterial systems with density-suppressed motility. Physical Review Letters 108, 198102. 

20. Chenli Liu#, Xiongfei Fu and Jian-Dong Huang*. (2013) Synthetic biology: a new approach to study biological pattern formation. Quantitative Biology, 1, 7. doi: 10.1007/s40484-013-0021-3. 

21. Chenli Liu#, Xiongfei Fu#, Lizhong Liu, Xiaojing Ren, Carlos K.L. Chau, Sihong Li, Lu Xiang, Hualing Zeng, Guanhua Chen, Lei-Han Tang, Peter Lenz, Xiaodong Cui, Wei Huang*, Terence Hwa* and Jian-Dong Huang*. (2011) Sequential establishment of stripe patterns in an expanding cell population. Science 334, 238-241. doi: 10.1126/science.1209042. 

22. Chenli Liu#, Wanpeng Wang#, Yehui Wu, Zhongwen Zhou, Qiliang Lai and Zongze Shao*. (2011) Multiple alkane hydroxylase systems in a marine alkane degrader, Alcanivorax dieselolei B-5. Environmental Microbiology 13, 1168-1178. doi: 10.1111/j.1462-2920.2010.02416.x. 

23. Chenli Liu#, Zai Wang, Michael S.Y. Huen, Lin-Yu Lu, De-Pei Liu and Jian-Dong Huang*. (2009) Cell death caused by single-stranded oligodeoxynucleotide-mediated targeted genomic sequence modification. Oligonucleotides 19, 281-286. doi: 10.1089/oli.2009.0191. 

24. Chenli Liu#, Yehui Wu, Li Li, Yingfei Ma and Zongze Shao*. (2007) Thalassospira xiamenensis sp. nov. and Thalassospira profundimaris sp. nov. International Journal of Systematic and Evolutionary Microbiology 57, 316-320. doi: 10.1099/ijs.0.64544-0. 

25. Chenli Liu#, Li Xia Xie, Min Li*, Siva Sundara Kumar Durairajan, Shinya Goto, Jian-Dong Huang*. (2007) Salvianolic Acid B Inhibits Hydrogen Peroxide-Induced Endothelial Cell Apoptosis through Regulating PI3K/Akt Signaling. PloS One 2. 12 doi:10.1371/journal.pone.0001321. 

26. Chenli Liu#, Zongze Shao.* (2005) Alcanivorax dieselolei sp. nov., a novel alkane-degrading bacterium isolated from sea water and deep-sea sediment. International Journal of Systematic and Evolutionary Microbiology 55, 1181-1186. doi: 10.1099/ijs.0.63443-0. 


Research Interests

Synthetic Quantitative Microbiology

SynBio Tumor Therapy

Directed Evolution System

Chromosome Biology


Students

现指导学生

刘为荣  博士研究生  071010-生物化学与分子生物学  

周燕  硕士研究生  085238-生物工程  

郑海  博士研究生  071010-生物化学与分子生物学  

孙陈健  博士研究生  071010-生物化学与分子生物学  

陈茜  博士研究生  071010-生物化学与分子生物学  

黄雄亮  博士研究生  071010-生物化学与分子生物学  

董宇轩  硕士研究生  085238-生物工程  

Honors & Distinctions

Liu has won the “1000 Talents Plan Professorship for Young Scholars” from the Organization Department of the CPC Central Committee, China, “Distinguished Young Scholar” from Guangdong Natural Science Funds, China, “Young Scientist Award” from Hong Kong Institution of Science, and “Li Ka Shing Prize” from The University of Hong Kong.