071009-细胞生物学

乳腺（癌）干细胞
转基因动物模型

2004-09--2007-07   协和医科大学肿瘤研究所   博士
2001-09--2004-07   华中科技大学同济医学院   硕士
1996-09--2001-07   华中科技大学同济医学院   学士

   

2016-01~现在, 中国科学院昆明动物研究所, 研究员
2012-01~2015-12,中国科学院昆明动物研究所, 副研究员
2007-08~2011-12,美国Albany医学院, 博士后
2004-09~2007-07,协和医科大学肿瘤研究所, 博士
2001-09~2004-07,华中科技大学同济医学院, 硕士
1996-09~2001-07,华中科技大学同济医学院, 学士

   

（ 1 ） 米非司酮衍生物及其用途, 2019, 第 3 作者, 专利号: 201610821694.4

   

（1） Genetic basis of ruminant headgear and rapid antler regeneration, Science, 2019, 第 6 作者
（2） Krüpple-like factor 5 is essential for mammary gland development and tumorigenesis, Journal of Pathology, 2018, 第 1 作者
（3） Discovery of Novel Mifepristone Derivatives via Suppressing KLF5 Expression for the Treatment of Triple-Negative Breast Cancer, Eur J Med Che, 2018, 通讯作者
（4） Mithramycin A suppresses basal triple-negative breast cancer cell survival partially via down-regulating Krüppel-like factor 5 transcription by Sp1, Scientific Reports, 2018, 第 1 作者
（5） Hypoxia induces miR-153 through the IRE1α-XBP1 pathway to fine tune the HIF-1α/VEGFA axis in breast cancer angiogenesis, Oncogene, 2018, 通讯作者
（6） Ursolic acid derivative FZU-03,010 inhibits STAT3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells, Acta Biochim Biophys Sin, 2017, 通讯作者
（7） Dexamethasone induces docetaxel and cisplatin resistance partially through up-regulating Krüppel-like factor 5 in triple-negative breast cancer, Oncotarget, 2017, 通讯作者
（8） Transforming growth factor-beta increases breast cancer stem cell population partially through upregulatingPMEPA1 expression., Acta Biochim Biophys Sin (Shanghai), 2016, 通讯作者
（9） Mifepristone Suppresses Basal Triple-Negative Breast Cancer Stem Cells by Down-regulating KLF5 Expression, Theranostics, 2016, 第 1 作者
（10） WWOX suppresses KLF5 expression and breast cancer cell growth, Chin J Cancer Res, 2014, 通讯作者
（11） E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation, Cancer Research, 2013, 通讯作者
（12） Role of KLF5 in Hormonal Signaling and Breast Cancer Development, Vitam Horm., 2013, 第 1 作者
（13） RNF115/BCA2 E3 ubiquitin ligase promotes breast cancer cell proliferation through targeting p21Waf1/Cip1 for ubiquitin-mediated degradation, Neoplasia, 2013, 通讯作者
（14） YAP promotes breast cell proliferation and survival partially through stabilizing the KLF5 transcription factor, American Journal of Pathology, 2012, 第 4 作者
（15） The WWP1 ubiquitin E3 ligase increases TRAIL resistance in breast cancer, International Journal of Cancer, 2012, 第 2 作者
（16） The induction of KLF5 transcription factor by progesterone contributes to progesterone-induced breast cancer cell proliferation and dedifferentiation, Molecular Endocrinology, 2011, 第 1 作者
（17） PMEPA1 promotes androgen receptor-negative prostate cell proliferation through suppressing the Smad3/4-c-Myc-p21Cip1 signaling pathway, Journal of Pathology, 2011, 第 1 作者
（18） Centrosomal Nlp is an oncogenic protein that is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice, Journal of Clinical Investigation, 2010, 第 1 作者
（19） KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization., Journal of Biological chemistry , 2009, 第 1 作者
（20） Gadd45a regulates beta-catenin distribution and maintains cell-cell adhesion/contact, Oncogene, 2007, 第 1 作者

   

（ 1 ） 应用基因工程小鼠研究转录因子KLF5在乳腺（癌）干细胞中的功能, 负责人, 国家任务, 2013-01--2016-12
（ 2 ） 一个新的泛素连接酶RNFX在乳腺癌中作用机制的研究, 负责人, 地方任务, 2012-10--2015-09
（ 3 ） 肿瘤细胞生物学, 负责人, 国家任务, 2014-01--2016-12
（ 4 ） 三阴性乳腺癌的靶向治疗, 负责人, 中国科学院计划, 2013-10--2017-09
（ 5 ） microRNAs在云南个旧矿工肺癌中的功能、机制及临床应用研究, 参与, 国家任务, 2016-01--2019-12
（ 6 ） 丝裂原活化蛋白激酶磷酸酶-1（MKP-1）去泛素化酶促进乳腺癌化疗耐药的研究, 负责人, 国家任务, 2018-01--2021-12
（ 7 ） 中国科学院昆明动物研究所肿瘤干细胞研究省创新团队, 负责人, 地方任务, 2018-08--2021-07

（1）Mifepristone Suppresses Triple-negative Breast Cancer Cell Growth and Cancer Stem Cell Maintenance via Down-regulating KLF5 Expression   Rong Liu， Peiguo Shi, Zhongmei Zhou, Ceshi Chen   2014-05-16
（2）Mifepristone suppresses triple-negative breast cancer cell growth via miR-153 mediated downregulation   Rong Liu, Ceshi Chen   2013-04-06
（3）The induction of KLF5 transcription factor by progesterone contributes to progesterone-induced breast cancer cell proliferation and dedifferentiation   Rong Liu, Ceshi Chen   2012-05-18
（4）The Fbw7 tumor suppressor targets KLF5 for ubiqutin mediated degradation in a phosphorylation dependent manner   Rong Liu, Ceshi Chen   2010-08-08
（5）PMEPA1 promotes prostate cell proliferation through downregulating p21Waf1/Cip1   Rong Liu, Zhongmei Zhou, Jian Huang, Ceshi Chen   2010-05-29
（6）KLF5 promotes breast cell survival partly through pERK mediated MKP-1 protein phosphorylation and stabilization   Rong Liu, Hanqiu Zheng, Zhongmei Zhou, Jin-Tang Dong and Ceshi Chen   2008-12-10