基本信息
林文楚 男 博导 中国科学院合肥物质科学研究院
电子邮件： linwenc@yahoo.com
通信地址： 安徽省合肥市蜀山湖路350号
邮政编码：
电子邮件： linwenc@yahoo.com
通信地址： 安徽省合肥市蜀山湖路350号
邮政编码：
研究领域
癌症表观遗传学，肿瘤转移与耐药，肿瘤小鼠动物模型，肿瘤分子诊断与治疗
招生信息
考试科目：
肿瘤学
遗传学
招生方向：分子遗传和表观遗传学方向
招收有志于运用肿瘤动物模型从事下列研究方向的考生：
1. 表观遗传因子在肿瘤的发展，转移和耐药中的机制研究
2. 恶性肿瘤发生早期的生物标志物的研究
3. 恶性肿瘤的药物治疗
招生专业
(二级学科) 肿瘤遗传与表观遗传
招收人数： 2人
春博 1
秋博 1
考生需要具有良好的遗传学和肿瘤学基础理论知识。有操作动物实验的经验的考生可以优先考虑。
肿瘤学
遗传学
招生方向：分子遗传和表观遗传学方向
招收有志于运用肿瘤动物模型从事下列研究方向的考生：
1. 表观遗传因子在肿瘤的发展，转移和耐药中的机制研究
2. 恶性肿瘤发生早期的生物标志物的研究
3. 恶性肿瘤的药物治疗
招生专业
(二级学科) 肿瘤遗传与表观遗传
招收人数： 2人
春博 1
秋博 1
考生需要具有良好的遗传学和肿瘤学基础理论知识。有操作动物实验的经验的考生可以优先考虑。
招生
招生方向
教育背景
学历
博士
学位
博士
工作经历
1996/08-1998-08 技术员 湖北省鄂州市卫生防疫站
1998/09-2001/07 硕士研究生 中科院上海生命科学研究院上海生物工程研究中心
2002/05-2006/12 博士研究生 德州大学MD Anderson 癌症中心生化与分子生物学系，美国
2006/12-2007/04 博士后 德州大学MD Anderson 癌症中心生化与分子生物学系，美国
2007/05-2012/03 研究人员（Research Fellow) Dana-Farber 癌症研究所, 哈佛大学医学院，美国
2012/04-2012/12 研究科学家 (Research Scientist/Faculty) Dana-Farber 癌症研究所, 哈佛大学医学院，美国
2012/12-迄今 研究员 中国科学院合肥物质科学研究院强磁场科学中心
本人在过去10多年的研究工作中对肿瘤生物学，肿瘤表观遗传学，生物信息学，神经科学，病理学，动物学和微生物学等多种学科均有广泛的涉猎并且积累了相当的经验。在研究中擅长结合不同学科领域的技术和研究方法，以开放性的思路将基础生命科学研究与临床的医学问题有机的结合，能同时开展多种肿瘤的致病机制研究和肿瘤的转化应用研究。
出版信息
科研文献:
1. Hideo Watanabe, Joshua Y. Francis, Michele S. Woo, Banafsheh Etemad, Wenchu Lin, Daniel Fries,
Shouyang Peng, Eric L.Snyder, Purushothama Rao Tata, Anna Schinzel, Jeoghee Cho, Peter S.
Hammerman, Roel G. Verhaak, William C. Hahn, Jayaraj Rajagopal Tyler Jacks, Matthew Meyerson.Integrated cistromic and expression analysis of amplified NKX2-1 in Lung adenocarcinoma identifies LMO3 as a functional transcriptional target. (2013) Genes & Development. 27(2):197- 210 (IF～14.20)
2. Veronica Martínez-Cerdeño V, Jessica M. Lemen, Vanessa Chan, Alice Wey, Wenchu Lin, Sharon R. Dent, Paul S. Knoepfler N-Myc and GCN5 Regulate Significantly Overlapping Transcriptional Programs in Neural Stem Cells. (2012) PLoS One. 7(6): e39456. (IF～4.11)
3. Wenchu Lin, Jian Cao, Jiayun Liu, Michael L. Beshiri, Yuko Fujiwara, Joshua Francis, Andrew D. Cherniack, Christoph Geisen, Lauren P. Blair, Mike R. Zou, Xiaohua Shen, Dan Kawamori, Zongzhi Liu, Chiara Grisanzio, Hideo Watanabe, Yoji Andrew Minamishima, Qing Zhang, Rohit N. Kulkarni,
Sabina Signoretti, Scott J. Rodig, Roderick T. Bronson, Stuart H. Orkin, David P. Tuck, Elizaveta V. Benevolenskaya, Matthew Meyerson, William G. Kaelin, Jr.,and Qin Yan. Loss of the RBP2 histone demethylase suppresses tumorigenesis in mouse models of Rb1 and Men1 tumor suppressor gene inactivation. (2011) PNAS. 108(33): 13379-86. * Equal contribution. (IF～10.50)
4. Peter S. Hammerman，Martin L. Sos，Alex H. Ramos，Chunxiao Xu，Amit Dutt，Wenjun Zhou，Lear E. Brace ， Brittany A. Woods ， Wenchu Lin ， Jianming Zhang ， Xianming Deng ， Sang Min Lim ， Stefanie Heynck ， Martin Peifer ， Jeffrey R. Simard ， Michael S. Lawrence ， Robert C. Onofrio ， Helga B. Salvesen，Danila Seidel，Thomas Zander，Johannes M. Heuckmann，Alex Soltermann，Holger Moch， Mirjam Koker ， Frauke Leenders ， Franziska Gabler ， Silvia Querings ， Sascha Ansén ， Elisabeth Brambilla，Christian Brambilla， Philippe Lorimier，Odd Terje Brustugun，Åslaug Helland，Iver Petersen，Joachim H. Clement，Harry Groen，Wim Timens，Hannie Sietsma，Erich Stoelben，Jürgen Wolf ， David G. Beer ， Ming Sound Tsao ， Megan Hanna ， Charles Hatton ， Michael J. Eck ， Pasi A. Janne ， Bruce E. Johnson ， Wendy Winckler ， Heidi Greulich ， Adam J. Bass ， Jeonghee Cho ， Daniel Rauh ， Nathanael S. Gray ， Kwok-Kin Wong ， Eric B. Haura ， Roman K. Thomas ， Matthew Meyerson. Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer. (2011) Cancer Discovery. 1(1): 78-89.
5. Joshua Francis, Wenchu Lin, Orit Rozenblatt-Rosen, Matthew Meyerson. The menin tumor suppressor protein is phosphorylated in response to DNA damage. (2011) PLoS One. 6(1): e16119. (IF～4.11)
6. Wenchu Lin, Zhijing Zhang, Geraldine Srajer, Yi Chun Chen, Maosheng Huang, Huy M. Phan, and Sharon Y.R. Dent. Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos. (2008) Dev. Dyn. 237(4): 928-940. (IF～3.02)
7. Wenchu Lin, Chih-Hsin Chen, Richard R. Behringer, and Sharon Y.R. Dent. Proper Gcn5 histone acetyltransferase expression is required for normal anteroposterior patterning of the mouse skeleton. (2008) Dev Growth Differ. 50(5): 321-30.(IF～2.32)
8. Wenchu Lin, Geraldine Srajer, Yvonne A. Evrard, Huy M. Phan, Yas Furuta, and Sharon Y.R. Dent. Developmental potential of Gcn5-/- ES cells in vivo and in vitro. (2007) Dev. Dyn. 236(6): 1547- 1557. * Equal contribution. (IF～3.02)
9. Ke Zhang, Wenchu Lin, John A. Latham, Gary M. Riefler, Jill M. Schumacher,Clarence Chan, Kelly Tatchell, David H. Hawke,Ryuji Kobayashi, and Sharon Y.R. Dent. The Set1 methyltransferase opposes Ipl1 Aurora kinase functions in chromosome segregation. (2005) Cell. 122: 1-12. (IF ～34.77)
10. 林文楚，叶晴，乔春红，尹光琳。微生物混合培养从D-山梨醇产生维生素前体-2-酮基-L-古龙酸发酵条件的研 究。(2002) 微生物学通报 29(4): 27-41.
11. 尹光琳，林文楚，乔春红，叶晴。微生物混合培养从D-山梨醇产生维生素前体-2-酮基-L-古龙酸 (2001) 微生 物学报 41(6):709-715
12. 林文楚，尹光琳。氧化葡萄酸杆菌SCB329 基因组大小与结构的研究。(2001) 微生物学报41(5): 530-535.
13. 林文楚，尹光琳。氧化葡萄酸杆菌SCB329 染色体的测定。(2001) 微生物学报 41(1): 49-52.
14. 薛震役，林文楚，尹光琳。微生物发酵中L-山梨糖脱氢酶的研究 (2001) 中国医药工业杂志32(3): 102-104.
受邀综述:
1. Wenchu Lin，and Sharon YR Dent. Functions of histone modifying enzymes in development. Current
Opinion in Genetics and Development. (2006) 16(2):137-42. (IF～8.98)
2. 林文楚。 氧化葡萄酸杆菌SCB329基因组与纯培养的研究进展。 (2000) 工业微生物 30(2): 18.
1. Hideo Watanabe, Joshua Y. Francis, Michele S. Woo, Banafsheh Etemad, Wenchu Lin, Daniel Fries,
Shouyang Peng, Eric L.Snyder, Purushothama Rao Tata, Anna Schinzel, Jeoghee Cho, Peter S.
Hammerman, Roel G. Verhaak, William C. Hahn, Jayaraj Rajagopal Tyler Jacks, Matthew Meyerson.Integrated cistromic and expression analysis of amplified NKX2-1 in Lung adenocarcinoma identifies LMO3 as a functional transcriptional target. (2013) Genes & Development. 27(2):197- 210 (IF～14.20)
2. Veronica Martínez-Cerdeño V, Jessica M. Lemen, Vanessa Chan, Alice Wey, Wenchu Lin, Sharon R. Dent, Paul S. Knoepfler N-Myc and GCN5 Regulate Significantly Overlapping Transcriptional Programs in Neural Stem Cells. (2012) PLoS One. 7(6): e39456. (IF～4.11)
3. Wenchu Lin, Jian Cao, Jiayun Liu, Michael L. Beshiri, Yuko Fujiwara, Joshua Francis, Andrew D. Cherniack, Christoph Geisen, Lauren P. Blair, Mike R. Zou, Xiaohua Shen, Dan Kawamori, Zongzhi Liu, Chiara Grisanzio, Hideo Watanabe, Yoji Andrew Minamishima, Qing Zhang, Rohit N. Kulkarni,
Sabina Signoretti, Scott J. Rodig, Roderick T. Bronson, Stuart H. Orkin, David P. Tuck, Elizaveta V. Benevolenskaya, Matthew Meyerson, William G. Kaelin, Jr.,and Qin Yan. Loss of the RBP2 histone demethylase suppresses tumorigenesis in mouse models of Rb1 and Men1 tumor suppressor gene inactivation. (2011) PNAS. 108(33): 13379-86. * Equal contribution. (IF～10.50)
4. Peter S. Hammerman，Martin L. Sos，Alex H. Ramos，Chunxiao Xu，Amit Dutt，Wenjun Zhou，Lear E. Brace ， Brittany A. Woods ， Wenchu Lin ， Jianming Zhang ， Xianming Deng ， Sang Min Lim ， Stefanie Heynck ， Martin Peifer ， Jeffrey R. Simard ， Michael S. Lawrence ， Robert C. Onofrio ， Helga B. Salvesen，Danila Seidel，Thomas Zander，Johannes M. Heuckmann，Alex Soltermann，Holger Moch， Mirjam Koker ， Frauke Leenders ， Franziska Gabler ， Silvia Querings ， Sascha Ansén ， Elisabeth Brambilla，Christian Brambilla， Philippe Lorimier，Odd Terje Brustugun，Åslaug Helland，Iver Petersen，Joachim H. Clement，Harry Groen，Wim Timens，Hannie Sietsma，Erich Stoelben，Jürgen Wolf ， David G. Beer ， Ming Sound Tsao ， Megan Hanna ， Charles Hatton ， Michael J. Eck ， Pasi A. Janne ， Bruce E. Johnson ， Wendy Winckler ， Heidi Greulich ， Adam J. Bass ， Jeonghee Cho ， Daniel Rauh ， Nathanael S. Gray ， Kwok-Kin Wong ， Eric B. Haura ， Roman K. Thomas ， Matthew Meyerson. Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer. (2011) Cancer Discovery. 1(1): 78-89.
5. Joshua Francis, Wenchu Lin, Orit Rozenblatt-Rosen, Matthew Meyerson. The menin tumor suppressor protein is phosphorylated in response to DNA damage. (2011) PLoS One. 6(1): e16119. (IF～4.11)
6. Wenchu Lin, Zhijing Zhang, Geraldine Srajer, Yi Chun Chen, Maosheng Huang, Huy M. Phan, and Sharon Y.R. Dent. Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos. (2008) Dev. Dyn. 237(4): 928-940. (IF～3.02)
7. Wenchu Lin, Chih-Hsin Chen, Richard R. Behringer, and Sharon Y.R. Dent. Proper Gcn5 histone acetyltransferase expression is required for normal anteroposterior patterning of the mouse skeleton. (2008) Dev Growth Differ. 50(5): 321-30.(IF～2.32)
8. Wenchu Lin, Geraldine Srajer, Yvonne A. Evrard, Huy M. Phan, Yas Furuta, and Sharon Y.R. Dent. Developmental potential of Gcn5-/- ES cells in vivo and in vitro. (2007) Dev. Dyn. 236(6): 1547- 1557. * Equal contribution. (IF～3.02)
9. Ke Zhang, Wenchu Lin, John A. Latham, Gary M. Riefler, Jill M. Schumacher,Clarence Chan, Kelly Tatchell, David H. Hawke,Ryuji Kobayashi, and Sharon Y.R. Dent. The Set1 methyltransferase opposes Ipl1 Aurora kinase functions in chromosome segregation. (2005) Cell. 122: 1-12. (IF ～34.77)
10. 林文楚，叶晴，乔春红，尹光琳。微生物混合培养从D-山梨醇产生维生素前体-2-酮基-L-古龙酸发酵条件的研 究。(2002) 微生物学通报 29(4): 27-41.
11. 尹光琳，林文楚，乔春红，叶晴。微生物混合培养从D-山梨醇产生维生素前体-2-酮基-L-古龙酸 (2001) 微生 物学报 41(6):709-715
12. 林文楚，尹光琳。氧化葡萄酸杆菌SCB329 基因组大小与结构的研究。(2001) 微生物学报41(5): 530-535.
13. 林文楚，尹光琳。氧化葡萄酸杆菌SCB329 染色体的测定。(2001) 微生物学报 41(1): 49-52.
14. 薛震役，林文楚，尹光琳。微生物发酵中L-山梨糖脱氢酶的研究 (2001) 中国医药工业杂志32(3): 102-104.
受邀综述:
1. Wenchu Lin，and Sharon YR Dent. Functions of histone modifying enzymes in development. Current
Opinion in Genetics and Development. (2006) 16(2):137-42. (IF～8.98)
2. 林文楚。 氧化葡萄酸杆菌SCB329基因组与纯培养的研究进展。 (2000) 工业微生物 30(2): 18.
科研活动
会议摘要：
1. Wenchu Lin, Joshua Francis, Andrew D. Cherniack, Hideo Watanabe, Qin Yan, William G. Kaelin Jr.,Matthew Meyerson，“Inhibition of Men1-deficient tumor growth by inactivation of the RBP2 histone demethylase” AACR 102nd annual meeting, Orlando, FL， 2011
2. Joshua Francis, Wenchu Lin, Alex H.Ramos, Trevor J. Pugh, Matthew H.Kulke, Ramesh A.Shivdasani,Meyerson M. “Genomic analysis of human carcinoids”. Carcinoid and Neuroendocrine Tumor Scientific Forum, 2010, Boston, MA
3. Wenchu Lin, Huy M. Phan, and Shraon YR Dent. “Requirement of Gcn5 histone acetyltransferase in mouse skeletal patterning and neural tube closure”. Experimental Biology, 2006, San Francisco, CA
4. Sharon YR Dent, Yvonne A. Evrard, Wenchu Lin, Ping Bu, Huy M. Phan, Sandy Chang, Alsha S.Multani. “GCN5 Functions in Telomere Maintenance and Neural Development”, Experimental Biology,2006, San Francisco, CA
5. Sharon YR Dent, Yvonne A. Evrard, Wenchu Lin, Ke Zhang, John Latham. “New functions for histone-modifying enzymes”. Chromatin Structure and Function, 2005, Bassau, Bahamas
6. Wenchu Lin, Huy M. Phan, and Shraon YR Dent. “The roles of mammalian Gcn5 histone acetyltransferase in murine embryogenesis”. Mechanisms of Eukaryotic Transcription, 2005. Cold Spring harbor, NY
受邀报告：
1. “The Role of Menin-mediated Histone Methylation in Neuroendocrine Tumorigenesis” Translational Approaches to Cancer, CSH - Asia Meetings, 2011, Suzhou, China， May 2011
2. “Rbp2 histone demethylase ablation: effects on neuroendocrine tumorigenesis” Carcinoid and Neuroendocrine Tumor Scientific Forum, Boston, US, September, 2008
3. “Requirement of Gcn5 histone acetyltransferase in mouse skeletal patterning and neural tube closure.” 10th Trainee Recognition 2006, UT M D Anderson Cancer Center, Houston, TX, US，June 2006
4. “Investigation on the Genome size and Structure of Gluconobacter oxydans” the 1st conference on Biomedical Technology and its Clinical Application, Beijing, China， October 2000
1. Wenchu Lin, Joshua Francis, Andrew D. Cherniack, Hideo Watanabe, Qin Yan, William G. Kaelin Jr.,Matthew Meyerson，“Inhibition of Men1-deficient tumor growth by inactivation of the RBP2 histone demethylase” AACR 102nd annual meeting, Orlando, FL， 2011
2. Joshua Francis, Wenchu Lin, Alex H.Ramos, Trevor J. Pugh, Matthew H.Kulke, Ramesh A.Shivdasani,Meyerson M. “Genomic analysis of human carcinoids”. Carcinoid and Neuroendocrine Tumor Scientific Forum, 2010, Boston, MA
3. Wenchu Lin, Huy M. Phan, and Shraon YR Dent. “Requirement of Gcn5 histone acetyltransferase in mouse skeletal patterning and neural tube closure”. Experimental Biology, 2006, San Francisco, CA
4. Sharon YR Dent, Yvonne A. Evrard, Wenchu Lin, Ping Bu, Huy M. Phan, Sandy Chang, Alsha S.Multani. “GCN5 Functions in Telomere Maintenance and Neural Development”, Experimental Biology,2006, San Francisco, CA
5. Sharon YR Dent, Yvonne A. Evrard, Wenchu Lin, Ke Zhang, John Latham. “New functions for histone-modifying enzymes”. Chromatin Structure and Function, 2005, Bassau, Bahamas
6. Wenchu Lin, Huy M. Phan, and Shraon YR Dent. “The roles of mammalian Gcn5 histone acetyltransferase in murine embryogenesis”. Mechanisms of Eukaryotic Transcription, 2005. Cold Spring harbor, NY
受邀报告：
1. “The Role of Menin-mediated Histone Methylation in Neuroendocrine Tumorigenesis” Translational Approaches to Cancer, CSH - Asia Meetings, 2011, Suzhou, China， May 2011
2. “Rbp2 histone demethylase ablation: effects on neuroendocrine tumorigenesis” Carcinoid and Neuroendocrine Tumor Scientific Forum, Boston, US, September, 2008
3. “Requirement of Gcn5 histone acetyltransferase in mouse skeletal patterning and neural tube closure.” 10th Trainee Recognition 2006, UT M D Anderson Cancer Center, Houston, TX, US，June 2006
4. “Investigation on the Genome size and Structure of Gluconobacter oxydans” the 1st conference on Biomedical Technology and its Clinical Application, Beijing, China， October 2000
合作情况
项目协作单位
Dana-Farber癌症研究所， 哈佛大学医学院