癌症、炎症、免疫制药

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071010-生物化学与分子生物学
071009-细胞生物学

癌症
炎症
免疫制药

1989-09--1993-05   加拿大曼尼托巴大学   免疫学博士
1983-09--1986-07   山东大学   免疫学硕士
1978-09--1983-07   山东大学   医学学士

   

2020-10~现在, 深圳理工大学, 药学院院长
2020-10~现在, 中国科学院深圳先进技术研究院, 癌症免疫研究中心主任
2008-09~2020-10,美国宾夕法尼亚大学，医学院病理及实验室医学系, 终身教授
2001-09~2008-09,美国宾夕法尼亚大学，医学院病理及实验室医学系, 副教授（终身）
2001-01~2001-09,美国宾夕法尼亚大学，医学院分子和细胞工程系, 副教授
1995-11~2000-12,美国宾夕法尼亚大学，医学院分子和细胞工程系, 助理教授
1993-05~1995-05,哈佛大学, 免疫学博士后

Immunology

1990-1993   荣获加拿大医学研究委员会(MRC)“优秀研究员奖”
1992            荣获加拿大免疫协会“旅行奖”
1994-1995   荣获加拿大医学研究委员会(MRC)“学者奖”
2002             荣获美国Lady Barbara Colyton Prize
2008            入选美国Henry Kunkel Society会士
2008            入选教育部长江学者奖励计划“讲座教授”
2021            入选全球前1%顶尖科学家终身影响力榜单 
2022            入选美国医学与生物工程院院士(Elected Fellow) 
2022            当选欧洲科学院 (Academia Europaea) 院士

   

（1） Tumor Necrosis Factor-a-Induced Protein 8-Like 2 Fosters Tumor-Associated Microbiota to Promote the Development of Colorectal Cancer, CANCER IMMUNOLOGY RESEARCH, 2022, 
（2） TNFAIP8 protein functions as a tumor suppressor in inflammation-associated colorectal tumorigenesis, CELL DEATH & DISEASE, 2022, 
（3） TIPE2 Promotes Tumor Initiation But Inhibits Tumor Progression in Murine Colitis-Associated Colon Cancer, Inflammatory Bowel Diseases, 2021, 
（4） Decoupling Tumor Cell Metastasis From Growth By Cellular Pilot Protein TNFAIP8, Oncogene, 2021, 
（5） c-Rel is a myeloid checkpoint for cancer immunotherapy, NATURE CANCER, 2020, 
（6） TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis, The Journal of Experimental Medicine, 2020, 
（7） Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats, SCIENCE TRANSLATIONAL MEDICINE, 2020, 
（8） TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis, Journal of Experimental Medicine, 2020, 
（9） TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling, NATURE COMMUNICATIONS, 2020, 
（10） Treatment of acetaminophen-induced liver failure by blocking the death checkpoint protein TRAIL, BBA - Molecular Basis of Disease, 2020, 
（11） Preclinical studies of a death receptor-5 fusion protein that ameliorates acute liver failure and inflammation, Journal of Molecular Medicine, 2019, 
（12） Exosomal PD-L1 Contributes to Immunosuppression and is Associated with anti-PD-1 Response, NATURE, 2018, 
（13） Regulation of NF-κB by PML and PML-RARα, Scientific Reports, 2017, 
（14） NK Cells Alleviate Lung Inflammation by Negatively Regulating Group 2 Innate Lymphoid Cells., JOURNAL OF IMMUNOLOGY, 2017, 第 5 作者
（15） Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2, NATURE IMMUNOLOGY, 2017, 
（16） TIPE3 Is the Transfer Protein of Lipid Second Messengers that Promote Cancer, CANCER CELL, 2014, 
（17） The Anti-inflammatory TIPE2 Is an Inhibitor of the Oncogenic Ras, MOLECULAR CELL, 2012, 
（18） The Th17 immune response is controlled by the Rel-RORγ-RORγ T transcriptional axis, JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 
（19） The Th17 immune response is controlled by the Rel-ROR gamma-ROR gamma T transcriptional axis, JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 
（20） Transcriptional regulation of the Th17 immune response by IKK alpha, JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 
（21） Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21, NATURE IMMUNOLOGY, 2010, 第 8 作者
（22） Development of Foxp3 + Regulatory T Cells Is Driven by the c-Rel Enhanceosome, IMMUNITY, 2009, 
（23） TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis, CELL, 2008, 
（24） TIPE2, a novel negative regulator of innate and adaptive immunity that maintains immune homeostasis, Cell, 2008, 
（25） Negative regulation of Toll-like receptor signaling by NF-kB p50 ubiquitination blockade, Science, 2007, 
（26） Critical roles of TRAIL in hepatic cell death and hepatic inflammation, JOURNAL OF CLINICAL INVESTIGATION, 2004, 
（27） Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice, FASEB JOURNAL, 2003, 
（28） Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL(-/-) mice, NATURE IMMUNOLOGY, 2003, 
（29） Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation, JOURNAL OF CLINICAL INVESTIGATION, 2002, 
（30） Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an inhibitor of autoimmune inflammation and cell cycle progression, JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 
（31） Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 
（32） PERIPHERAL DELETION OF ANTIGEN-REACTIVE T-CELLS IN ORAL TOLERANCE, NATURE, 1995, 
（33） REGULATORY T-CELL CLONES INDUCED BY ORAL TOLERANCE - SUPPRESSION OF AUTOIMMUNE ENCEPHALOMYELITIS, SCIENCE, 1994, 

（1） REL INHIBITORS AND METHODS OF USE THEREOF, 发明, 2009, 第 1 作者, 专利号: USA Patent Number US8609730B2
（2） Treatment of autoimmune psoriasis with c-Rel-specific siRNA, 发明, 2015, 第 2 作者, 专利号: PCT Patent Number WPI15CN0190X

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（ 1 ） 髓系抑制性细胞的分化调控新机制与肿瘤免疫治疗, 负责人, 国家任务, 2022-01--2026-12
（ 2 ） 实体瘤响应工程免疫细胞的设计合成与应用, 负责人, 国家任务, 2022-11--2027-10
（ 3 ） 基 20220217 炎症性肠病发病机制及干预策略研究, 负责人, 地方任务, 2022-11--2025-10