基本信息
徐自祥 男 硕导 中国科学院天津工业生物技术研究所
电子邮件: xu_zx@tib.cas.cn
通信地址: 天津市空港经济区西七道32号
邮政编码:
电子邮件: xu_zx@tib.cas.cn
通信地址: 天津市空港经济区西七道32号
邮政编码:
招生信息
招生专业
0710J3-生物信息学
招生方向
计算生物学合成生物学系统生物学
教育背景
2001-09--2006-09 西北工业大学 博士1998-09--2001-06 江苏大学 硕士1993-09--1995-06 合肥师范学院 本科毕业
工作经历
工作简历
2014-04~现在, 中国科学院天津工业生物技术研究所, 副研究员2009-04~2014-04,中国科学院天津工业生物技术研究所, 助理研究员2006-11~2009-03,东南大学, 博士后2001-09~2006-09,西北工业大学, 博士1998-09~2001-06,江苏大学, 硕士1993-09~1995-06,合肥师范学院, 本科毕业
专利与奖励
专利成果
( 1 ) 基因工程菌及其制备9α,22-二羟基-23,24-双降胆甾-4-烯-3-酮的应用, 2021, 第 8 作者, 专利号: CN112094797B
出版信息
发表论文
(1) Reconstruction and analysis of genome-scale metabolic model for thermophilic fungus Myceliophthora thermophila, BIOTECHNOLOGY AND BIOENGINEERING, 2022, 第 2 作者(2) Signal Recognition Particle Suppressor Screening Reveals the Regulation of Membrane Protein Targeting by the Translation Rate, MBIO, 2021, 第 4 作者(3) Genomic, transcriptomic, and metabolic characterizations of Escherichia coli adapted to branched-chain higher alcohol tolerance, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2020, 第 3 作者(4) IN SILICO GENOME-SCALE RECONSTRUCTION AND ANALYSIS OF THE SHEWANELLA LOIHICA PV-4 METABOLIC NETWORK, JOURNAL OF BIOLOGICAL SYSTEMS, 2018, 第 1 作者(5) High-throughput metagenomic analysis of petroleum-contaminated soil microbiome reveals the versatility in xenobiotic aromatics metabolism, JOURNAL OF ENVIRONMENTAL SCIENCES, 2017, 第 2 作者(6) Saccharomyces cerevisiae transcription factors involved in multidrug resistance and their roles in the response to lignocellulose-derived inhibitors, Microbial Cell Factories, 2017, 第 1 作者(7) Find_tfSBP: find thermodynamics-feasible and smallest balanced pathways with high yield from large-scale metabolic networks, SCIENTIFIC REPORTS, 2017, 通讯作者(8) Profiling of Saccharomyces cerevisiae transcription factors for engineering the resistance of yeast to lignocellulose-derived inhibitors in biomass conversion, MICROBIAL CELL FACTORIES, 2017, 第 2 作者(9) Bioleaching of heavy metals from contaminated sediments by the Aspergillus niger strain SY1, JOURNAL OF SOILS AND SEDIMENTS, 2015, 第 10 作者(10) Reconstruction of Whole Cell Network and Design of Cell Factory, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2014, 第 1 作者(11) Reconstruction of Whole Cell Network and Design of Cell Factory, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2014, 第 1 作者(12) 全细胞网络重建与细胞工厂设计, 生物化学与 生物物理进展, 2014, (13) Saccharomyces cerevisiae transcription factors involved in multidrug resistance, YEAST, 2013, 第 3 作者(14) Construction and analysis of the weighted-network model of energy metabolism in Escherichia. coli, PLoS ONE, 2013, 第 1 作者(15) ReacKnock: Identifying Reaction Deletion Strategies for Microbial Strain Optimization Based on Genome-Scale Metabolic Network, PLOS ONE, 2013, 第 1 作者(16) Construction and Analysis of the Model of Energy Metabolism in E. coli, PLOS ONE, 2013, 第 1 作者(17) Development of thermodynamic optimum searching (TOS) to improve the prediction accuracy of flux balance analysis, BIOTECHNOLOGY AND BIOENGINEERING, 2013, 第 3 作者(18) Analysis of Enhanced Current-Generating Mechanism of Geobacter sulfurreducens Strain via Model-Driven Metabolism Simulation, PLOS ONE, 2013, 第 2 作者(19) 产电微生物基因组及代谢网络分析, 应用与环境 生物学报, 2012, 第 1 作者(20) In-silico search for optimal fluxes and theoretical gene knockout strategies for E. coli, Chemical and Biochemical Engineering Quarterly, 2011, 第 1 作者
科研活动
科研项目
( 1 ) 黑曲霉中央代谢与调控动态建模与柠檬酸高产机理研究, 负责人, 国家任务, 2014-01--2017-12( 2 ) 细胞网络重构与途径设计, 参与, 国家任务, 2011-01--2015-08( 3 ) 工业微生物基因组测序及分析, 参与, 国家任务, 2011-01--2013-12( 4 ) 化学品生物合成路线的计算模拟和优化, 负责人, 地方任务, 2015-04--2018-03( 5 ) “微生物天然产物的智能创制与改良”课题三子课题, 负责人, 国家任务, 2019-07--2024-06( 6 ) “非完全信息条件下的博弈决策”课题一子课题, 负责人, 国家任务, 2019-07--2022-06
参与会议
(1)微分博弈的辛算法 及其新进展 第二届全国大数据与人工智能科学大会 2019-07-05(2)RegKnock: identifying gene knockout strategies for microbial strain optimization based on regulatory and metabolic integrated network 第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 Zixiang Xu 2014-10-06(3)Find Smallest Balanced Pathway in Large-scale Metabolic Networks in Pseudo-Steady State Condition Zixiang Xu 2012-06-24