主要从事甲壳动物分子遗传学和免疫学研究。系统解析了三疣梭子蟹酚氧化酶原激活系统、补体凝集素途径和免疫效应分子抗菌肽，绘制了蟹类免疫调控网络，发现了补体途径参与的母源免疫过程；构建了中华绒螯蟹高密度遗传连锁图谱，基于性别偏向性基因表达谱，研究了雌雄参与能量代谢、免疫和繁殖调控等过程的差异基因，揭示了中华绒螯蟹性别二态性分子机制；破译了中华绒螯蟹染色体水平的全基因组图谱，揭示了中华绒螯蟹环境适应、短尾化变态发育和性别分化的调控机制，研究成果在Nature子刊Nature Communications上发表。

    共发表SCI论文58篇，近5年SCI他引600余次，其中发表第一作者和通讯作者论文SCI论文23篇（JCR一区18篇，累计影响因子77.534），授权发明专利6项、软件著作权1项，获批水产新品种1项。以共同一作（第2位）完成的NC文章自今年4月22日发表以来浏览次数超2000次；发表在Heredity的文章入选 2015年“ESI热点论文”。先后荣获青岛市自然科学二等奖（第2位）、海洋科学技术二等奖（第2位）、山东省自然科学三等奖（第3位）、辽宁省科技进步一等奖（第4位）、教育部科技进步二等奖（第5位）、宁波市科学技术二等奖（第5位）和中华农业科技一等奖（第7位）。

   

070703-海洋生物学

免疫学基础及应用
遗传学与遗传工程

   

2013-01~现在, 中国科学院海洋研究所, 副研究员
2011-07~2012-12,中国科学院海洋研究所, 助理研究员

   

（1） 三疣梭子蟹“科甬1号”新品种选育与高效养殖技术, 二等奖, 部委级, 2016
（2） 三疣梭子蟹“科甬1号”新品种选育与养殖新技术, 一等奖, 市地级, 2016
（3） “光合1 号”河蟹新品种选育及应用推广, 一等奖, 省级, 2015
（4） 三疣梭子蟹的良种选育及规模化养殖, 一等奖, 部委级, 2015
（5） 三疣梭子蟹抗病选育的分子遗传学基础及其育种应用, 三等奖, 省级, 2014
（6） 三疣梭子蟹抗病选育的分子遗传学基础研究, 二等奖, 市地级, 2013
（7） 三疣梭子蟹育种的遗传学基础, 二等奖, 其他, 2013

[1] 刘媛, 张奥, 李富花. 三疣梭子蟹纤维蛋白原相关蛋白PtFREP基因及其编码蛋白和应用. CN: CN112877334A, 2021-06-01.
[2] 刘媛, 张奥, 李富花. 三疣梭子蟹血管生成素PtANG基因及其编码蛋白和应用. CN: CN112877335A, 2021-06-01.
[3] 刘媛, 苏越, 崔朝霞. 三疣梭子蟹C型凝集素PtCLec1基因及其编码蛋白和应用. CN: CN110343703A, 2019-10-18.
[4] 刘媛, 苏越, 崔朝霞. 三疣梭子蟹C型凝集素PtCLec2基因及其编码蛋白和应用. CN: CN110317813A, 2019-10-11.
[5] 刘媛, 崔朝霞, 张孟洁. 三疣梭子蟹甘露糖结合凝集素PtMBL基因及其编码蛋白和应用. CN: CN109797155A, 2019-05-24.
[6] 刘媛, 宁军号, 崔朝霞, 宋呈文, 刘厚荣. 三疣梭子蟹C1q受体PtgC1qR基因及其编码蛋白和应用. 中国: CN108558994A, 2018.09.21.
[7] 刘媛, 崔朝霞, 王双艳, 师国慧. 三疣梭子蟹Pacifastin型丝氨酸蛋白酶抑制剂蛋白的应用. CN: CN104491851A, 2015-04-08.
[8] 崔朝霞, 王鸿霞, 吴丹华, 刘媛, 李倩倩. 一种中华绒螫蟹多元高通量遗传标记系统及遗传分析方法. CN: CN101613742B, 2014-12-24.
[9] 崔朝霞, 刘媛, 宋呈文, 李倩倩. 三疣梭子蟹丝氨酸蛋白酶基因的应用. CN: CN104117059A, 2014-10-29.
[10] 崔朝霞, 刘媛, 宋呈文, 李倩倩. 三疣梭子蟹丝氨酸蛋白酶同源物基因的应用. CN: CN104120139A, 2014-10-29.
[11] 崔朝霞, 刘媛, 王双艳. 三疣梭子蟹Pacifastin型丝氨酸蛋白酶抑制剂PtPLC基因及其编码蛋白和应用. CN: CN103014013A, 2013-04-03.
[12] 崔朝霞, 刘媛, 宋呈文, 李希红. 三疣梭子蟹PtCrustin-2基因及其编码蛋白和应用. CN: CN102586261A, 2012-07-18.
[13] 崔朝霞, 刘媛, 宋呈文, 李希红. 三疣梭子蟹PtCrustin-1基因及其编码蛋白和应用. CN: CN102586260A, 2012-07-18.
[14] 崔朝霞, 刘媛. 三疣梭子蟹抗脂多糖因子PtALF-2基因及其编码蛋白和应用. CN: CN102337271A, 2012-02-01.
[15] 崔朝霞, 刘媛. 三疣梭子蟹抗脂多糖因子PtALF-5基因及其编码蛋白和应用. CN: CN102337273A, 2012-02-01.
[16] 崔朝霞, 刘媛. 三疣梭子蟹抗脂多糖因子PtALF-3基因及其编码蛋白和应用. CN: CN102337272A, 2012-02-01.
[17] 崔朝霞, 刘媛. 三疣梭子蟹抗脂多糖因子PtALF-1基因及其编码蛋白和应用. CN: CN102329801A, 2012-01-25.
[18] 崔朝霞, 刘媛. 三疣梭子蟹抗脂多糖因子PtALF-6基因及其编码蛋白和应用. CN: CN102329803A, 2012-01-25.
[19] 崔朝霞, 刘媛. 三疣梭子蟹抗脂多糖因子PtALF-4基因及其编码蛋白和应用. CN: CN102329802A, 2012-01-25.
[20] 崔朝霞, 张姝, 栾维莎, 刘媛. 一种海蜇基因组DNA的提取方法. CN: CN101988055A, 2011-03-23.
[21] 崔朝霞, 李喜莲, 刘媛, 王鸿霞. 一种三疣梭子蟹抗病品系的构建方法. CN: CN101617638A, 2010-01-06.
[22] 崔朝霞, 王鸿霞, 谭烽, 刘媛, 吴丹华. 一种三疣梭子蟹多元高通量遗传标记系统及遗传分析方法. CN: CN101565744A, 2009-10-28.
[23] 崔朝霞, 张姝, 栾维莎, 刘媛. 一种海蜇基因组DNA的提取方法. CN: CN101343631A, 2009-01-14.

   

[1] Yuan Liu, Yang Yu, Shihao Li, Mingzhe Sun, Fuhua Li. Comparative transcriptomic analysis of gill reveals genes belonging to mTORC1 signaling pathway associated with the resistance trait of shrimp to VPAHPND. FRONTIERS IN IMMUNOLOGY[J]. 2023, 14: https://doaj.org/article/92eefc920e884fcfa2a402f0475349f9.
[2] Zhang, Ao, Liu, Yuan, Guo, Na, Li, Shihao, Li, Fuhua. Two LRR-Only Proteins Involved in Antibacterial Defense and Prophenoloxidase System of Swimming Crab Portunus trituberculatus. FRONTIERS IN MARINE SCIENCE[J]. 2022, 9: [3] Yuan Liu, Ao Zhang, Na Guo, Qiang Hao, Fuhua Li. A pattern recognition receptor fcolin from Portunus trituberculatus (Ptfcolin) regulating immune defense and hemolymph coagulation. International Journal of Biological Macromolecules[J]. 2022, 221: 558-571, https://www.sciencedirect.com/science/article/pii/S0141813022019638?via%3Dihub.
[4] Liu, Yuan, Su, Yue, Zhang, Ao, Cui, Zhaoxia. A C-Type Lectin Highly Expressed in Portunus trituberculatus Intestine Functions in AMP Regulation and Prophenoloxidase Activation. ANTIBIOTICS-BASEL[J]. 2021, 10(5): http://dx.doi.org/10.3390/antibiotics10050541.
[5] Zhaoxia Cui, Yuan Liu, Jianbo Yuan, Xiaojun Zhang, Tomer Ventura, Ka Yan Ma, Shuai Sun, Chengwen Song, Dongliang Zhan, Yanan Yang, Hourong Liu, Guangyi Fan, Qingle Cai, Jing Du, Jing Qin, Chengcheng Shi, Shijie Hao, Quinn P Fitzgibbon, Gregory G Smith, Jianhai Xiang, TinYam Chan, Min Hui, Chenchang Bao, Fuhua Li, Ka Hou Chu. The Chinese mitten crab genome provides insights into adaptive plasticity and developmental regulation. NATURE COMMUNICATIONS[J]. 2021, 12(1): http://dx.doi.org/10.1038/s41467-021-22604-3.
[6] Su, Yue, Liu, Yuan, Gao, Fengtao, Cui, Zhaoxia. A novel C-type lectin with a YPD motif from Portunus trituberculatus (PtCLec1) mediating pathogen recognition and opsonization. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY[J]. 2020, 106: http://dx.doi.org/10.1016/j.dci.2020.103609.
[7] Liu, Hourong, Song, Chengwen, Ning, Junhao, Liu, Yuan, Cui, Zhaoxia. Identification, functional characterization and the potential role of variable lymphocyte receptor EsVLRA from Eriocheir sinensis in response to secondary challenge after Vibrio parahaemolyticus vaccine. FISH & SHELLFISH IMMUNOLOGY[J]. 2020, 98: 201-209, http://dx.doi.org/10.1016/j.fsi.2020.01.011.
[8] Bao, Chenchang, Song, Chengwen, Liu, Yuan, Yang, Yanan, Cui, Zhaoxia. Large-scale lysine crotonylation analysis reveals its potential role in spermiogenesis in the Chinese mitten crab Eriocheir sinensis. JOURNAL OF PROTEOMICS[J]. 2020, 226: http://dx.doi.org/10.1016/j.jprot.2020.103891.
[9] Ning, Junhao, Liu, Yuan, Gao, Fengtao, Liu, Hourong, Cui, Zhaoxia. Characterization and functional analysis of a novel gC1qR in the swimming crab Portunus trituberculatus. FISH & SHELLFISH IMMUNOLOGY[J]. 2019, 84: 970-978, http://dx.doi.org/10.1016/j.fsi.2018.11.005.
[10] Liu, Hourong, Liu, Yuan, Song, Chengwen, Ning, Junhao, Cui, Zhaoxia. Functional characterization of two clip-domain serine proteases in the swimming crab Portunus trituberculatus. FISH & SHELLFISH IMMUNOLOGY[J]. 2019, 89: 98-107, http://dx.doi.org/10.1016/j.fsi.2018.12.047.
[11] Ning, Junhao, Song, Chengwen, Luo, Danli, Liu, Yuan, Liu, Hourong, Cui, Zhaoxia. Comparative transcriptome analysis explores maternal to zygotic transition during Eriocheir sinensis early embryogenesis. GENE[J]. 2019, 685: 12-20, http://dx.doi.org/10.1016/j.gene.2018.10.036.
[12] Ning, Junhao, Liu, Yuan, Gao, Fengtao, Song, Chengwen, Cui, Zhaoxia. Two alpha-2 macroglobulin from Portunus trituberculatus involved in the prophenoloxidase system, phagocytosis and regulation of antimicrobial peptides. FISH & SHELLFISH IMMUNOLOGY[J]. 2019, 89: 574-585, http://dx.doi.org/10.1016/j.fsi.2019.04.033.
[13] Liu, Hourong, Liu, Yuan, Song, Chengwen, Ning, Junhao, Cui, Zhaoxia. Functional characterization of two clip-domain serine proteases in the swimming crab Portunus trituberculatus. FISH & SHELLFISH IMMUNOLOGY[J]. 2019, 89: 98-107, http://dx.doi.org/10.1016/j.fsi.2018.12.047.
[14] Du, Jing, Liu, Yuan, Song, Chengwen, Cui, Zhaoxia. Discovery of sex-related genes from embryonic development stage based on transcriptome analysis in Eriocheir sinensis. GENE[J]. 2019, 710: 1-8, http://ir.qdio.ac.cn/handle/337002/162864, http://www.irgrid.ac.cn/handle/1471x/6861243, http://ir.qdio.ac.cn/handle/337002/162865, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000483423500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[15] Ning, Junhao, Liu, Yuan, Gao, Fengtao, Song, Chengwen, Cui, Zhaoxia. Two alpha-2 macroglobulin from Portunus trituberculatus involved in the prophenoloxidase system, phagocytosis and regulation of antimicrobial peptides. FISH & SHELLFISH IMMUNOLOGY[J]. 2019, 89: 574-585, http://dx.doi.org/10.1016/j.fsi.2019.04.033.
[16] Junhao Ning, Yuan Liu, Fengtao Gao, Hourong Liu, Zhaoxia Cui. Characterization and functional analysis of a novel gC1qR in the swimming crab Portunus trituberculatus. FISH AND SHELLFISH IMMUNOLOGY. 2019, 84: 970-978, http://dx.doi.org/10.1016/j.fsi.2018.11.005.
[17] Song Chengwen, Liu Lei, Hui Min, Liu Yuan, Liu Hourong, Cui Zhaoxia. Primary molecular basis of androgenic gland endocrine sex regulation revealed by transcriptome analysis in Eriocheir sinensis. JOURNAL OF OCEANOLOGY AND LIMNOLOGY[J]. 2019, 37(1): 223-234, http://lib.cqvip.com/Qikan/Article/Detail?id=7001285140.
[18] Ning, Junhao, Li, Yuan, Cui, Zhaoxia. Identification and functional analysis of a thioester-containing protein from Portunus trituberculatus reveals its involvement in the prophenoloxidase system, phagocytosis and AMP synthesis. AQUACULTURE[J]. 2019, 510: 9-21, http://dx.doi.org/10.1016/j.aquaculture.2019.05.025.
[19] Zhang, Mengjie, Liu, Yuan, Song, Chengwen, Ning, Junhao, Cui, Zhaoxia. Characterization and functional analysis of a novel mannose-binding lectin from the swimming crab Portunus trituberculatus. FISH & SHELLFISH IMMUNOLOGY[J]. 2019, 89: 448-457, http://dx.doi.org/10.1016/j.fsi.2019.04.007.
[20] Zhang, Mengjie, Liu, Yuan, Song, Chengwen, Ning, Junhao, Cui, Zhaoxia. Characterization and functional analysis of a novel mannose-binding lectin from the swimming crab Portunus trituberculatus. FISH & SHELLFISH IMMUNOLOGY[J]. 2019, 89: 448-457, http://dx.doi.org/10.1016/j.fsi.2019.04.007.
[21] Hui, Min, Shi, Guohui, Sha, Zhongli, Liu, Yuan, Cui, Zhaoxia. Genetic population structure in the swimming crab, Portunus trituberculatus and its implications for fishery management. JOURNAL OF THE MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM[J]. 2019, 99(4): 891-899, http://dx.doi.org/10.1017/S0025315418000796.
[22] Liu, Hourong, Liu, Yuan, Song, Chengwen, Cui, Zhaoxia. A chymotrypsin-like serine protease from Portunus trituberculatus involved in pathogen recognition and AMP synthesis but not required for prophenoloxidase activation. FISH & SHELLFISH IMMUNOLOGY[J]. 2017, 66: 307-316, http://ir.qdio.ac.cn/handle/337002/137151.
[23] Li Peiyao, Liu Yuan, Luo Danli, Song Chengwen, Cui Zhaoxia. Two spliced isoforms of the sex-determination gene fruitless in the Chinese mitten crab Eriocheir sinensis. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY - PART B: BIOCHEMISTRY AND MOLECULAR BIOLOGY[J]. 2017, [24] Hui, Min, Cui, Zhaoxia, Liu, Yuan, Song, Chengwen, Li, Yingdong, Shi, Guohui, Luo, Danli. Identification of genomic regions and candidate genes associated with growth of Eriocheir Sinensis by QTL mapping and marker annotation. AQUACULTURE RESEARCH[J]. 2017, 48(1): 246-258, https://www.webofscience.com/wos/woscc/full-record/WOS:000390268300021.
[25] Liu Meng, Liu Yuan, Hui Min, Song Chengwen, Cui Zhaoxia. Polymorphisms of clip domain serine proteinase and serine proteinase homolog in the swimming crab Portunus trituberculatus and their association with Vibrio alginolyticus. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY[J]. 2017, 35(2): 235-243, http://ir.qdio.ac.cn/handle/337002/136778.
[26] Hui Min, Cui Zhaoxia, Liu Yuan, Song Chengwen. Transcriptome profiles of embryos before and after cleavage in Eriocheir sinensis: identification of developmental genes at the earliest stages. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY[J]. 2017, 35(4): 770-781, http://ir.qdio.ac.cn/handle/337002/137129.
[27] Hourong Liu, Yuan Liu, Chengwen Song, Zhaoxia Cui. A chymotrypsin-like serine protease from Portunus trituberculatus involved in pathogen recognition and AMP synthesis but not required for prophenoloxidase activation. FISH AND SHELLFISH IMMUNOLOGY. 2017, 66: 307-316, http://dx.doi.org/10.1016/j.fsi.2017.05.031.
[28] Zhang, Na, Song, Chengwen, Wang, Minxiao, Liu, Yuan, Hui, Min, Cui, Zhaoxia. Diversity and characterization of bacteria associated with the deep-sea hydrothermal vent crab Austinograea sp comparing with those of two shallow-water crabs by 16S ribosomal DNA analysis. PLOS ONE[J]. 2017, 12(11): http://ir.qdio.ac.cn/handle/337002/143067.
[29] Li, Peiyao, Liu, Yuan, Luo, Danli, Song, Chengwen, Cui, Zhaoxia. Two spliced isoforms of the sex-determination gene fruitless in the Chinese mitten crab Eriocheir sinensis. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY[J]. 2017, 208: 75-83, http://ir.qdio.ac.cn/handle/337002/136842.
[30] Liu Hourong, Liu Yuan, Song Chengwen, Cui Zhaoxia. A chymotrypsin-like serine protease from Portunus trituberculatus involved in pathogen recognition and AMP synthesis but not required for prophenoloxidase activation. FISH AND SHELLFISH IMMUNOLOGY[J]. 2017, [31] Luo Danli, Liu Yuan, Hui Min, Song Chengwen, Liu Hourong, Cui Zhaoxia. Molecular characterization and expression profiles of four transformer-2 isoforms in the Chinese mitten crab Eriocheir sinensis. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY[J]. 2017, 35(4): 782-791, http://ir.qdio.ac.cn/handle/337002/137121.
[32] 崔朝霞. Molecular characterization and expression profile of four sex-related transformer-2 isoforms in the Chinese mitten crab, Eriocheir sinensis. Chinese Journal of Oceanology and Limnology. 2017, [33] Hui, Min, Song, Chengwen, Liu, Yuan, Li, Chaolun, Cui, Zhaoxia. Exploring the molecular basis of adaptive evolution in hydrothermal vent crab Austinograea alayseae by transcriptome analysis. PLOS ONE[J]. 2017, 12(5): http://ir.qdio.ac.cn/handle/337002/137101.
[34] Hui, Min, Liu, Yuan, Cui, Zhaoxia. First complete mitochondrial genome of primitive crab Homologenus malayensis (Decapoda: Brachyura: Podotremata: Homolidae). MITOCHONDRIAL DNA PART A[J]. 2016, 27(2): 859-860, https://www.webofscience.com/wos/woscc/full-record/WOS:000366464400031.
[35] Liu Lei, Cui Zhaoxia, Song Chengwen, Liu Yuan, Hui Min, Wang Chunlin. Flow cytometric analysis of DNA content for four commercially important crabs in China. ACTA OCEANOLOGICA SINICA[J]. 2016, 35(6): 7-11, http://lib.cqvip.com/Qikan/Article/Detail?id=669137826.
[36] Shi, Guohui, Cui, Zhaoxia, Hui, Min, Liu, Yuan, Chan, TinYam, Song, Chengwen. Unusual sequence features and gene rearrangements of primitive crabs revealed by three complete mitochondrial genomes of Dromiacea. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS[J]. 2016, 20: 65-73, http://dx.doi.org/10.1016/j.cbd.2016.07.004.
[37] Yingdong Li, Min Hui, Zhaoxia Cui, Yuan Liu, Chengwen Song, Guohui Shi. Comparative transcriptomic analysis provides insights into the molecular basis of the metamorphosis and nutrition metabolism change from zoeae to megalopae in Eriocheir sinensis. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY - PART D: GENOMICS AND PROTEOMICS. 2015, 13: 1-9, http://dx.doi.org/10.1016/j.cbd.2014.10.002.
[38] 李应东, 刘媛, 崔朝霞. 大西洋鲑工厂化养殖排放水池塘的污损生物组成及次级生产力评估. 渔业现代化[J]. 2015, 42(4): 1-5, http://lib.cqvip.com/Qikan/Article/Detail?id=665963375.
[39] Cui, Z, Hui, M, Liu, Y, Song, C, Li, X, Li, Y, Liu, L, Shi, G, Wang, S, Li, F, Zhang, X, Liu, C, Xiang, J, Chu, K H. High-density linkage mapping aided by transcriptomics documents ZW sex determination system in the Chinese mitten crab Eriocheir sinensis. HEREDITY[J]. 2015, 115(3): 206-215, http://dx.doi.org/10.1038/hdy.2015.26.
[40] Song, Chengwen, Luo, Danli, Cui, Zhaoxia, Liu, Yuan, Li, Xihong, Shi, Guohui, Wang, Chunlin. Polymorphism of crustins in the swimming crab (Portunus trituberculatus) and its association with Vibrio alginolyticus. AQUACULTURE RESEARCH[J]. 2015, 46(5): 1261-1268, https://www.webofscience.com/wos/woscc/full-record/WOS:000352633300022.
[41] Liu, Yuan, Hui, Min, Cui, Zhaoxia, Luo, Danli, Song, Chengwen, Li, Yingdong, Liu, Lei. Comparative Transcriptome Analysis Reveals Sex-Biased Gene Expression in Juvenile Chinese Mitten Crab Eriocheir sinensis. PLOS ONE[J]. 2015, 10(7): https://doaj.org/article/6d734ef65fc54bfd84d02f8787102c65.
[42] Shi, Guohui, Cui, Zhaoxia, Hui, Min, Liu, Yuan, Chan, TinYam, Song, Chengwen. The complete mitochondrial genomes of Umalia orientalis and Lyreidus brevifrons: The phylogenetic position of the family Raninidae within Brachyuran crabs. MARINE GENOMICS[J]. 2015, 21: 53-61, http://www.corc.org.cn/handle/1471x/2376695.
[43] Liu, Yuan, Cui, Zhaoxia, Shi, Guohui, Luo, Danli, Wang, Shuangyan, Wang, Chunlin. PtPLC, a pacifastin-related inhibitor involved in antibacterial defense and prophenoloxidase cascade of the swimming crab Portunus trituberculatus. FISH & SHELLFISH IMMUNOLOGY[J]. 2015, 43(1): 36-42, http://dx.doi.org/10.1016/j.fsi.2014.12.017.
[44] Song, Chengwen, Cui, Zhaoxia, Hui, Min, Liu, Yuan, Li, Yingdong, Li, Xihong. Comparative transcriptomic analysis provides insights into the molecular basis of brachyurization and adaptation to benthic lifestyle in Eriocheir sinensis. GENE[J]. 2015, 558(1): 88-98, http://dx.doi.org/10.1016/j.gene.2014.12.048.
[45] Song, Chengwen, Cui, Zhaoxia, Hui, Min, Liu, Yuan, Li, Yingdong. Molecular characterization and expression profile of three Fem-1 genes in Eriocheir sinensis provide a new insight into crab sex-determining mechanism. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY[J]. 2015, 189: 6-14, http://dx.doi.org/10.1016/j.cbpb.2015.07.003.
[46] Liu, Yuan, Hui, Min, Cui, Zhaoxia, Luo, Danli, Song, Chengwen, Li, Yingdong, Liu, Lei. Comparative Transcriptome Analysis Reveals Sex-Biased Gene Expression in Juvenile Chinese Mitten Crab Eriocheir sinensis. PLOS ONE[J]. 2015, 10(7): http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201903250011601LS.
[47] Li, Yingdong, Hui, Min, Cui, Zhaoxia, Liu, Yuan, Song, Chengwen, Shi, Guohui. Comparative transcriptomic analysis provides insights into the molecular basis of the metamorphosis and nutrition metabolism change from zoeae to megalopae in Eriocheir sinensis. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS[J]. 2015, 13: 1-9, http://dx.doi.org/10.1016/j.cbd.2014.10.002.
[48] Yang, ChienHui, Liu, Yuan, Cui, Zhaoxia, Chan, TinYam. Complete mitochondrial genome of the furry lobster Palinurellus wieneckii (De Man, 1881) (Decapoda, Achelata, Palinuridae). MITOCHONDRIAL DNA[J]. 2014, 25(4): 295-297, http://dx.doi.org/10.3109/19401736.2013.796521.
[49] Liu, Yuan, Shi, Guohui, Cui, Zhaoxia, Luo, Danli, Song, Chengwen, Li, Xihong, Hui, Min, Li, Yingdong. PtSerpin from the swimming crab Portunus trituberculatus, a putative regulator of prophenoloxidase activation with antibacterial activity. FISH & SHELLFISH IMMUNOLOGY[J]. 2014, 39(2): 365-371, http://dx.doi.org/10.1016/j.fsi.2014.05.018.
[50] Hui, Min, Liu, Yuan, Song, Chengwen, Li, Yingdong, Shi, Guohui, Cui, Zhaoxia. Transcriptome Changes in Eriocheir sinensis Megalopae after Desalination Provide Insights into Osmoregulation and Stress Adaption in Larvae. PLOS ONE[J]. 2014, 9(12): https://doaj.org/article/00cc5a0b59dc4cc99d30479216d5b9f2.
[51] Liu, Yuan, Cui, Zhaoxia, Li, Xihong, Song, Chengwen, Shi, Guohui, Wang, Chunlin. Molecular cloning, genomic structure and antimicrobial activity of PtALF7, a unique isoform of anti-lipopolysaccharide factor from the swimming crab Portunus trituberculatus. FISH & SHELLFISH IMMUNOLOGY[J]. 2013, 34(2): 652-659, http://dx.doi.org/10.1016/j.fsi.2012.12.002.
[52] Li, Xihong, Cui, Zhaoxia, Liu, Yuan, Song, Chengwen, Shi, Guohui, Wang, Chunlin. Polymorphisms of anti-lipopolysaccharide factors in the swimming crab Portunus trituberculatus and their association with resistance/susceptibility to Vibrio alginolyticus. FISH & SHELLFISH IMMUNOLOGY[J]. 2013, 34(6): 1560-1568, http://dx.doi.org/10.1016/j.fsi.2013.03.373.
[53] Liu, Yuan, Cui, Zhaoxia, Li, Xihong, Song, Chengwen, Shi, Guohui. A newly identified anti-lipopolysaccharide factor from the swimming crab Portunus trituberculatus with broad spectrum antimicrobial activity. FISH & SHELLFISH IMMUNOLOGY[J]. 2013, 34(2): 463-470, http://dx.doi.org/10.1016/j.fsi.2012.11.050.
[54] Guo, Enmian, Cui, Zhaoxia, Wu, Danhua, Hui, Min, Liu, Yuan, Wang, Hongxia. Genetic structure and diversity of Portunus trituberculatus in Chinese population revealed by microsatellite markers. BIOCHEMICAL SYSTEMATICS AND ECOLOGY[J]. 2013, 50: 313-321, http://dx.doi.org/10.1016/j.bse.2013.05.006.
[55] Song, Chengwen, Cui, Zhaoxia, Liu, Yuan, Li, Qianqian, Li, Xihong, Shi, Guohui, Wang, Chunlin. Characterization and functional analysis of serine proteinase and serine proteinase homologue from the swimming crab Portunus trituberculatus. FISH & SHELLFISH IMMUNOLOGY[J]. 2013, 35(2): 231-239, http://dx.doi.org/10.1016/j.fsi.2013.04.024.
[56] Cui, Zhaoxia, Li, Xihong, Liu, Yuan, Song, Chengwen, Hui, Min, Shi, Guohui, Luo, Danli, Li, Yingdong. Transcriptome Profiling Analysis on Whole Bodies of Microbial Challenged Eriocheir sinensis Larvae for Immune Gene Identification and SNP Development. PLOS ONE[J]. 2013, 8(12): https://doaj.org/article/120aaf7cf0e54ae49a9ce672c31a179d.
[57] Xihong Li, Zhaoxia Cui, Yuan Liu, Chengwen Song, Guohui Shi. Transcriptome analysis and discovery of genes involved in immune pathways from hepatopancreas of microbial challenged mitten crab Eriocheir sinensis.. PLOS ONE[J]. 2013, 8(7): https://doaj.org/article/49454638c2cd49b3962559a763df17e3.
[58] Xing, Mengxin, Hou, Zhanhui, Yuan, Jianbo, Liu, Yuan, Qu, Yanmei, Liu, Bin. Taxonomic and functional metagenomic profiling of gastrointestinal tract microbiome of the farmed adult turbot (Scophthalmus maximus). FEMS MICROBIOLOGY ECOLOGY[J]. 2013, 86(3): 432-443, https://www.webofscience.com/wos/woscc/full-record/WOS:000326960000006.
[59] Xihong Li, Zhaoxia Cui, Yuan Liu, Chengwen Song, Guohui Shi, Chunlin Wang. Polymorphisms of anti-lipopolysaccharide factors in the swimming crab Portunus trituberculatus and their association with resistance/susceptibility to Vibrio alginolyticus. FISH AND SHELLFISH IMMUNOLOGY. 2013, 34(6): 1560-1568, http://dx.doi.org/10.1016/j.fsi.2013.03.373.
[60] Cui, Zhaoxia, Song, Chengwen, Liu, Yuan, Wang, Shuangyan, Li, Qianqian, Li, Xihong. Crustins from eyestalk cDNA library of swimming crab Portunus trituberculatus: Molecular characterization, genomic organization and expression analysis. FISH & SHELLFISH IMMUNOLOGY[J]. 2012, 33(4): 937-945, http://dx.doi.org/10.1016/j.fsi.2012.08.002.
[61] Song, Chengwen, Cui, Zhaoxia, Liu, Yuan, Wang, Shuangyan, Li, Qianqian. First report of two thioredoxin homologues in crustaceans: Molecular characterization, genomic organization and expression pattern in swimming crab Portunus trituberculatus. FISH & SHELLFISH IMMUNOLOGY[J]. 2012, 32(5): 855-861, http://dx.doi.org/10.1016/j.fsi.2012.02.013.
[62] Li, Qianqian, Cui, Zhaoxia, Liu, Yuan, Wang, Shuangyan, Song, Chengwen. Three clip domain serine proteases (cSPs) and one clip domain serine protease homologue (cSPH) identified from haemocytes and eyestalk cDNA libraries of swimming crab Portunus trituberculatus. FISH & SHELLFISH IMMUNOLOGY[J]. 2012, 32(4): 565-571, http://dx.doi.org/10.1016/j.fsi.2012.01.006.
[63] Wang, Shuangyan, Cui, Zhaoxia, Liu, Yuan, Li, Qianqian, Song, Chengwen. The first homolog of pacifastin-related precursor in the swimming crab (Portunus trituberculatus): Characterization and potential role in immune response to bacteria and fungi. FISH & SHELLFISH IMMUNOLOGY[J]. 2012, 32(2): 331-338, http://dx.doi.org/10.1016/j.fsi.2011.11.025.
[64] Wang, Shuangyan, Cui, Zhaoxia, Liu, Yuan, Li, Qianqian, Song, Chengwen. The first kazal-type serine proteinase inhibitor in the swimming crab Portunus trituberculatus involved in immune response to bacteria and fungi. AQUACULTURE[J]. 2012, 356: 55-60, http://dx.doi.org/10.1016/j.aquaculture.2012.05.036.
[65] Wang, Shuangyan, Cui, Zhaoxia, Liu, Yuan, Li, Qianqian, Song, Chengwen. Identification and characterization of a serine protease inhibitor (PtSerpin) in the swimming crab Portunus trituberculatus. FISH & SHELLFISH IMMUNOLOGY[J]. 2012, 32(4): 544-550, http://dx.doi.org/10.1016/j.fsi.2012.01.002.
[66] Song, Chengwen, Cui, Zhaoxia, Liu, Yuan, Li, Qianqian, Wang, Shuangyan. Cloning and expression of arginine kinase from a swimming crab, Portunus trituberculatus. MOLECULAR BIOLOGY REPORTS[J]. 2012, 39(4): 4879-4888, https://www.webofscience.com/wos/woscc/full-record/WOS:000301108500173.
[67] Lin, FengJiau, Liu, Yuan, Sha, Zhongli, Tsang, Ling Ming, Chu, Ka Hou, Chan, TinYam, Liu, Ruiyu, Cui, Zhaoxia. Evolution and phylogeny of the mud shrimps (Crustacea: Decapoda) revealed from complete mitochondrial genomes. BMC GENOMICS[J]. 2012, 13(1): 631-631, http://dx.doi.org/10.1186/1471-2164-13-631.
[68] Liu, Yuan, Cui, Zhaoxia, Li, Xihong, Song, Chengwen, Li, Qianqian, Wang, Shuangyan. A new anti-lipopolysaccharide factor isoform (PtALF4) from the swimming crab Portunus trituberculatus exhibited structural and functional diversity of ALFs. FISH & SHELLFISH IMMUNOLOGY[J]. 2012, 32(5): 724-731, http://dx.doi.org/10.1016/j.fsi.2012.01.021.
[69] Guo, Enmian, Liu, Yuan, Cui, Zhaoxia, Li, Xilian, Cheng, Yongxu, Wu, Xugan. Genetic variation and population structure of swimming crab (Portunus trituberculatus) inferred from mitochondrial control region. MOLECULAR BIOLOGY REPORTS[J]. 2012, 39(2): 1453-1463, http://dx.doi.org/10.1007/s11033-011-0882-3.
[70] Cui, Zhaoxia, Liu, Yuan, Wang, Hongxia, Wu, Danhua, Luan, Weisha, Tan, Feng, Huang, Minde. Isolation and characterization of microsatellites in Portunus trituberculatus. CONSERVATION GENETICS RESOURCES[J]. 2012, 4(2): 251-255, https://www.webofscience.com/wos/woscc/full-record/WOS:000303536400010.
[71] Wang, Hongxia, Cui, Zhaoxia, Wu, Danhua, Guo, Enmian, Liu, Yuan, Wang, Chunlin, Su, Xiurong, Li, Taiwu. Application of microsatellite DNA parentage markers in the swimming crab Portunus trituberculatus. AQUACULTURE INTERNATIONAL[J]. 2012, 20(4): 649-656, https://www.webofscience.com/wos/woscc/full-record/WOS:000306283000004.
[72] Li, Qianqian, Cui, Zhaoxia, Liu, Yuan, Wang, Shuangyan, Song, Chengwen. Identification and characterization of two novel types of non-clip domain serine proteases (PtSP and PtSPH1) from cDNA haemocytes library of swimming crab Portunus trituberculatus. FISH & SHELLFISH IMMUNOLOGY[J]. 2012, 32(5): 683-692, http://dx.doi.org/10.1016/j.fsi.2012.01.014.
[73] Liu, Yuan, Cui, Zhaoxia, Li, Xihong, Song, Chengwen, Li, Qianqian, Wang, Shuangyan. Molecular cloning, expression pattern and antimicrobial activity of a new isoform of anti-lipopolysaccharide factor from the swimming crab Portunus trituberculatus. FISH & SHELLFISH IMMUNOLOGY[J]. 2012, 33(1): 85-91, http://dx.doi.org/10.1016/j.fsi.2012.04.004.
[74] Liu, Yuan, Cui, Zhaoxia, Luan, Weisha, Song, Chengwen, Nie, Qing, Wang, Shuangyan, Li, Qianqian. Three isoforms of anti-lipopolysaccharide factor identified from eyestalk cDNA library of swimming crab Portunus trituberculatus. FISH & SHELLFISH IMMUNOLOGY[J]. 2011, 30(2): 583-591, http://dx.doi.org/10.1016/j.fsi.2010.12.005.
[75] Liu, Yuan, Cui, Zhaoxia. Complete mitochondrial genome of the Chinese spiny lobster Panulirus stimpsoni (Crustacea: Decapoda): genome characterization and phylogenetic considerations. MOLECULAR BIOLOGY REPORTS[J]. 2011, 38(1): 403-410, http://ir.qdio.ac.cn/handle/337002/11812.
[76] Liu, Yuan, Cui, Zhaoxia, Song, Chengwen, Wang, Shuangyan, Li, Qianqian. Multiple isoforms of immune-related genes from hemocytes and eyestalk cDNA libraries of swimming crab Portunus trituberculatus. FISH & SHELLFISH IMMUNOLOGY[J]. 2011, 31(1): 29-42, http://ir.qdio.ac.cn/handle/337002/11906.
[77] Cui, Zhaoxia, Liu, Yuan, Li, Chi Pang, Chu, Ka Hou. Species delineation in Pampus (Perciformes) and the phylogenetic status of the Stromateoidei based on mitogenomics. MOLECULAR BIOLOGY REPORTS[J]. 2011, 38(2): 1103-1114, http://dx.doi.org/10.1007/s11033-010-0207-y.
[78] Cui, Zhaoxia, Liu, Yuan, Liu, Jing, Luan, Weisha. Molecular identification of Pampus fishes (Perciformes, Stromateidae). ICHTHYOLOGICAL RESEARCH[J]. 2010, 57(1): 32-39, http://ir.qdio.ac.cn/handle/337002/8079.
[79] Liu, Yuan, Cui, Zhaoxia. Complete mitochondrial genome of the Asian paddle crab Charybdis japonica (Crustacea: Decapoda: Portunidae): gene rearrangement of the marine brachyurans and phylogenetic considerations of the decapods. MOLECULAR BIOLOGY REPORTS[J]. 2010, 37(5): 2559-2569, http://ir.qdio.ac.cn/handle/337002/5805.
[80] Cui, Zhaoxia, Liu, Yuan, Luan, Weisha, Li, Qianqian, Wu, Danhua, Wang, Shuangyan. Molecular cloning and characterization of a heat shock protein 70 gene in swimming crab (Portunus trituberculatus). FISH & SHELLFISH IMMUNOLOGY[J]. 2010, 28(1): 56-64, http://www.corc.org.cn/handle/1471x/2408911.
[81] 崔朝霞, 刘媛, 朱嘉濠. Broader pattern of tandem repeats in the mitochondrial control region of Perciformes. 中国海洋湖沼学报：英文版[J]. 2010, 28(4): 785-794, http://lib.cqvip.com/Qikan/Article/Detail?id=34855092.
[82] Guo Enmian, Liu Yuan, Liu Jing, Cui Zhaoxia. DNA barcoding discriminates Pampus minor (Liu et al, 1998) from Pampus species. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY[J]. 2010, 28(6): 1266-1274, http://lib.cqvip.com/Qikan/Article/Detail?id=35850659.
[83] Cui Zhaoxia, Liu Yuan, Chu Ka Hou. Broader pattern of tandem repeats in the mitochondrial control region of Perciformes. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY[J]. 2010, 28(4): 785-794, http://lib.cqvip.com/Qikan/Article/Detail?id=34855092.
[84] Cui, Zhaoxia, Liu, Yuan, Wu, Danhua, Luan, Weisha, Wang, Shuangyan, Li, Qianqian, Song, Chengwen. Molecular cloning and characterization of a serine proteinase homolog prophenoloxidase-activating factor in the swimming crab Portunus trituberculatus. FISH & SHELLFISH IMMUNOLOGY[J]. 2010, 29(4): 679-686, http://ir.qdio.ac.cn/handle/337002/5879.
[85] Liu, Yuan, Cui, Zhaoxia. The complete mitochondrial genome of the mantid shrimp Oratosquilla oratoria (Crustacea: Malacostraca: Stomatopoda): Novel non-coding regions features and phylogenetic implications of the Stomatopoda. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS[J]. 2010, 5(3): 190-198, http://ir.qdio.ac.cn/handle/337002/5937.
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（ 1 ） 三疣梭子蟹丝氨酸蛋白酶功能多样性及其调控机制, 主持, 国家级, 2013-01--2015-12
（ 2 ） 养殖排放废水资源化、无害化处理技术, 主持, 国家级, 2012-01--2015-12
（ 3 ） 三疣梭子蟹丝氨酸蛋白酶抑制剂基因的功能研究, 主持, 市地级, 2013-12--2015-12
（ 4 ） 三疣梭子蟹补体凝集素激活途径及介导的母源免疫机制研究, 主持, 国家级, 2018-01--2021-12
（ 5 ） 中华绒螯蟹补体凝集素途径解析及其母源传递研究, 主持, 省级, 2017-07--2019-07
（ 6 ） 三疣梭子蟹补体凝集素途径的分子组成和功能解析, 主持, 省级, 2017-03--2019-03
（ 7 ） 三疣梭子蟹抗病高通量性状测定技术, 主持, 国家级, 2018-12--2022-12

（1）A novel C-type lectin with YPD motif from Portunus trituberculatus (PtCLec1) involved in pathogen recognition and opsonization   2019-11-01
（2）Embryonic immune defense and maternal complement activity in Eriocheir sinensis and Portunus trituberculatus   2019-05-26
（3）三疣梭子蟹gC1qR分子特征及功能分析   第十一届世界华人虾蟹养殖研讨会   2018-11-27
（4）Comparative transcriptome analysis reveals sex-biased gene expression in juvenile Chinese mitten crab Eriocheir sinensis   第十届世界华人虾蟹养殖研讨会   2016-11-12

已指导学生

苏越  硕士研究生  085238-生物工程