071009-细胞生物学

NMDA受体，精神类疾病
阿尔兹海默症

2009-01--2015-02   Genentech Inc (Roche group)   博士后
2008-01--2009-01   麻省理工学院   博士后
2002-09--2007-12   范德堡大学   博士
2001-07--2002-06   National University of Singapore   硕士
1997-09--2001-06   北京大学   学士

   

2009-01~2015-02,Genentech Inc (Roche group), 博士后
2008-01~2009-01,麻省理工学院, 博士后
2002-09~2007-12,范德堡大学, 博士
2001-07~2002-06,National University of Singapore, 硕士
1997-09~2001-06,北京大学, 学士

   

（1） Gordon Research Conference优秀墙报奖, 一等奖, 其他, 2014

   

（1） Differential and substrate-specific inhibition of γ-secretase by the C-terminal region of ApoE2, ApoE3, and ApoE4, Neuron, 2023, 通讯作者
（2） NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury, CELL REPORTS, 2022, 通讯作者
（3） CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1, JOURNAL OF CELL BIOLOGY, 2021, 第 10 作者
（4） Loss of TDP-43 function underlies hippocampal and cortical synaptic deficits in TDP-43 proteinopathies, MOLECULAR PSYCHIATRY, 2021, 通讯作者
（5） GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models, CELL REPORTS, 2020, 第11作者
（6） GluN2A-selective positive allosteric modulator-nalmefene-flumazenil reverses ketamine-fentanyl-dexmedetomidine-induced anesthesia and analgesia in rats, SCIENTIFIC REPORTS, 2020, 通讯作者
（7） Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker, NATURE COMMUNICATIONS, 2019, 第 16 作者
（8） Synapse engineering: A new level of brain modulation, BRAIN RESEARCH BULLETIN, 2017, 通讯作者
（9） Development of fast neurotransmitter synapses: General principle and recent progress, BRAIN RESEARCH BULLETIN, 2017, 通讯作者
（10） Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function, NEURON, 2016, 第 4 作者
（11） Activity-Induced Nr4a1 Regulates Spine Density and Distribution Pattern of Excitatory Synapses in Pyramidal Neurons, NEURON, 2014, 第 1 作者
（12） Phosphorylation of Threonine-19 of PSD-95 by GSK-3β is Required for PSD-95 Mobilization and Long-Term Depression, THE JOURNAL OF NEUROSCIENCE, 2013, 第 4 作者
（13） Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series (vol 21, pg 3243, 2011), BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 第 3 作者
（14） Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 第 3 作者
（15） mGluR5 Positive Allosteric Modulators Facilitate both Hippocampal LTP and LTD and Enhance Spatial Learning, NEUROPSYCHOPHARMACOLOGY, 2009, 第 2 作者
（16） N-{4-chloro-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methylphenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors, MOLECULAR PHARMACOLOGY, 2008, 第 1 作者
（17） A Positive Allosteric Modulator of mGluR5 Potentiates DHPG-induced Long Term Depression at the Schaffer Collateral-CA1 Synapse of the Rat Hippocampus, FASEB JOURNAL, 2008, 第 2 作者
（18） mGluR(5) positive allosteric modulators, DRUGS OF THE FUTURE, 2008, 第 1 作者
（19） nteraction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses., Molecular Pharmacology, 2007, 第 1 作者
（20） Allosteric potentiators of mGluR5 as a novel approach to treatment of schizophrenia and other cognitive disorders, NEUROPSYCHOPHARMACOLOGY, 2006, 第 4 作者
（21） Two families of mGluR5 allosteric potentiators act through binding to two distinct sites of the receptor., ACTA PHARMACOLOGICA SINICA, 2006, 第 1 作者
（22） Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes, JOURNAL OF MEDICINAL CHEMISTRY, 2006, 第 3 作者
（23） A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators, MOLECULAR PHARMACOLOGY, 2006, 第 3 作者
（24） Regulation of Neuronal Gene Expression and Survival by Basal NMDA Receptor Activity: A Role for Histone Deacetylase 4, THE JOURNAL OF NEUROSCIENCE, 第 1 作者
（25） mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning, NEUROPSYCHOPHARMACOLOGY : OFFICIAL PUBLICATION OF THE AMERICAN COLLEGE OF NEUROPSYCHOPHARMACOLOGY, 第 2 作者

   

（ 1 ） 探索神经活动调控β淀粉样蛋白代谢的分子和细胞机制, 负责人, 国家任务, 2017-01--2020-12
（ 2 ） 神经退行性疾病中细胞死亡机理和干预的研究, 参与, 国家任务, 2016-07--2021-06

（1）Activity--‐ induced Nr4a1 regulates spine density and distribution pattern of excitatory synapses in pyramidal neurons.   Chen Y, Wang Y, Ertürk A, Kallop D, Jiang Z, Weimer RM, Kaminker J, Sheng M.   2014-06-24