071007-遗传学

酵母菌分子遗传与生理代谢工程
酵母菌风味物质代谢与调控
食品级微生物表达系统构建

2002-09--2005-06   浙江大学   博士

   

2013-09~2014-09,University of Massachusetts Dartmouth, 访问学者
2008-12~现在, 中国科学院微生物研究所, 副研究员
2007-05~2008-12,中国科学院微生物研究所, 助理研究员
2005-07~2007-05,中国科学院微生物研究所, 博士后
2002-09~2005-06,浙江大学, 博士

   

（1） Reconstruction of metabolic module with improved promoter strength increases the productivity of 2-phenylethanol in Saccharomyces cerevisiae, Microbial Cell Factories, 2018, 第 1 作者
（2） Regulation of crucial enzymes and transcription factors on 2-phenylethanol biosynthesis via Ehrlich pathway in Saccharomyces cerevisiae, Journal of Industrial Microbiology and Biotechnology, 2017, 第 1 作者
（3） Regulation of general amino acid permeases Gap1p, GATA transcription factors Gln3p and Gat1p on 2-phenylethanol biosynthesis via Ehrlich pathway, Journal of Biotechnology, 2017, 通讯作者
（4） 毕赤酵母中猪β-防御素的表达纯化鉴定及其在猪饲料行业的潜在应用研究, High-level expression, purification and characterization of porcine β-defensin 2 in Pichia pastoris and its potential as a cost-efficient growth promoter in porcine feed, Applied Microbiology and Biotechnology, 2014, 通讯作者
（5） SOD1/GSH在啤酒酵母中协同过表达调节啤酒风味及抗老化能力, Secretion expression of SOD1 and its overlapping function with GSH in brewing yeast strain for better flavor and anti-aging ability, Journal of Industrial Microbiology and Biotechnology, 2014, 第 1 作者
（6） 淀粉酶/葡聚糖酶/谷胱甘肽合成酶基因整合表达的工业酿酒酵母菌株, Integrated expression of the α-amylase, dextranase and glutathione gene in an industrial brewer’s yeast strain, World Journal of Microbiology and Biotechnology, 2012, 通讯作者
（7） 高甘油+谷胱甘肽的自克隆葡萄酒酵母菌株, Construction of self-cloning, indigenous wine strains of Saccharomyces cerevisiae with enhanced glycerol and glutathione production, Biotechnology Letters, 2012, 通讯作者
（8） 具有淀粉分解能力的高谷胱甘肽酵母菌株改善啤酒抗老化及风味, Construction of an amylolytic industrial brewing yeast strain with high glutathione content to manufacture beer with improved anti-staling capability and flavor, Journal of Microbiology and Biotechnology, 2010, 通讯作者
（9） 生产低热能及风味改良啤酒的工业酵母菌株, Construction of an industrial brewing yeast strain to manufacture beer with low caloric content and improved flavor, Journal of Microbiology and Biotechnology, 2010, 通讯作者
（10） 工业酿酒酵母菌株中GAI表达及PEP4缺失研究, Expression of GAI gene and disruption of PEP4 gene in an industrial brewer’s yeast strain, Letters in Applied Microbiology, 2009, 第 1 作者
（11） 自克隆表达盒GSH1+CUP1阻断ADH2的重组工业酿酒酵母菌株, Recombinant industrial brewing yeast strains with ADH2 interruption by using self-cloning GSH1+CUP1 cassette,  FEMS Yeast Research, 2009, 第 1 作者
（12） ILV2缺失/LSD1表达的新型工业酵母菌株, New industrial brewing yeast strains with ILV2 disruption and LSD1 expression, International Journal of Food Microbiology, 2008, 第 1 作者
（13） 高谷胱甘肽低双乙酰自克隆工业酵母菌株的构建, Construction of self-cloning industrial brewing yeast with high-glutathione and low-diacetyl production., International Journal of Food Science and Technology, 2008, 第 1 作者
（14） 自克隆工业酵母菌中GSH1基因过表达及PEP4缺失, Over-expression of GSH1 gene and disruption of PEP4 gene in self-cloning industrial brewer？s yeast, International Journal of Food Microbiology, 2007, 第 1 作者
（15） 蛋白酶A缺失的工业酿酒酵母菌株构建, Construction of proteinase A deficient transformant of industrial brewing yeast,  European Food Research and Technology, 2007, 第 1 作者
（16） 鲜啤酒中酵母蛋白酶A的分离纯化及其对泡沫蛋白的特异性研究, Purification of yeast proteinase A from fresh beer and its specificity on foam proteins, International Journal of Food Science and Technology, 2005, 第 1 作者

   

（ 1 ） 微生物高通量筛选及功能基因高效表达体系构建, 负责人, 其他国际合作项目, 2011-04--2016-04
（ 2 ） 酿酒酵母2-苯乙醇生物合成全局调控及其毒性机制研究, 负责人, 国家任务, 2012-01--2015-12
（ 3 ） 酿酒酵母转录因子协同调控2-苯乙醇生物合成及其调控元件功能差异分析研究, 负责人, 其他国际合作项目, 2016-01--2017-12
（ 4 ） 基于Cat8p转录激活模体鉴定及其与酿酒酵母2-苯乙醇合成相关基因互作, 负责人, 国家任务, 2018-01--2021-12

（1）Genetically incorporating fluorescent amino acids into proteins for molecular imaging in living cells    金属医学——无机化学在未来医学中的应用   Zhaoyue Wang, Zhiwei Liu, Bing Yan and Maolin Guo*    2014-06-22