一直从事基因组学实验技术及最新生物技术平台开发，以及人类健康领域应用技术和工具开发工作，重点攻克测序仪及配套检测机器开发、通用测序试剂研制等工作。

2011-10--2015-11   丹麦哥本哈根大学   博士研究生
2004-09--2007-07   湖南师范大学   硕士
2000-09--2004-07   湖南师范大学   本科

   

2017-02~现在, 深圳华大智造科技有限公司, 副总裁、首席运营官
2015-12~2017-02,深圳华大生命科学研究院, 执行院长
2012-12~2015-12,深圳华大生命科学研究院, 副院长
2007-08~2012-12,深圳华大生命科学研究院, 项目负责人

2018-05-12-今,深圳市分析测试协会生化专委会, 主任委员
2017-03-09-2020-09-20,全国生化检测标准化技术委员会, 委员
2016-03-16-今,中国医学装备协会临床检验装备技术专业委员会, 委员
2015-05-18-今,深圳市经济贸易和信息化委员会, 委员

现代分子生物学

   

（1） 广东省博士博士后“三百行动”—100位博士博士后创新人物, 省级, 2019
（2） 全国五一巾帼标兵, , 国家级, 2019
（3） 深圳市科技进步奖, 二等奖, 市地级, 2015

（ 1 ） 用于基于血液样品构建测序文库的方法及其在确定胎儿遗传异常中的用途, 发明, 2014, 第 3 作者, 专利号: PCT/CN2014/086418
（ 2 ） 一种基于甲基化特异性多重 QPCR 的 DNA 定量方法, 发明, 2013, 第 3 作者, 专利号: PCT/CN2013/080419
（ 3 ） 一种基于家系的单倍体型分析用于胚胎细胞遗传变异检测的方法, 发明, 2013, 第 2 作者, 专利号: PCT/CN2013/073375
（ 4 ） MHC区域核酸文库的构建方法及用途, 发明, 2015, 第 2 作者, 专利号: 11111242.0
（ 5 ） 甲基化高通量检测方法, 发明, 2015, 第 3 作者, 专利号: US14/119266
（ 6 ） 确定单细胞染色体非整倍性的方法和系统, 发明, 2016, 第 5 作者, 专利号: 201180071288.6
（ 7 ） 微量核酸样本的文库制备方法及其应用, 发明, 2016, 第 3 作者, 专利号: 201110316066.8
（ 8 ） 核酸文库的制备方法及其应用以及试剂盒, 发明, 2016, 第 3 作者, 专利号: US14/352492
（ 9 ） 确定基因组是否存在异常的方法及系统, 发明, 2016, 第 3 作者, 专利号: 201180075423.4
（ 10 ） 对核酸样本中预定区域进行基因分型的方法和系统, 发明, 2016, 第 1 作者, 专利号: 201180074176.6
（ 11 ） 对核酸样本中预定区域进行基因分型的方法和系统, 发明, 2017, 第 1 作者, 专利号: 14107084.6
（ 12 ） 一种超级芯片及其制备方法和应用, 发明, 2017, 第 3 作者, 专利号: 201180074174.7
（ 13 ） 用于确定人体具有异常状态的系统和方法, 发明, 2016, 第 4 作者, 专利号: 201280029759.1
（ 14 ） 确定胚胎基因组中预定区域碱基信息的方法,系统和计算机可读介质, 发明, 2017, 第 2 作者, 专利号: 201380074395.3
（ 15 ） AQP5基因突变体及其应用, 发明, 2015, 第 3 作者, 专利号: 201310242094.9
（ 16 ） 开盖装置及开盖系统, 发明, 2017, 第 2 作者, 专利号: 201710073969.5
（ 17 ） 鉴定和分析古DNA样本的方法, 发明, 2017, 第 3 作者, 专利号: 201710667605.X
（ 18 ） 一种用于胎儿性别鉴定的试剂、方法、试剂盒及应用, 发明, 2017, 第 5 作者, 专利号: 201710606746.0
（ 19 ） 一种包虫病的移动检测系统, 实用新型, 2017, 第 3 作者, 专利号: 201720719671.2
（ 20 ） 一种基于BGISEQ-500测序平台的乳腺癌/卵巢癌BRCA1&2基因检测试剂盒, 发明, 2018, 第 5 作者, 专利号: 201810762843.3
（ 21 ） 全基因组甲基化文库单链建库方法和得到的全基因组甲基化文库, 发明, 2018, 第 4 作者, 专利号: 201811216020.7
（ 22 ） 试剂盒及从宫颈分泌物中检测BRCA基因突变的方法, 发明, 2018, 第 5 作者, 专利号: 201811581390.0
（ 23 ） 全基因组结合靶向扩增建库方法和试剂及病原检测方法, 发明, 2019, 第 5 作者, 专利号: 201910198649.1
（ 24 ） 一种检测鸭星状病毒的方法及其使用的试剂盒, 发明, 2019, 第 4 作者, 专利号: 201910259995.6
（ 25 ） mRNA片段化方法及基于其构建测序文库的方法, 发明, 2019, 第 4 作者, 专利号: CN201510049847.3
（ 26 ） 分离的编码FHL1突变体的核酸及其应用, 发明, 2019, 第 4 作者, 专利号: CN201410836230.1
（ 27 ） A METHOD AND A SEQUENCE COMBINATION FOR PRODUCING NUCLEIC ACID FRAGMENTS, 发明, 2019, 第 5 作者, 专利号: US15/518760
（ 28 ） 构建测序文库的方法及装置, 发明, 2019, 第 5 作者, 专利号: CN201510072010.0
（ 29 ） Target region enrichment method based on multiplex pcr, and reagent, 发明, 2019, 第 5 作者, 专利号: US15/537396
（ 30 ） Method of constructing sequencing library, 发明, 2019, 第 5 作者, 专利号: US15/667841
（ 31 ） 一种唾液保存液及其制备方法和用途, 发明, 2019, 第 5 作者, 专利号: HK16103221.7
（ 32 ） 开盖装置及开盖系统, 发明, 2020, 第 2 作者, 专利号: CN201710073969.5
（ 33 ） 一种锚定巢式多重PCR富集DNA目标区域的方法和试剂盒, 发明, 2020, 第 2 作者, 专利号: CN201510229173.5

   

[1] 陈明辉, 龙发, 王琼萍, 蒋慧, 黄文婷. 高频喷射通气及改良喉罩控制通气在支气管热成形术中的应用效果对比. 中国社区医师. 2021, 37(7): 20-21, http://lib.cqvip.com/Qikan/Article/Detail?id=7104057980.
[2] 付鹏, 龙发, 胡斯育, 黄文婷, 董洪波, 蒋慧, 龙亮, 胡凤波, 甘景帆. 经内科胸腔镜冷冻胸膜活检对不明原因胸腔积液诊断的有效性及安全性研究. 临床肺科杂志. 2021, 26(5): 649-653, http://lib.cqvip.com/Qikan/Article/Detail?id=7104415550.
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[4] Guo, Jianping, Zhang, Tao, Cao, Hongzhi, Li, Xiaowei, Liang, Hao, Liu, Mengru, Zou, Yundong, Zhang, Yuanwei, Wang, Yuxuan, Sun, Xiaolin, Hu, Fanlei, Du, Yan, Mo, Xiaodong, Liu, Xu, Yang, Yue, Yang, Huanjie, Wu, Xinyu, Zhang, Xuewu, Jia, Huijue, Jiang, Hui, Hou, Yong, Liu, Xin, Su, Yin, Zhang, Mingrong, Yang, Huanming, Wang, Jian, Sun, Liangdan, Liu, Liang, Padyukov, Leonid, Lai, Luhua, Yamamoto, Kazuhiko, Zhang, Xuejun, Klareskog, Lars, Xu, Xun, Li, Zhanguo. Sequencing of the MHC region defines HLA-DQA1 as the major genetic risk for seropositive rheumatoid arthritis in Han Chinese population. ANNALS OF THE RHEUMATIC DISEASES[J]. 2019, 78(6): 773-780, [5] Wang, Jun, Cui, Yaxiong, Yu, Zhenyang, Wang, Wenjing, Cheng, Xuan, Ji, Wenliang, Guo, Shuyue, Zhou, Qing, Wu, Ning, Chen, Yan, Chen, Ying, Song, Xiaopeng, Jiang, Hui, Wang, Yanxiao, Lan, Yu, Zhou, Bin, Mao, Lanqun, Li, Jin, Yang, Huanming, Guo, Weixiang, Yang, Xiao. Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis. CELL STEM CELL[J]. 2019, 25(6): 754-+, http://dx.doi.org/10.1016/j.stem.2019.09.009.
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[9] 蒋慧. Balanced Chromosomal Rearrangement Detection by Low-Pass Whole-Genome Sequencing. Current Protocols in Human Genetics.. 2018, [10] Patch, AnnMarie, Nones, Katia, Kazakoff, Stephen H, Newell, Felicity, Wood, Scott, Leonard, Conrad, Holmes, Oliver, Xu, Qinying, Addala, Venkateswar, Creaney, Jenette, Robinson, Bruce W, Fu, Shujin, Geng, Chunyu, Li, Tong, Zhang, Wenwei, Liang, Xinming, Rao, Junhua, Wang, Jiahao, Tian, Mingyu, Zhao, Yonggang, Teng, Fei, Gou, Honglan, Yang, Bicheng, Jiang, Hui, Mu, Feng, Supsup, John V Pearson, Waddell, Nicola. Germline and somatic variant identification using BGISEQ-500 and HiSeq X Ten whole genome sequencing. PLOS ONE[J]. 2018, 13(1): https://doaj.org/article/aceacc63d8324da48d04e8b7acfad0b5.
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[12] 蒋慧. Comparative performance of the BGISEQ-500 versus Illumina HiSeq2500 sequencing platforms for palaeogenomic sequencing. GigaScience.. 2017, [13] Shen, Yue, Wang, Yun, Chen, Tai, Gao, Feng, Gong, Jianhui, Abramczyk, Dariusz, Walker, Roy, Zhao, Hongcui, Chen, Shihong, Liu, Wei, Luo, Yisha, Mueller, Carolin A, PaulDuboisTaine, Adrien, Alver, Bonnie, Stracquadanio, Giovanni, Mitchell, Leslie A, Luo, Zhouqing, Fan, Yanqun, Zhou, Baojin, Wen, Bo, Tan, Fengji, Wang, Yujia, Zi, Jin, Xie, Zexiong, Li, Bingzhi, Yang, Kun, Richardson, Sarah M, Jiang, Hui, French, Christopher E, Nieduszynski, Conrad A, Koszul, Romain, Marston, Adele L, Yuan, Yingjin, Wang, Jian, Bader, Joel S, Dai, Junbiao, Boeke, Jef D, Xu, Xun, Cai, Yizhi, Yang, Huanming. Deep functional analysis of synII, a 770-kilobase synthetic yeast chromosome. SCIENCE[J]. 2017, 355(6329): http://dx.doi.org/10.1126/science.aaf4791.
[14] Peng, Wenhui, Li, Miaoxin, L, Hailing, I, Tang, Kai, Zhuang, Jianhui, Zhang, Jianguo, Xiao, Jingjing, Jiang, Hui, Li, Dali, Yu, Yongchun, Sham, Pak C, Nattel, Stanley, Xu, Yawei. Dysfunction of Myosin Light-Chain 4 (MYL4) Leads to Heritable Atrial Cardiomyopathy With Electrical, Contractile, and Structural Components: Evidence From Genetically-Engineered Rats. JOURNAL OF THE AMERICAN HEART ASSOCIATION[J]. 2017, 6(11): http://www.corc.org.cn/handle/1471x/2224518.
[15] Guo, Yiran, Hwang, LiangDar, Li, Jiankang, Eades, Jason, Yu, Chung Wen, Mansfield, Corrine, BurdickWill, Alexis, Chang, Xiao, Chen, Yulan, Duke, Fujiko F, Zhang, Jianguo, Fakharzadeh, Steven, Fennessey, Paul, Keating, Brendan J, Jiang, Hui, Hakonarson, Hakon, Reed, Danielle R, Preti, George. Genetic analysis of impaired trimethylamine metabolism using whole exome sequencing. BMC MEDICAL GENETICS[J]. 2017, 18(1): http://dx.doi.org/10.1186/s12881-017-0369-8.
[16] Mak, Sarah Siu Tze, Gopalakrishnan, Shyam, Caroe, Christian, Geng, Chunyu, Liu, Shanlin, Sinding, MikkelHolger S, Kuderna, Lukas F K, Zhang, Wenwei, Fu, Shujin, Vieira, Filipe G, Germonpre, Mietje, Bocherens, Herve, Fedorov, Sergey, Petersen, Bent, SicheritzPonten, Thomas, MarquesBonet, Tomas, Zhang, Guojie, Jiang, Hui, Gilbert, M Thomas P. Comparative performance of the BGISEQ-500 vs Illumina HiSeq2500 sequencing platforms for palaeogenomic sequencing. GIGASCIENCE[J]. 2017, 6(8): 1-13, https://www.webofscience.com/wos/woscc/full-record/WOS:000406862700001.
[17] Chen, Fang, Liu, Ping, Gu, Ying, Zhu, Zhu, Nanisetti, Amulya, Lan, Zhangzhang, Huang, Zhiwei, Liu, Jia Sophie, Kang, Xiongbin, Deng, Yuqing, Luo, Liqiong, Jiang, Dan, Qiu, Yong, Pan, Jianchang, Xia, Jun, Xiong, Ken, Liu, Chao, Xie, Lin, Shi, Qianyu, Li, Jing, Zhang, Xiuqing, Wang, Wei, Drmanac, Snezana, Bolund, Lars, Jiang, Hui, Drmanac, Radoje, Xu, Xun. Isolation and whole genome sequencing of fetal cells from maternal blood towards the ultimate non-invasive prenatal testing. PRENATAL DIAGNOSIS[J]. 2017, 37(13): 1311-1321, https://www.webofscience.com/wos/woscc/full-record/WOS:000418941300006.
[18] Dong, Guoyi, Shang, Zhouchun, Liu, Longqi, Liu, Chuanyu, Ge, Yuping, Wang, Quanlei, Wu, Liang, Chen, Fang, Li, Baolin, Liu, Xin, Xu, Xun, Yang, Huanming, Du, Yutao, Jiang, Hui. Retinoic acid combined with spermatogonial stem cell conditions facilitate the generation of mouse germ-like cells. BIOSCIENCE REPORTS[J]. 2017, 37(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000406241300033.
[19] Huang, Jie, Liang, Xinming, Xuan, Yuankai, Geng, Chunyu, Li, Yuxiang, Lu, Haorong, Qu, Shoufang, Mei, Xianglin, Chen, Hongbo, Yu, Ting, Sun, Nan, Rao, Junhua, Wang, Jiahao, Zhang, Wenwei, Chen, Ying, Liao, Sha, Jiang, Hui, Liu, Xin, Yang, Zhaopeng, Mu, Feng, Gao, Shangxian. A reference human genome dataset of the BGISEQ-500 sequencer. GIGASCIENCE[J]. 2017, 6(5): 1-9, https://www.webofscience.com/wos/woscc/full-record/WOS:000403836800001.
[20] Hu, Ping, Qiao, Fengchang, Yuan, Yuan, Sun, Ruihong, Wang, Yan, Meng, Lulu, Lin, Ying, Li, Hang, Wang, Yaoshen, Han, Rui, Liang, Dong, Ma, Dingyuan, Jiang, Tao, Jiang, Hui, Xu, Zhengfeng. Noninvasive prenatal diagnosis for X-linked disease by maternal plasma sequencing in a family of Hemophilia B. TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY[J]. 2017, 56(5): 686-690, http://dx.doi.org/10.1016/j.tjog.2017.08.020.
[21] Zirui Dong, Huilin Wang, Haixiao Chen, Hui Jiang, Jianying Yuan, Zhenjun Yang, WenJing Wang, Fengping Xu, Xiaosen Guo, Ye Cao, Zhenzhen Zhu, Chunyu Geng, Wan Chee Cheung, Yvonne K Kwok, Huangming Yang, Tak Yeung Leung, Cynthia C Morton, Sau Wai Cheung, Kwong Wai Choy. Identification of Balanced Chromosomal Rearrangements Previously Unknown Among Participants in the 1000 Genomes Project: Implications for Interpretation of Structural Variation in Genomes and the Future of Clinical Cytogenetics. Genetics in medicine : official journal of the American College of Medical Genetics. 2017, 20(7): 697-707, [22] Liang, D, Wang, Y, Ji, X, Hu, H, Zhang, J, Meng, L, Lin, Y, Ma, D, Jiang, T, Jiang, H, Asan, Song, L, Guo, J, Hu, P, Xu, Z. Clinical application of whole-genome low-coverage next-generation sequencing to detect and characterize balanced chromosomal translocations. CLINICAL GENETICS[J]. 2017, 91(4): 605-610, https://www.webofscience.com/wos/woscc/full-record/WOS:000398538300011.
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[24] Pei, Na, Zhang, Jiaosheng, Ma, Jinmin, Li, Liqiang, Li, Meng, Li, Jiandong, Sun, Yisuo, Ji, Jingkai, Jiang, Hui, Hou, Yong, Xu, Fengping, Lu, Haorong, Zhang, Ruimu, Wei, Xuemei, Xu, Xun, Deng, Jikui. First report of human salivirus/klassevirus in respiratory specimens of a child with fatal adenovirus infection. VIRUS GENES[J]. 2016, 52(5): 620-624, https://www.webofscience.com/wos/woscc/full-record/WOS:000382637500004.
[25] Liu, Shanlin, Wang, Xin, Xie, Lin, Tan, Meihua, Li, Zhenyu, Su, Xu, Zhang, Hao, Misof, Bernhard, Kjer, Karl M, Tang, Min, Niehuis, Oliver, Jiang, Hui, Zhou, Xin. Mitochondrial capture enriches mito-DNA 100 fold, enabling PCR-free mitogenomics biodiversity analysis. MOLECULAR ECOLOGY RESOURCES[J]. 2016, 16(2): 470-479, [26] Demontis, Ditte, Lescai, Francesco, Borglum, Anders, Glerup, Simon, Ostergaard, Soren Dinesen, Mors, Ole, Li, Qibin, Liang, Jieqin, Jiang, Hui, Li, Yingrui, Wang, Jun, Lesch, KlausPeter, Reif, Andreas, Buitelaar, Jan K, Franke, Barbara. Whole-Exome Sequencing Reveals Increased Burden of Rare Functional and Disruptive Variants in Candidate Risk Genes in Individuals With Persistent Attention-Deficit/Hyperactivity Disorder. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRYnull. 2016, 55(6): 521-523, http://dx.doi.org/10.1016/j.jaac.2016.03.009.
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（1） 神经系统单基因病诊断学, 科学出版社, 2017-03, 第 3 作者

   

（ 1 ） 中国（东亚）人群样品收集和大规模数据产出, 参与, 国家级, 2011-01--2015-08
（ 2 ） 重要疾病相关的基因组学和生物信息学技术, 参与, 国家级, 2012-01--2015-12
（ 3 ） 深圳市乳腺癌高发人群基因筛查技术应用示范, 主持, 省级, 2014-07--2017-06
（ 4 ） 高通量靶向区域研究技术开发及单基因病研究应用----重点实验室提升项目, 参与, 省级, 2013-06--2015-12
（ 5 ） 血液中极微量疾病标记物分离以及重要疾病的研究, 参与, 省级, 2014-08--2016-08
（ 6 ） 基于高通量测序和纳米芯片的单细胞技术开发----重点实验室提升项目, 参与, 省级, 2014-08--2016-08
（ 7 ） 新一代测序仪及配套产品研发, 参与, 省级, 2014-01--2017-04
（ 8 ） 慢阻肺危险因素、病因与发病机制研究, 主持, 国家级, 2016-07--2020-12
（ 9 ） 胞外游离DNA靶向富集测序技术的临床应用技术研究, 主持, 省级, 2017-05--2020-06
（ 10 ） 国家质量基础（NQI）作用机理及评估技术研究, 参与, 国家级, 2016-07--2020-12
（ 11 ） 生殖健康与重大出生缺陷相关发病机制和评估体系研究, 主持, 省级, 2018-11--2021-11

（1）从人人基因组到百万基因组   2019测序者大会   2019-12-19
（2）MGI新产品发布   第十四届国际基因组学大会（ICG-14）   2019-10-24
（3）华大智造测序技术白皮书   2019测序技术和应用高峰论坛   2019-06-21
（4）从B端走向C端的生命科学仪器发展新思路   2019中国科学仪器发展年会   2019-04-18
（5）基因大数据研究与展望   DeepTech 2019生命科学论坛   2019-03-22
（6）国产测序平台助力生活染   2019年（第四届）易贸生物产业大会   2019-03-02
（7）About MGI   2019-01-07
（8）Comparison of NIPT clinical performance in 72,382 high-risk pregnant women and 40,287 low-risk pregnant women   2014-07-21
（9） Noninvasive prenatal testing of Trisomy 21 and 18 by maternal plasma sequencing in twin pregnancies. Prenat Diagn   2013-06-03

现指导学生

张理菁  硕士研究生  0710Z1-基因组学  

邢彦如  博士研究生  0710Z1-基因组学  

黄翔  硕士研究生  0710Z1-基因组学  

梁郎超  博士研究生  0710Z1-基因组学  

柴超超  博士研究生  0710Z1-基因组学