采用结构生物学方法解析病原微生物侵入宿主的分子机制。基于病原与宿主的互作机制,进一步开展病原微生物防控研究，具体包括如下三个个方面：

1.基于病原优势表位设计纳米颗粒亚单位疫苗（nano-paiticle vaccine），来预防病原微生物的侵入；

2.基于已有抗原优势表位信息设计特异性抗体，来阻断病原微生物的侵入；

3.基于病原生命周期中关键酶设计小分子抑制剂，来阻断病原的生命周期，进而开发成高效阻断病原的抑制剂。

每年招收一名硕士研究生和一名博士研究生。

100103-病原生物学
071011-生物物理学

病原微生物侵入宿主细胞的分子机制研究
基于优势表位的疫苗设计
抑制剂设计

2004-09--2008-07   中国科学院物理研究所   研究生学历博士学位

   

2016-08~现在, 中国科学院微生物研究所, 研究员
2011-08~2016-06,中国科学院微生物研究所, 副研究员
2008-07~2011-08,中国科学院微生物研究所, 助理研究员

2020-10-24-今,中国性病艾滋病防治协会, 委员

结构生物学与医学研究
结构生物学在医学中的应用

   

（1） 中华预防医学会科学技术奖, 一等奖, 部委级, 2017
（2） 北京市科学技术奖, 一等奖, 省级, 2011

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[2] 高福, 王奇慧, 戴连攀, 杜沛, 齐建勋, 徐坤, 马雪慧. 新冠病毒三聚体嵌合疫苗及其用途. CN: CN115947872A, 2023-04-11.

[3] 高福, 齐建勋, 傅立峰. 一种氮杂双环[3.1.0]己烷衍生物及其制备方法和用途. CN: CN115433256A, 2022-12-06.

[4] 高福, 王奇慧, 戴连攀, 杜沛, 齐建勋, 徐坤, 马雪慧. 新冠病毒三聚体嵌合疫苗及其用途. CN: CN115197331A, 2022-10-18.

[5] 高福, 仝舟, 赵欣, 仝剑宇, 齐建勋, 刘科芳, 马素芳, 谢谊. 一种新型冠状病毒稀有广谱表位的人源抗体及其应用. CN: CN114456264A, 2022-05-10.

[6] 高福, 仝舟, 赵欣, 仝剑宇, 齐建勋, 刘科芳, 马素芳, 谢谊. 一种新型冠状病毒稀有广谱表位的人源抗体及其应用. CN: CN114456264A, 2022-05-10.

[7] 高福, 仝舟, 赵欣, 仝剑宇, 齐建勋, 刘科芳, 马素芳, 谢谊. 一种高效中和新型冠状病毒的人源抗体及其应用. CN: CN114395034A, 2022-04-26.

[8] 严景华, 史瑞, 王奇慧, 齐建勋, 高福. 与新型冠状病毒的抗体有效结合的表位. CN: CN113527444A, 2021-10-22.

[9] 高福, 齐建勋, 谭文杰, 傅立峰, 叶飞, 李学兵, 冯永. 博赛泼维在治疗或改善新型冠状病毒肺炎中的应用. CN: CN113143918A, 2021-07-23.

[10] 高福, 谭文杰, 齐建勋, 傅立峰, 叶飞, 李学兵, 冯永. GC376化合物的新用途. CN: CN113143917A, 2021-07-23.

[11] 高福, 严景华, 李燕, 逯光文, 齐建勋. 一种中东呼吸综合征冠状病毒抗体及其制备方法. CN: CN103864924A, 2014-06-18.

   

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[204] Xuan, Chunling, Shi, Yi, Qi, Jianxun, Zhang, Wei, Xiao, Haixia, Gao, George F. Structural vaccinology: structure-based design of influenza A virus hemagglutinin subtype-specific subunit vaccines. PROTEIN & CELL[J]. 2011, 2(12): 997-1005, http://124.16.173.210/handle/834782/1473.
[205] Zhang, Nianzhi, Qi, Jianxun, Pan, Xiaocheng, Chen, ZhaoSan, Li, Xin, Gao, Feng, Xia, Chun. Crystallization and preliminary X-ray crystallographic studies of swine CD8 alpha. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2011, 67: 888-891, http://dx.doi.org/10.1107/S1744309111020392.
[206] Yi, Yong, Gao, Feng, Mao, Xuhu, Xiao, Ming, Luo, Ping, Qi, Jianxun, Guo, Gang, Jing, Hua, Cui, Yan, Zou, Quanming. Crystallization and preliminary X-ray studies of native and mutant intimin from enterohaemorrhagic Escherichia coli. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2011, 67: 41-43, https://www.webofscience.com/wos/woscc/full-record/WOS:000285928500008.
[207] 刘军, 齐建勋, 高峰, 严景华, 高福. T细胞功能学与结构免疫学结合方法鉴定HLA-A2限制性的细胞毒性T淋巴细胞表位富集区. 科技导报[J]. 2011, 29(27): 19-26, http://lib.cqvip.com/Qikan/Article/Detail?id=39427917.
[208] Liu, Jun, Dai, Lianpan, Qi, Jianxun, Gao, Feng, Feng, Youjun, Liu, Wenjun, Yan, Jinghua, Gao, George F. Diverse Peptide Presentation of Rhesus Macaque Major Histocompatibility Complex Class I Mamu-A*02 Revealed by Two Peptide Complex Structures and Insights into Immune Escape of Simian Immunodeficiency Virus. JOURNAL OF VIROLOGY[J]. 2011, 85(14): 7372-7383, http://dx.doi.org/10.1128/JVI.00350-11.
[209] Zhang, Wei, Qi, Jianxun, Shi, Yi, Li, Qing, Gao, Feng, Sun, Yeping, Lu, Xishan, Lu, Qiong, Vavricka, Christopher J, Liu, Di, Yan, Jinghua, Gao, George F. Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus. PROTEIN & CELL[J]. 2010, 1(5): 459-467, http://www.corc.org.cn/handle/1471x/2374127.
[210] Zhang, Jianhua, Chen, Yong, Gao, Feng, Chen, Weihong, Qi, Jianxun, Xia, Chun. Complex assembly, crystallization and preliminary X-ray crystallographic studies of duck MHC class I molecule. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2010, 66: 99-101, https://www.webofscience.com/wos/woscc/full-record/WOS:000273072500027.
[211] Chen, Yong, Liu, Peipei, Gao, Feng, Cheng, Hao, Qi, Jianxun, Gao, George F. A dimeric structure of PD-L1: functional units or evolutionary relics?. PROTEIN & CELL[J]. 2010, 1(2): 153-160, http://www.corc.org.cn/handle/1471x/2406038.
[212] Gu, Jiang, Ji, Xiaowei, Qi, Jianxun, Ma, Ying, Mao, Xuhu, Zou, Quanming. Crystallization and preliminary X-ray crystallographic studies of human FAIM protein. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2010, 66: 929-931, https://www.webofscience.com/wos/woscc/full-record/WOS:000280708200016.
[213] 齐建勋, 江凡. An improved loopless mounting method for cryocrystallography. 中国物理：英文版[J]. 2010, 212-221, http://lib.cqvip.com/Qikan/Article/Detail?id=32672862.
[214] 安敏, 高福, 齐建勋, 李锋, 刘杏忠. 灵芝免疫调节蛋白LZ-8的制备和晶体分析. 生物工程学报[J]. 2010, 1563-1568, http://lib.cqvip.com/Qikan/Article/Detail?id=35968927.
[215] Cheng, Xia, Lu, Guangwen, Qi, Jianxun, Cheng, Hao, Gao, Feng, Wang, Jundong, Yan, Jinghua. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of SAICAR synthase from Streptococcus suis serotype 2. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2010, 66: 909-912, http://dx.doi.org/10.1107/S1744309110020518.
[216] Qi JianXun, Jiang Fan. An improved loopless mounting method for cryocrystallography. CHINESE PHYSICS B[J]. 2010, 19(1): http://lib.cqvip.com/Qikan/Article/Detail?id=32672862.
[217] 高福. The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2010, 17(10): 1266-1268, http://dx.doi.org/10.1038/nsmb.1909.
[218] Liu, Jun, Wu, Peng, Gao, Feng, Qi, Jianxun, KawanaTachikawa, Ai, Xie, Jing, Vavricka, Christopher J, Iwamoto, Aikichi, Li, Taisheng, Gao, George F. Novel Immunodominant Peptide Presentation Strategy: a Featured HLA-A*2402-Restricted Cytotoxic T-Lymphocyte Epitope Stabilized by Intrachain Hydrogen Bonds from Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein. JOURNAL OF VIROLOGY[J]. 2010, 84(22): 11849-11857, http://www.corc.org.cn/handle/1471x/2413817.
[219] Liu, Jun, Sun, Yeping, Qi, Jianxun, Chu, Fuliang, Wu, Hao, Gao, Feng, Li, Taisheng, Yan, Jinghua, Gao, George F. The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Acts as a Dominant Immunogen Revealed by a Clustering Region of Novel Functionally and Structurally Defined Cytotoxic T-Lymphocyte Epitopes. JOURNAL OF INFECTIOUS DISEASES[J]. 2010, 202(8): 1171-1180, http://www.corc.org.cn/handle/1471x/2407379.
[220] Ju, Jiansong, Qi, Jianxun, Xu, Shujing, Ohnishi, Kouhei, Benedik, Michael J, Xue, Yanfen, Ma, Yanhe. Crystallization and preliminary X-ray study of alkaline alanine racemase from Bacillus pseudofirmus OF4. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2009, 65: 166-168, http://dx.doi.org/10.1107/S174430910900013X.
[221] Ju Jiansong, Qi Jianxun, Xu Shujing, Ohnishi Kouhei, Benedik Michael J, Xue Yanfen, Ma Yanhe. Crystallization and preliminary X-ray study of alkaline alanine racemase from Bacillus pseudofirmus OF4. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS[J]. 2009, 65(Pt 2): 166-168, http://ir.iphy.ac.cn/handle/311004/35438.
[222] Qian, Xiaomin, Qi, Jianxun, Chu, Fuliang, Liu, Jun, Li, Qing, Yan, Jinghua. Crystallization and preliminary X-ray analysis of the V domain of human nectin-2. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2009, 65: 615-617, https://www.webofscience.com/wos/woscc/full-record/WOS:000266452100019.
[223] Qian Xiaomin, Qi Jianxun, Chu Fuliang, Liu Jun, Li Qing, Yan Jinghua. Crystallization and preliminary X-ray analysis of the V domain of human nectin-2. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS[J]. 2009, 65(6): 615-617, http://ir.iphy.ac.cn/handle/311004/35437.
[224] 戴连攀, 周斌, 齐建勋, 马颖, 高福, 杨希才. 恒河猴MHC-I类分子Mamu-A^＊02与猴免疫缺陷病毒抗原表位复合物的纯化和晶体学分析. 生物工程学报[J]. 2009, 1028-1034, http://lib.cqvip.com/Qikan/Article/Detail?id=31187163.
[225] Chen Weihong, Chu Fuliang, Peng Hao, Zhang Jianhua, Qi Jianxun, Jiang Fan, Xia Chun, Gao Feng. Expression, purification, crystallization and preliminary X-ray diffraction analysis of grass carp beta(2)-microglobulin. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS[J]. 2008, 64: 200-202, http://ir.iphy.ac.cn/handle/311004/37838.
[226] Zhang Yueling, Gao Feng, Xue Yanfen, Zeng Yan, Peng Hao, Qi Jianxun, Ma Yanhe. Crystallization and preliminary X-ray study of native and selenomethionyl beta-1,4-mannanase AaManA from Alicyclobacillus acidocaldarius Tc-12-31. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS[J]. 2008, 64: 209-212, http://ir.iphy.ac.cn/handle/311004/35439.
[227] Zhang Jie, Gao Feng, Zhang Qianmin, Chen Qianying, Qi Jianxun, Yan Jinghua. Crystallization and crystallographic analysis of human NUDT16. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS[J]. 2008, 64(Pt 7): 639-640, http://www.irgrid.ac.cn/handle/1471x/757722.
[228] Zhang, Qiangmin, Gao, Feng, Qi, Jianxun, Cheng, Hao, Liu, Yiwei, Gao, George F. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase from Streptococcus suis serotype 2. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2008, 64: 997-999, http://dx.doi.org/10.1107/S1744309108028340.
[229] Zhang, Jie, Gao, Feng, Zhang, Qianmin, Chen, Qianying, Qi, Jianxun, Yan, Jinghua. Crystallization and crystallographic analysis of human NUDT16. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2008, 64: 639-640, https://www.webofscience.com/wos/woscc/full-record/WOS:000257249000018.
[230] Chen, Weihong, Chu, Fuliang, Peng, Hao, Zhang, Jianhua, Qi, Jianxun, Jiang, Fan, Xia, Chun, Gao, Feng. Expression, purification, crystallization and preliminary X-ray diffraction analysis of grass carp beta(2)-microglobulin. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2008, 64: 200-202, https://www.webofscience.com/wos/woscc/full-record/WOS:000253791100013.
[231] Zhang, Yueling, Gao, Feng, Xue, Yanfen, Zeng, Yan, Peng, Hao, Qi, Jianxun, Ma, Yanhe. Crystallization and preliminary X-ray study of native and selenomethionyl beta-1,4-mannanase AaManA from Alicyclobacillus acidocaldarius Tc-12-31. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2008, 64: 209-212, https://www.webofscience.com/wos/woscc/full-record/WOS:000253791100016.
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（ 1 ） H7N9等新型流感病毒跨种传播机制研究, 主持, 国家级, 2014-01--2016-12
（ 2 ） 寨卡病毒致病机制及其防控策略研究, 主持, 国家级, 2016-07--2017-06
（ 3 ） 病原与宿主互作的重要蛋白结构解析, 主持, 国家级, 2016-07--2020-12
（ 4 ） 基于配体-受体互作埃博拉病毒抑制剂的研究, 主持, 国家级, 2017-01--2020-12
（ 5 ） 非洲猪瘟病毒主要蛋白结构与功能研究, 主持, 国家级, 2020-01--2022-12
（ 6 ） 新型冠状病毒S蛋白识别受体分子机制研究, 主持, 省级, 2020-02--2020-08
（ 7 ） 病毒感染相关大分子信号识别的分子机制及阻断研究, 主持, 部委级, 2020-01--2024-12
（ 8 ） 肠具核梭杆菌和产毒性脆弱拟杆菌与宿主的关键蛋白 质机器结构、组成和功能及作用机制的解析, 参与, 国家级, 2020-11--2025-10
（ 9 ） 针对重要病原的免疫原设计, 主持, 国家级, 2021-11--2024-10
（ 10 ） 冠状病毒广谱抑制剂的开发及其对长效免疫记忆的影响, 主持, 国家级, 2022-01--2025-12

（1）冠状病毒入侵机制及抑制剂的阻断研究   冠状病毒国际前沿研究与创新论坛   2021-11-01
（2）新冠病毒入侵分子机制及阻断的结构生物学研究   第八届（重庆）生命前言技术与医药高峰论坛   2020-11-06
（3）SARS-CoV-2：structural insights of virus entry and blocking by MABs and inhibitors   2020-07-16
（4）Structural biology of Zika virus   2018-09-02
（5）Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy   2017-07-16

已指导学生

张艳芳  博士研究生  100103-病原生物学  

王晓敏  硕士研究生  077803-病原生物学  

张玉琴  硕士研究生  085238-生物工程  

现指导学生

陈雨露  博士研究生  100103-病原生物学  

丛龙飞  博士研究生  100103-病原生物学  

张曼玲  博士研究生  100103-病原生物学  

贾明珠  博士研究生  100103-病原生物学  

庞尔琪  硕士研究生  077803-病原生物学  

马超  博士研究生  100103-病原生物学  

廖焓伊  硕士研究生  077803-病原生物学  

张缯原  硕士研究生  077803-病原生物学  

孟玉敏  博士研究生  071010-生物化学与分子生物学  

李维维  硕士研究生  077803-病原生物学  

郭文静  硕士研究生  086000-生物与医药  

杨金月  硕士研究生  086000-生物与医药  

袁斌  博士研究生  100103-病原生物学  

燕浩飞  硕士研究生  077803-病原生物学  

郑婷婷  硕士研究生  077803-病原生物学  

张玉琴  博士研究生  100103-病原生物学  

杨金蕾  博士研究生  100103-病原生物学