基本信息

2005年毕业于东北林业大学,获生物技术专业学士学位。2011年毕业于北京大学,获细胞生物学专业博士学位。2011年至2016年先后在美国约翰霍普金斯大学 (The Johns Hopkins University) 和纪念斯隆凯特琳癌症研究所 (Memorial Solan Kerttering Cancer Center) 接受博士后训练,从事肿瘤生物学研究。20168月受聘于中科院分子细胞科学卓越创新中心(原中科院上海生物化学与细胞生物学研究所),任研究员,研究组长,博士生导师。获得国家杰出青年科学基金,中组部“国家高层次人才”青年项目,中科院创新交叉团队,上海市优秀青年学术带头人等项目的支持


研究领域

成体干细胞、类器官与组织重建、前列腺癌、胰腺癌、细胞可塑性与肿瘤的抗药性、肿瘤类器官模型库。


招生信息

2018年计划招收1名硕博连读研究生,欢迎有志于从事成体干细胞和肿瘤研究的学生报考本实验室。

招生专业
071009-细胞生物学
招生方向
类器官模型与肿瘤的靶向治疗
肿瘤细胞抗药性机理

教育背景

2006-09--2011-07   北京大学   理学博士
2001-09--2005-07   东北林业大学   理学学士

指导学生

已指导学生

热比古丽·阿吉  硕士研究生  071009-细胞生物学  

郭旺昕  博士研究生  071009-细胞生物学  

李飞  博士研究生  071009-细胞生物学  

现指导学生

韩铭  博士研究生  071009-细胞生物学  

何娟  博士研究生  071009-细胞生物学  

夏欣祎  博士研究生  071009-细胞生物学  

刘壮  博士研究生  071009-细胞生物学  

张晓雨  博士研究生  071009-细胞生物学  

王健  硕士研究生  071010-生物化学与分子生物学  

张晔晗  硕士研究生  071010-生物化学与分子生物学  

戴鹏飞  博士研究生  071009-细胞生物学  

韩甜甜  硕士研究生  071009-细胞生物学  

石惠莉  硕士研究生  077802-免疫学  

论文

1.       Wang YQ, Zhang LP, Liu Y, Tang LL, He J, Sun XQ, Younis MH, Cui DX, Xiao HH, Gao D*, Kong XY*, Cai WB*, Song J*. Engineering CpG-ASO-Pt-loaded Macrophages (CAP@M) For Synergistic Chemo-/Gene-/Immuno-Therapy. Adv Healthc Mater. 2022 Jun 6:e2201178.

2.       Wang WW#, Yuan TG#,  Ma LL#, Zhu YJ#, Bao JX, Zhao XF, Zhao Y, Zong YL, Zhang YN, Yang S, Qiu XY, Shen SY, Wu R, Wu T, Wang HY*, Gao D*, Wang P*, Chen L*. Hepatobiliary tumor organoids reveal HLA I neoantigen landscape and antitumoral activity of neoantigen peptide enhanced with ICIs. Adv Sci (Weinh). 2022 Jun 5;e2105810.

3.       Tang FY#, Xu D#, Wang SQ#, Wong CK#, Fundichely AM, Lee CJ, Cohen S, Park J, Hill CE, Eng K, Bareja R, Han T, Liu EM, Palladino A, Di W, Gao D, Abida W, Beg S, Puca L, Meneses M, Stanchina E, Berger MF, Gopalan A, Dow L,  Mosquera JM, Beltran H, Sternberg CN, Chi P, Scher HI, Sboner A, Chen Y*, Ekta Khurana E*. Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targe. Science. 2022 May 27;376(6596):eabe1505.

4.       Shi XH#, Li YG#, Yuan QY#, Tang SJ#, Guo SW#, Zhang YH, He J, Zhang XY, Han M, Liu Z, Zhu YQ, Gao SZ, Wang H, Xu XF, Zheng KL, Jing W, Chen LN*, Wang Y*, Jin G*, Gao D*. Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility to drug sensitivity networks. Nat Commun. 2022 Apr 21;13(1):2169.

5.       Gu YQ#, Cao J#, Zhang XY#, Gao H#, Wang YY#, Wang J#, He J#, Jiang XY#, Zhang JL, Shen GH, Yang J, Zheng XC, Hu GW, Zhu YF, Du SJ, Zhu YK, Zhang R, Xu JQ, Zhang CC, Lan F, Qu D, Xu GL, Zhao Y*, Gao D*, Xie YH*, Luo M*, Lu ZG*. Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2. Cell Res. 2022 Jan;32(1):24-37.

6.       Fu X#, He Q#, Tao Y#, Wang DM#, Wang W#, Wang YL#, Yu QC#, Zhang F#, Zhang XY#, Chen YG*, Gao D*, Hu P*, Hui LJ*, Wang XQ*, Zeng YA*. Recent advances in tissue stem cells. Sci China Life Sci. 2021 Dec;64(12):1998-2029.

7.       Jiang YA#, Peng JY#, Song JW, Jiang M, Wang J, Ma LY, Wang YA, Zhang Z, Wu HL, Gao D, Zhao Y*. Loss of Hilnc prevents the development of diet-induced hepatic steatosis through IGF2BP2. Nat Metab. 2021 Nov;3(11):1569-1584.

8.       Zhao Y#, Li ZX#, Zhu YJ#, Fu J#, Zhao XF, Zhang YN, Wang S, Wu JM, Wang KT, Wu R, Sui CJ, Shen SY, Wu X, Wang HY*, Gao D*, Chen L*. Single cell transcriptome analysis uncovers intra-tumoral heterogeneity and underlying mechanisms for drug resistance in hepatobiliary tumor organoids. Adv Sci (Weinh). 2021 Jun;8(11):e2003897.

9.       Li F#, Han M#, Dai PF#, Xu W#, He J#, Tao XT#, Wu Y#, Tong XY, Xia XY, Guo WX, Zhou YJ, Li YG, Zhu YQ, Zhang XY, Liu Z, Aji R, Cai X, Li YT, Qu D, Chen Y, Jiang SB, Wang Q, Ji HB, Xie YH*, Sun YH*, Lu L*, Gao D*. Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide. Nat Commun. 2021 Feb 8;12(1):866. 

10.   Dhimolea E*, de Matos Simoes R, Kansara D, Al'Khafaji A, Bouyssou J, Weng X, Sharma S, Raja J, Awate P, Shirasaki R, Tang H, Glassner BJ, Liu ZY, Gao D, Bryan J, Bender S, Roth J, Scheffer M, Jeselsohn R, Gray NS, Georgakoudi I, Vazquez F, Tsherniak A, Chen Y, Welm A, Duy C, Melnick A, Bartholdy B, Brown M, Culhane AC, Mitsiades CS*. An embryonic diapause-like state with suppressed Myc activity enables tumor treatment persistence. Cancer Cell. 2021 Feb 8;39(2):240-256.e11.

11.   Li F#, Yuan QY#, Di W#, Xia XY#, Liu Z, Mao NH, Li L, Li CF, He J, Li YG, Guo WX, Zhang XY, Zhu YQ, Aji R, Wang SQ, Chi P, Carver B, Wang Y*, Chen Y*, Gao D*. ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming. J Clin Invest. 2020 Nov 2;130(11):5924-5941.

12.   Guo WX#, Li L#, He J, Liu Z, Han M, Li F, Xia XY, Zhang XY, Zhu Y, Wei Y, Li YG, Aji R, Dai H, Wei H, Li CF, Chen Y*, Chen LN*, Gao D*. Single-cell transcriptomics identifies a distinct luminal progenitor cell type in distal prostate invagination tips.  Nat Genet. 2020 Sep;52(9):908-918.

13.   He J, Zhang X, Xia XY, Han M, Li F, Li CF, Li YG, Gao D*. Organoid technology for tissue engineering. J Mol Cell Biol. 2020 Aug 1;12(8):569-579. (Invited review)

14.   Tang J#, Wang HX#, Huang XZ#, Li F#, Zhu H, Li Y, He LJ, Zhang H, Pu WJ, Liu K, Zhao H, Bentzon JF, Yu Y, Ji Y, Nie Y, Zhang L*, Gao D*, Zhou B*. Sca1+ Vascular Stem Cells Contribute to Smooth Muscle for Artery Repair and Regeneration. Cell Stem Cell. 2020 Jan 2;26(1):81-96.

15.   Xia XY, Li F, He J, Aji R, Gao D*. Organoid technology in cancer precision medicine. Cancer Lett. 2019 Aug 10;457:20-27. (Invited review)

16.   Ding YF#, Li N#, Dong BJ#, Guo WX, Wei H, Chen QL, Yuan HR, Han Y, Chang HW, Kan S, Wang XG, Pan Q, Wu P, Peng C, Qiu T, Li QT, Gao D*, Xue W*, Qin J*. Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer. J Clin Invest. 2019 Feb 1;129(2):759-773.

17.   Zhang K#, Zhang L#,*, Liu W#, Ma X, Cen J, Sun Z, Wang C, Feng S, Zhang Z, Yue L, Sun L, Zhu Z, Chen X, Feng A, Wu J, Jiang Z, Li P, Cheng X, Gao D, Peng L*, Hui L*. In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity. Cell Stem Cell. 2018 Dec 6;23(6):806-819.e4.

18.   Kim SM, Nguyen TT, Ravi A, Kubiniok P, Finicle BT, Jayashankar V, Malacrida L, Hou J, Robertson J, Gao D, Chernoff J, Digman MA, Potma EO, Tromberg BJ, Thibault P, Edinger AL*. PTEN deficiency and AMPK activation promote nutrient scavenging and anabolism in prostate cancer cells. Cancer Discovery. 2018 Jul;8(7):866-883.

19.   Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Andrew J. Aguirre AJ, Viswanathan SR, Tamayo P, Yang WS, Rees MG, Chen SX, Boskovic ZV, Javaid S, Huang C, Wu XY, Tseng YY, Roider EM, Gao D, Cleary JM, Wolpin BM, Mesirov JP, Daniel A. Haber DA, Engelman JA, Boehm JS, Kotz JD, Hon CS, Chen Y, Hahn WC, Levesque MP, Doench JG, Berens ME, Shamji AF, Clemons PA, Stockwell BR & Schreiber SL*. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. 2017 Jul 27;547(7664):453-457.

20.   Wang SQ, Gao D, Chen Y*. The potential of organoids in urological cancer research. Nature Rev Urol. 2017 Jul;14(7):401-414. (Invited review)

21.   Blattner M, Liu D, Robinson BD, Huang D, Poliakov A, Gao D, Nataraj S, Deonarine LD, Augello MA, Sailer V, Ponnala L, Ittmann M, Chinnaiyan AM, Sboner A, Chen Y, Rubin MA*, Barbieri CE*. SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling. Cancer Cell. 2017 Mar 13;31(3):436-451.

22.   Mu P, Zhang Z, Benelli M, Karthaus WR, Hoover E, Chen CC, Wongvipat J, Ku SY, Gao D, Cao Z, Shah N, Adams EJ, Abida W, Watson PA, Prandi D, Huang CH, de Stanchina E, Lowe SW, Ellis L, Beltran H, Rubin MA, Goodrich DW, Demichelis F, Sawyers CL*. SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer. Science. 2017 Jan 6;355(6320):84-88.

23.   Dardenne E#, Beltran H#, Benelli M, Gayvert K, Berger A, Puca L, Cyrta J, Sboner A, Noorzad Z, MacDonald T, Cheung C, Gao D, Chen Y, Eilers M, Mosquera JM, Robinson BD, Elemento O, Rubin MA, Francesca Demichelis F and Rickman DS*. N-Myc induces an EZH2-mediated transcriptional program driving neuroendocrine prostate cancer. Cancer Cell. 2016 Oct; 30:563-577.

24.   Drost J#, Karthaus WR#, Gao D, Driehuis E, Sawyers CL, Chen Y and Clevers H*. Organoid culture systems for prostate epithelial tissue and prostate cancer tissue. Nat Protoc. 2016 Feb;11(2):347-58.

25.   Wiesner T, Lee W, Obenauf A, Ran L, Murali R, Zhang Q, Wong E, Hu W, Sasinya S,  Shah R, Scott S, Sboner A, Button J, Landa I, Gao D, Cao Z, Shukla S, , Merghoub T, Schwartz G, Wang L, Ladanyi M, Fagin J, Hollmann T, Busam K, BergerM , Chen Y* and Chi P*. Alternative transcription initiation leads to expression of a novel ALK isoform in cancer. Nature. 2015 Oct 15;526(7573):453-7.

26.   Ran LL, Sirota I, Cao Z, Murphy D, Chen YD, Shukla S, Xie YY, Gao D, Zhu S, Rossi F, Wongvipat J, Taguchi T, Tap WD, Mellinghoff IK, Besmer P, Antonescu CR, Chen Y* and Chi P*. Combined inhibition of MAP kinase and KIT signaling pathways destabilizes the ETV1 protein and synergistically suppress GIST tumorigenesis. Cancer Discovery. 2015 Mar;5(3):304-15.

27.   Gao D and Chen Y*. Organoid Development in Cancer Genome Discovery. Curr Opin Genet Dev. 2015 Mar 18; 30:42-48. (Invited Cover Review) 

28.   Gao D#, Vela I#, Sboner A#, Iaquinta PJ#, Karthaus WL, Gopalan A, Wanjala JN, Dowling C, Undvall EA, Wongvipat J, Kossai M, Barboza LP, Di W, Cao Z, Zhang QF, Sirota I, Ran Ll, Solomon SB, MacDonald TY, Beltran H, Mosquera J,  Eastham JA, Touijer KA, Scardino PT, Laudone VP, Rathkopf DE, Morris MJ, Danila DC, Slovin SF, Chi P, Clevers H, Carver B, Rubin MA, Scher HI, Sawyers CL*, Chen Y*. Generation of in vitro organoids cultures derived from patients with advanced prostate cancer. Cell. 2014 Sep;159(1): 176-187.  

29.   Karthaus WR, Iaquinta PJ, Drost J, Gracanin A, Wongvipat J, Gao D, Befthel H, Sachs N, Vries RG.J, Cuppen E, Chen Y, Sawyers CL and Clevers H*. Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Cell. 2014 Sep; 159: 163-175.  

30.   Chen Y*, Chi P, Rockowitz S, Iaquinta P.J, Shamu T, Shukla S, Gao D, Sirota I, Carver B.S, Wongvipat J, Scher H.I, Zheng D, Sawyers CL*.  ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss. Nat Med. 2013 Aug; 19(8):1023-9. 11.