以海洋生物资源为基础，深入开展海洋生物资源特别是糖类化合物的基础及应用基础研究，解决海洋糖类化合物创新药物与生物制品研究中的理论与技术问题，研究开发防治疾病的创新药物、功能食品及新型海洋生物制品，实现海洋生物资源的高值化利用。

   

070703-海洋生物学

海洋药物与制品
海洋天然产物及生物制品

2005-09--2010-06   中国科学院海洋研究所   博士
2001-09--2005-06   内蒙古大学   学士

   

2016-09~2017-09,美国加州大学戴维斯分校, 访问学者
2013-01~现在, 中国科学院海洋研究所, 副研究员
2010-09~2012-12,中国科学院海洋研究所, 助理研究员

2019-06-01-2023-06-01,中国分子生物学会糖复合物专业委员会青年工作委员会, 委员

   

（1） 海洋科学技术奖二等奖, 二等奖, 其他, 2019
（2） 中国科学院2016年度青年创新促进会会员, 院级, 2016
（3） 海昆肾喜胶囊的开发与应用, 二等奖, 省级, 2016
（4） 山东省科技进步二等奖, 二等奖, 省级, 2015
（5） 中国科学院沈阳分院第四届优秀青年科技人才奖, 院级, 2014

[1] 王晶. 一种从含珍珠岩的红藻渣中提取可溶性膳食纤维的方法. 202310510338.0, 2023-05-08.
[2] 王晶, 吴雨萌, 张全斌. 一种褐藻胶寡糖衍生物的应用. 202211493499.5, 2022-11-26.
[3] 王晶, 吴雨萌, 张全斌, 吴宁, 耿丽华, 岳洋. 抗光老化卡拉胶衍生物水凝胶及应用. 202210828395.9, 2022-07-13.
[4] 王晶, 刘阳, 张全斌, 耿丽华, 岳洋, 吴宁. 一种硫酸化甘露葡萄糖醛酸水凝胶的制备及应用. CN113354836A, 2021-09-07.
[5] 王晶, 刘阳, 张全斌, 耿丽华, 岳洋, 吴宁. 一种半乳岩藻聚糖硫酸酯水凝胶制备方法和应用. CN113307988A, 2021-08-27.
[6] 张全斌, 鞠豪, 耿丽华, 岳洋, 王晶. 一种高品质琼脂糖的制备方法. CN: CN110698573B, 2021-07-30.
[7] 王晶, 王晓晴, 张全斌, 刘婧, 吴宁, 耿丽华, 岳洋. 一种紫菜寡糖的制备方法及其在鱼饲料中的应用. CN: CN113045683A, 2021-06-29.
[8] 张全斌, 王清池, 孙超岷, 王晶, 吴宁, 岳洋, 耿丽华. 一种海洋盐单胞菌胞外多糖在制备免疫增强剂中的应用. CN: CN112458128A, 2021-03-09.
[9] 张全斌, 耿丽华, 王晶, 岳洋, 吴宁, 张虹. 葡萄糖醛酸甘露寡糖的关键二糖重复单元及其制备方法. CN: CN112266398A, 2021-01-26.
[10] 王晶, 王晓晴, 张全斌, 耿丽华, 岳洋, 吴宁. 一种紫菜提取物的制备方法及在水产养殖中的应用. CN: CN111919965A, 2020-11-13.
[11] 岳洋, 张全斌, 王晶, 牛锡珍, 耿丽华. 海蟑螂有机溶剂提取物的应用及组合物. CN: CN111714519A, 2020-09-29.
[12] 张全斌, 邓真真, 王晶, 吴宁, 岳洋, 耿丽华. 一种褐藻膳食纤维在制备治疗或预防代谢综合症的药品、食品和/或保健品中的应用. CN: CN111671765A, 2020-09-18.
[13] 张全斌, 谭姣姣, 乔寿阁, 王晶, 岳洋, 耿丽华. 一种褐藻多糖硫酸酯胶囊剂的制备方法及其应用. CN: CN110833535A, 2020-02-25.
[14] 王晶, 张全斌, 耿丽华, 岳洋, 张虹, 吴宁. 一种用于创伤修复的有机-无机杂化敷料及其制备方法和应用. CN: CN110507847A, 2019-11-29.
[15] 王晶, 张全斌, 耿丽华, 岳洋, 张虹, 吴宁. 一种用于创伤修复的多糖敷料及其制备方法和应用. CN: CN110404106A, 2019-11-05.
[16] 张全斌, 刘英娟, 耿丽华, 王晶, 张齐, 岳洋. 硫酸化半乳寡糖的应用及药物组合物. CN: CN108210504A, 2018-06-29.
[17] 王晶, 张全斌, 张虹, 牛锡珍. 一种制备岩藻黄素顺式异构体的方法. CN: CN108047167A, 2018-05-18.
[18] 张全斌, 谭姣姣, 王晶, 岳洋, 张虹, 牛锡珍. 一种褐藻多糖硫酸酯胶囊的制备方法. CN: CN108014086A, 2018-05-11.
[19] 张全斌, 耿丽华, 王晶, 岳洋, 张虹, 牛锡珍. 一种低硫酸化岩藻半乳聚糖在制备免疫增强剂中的应用. CN: CN107987179A, 2018-05-04.
[20] 张全斌, 王晓龙, 王晶, 金维华. 一种低凝固温度琼脂糖的制备方法. CN: CN105542035B, 2018-02-23.
[21] 王晶, 张全斌, 张虹, 金维华, 牛锡珍. 一种低粘度褐藻胶的应用. CN: CN106139816A, 2016-11-23.
[22] 王晶, 张全斌, 张虹, 牛锡珍. 一种高硫酸化的海藻多糖在晒后修复面膜中的应用. CN: CN106038355A, 2016-10-26.
[23] 张全斌, 张文静, 金维华, 王晶. 一种褐藻多糖硫酸酯的降解方法. CN: CN105131147A, 2015-12-09.
[24] 张全斌, 金维华, 王晶, 耿丽华, 张文静. 甘露葡萄糖醛酸寡糖及衍生物在制备治疗和/或预防肾病药物或保健品中的应用. CN: CN105125566A, 2015-12-09.
[25] 张全斌, 张文静, 金维华, 王晶. 一种褐藻多糖硫酸酯的质量分析方法. CN: CN104280490A, 2015-01-14.
[26] 张全斌, 张文静, 金维华, 王晶. 一种葡聚糖的应用. CN: CN103919800A, 2014-07-16.
[27] 张全斌, 张文静, 王晶, 金维华. 一种海盘车多糖的应用. CN: CN103919801A, 2014-07-16.
[28] 张全斌, 王晶, 牛锡珍, 张虹. 一种从鲜海带漂烫废水中提取褐藻多糖硫酸酯的方法. CN: CN103923223A, 2014-07-16.
[29] 张全斌, 金维华, 张文静, 王晶. 甘露葡萄糖醛酸寡糖在制备治疗或预防帕金森病和/或老年痴呆药物和/或保健品中的应用. CN: CN103800348A, 2014-05-21.
[30] 张全斌, 王晶, 张虹, 牛锡珍. 一种松藻多糖的应用. CN: CN103622990A, 2014-03-12.
[31] 王晶, 张全斌, 张虹, 牛锡珍. 一种羽藻多糖的应用. CN: CN103610690A, 2014-03-05.
[32] 张全斌, 金维华, 王晶, 牛锡珍, 张虹. 褐藻来源的富含葡萄糖醛酸的低硫酸化杂聚糖在制备治疗帕金森病药物和保健品中的应用. CN: CN103539863A, 2014-01-29.
[33] 张全斌, 金维华, 符大勇, 王晶, 张虹, 牛锡珍. 甲基化岩藻寡糖或甲基化硫酸酯化岩藻寡糖或其盐及制备和应用. CN: CN103374079A, 2013-10-30.
[34] 张全斌, 侯赟, 王晶, 张文静, 金维华, 张虹, 牛锡珍. 紫菜寡糖在紫菜病害防治中的应用. CN: CN103168784A, 2013-06-26.
[35] 张全斌, 侯赟, 王晶, 金维华, 张虹, 牛锡珍. 紫菜多糖在制备肾脏疾病治疗药物或预防保健品中的应用. CN: CN102319256A, 2012-01-18.
[36] 张全斌, 王晶, 张忠山, 张虹, 牛锡珍. 一种岩藻半乳聚糖硫酸酯及其提取分离纯化方法与应用. CN: CN102234336A, 2011-11-09.
[37] 张全斌, 张忠山, 王晶, 宋厚芳, 张虹, 牛锡珍. 一种半乳聚糖硫酸酯5-氟尿嘧啶复合物及其制备和应用. CN: CN102028952A, 2011-04-27.

   

[1] Xiaoqing Wang, Wang Jing. Characterization, functional properties and antioxidant activities of macromolecular extracts isolate from Porphyra yezoensis. Journal of Oceanology and Limnology[J]. 2022, 40(1): 278-283, [2] Xiaoqing Wang, Jing Liu, Lihua Geng, Yang Yue, Ning Wu, Quanbin Zhang, Jing Wang. Effects of Pyropia yezoensis enzymatic hydrolysate on the growth and immune regulation of the zebrafish. Fish and Shellfish Immunology[J]. 2022, 122: 21-28, [3] Wang, Xiaoqing, Wei, Maosheng, Wang, Jing, Liu, Jing, Zhang, Quanbin. Effects of oligo-porphyran on immunological parameters related to immunoregulation and growth in RAW264.7 macrophages and zebrafish model. AQUACULTURE INTERNATIONAL[J]. 2022, [4] Yang Liu, Ning Wu, Lihua Geng, Yang Yue, Quanbin Zhang, Jing Wang. Fabrication of Sulfated Heterosaccharide/Poly (Vinyl Alcohol) Hydrogel Nanocomposite for Application asWound Healing Dressing. Moleculars[J]. 2022, 27: 1801-1814, [5] Wu, Ning, Li, Zhi, Wang, Jing, Geng, Lihua, Yue, Yang, Deng, Zhenzhen, Wang, Qingchi, Zhang, Quanbin. Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition. CARBOHYDRATE POLYMERS[J]. 2021, 273: http://dx.doi.org/10.1016/j.carbpol.2021.118567.
[6] Wang, QingChi, Wei, Maosheng, Yue, Yang, Wu, Ning, Wang, Jing, Zhang, Quanbin. Structural characterization and immunostimulatory activity in vitro of a glycogen from sea urchin-Strongylocentyotus internedius. CARBOHYDRATE POLYMERS[J]. 2021, 258: http://dx.doi.org/10.1016/j.carbpol.2021.117701.
[7] Wang, QingChi, Wei, Maosheng, Zhang, Jingjing, Yue, Yang, Wu, Ning, Geng, Lihua, Sun, Chaomin, Zhang, Quanbin, Wang, Jing. Structural characteristics and immune-enhancing activity of an extracellular polysaccharide produced by marine Halomonas sp. 2E1. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2021, 183: 1660-1668, http://dx.doi.org/10.1016/j.ijbiomac.2021.05.143.
[8] Deng, Zhenzhen, Wu, Ning, Wang, Jing, Zhang, Quanbin. Dietary fibers extracted from Saccharina japonica can improve metabolic syndrome and ameliorate gut microbiota dysbiosis induced by high fat diet. JOURNAL OF FUNCTIONAL FOODS[J]. 2021, 85: http://dx.doi.org/10.1016/j.jff.2021.104642.
[9] Yingjuan Liu, Weihua Jin, Zhenzhen Deng, Quanbin Zhang, Jing Wang. Glucuronomannan GM2 from Saccharina japonica Enhanced Mitochondrial Function and Autophagy in a Parkinson’s Model. MARINE DRUGS[J]. 2021, 19(58): https://doaj.org/article/eca3128fa85e4a849cc81891b8f5fc69.
[10] Liu, Huaide, Wang, Jing, Zhang, Quanbin, Geng, Lihua, Yang, Yue, Wu, Ning. Protective Effect of Fucoidan against MPP+-Induced SH-SY5Y Cells Apoptosis by Affecting the PI3K/Akt Pathway. MARINE DRUGS[J]. 2020, 18(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000551180900005.
[11] Wang, Jing, Zhang, Quanbin, Li, Shuang, Chen, Zhihang, Tan, Jiaojiao, Yao, Jianting, Duan, Delin. Low molecular weight fucoidan alleviates diabetic nephropathy by binding fibronectin and inhibiting ECM-receptor interaction in human renal mesangial cells. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2020, 150: 304-314, http://dx.doi.org/10.1016/j.ijbiomac.2020.02.087.
[12] Tan, Jiaojiao, Wang, Jing, Geng, Lihua, Yue, Yang, Wu, Ning, Zhang, Quanbin. Comparative Study of Fucoidan from Saccharina japonica and Its Depolymerized Fragment on Adriamycin-Induced Nephrotic Syndrome in Rats. MARINE DRUGS[J]. 2020, 18(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000524256300015.
[13] Li, Xiaosong, Wu, Ning, Chen, Yongqiang, Tan, Jiaojiao, Wang, Jing, Geng, Lihua, Qin, Yimin, Zhang, Quanbin. Degradation of different molecular weight fucoidans and their inhibition of TGF-beta 1 induced epithelial-mesenchymal transition in mouse renal tubular epithelial cells. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2020, 151: 545-553, https://www.webofscience.com/wos/woscc/full-record/WOS:000528267400056.
[14] Liu, Yingjuan, Jin, Weihua, Deng, Zhenzhen, Wang, Jing, Zhang, Quanbin. Preparation and Neuroprotective Activity of Glucuronomannan Oligosaccharides in an MPTP-Induced Parkinson's Model. MARINE DRUGS[J]. 2020, 18(9): https://doaj.org/article/e40e51691f83414bb0e3aedb2e1a74e3.
[15] 刘淮德, 徐文飞, 王菲菲, 王晶. 岩藻聚糖硫酸酯降解酶产生菌的筛选鉴定及酶学特性研究. 安徽农业科学[J]. 2020, 48(23): 16-20, http://lib.cqvip.com/Qikan/Article/Detail?id=7103428296.
[16] Li, Zhi, Wu, Ning, Wang, Jing, Zhang, Quanbin. Roles of Endovascular Calyx Related Enzymes in Endothelial Dysfunction and Diabetic Vascular Complications. FRONTIERS IN PHARMACOLOGY[J]. 2020, 11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734331/.
[17] Wang, Jing, Geng, Lihua, Yue, Yang, Zhang, Quanbin, Zhang, L. Use of fucoidan to treat renal diseases: A review of 15 years of clinic studies. GLYCANS AND GLYCOSAMINOGLYCANS AS CLINICAL BIOMARKERS AND THERAPEUTICS, PT B[J]. 2019, 163: 95-111, http://ir.qdio.ac.cn/handle/337002/162810, http://www.irgrid.ac.cn/handle/1471x/6861239, http://ir.qdio.ac.cn/handle/337002/162811, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000486145100007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[18] Li, Yanhong, Li, Riyao, Yu, Hai, Sheng, Xue, Wang, Jing, Fisher, Andrew J, Chen, Xi. Enterococcus faecalis alpha 1-2-mannosidase (EfMan-I): an efficient catalyst for glycoprotein N-glycan modification. FEBS LETTERS[J]. 2019, http://ir.qdio.ac.cn/handle/337002/163348, http://www.irgrid.ac.cn/handle/1471x/6861258, http://ir.qdio.ac.cn/handle/337002/163349, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000489181900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[19] Geng, Lihua, Wang, Jing, Zhang, Zhongshan, Yue, Yang, Zhang, Quanbin. Structure and Bioactivities of Porphyrans and Oligoporphyrans. CURRENT PHARMACEUTICAL DESIGNnull. 2019, 25(11): 1163-1171, [20] Yue, Yang, Zhang, Quanbin, Wang, Jing. Integrated Gas Chromatograph-Mass Spectrometry (GC/MS) and MS/MS-Based Molecular Networking Reveals the Analgesic and Anti-Inflammatory Phenotypes of the Sea Slater Ligia exotica. MARINE DRUGS[J]. 2019, 17(7): https://doaj.org/article/3a73860801b64b349ab70e46c5eba246.
[21] Liu, YingJuan, Deng, Zhenzhen, Geng, Lihua, Wang, Jing, Zhang, Quanbin. In vitro evaluation of the neuroprotective effect of oligo-porphyran from Porphyra yezoensis in PC12 cells. JOURNAL OF APPLIED PHYCOLOGY[J]. 2019, 31(4): 2559-2571, [22] Geng, Lihua, Hu, Weicheng, Liu, Yingjuan, Wang, Jing, Zhang, Quanbin. A heteropolysaccharide from Saccharina japonica with immunomodulatory effect on RAW 264.7 cells. CARBOHYDRATE POLYMERS[J]. 2018, 201: 557-565, http://dx.doi.org/10.1016/j.carbpol.2018.08.096.
[23] Liu, Yingjuan, Geng, Lihua, Zhang, Jingjing, Wang, Jing, Zhang, Qi, Duan, Delin, Zhang, Quanbin. Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway. MARINE DRUGS[J]. 2018, 16(3): https://doaj.org/article/9c6c3b1fe8c44b5db6b9e7aff00a160e.
[24] Liu, Huaide, Wang, Jing, Zhang, Quanbin, Zhang, Hong. The effect of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activity. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2018, 113: 82-89, http://dx.doi.org/10.1016/j.ijbiomac.2018.02.109.
[25] Geng, Lihua, Zhang, Quanbin, Wang, Jing, Jin, Weihua, Zhao, Tingting, Hu, Weicheng. Glucofucogalactan, a heterogeneous low-sulfated polysaccharide from Saccharina japonica and its bioactivity. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2018, 113: 90-97, http://dx.doi.org/10.1016/j.ijbiomac.2018.02.008.
[26] Deng, Zhenzhen, Liu, Yingjuan, Wang, Jing, Wu, Suhuang, Geng, Lihua, Sui, Zhenghong, Zhang, Quanbin. Antihypertensive Effects of Two Novel Angiotensin I-Converting Enzyme (ACE) Inhibitory Peptides from Gracilariopsis lemaneiformis (Rhodophyta) in Spontaneously Hypertensive Rats (SHRs). MARINE DRUGS[J]. 2018, 16(9): https://doaj.org/article/d85543abf66f44ca97016789859967a8.
[27] Geng, Lihua, Hou, Ningning, Zhang, Meng, Xu, Yingjie, Zhang, Qi, Wang, Jing, Zhang, Lijuan, Zhang, Quanbin. Comparative study of the effect of different fucoidans from Sargassum maclurei and Saccharina japonica on FGFs/FGFR signaling activation in BaF3 cells. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2018, 107: 2429-2435, http://dx.doi.org/10.1016/j.ijbiomac.2017.10.122.
[28] Wang, Jing, Hou, Yun, Duan, Delin, Zhang, Quanbin. The Structure and Nephroprotective Activity of Oligo-Porphyran on Glycerol-Induced Acute Renal Failure in Rats. MARINE DRUGS[J]. 2017, 15(5): http://ir.qdio.ac.cn/handle/337002/137134.
[29] 王晶, 张全斌. 褐藻多糖硫酸酯的结构与生物活性研究. 海洋科学集刊[J]. 2017, 68-89, http://lib.cqvip.com/Qikan/Article/Detail?id=WD728975747475504849554849484855.
[30] 张齐, 王晶, 潭姣姣, 张全斌, 秦浩然. 低硫酸化杂多糖水解单糖高效液相色谱指纹图谱研究. 海洋科学[J]. 2017, 41(12): 96-103, http://lib.cqvip.com/Qikan/Article/Detail?id=7000611056.
[31] 侯宁宁, 王晶, 张全斌. 莫氏马尾藻多糖的分离及理化性质评价. 海洋科学[J]. 2017, 41(9): 102-109, http://lib.cqvip.com/Qikan/Article/Detail?id=7000480781.
[32] Li, Xinpeng, Wang, Jing, Zhang, Hong, Zhang, Quanbin. Renoprotective effect of low-molecular-weight sulfated polysaccharide from the seaweed Laminaria japonica on glycerol-induced acute kidney injury in rats. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2017, 95: 132-137, http://dx.doi.org/10.1016/j.ijbiomac.2016.11.051.
[33] Wang, Jing, Liu, Huaide, Zhang, Xuan, Li, Xinpeng, Geng, Lihua, Zhang, Hong, Zhang, Quanbin. Sulfated Hetero-Polysaccharides Protect SH-SY5Y Cells from H2O2-Induced Apoptosis by Affecting the PI3K/Akt Signaling Pathway. MARINE DRUGS[J]. 2017, 15(4): http://ir.qdio.ac.cn/handle/337002/137144.
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（1） Progress in molecular biology and translational scienceof clinic studies chapter six, elsevier, 2019-04, 第 1 作者

   

（ 1 ） 海带硫酸杂聚糖(UF)通过PI3K/Akt信号通路抑制多巴胺神经元凋亡的分子机制, 主持, 国家级, 2015-01--2017-12
（ 2 ） 辅助降血糖海藻多糖功能食品的研究开发, 主持, 省级, 2014-09--2016-08
（ 3 ） 中国科学院青年创新促进会, 主持, 部委级, 2016-01--2019-12
（ 4 ） 抗帕金森病海洋候选新药褐藻硫酸杂聚糖UF的研究, 主持, 省级, 2016-01--2017-12
（ 5 ） 紫菜功能性休闲食品的制备技术与应用, 主持, 省级, 2017-08--2020-07
（ 6 ） 褐藻多糖硫酸酯提取纯化工艺研究开发, 主持, 院级, 2018-06--2019-12
（ 7 ） 滩涂紫菜循环利用技术, 主持, 国家级, 2019-11--2022-12

现指导学生

王晓晴  硕士研究生  085238-生物工程  

吴雨萌  硕士研究生  086000-生物与医药