071006-神经生物学
071010-生物化学与分子生物学

认知障碍等相关脑疾病的分子机制，神经退行性疾病的机制和干预研究
线粒体稳态失衡与神经退行性疾病
蛋白质稳态与疾病

2003-12--2009-06   美国德克萨斯大学西南医学中心生理系   博士后研究员
1998-09--2003-07   中国科学院生物物理研究所生物大分子国家重点实验室   理学博士
1992-09--1996-06   北京师范大学生物系生物化学专业   理学学士

生物化学与分子生物学实验Ⅱ
生物化学与分子生物学实验（酶学）
生物化学与分子生物学实验

   

（1） 2022年度《生物化学与生物物理进展》优秀编委, 其他, 2022
（2） 2022年度北京市科学技术奖科学自然科学奖, 二等奖, 省级, 2022
（3） 美国Dystonia医学研究基金会博士后研究基金, , 专项, 2006
（4） 中国科学院冠名奖“刘永龄奖学金”, 二等奖, 院级, 2001
（5） 北京地区高等学校优秀毕业生, , 省级, 1996
（6） 北京市三好学生, , 省级, 1994

[1] 朱笠, 刘江红. TDP-43蛋白病诊断和治疗的新靶点. CN: CN111349697B, 2022-08-23.

[2] 孔瑞瑞, 朱笠, 刘江红. Myosin9b蛋白特异性抗体的制备及Myosin9b基因家族变化在肿瘤诊断及预后中的应用. CN: CN105331686A, 2016-02-17.

   

[1] Ma, Jinfa, Liu, Lei, Song, Lu, Liu, Jianghong, Yang, Lingyao, Chen, Quan, WU, JANE Y, Zhu, Li. Integration of FUNDC1-associated mitochondrial protein import and mitochondrial quality control contributes to TDP-43 degradation. Cell Death and Disease[J]. 2023, 14: 735-, https://www.nature.com/articles/s41419-023-06261-6.
[2] 王腈, 朱笠. 线粒体蛋白CHCHD10与神经退行性疾病. 生物化学与生物物理进展[J]. 2023, 50(05期): 978-987, [3] Shi, Lijun, Xu, Anqi, Zhu, Li. Protein aggregation and phase separation in TDP-43 associated neurodegenerative diseases. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2022, 49(1): 8-22, [4] 柯莎, 朱笠. 蛋白质和多肽的检测与疾病诊疗. 生物化学与生物物理进展[J]. 2022, 49(1): 5-7, [5] Ma, Jinfa, Jane Y. Wu, Zhu, Li. Detection of orthologous exons and isoforms using EGIO. Bioinformatics[J]. 2022, 38(19): 4474-4480, [6] Luan, Mingyue, Sun, Yunchuang, Chen, Jing, Jiang, Yanyan, Li, Fan, Wei, Luhua, Sun, Wei, Ma, Jinfa, Song, Lu, Liu, Jianghong, Liu, Bing, Pei, Yaohua, Wang, Zhaoxia, Zhu, Li, Deng, Jianwen. Diagnostic Value of Salivary Real-Time Quaking-Induced Conversion in Parkinson's Disease and Multiple System Atrophy. MOVEMENT DISORDERS[J]. 2022, 37(5): 1059-1063, [7] Peng Chen, Ziyang Liu, Qian Zhang, Dong Lin, Lu Song, Jianghong Liu, HuiFeng Jiao, Xinsheng Lai, Suqi Zou, Shunqi Wang, Tian Zhou, BaoMing Li, Li Zhu, BingXing Pan, Erkang Fei. DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors. THE JOURNAL OF NEUROSCIENCE[J]. 2022, 42(4): 532-551, [8] Wang, Fei, Chen, Xiaoping, Cheng, Haipeng, Song, Lu, Liu, Jianghong, Caplan, Steve, Zhu, Li, Wu, Jane Y. MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking. EMBO REPORTS[J]. 2021, 22(7): e52006-, http://dx.doi.org/10.15252/embr.202052006.
[9] Wang Fei, Zhang Yan, Zhu Li. Tunneling Nanotube: a Novel Type of Signal Transmission in The Nervous System. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2021, 48(1): 54-63, [10] Peng Wang, Jianwen Deng, Jie Dong, Jianghong Liu, Eileen H Bigio, Marsel Mesulam, Tao Wang, Lei Sun, Li Wang, Alan YuehLuen Lee, Warren A McGee, Xiaoping Chen, Kazuo Fushimi, Li Zhu, Jane Y Wu. TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response. PLOS GENETICS[J]. 2019, 15(5): e1007947-, [11] Chen, Xiaowei, Fan, Zhen, McGee, Warren, Chen, Mengmeng, Kong, Ruirui, Wen, Pushuai, Xiao, Tengfei, Chen, Xiaomin, Liu, Jianghong, Zhu, Li, Chen, Runsheng, Wu, Jane Y. TDP-43 regulates cancer-associated microRNAs. PROTEIN & CELL[J]. 2018, 9(10): 848-866, http://lib.cqvip.com/Qikan/Article/Detail?id=676568929.
[12] Chen, Yemeng, Chen, Mengmeng, Zhu, Li, Wu, Jane Y, Du, Sidan, Li, Yang. Measure and model a 3-D space-variant PSF for fluorescence microscopy image deblurring. OPTICS EXPRESS[J]. 2018, 26(11): 14375-14391, http://dx.doi.org/10.1364/OE.26.014375.
[13] Deng, Jianwen, Wang, Peng, Chen, Xiaoping, Cheng, Haipeng, Liu, Jianghong, Fushimi, Kazuo, Zhu, Li, Wu, Jane Y. FUS interacts with ATP synthase beta subunit and induces mitochondrial unfolded protein response in cellular and animal models. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 115(41): E9678-E9686, [14] Zhang, Yunjia, Chen, Mengmeng, Qiu, Zilong, Hu, Keping, McGee, Warren, Chen, Xiaoping, Liu, Jianghong, Zhu, Li, Wu, Jane Y. MiR-130a regulates neurite outgrowth and dendritic spine density by targeting MeCP2. PROTEIN & CELL[J]. 2016, 7(7): 489-500, https://doaj.org/article/568cddb88ff747d7ad9787cd71c3f29c.
[15] Chen, Yanbo, Deng, Jianwen, Wang, Peng, Yang, Mengxue, Chen, Xiaoping, Zhu, Li, Liu, Jianghong, Lu, Bingwei, Shen, Yan, Fushimi, Kazuo, Xu, Qi, Wu, Jane Y. PINK1 and Parkin are genetic modifiers for FUS-induced neurodegeneration. HUMAN MOLECULAR GENETICS[J]. 2016, 25(23): 5059-5068, https://www.webofscience.com/wos/woscc/full-record/WOS:000397063300001.
[16] 朱笠, 邓健文, 王鹏, 刘江红, Jane Y. Wu. 与神经退行性疾病相关的RNA结合蛋白在线粒体损伤中的作用. 生物化学与生物物理进展[J]. 2016, 43(4): 374-382, [17] Yi, Fengshuang, Kong, Ruirui, Ren, Jinqi, Zhu, Li, Lou, Jizhong, Wu, Jane Y, Feng, Wei. Noncanonical Myo9b-RhoGAP Accelerates RhoA GTP Hydrolysis by a Dual-Arginine-Finger Mechanism. JOURNAL OF MOLECULAR BIOLOGY[J]. 2016, 428(15): 3043-3057, http://www.corc.org.cn/handle/1471x/2374370.
[18] Chen, Mengmeng, Li, Yang, Yang, Mengxue, Chen, Xiaoping, Chen, Yemeng, Yang, Fan, Lu, Sheng, Yao, Shengyu, Zhou, Timothy, Liu, Jianghong, Zhu, Li, Du, Sidan, Wu, Jane Y. A new method for quantifying mitochondrial axonal transport. PROTEIN & CELL[J]. 2016, 7(11): 804-819, http://lib.cqvip.com/Qikan/Article/Detail?id=670753018.
[19] Huang, Zhaohui, Wen, Pushuai, Kong, Ruirui, Cheng, Haipeng, Zhang, Binbin, Quan, Cao, Bian, Zehua, Chen, Mengmeng, Zhang, Zhenfeng, Chen, Xiaoping, Du, Xiang, Liu, Jianghong, Zhu, Li, Fushimi, Kazuo, Hua, Dong, Wu, Jane Y. USP33 mediates Slit- Robo signaling in inhibiting colorectal cancer cell migration. INTERNATIONAL JOURNAL OF CANCER[J]. 2015, 136(8): 1792-1802, https://www.webofscience.com/wos/woscc/full-record/WOS:000349619000005.
[20] Kong, Ruirui, Yi, Fengshuang, Wen, Pushuai, Liu, Jianghong, Chen, Xiaoping, Ren, Jinqi, Li, Xiaofei, Shang, Yulong, Nie, Yongzhan, Wu, Kaichun, Fan, Daiming, Zhu, Li, Feng, Wei, Wu, Jane Y. Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression. JOURNAL OF CLINICAL INVESTIGATION[J]. 2015, 125(12): 4407-4420, [21] Deng, Jianwen, Yang, Mengxue, Chen, Yanbo, Chen, Xiaoping, Liu, Jianghong, Sun, Shufeng, Cheng, Haipeng, Li, Yang, Bigio, Eileen H, Mesulam, Marsel, Xu, Qi, Du, Sidan, Fushimi, Kazuo, Zhu, Li, Wu, Jane Y. FUS Interacts with HSP60 to Promote Mitochondrial Damage. PLOS GENETICS[J]. 2015, 11(9): e1005357-, [22] Xu, Yiliang, Sun, Yuhui, Ye, Haihong, Zhu, Li, Liu, Jianghong, Wu, Xiaofeng, Wang, Le, He, Tingting, Shen, Yan, Wu, Jane Y, Xu, Qi. Increased dysbindin-1B isoform expression in schizophrenia and its propensity in aggresome formation. CELL DISCOVERY[J]. 2015, 1: 15032-, https://www.webofscience.com/wos/woscc/full-record/WOS:000414776800032.
[23] Wen, Pushuai, Kong, Ruirui, Liu, Jianghong, Zhu, Li, Chen, Xiaoping, Li, Xiaofei, Nie, Yongzhan, Wu, Kaichun, Wu, Jane Y. USP33, a new player in lung cancer, mediates Slit-Robo signaling. PROTEIN & CELL[J]. 2014, 5(9): 704-713, http://lib.cqvip.com/Qikan/Article/Detail?id=662830436.
[24] Zhou HuaLin, Mangelsdorf, Marie, Liu JiangHong, Zhu Li, Wu, Jane Y. RNA-binding proteins in neurological diseases. SCIENCE CHINA-LIFE SCIENCES[J]. 2014, 57(4): 432-444, https://www.webofscience.com/wos/woscc/full-record/WOS:000334559600010.
[25] Li, Yang, Yang, Mengxue, Huang, Zhuo, Chen, Xiaoping, Maloney, Michael T, Zhu, Li, Liu, Jianghong, Yang, Yanmin, Du, Sidan, Jiang, Xingyu, Wu, Jane Y. AxonQuant: A Microfluidic Chamber Culture-Coupled Algorithm That Allows High-Throughput Quantification of Axonal Damage. NEUROSIGNALS[J]. 2014, 22(1): 14-29, https://doaj.org/article/46c2b62d3ba34c32860d1f2e9035ff30.
[26] Zhu, Li, Xu, Meng, Yang, Mengxue, Yang, Yanlian, Li, Yang, Deng, Jianwen, Ruan, Linhao, Liu, Jianghong, Du, Sidan, Liu, Xuehui, Feng, Wei, Fushimi, Kazuo, Bigio, Eileen H, Mesulam, Marsel, Wang, Chen, Wu, Jane Y. An ALS-mutant TDP-43 neurotoxic peptide adopts an anti-parallel beta-structure and induces TDP-43 redistribution. HUMAN MOLECULAR GENETICS[J]. 2014, 23(25): 6863-6877, [27] Zhu, Kun, Chen, Xiaoping, Liu, Jianghong, Ye, Haihong, Zhu, Li, Wu, Jane Y. AMPK interacts with DSCAM and plays an important role in Netrin-1 induced neurite outgrowth. PROTEIN & CELL[J]. 2013, 4(2): 155-161, http://www.irgrid.ac.cn/handle/1471x/756504.
[28] Xu, Meng, Zhu, Li, Liu, Jianghong, Yang, Yanlian, Wu, Jane Y, Wang, Chen. Characterization of beta-domains in C-terminal fragments of TDP-43 by scanning tunneling microscopy. JOURNAL OF STRUCTURAL BIOLOGY[J]. 2013, 181(1): 11-16, http://www.irgrid.ac.cn/handle/1471x/756651.
[29] Zhu, Li, L. Millen, J.L. Mendoza, P.J. Thomas. 1.270 A UNIQUE REDOX-SENSING SENSOR-II MOTIF IN TORSINA PLAYS A CRITICAL ROLE IN NUCLEOTIDE AND PARTNER BINDING. PARKINSONISM AND RELATED DISORDERS[J]. 2012, 18(Sup 2): S64-S64, http://dx.doi.org/10.1016/S1353-8020(11)70328-5.
[30] 朱笠, 刘江红, 吴瑛. 转录后基因调控异常与老年性痴呆. 生物化学与生物物理进展[J]. 2012, 39(8): 703-708, http://lib.cqvip.com/Qikan/Article/Detail?id=42769533.
[31] Xu, Yiliang, Ye, Haihong, Shen, Yan, Xu, Qi, Zhu, Li, Liu, Jianghong, Wu, Jane Y. Dscam mutation leads to hydrocephalus and decreased motor function. PROTEIN & CELL[J]. 2011, 2(8): 647-655, http://dx.doi.org/10.1007/s13238-011-1072-8.
[32] Guo, Weirui, Chen, Yanbo, Zhou, Xiaohong, Kar, Amar, Ray, Payal, Chen, Xiaoping, Rao, Elizabeth J, Yang, Mengxue, Ye, Haihong, Zhu, Li, Liu, Jianghong, Xu, Meng, Yang, Yanlian, Wang, Chen, Zhang, David, Bigio, Eileen H, Mesulam, Marsel, Shen, Yan, Xu, Qi, Fushimi, Kazuo, Wu, Jane Y. An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2011, 18(7): 822-U102, http://dx.doi.org/10.1038/nsmb.2053.
[33] Chen, Yanbo, Yang, Mengxue, Deng, Jianwen, Chen, Xiaoping, Ye, Ye, Zhu, Li, Liu, Jianghong, Ye, Haihong, Shen, Yan, Li, Yan, Rao, Elizabeth J, Fushimi, Kazuo, Zhou, Xiaohong, Bigio, Eileen H, Mesulam, Marsel, Xu, Qi, Wu, Jane Y. Expression of human FUS protein in Drosophila leads to progressive neurodegeneration. PROTEIN & CELL[J]. 2011, 2(6): 477-486, https://www.webofscience.com/wos/woscc/full-record/WOS:000310521600008.
[34] Zhu, Li, Millen, Linda, Mendoza, Juan L, Thomas, Philip J. A Unique Redox-sensing Sensor II Motif in TorsinA Plays a Critical Role in Nucleotide and Partner Binding. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2010, 285(48): 37271-37280, http://dx.doi.org/10.1074/jbc.M110.123471.
[35] Zhu, Li, Wrabl, JO, Hayashi AP, Rose LS, Thomas PJ. The torsinA-family AAA+ protein OOC-5 contains a critical disulfide adjacent to sensor-II that couples redox state and nucleotide binding. Molecular Biology of the Cell[J]. 2008, 19: 3599-3612, [36] Zhu, Li, Qin, ZJ, Zhou, JM, Kihara, H. Unfolding kinetics of dimeric creatine kinase measured by stopped-flow small angle X-ray scattering. BIOCHIMIE[J]. 2004, 86(2): 127-132, http://dx.doi.org/10.1016/j.biochi.2003.12.002.
[37] Zhu, Li, Kihara, H, Kojima, M, Zhou, JM, Perrett, S. Small angle X-ray scattering study of the yeast prion Ure2p. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2003, 311(2): 525-532, https://www.webofscience.com/wos/woscc/full-record/WOS:000186584100044.
[38] Zhu, Li, Zhang, XJ, Wang, LY, Zhou, JM, Perrett, S. Relationship between stability of folding intermediates and amyloid formation for the yeast prion Ure2p: A quantitative analysis of the effects of pH and buffer system. JOURNAL OF MOLECULAR BIOLOGY[J]. 2003, 328(1): 235-254, http://dx.doi.org/10.1016/S0022-2836(03)00249-3.
[39] Zhu, Li, Fan, YX, Perrett, S, Zhou, JM. Relationship between kinetic and equilibrium folding intermediates of creatine kinase. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2001, 285(4): 857-862, https://www.webofscience.com/wos/woscc/full-record/WOS:000170110800002.
[40] Zhu, Li, Fan, YX, Zhou, JM. Identification of equilibrium and kinetic intermediates involved in folding of urea-denatured creatine kinase. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY[J]. 2001, 1544(1-2): 320-332, http://dx.doi.org/10.1016/S0167-4838(00)00244-2.
[41] Zhu, L, Fan, YX, Zhou, JM. Influence of intersubunit cross-linking on the conformational changes of creatine kinase during denaturation by guanidine hydrochloride. BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL[J]. 1997, 43(1): 207-216, https://www.webofscience.com/wos/woscc/full-record/WOS:000073190800024.

（1） RNA and Cancer, Series Cancer Treatment and Research, Springer, 2012-07, 第 5 作者
（2） Posttranscriptional Gene Regulation: RNA Processing in Eukaryotes, Wiley-VCH, 2013-07, 第 5 作者

   

（ 1 ） 情感和记忆神经环路与额颞叶痴呆, 负责人, 国家任务, 2012-01--2014-12
（ 2 ） 内质网ATP酶torsinA与其相互作用蛋白结合的结构基础, 负责人, 国家任务, 2013-01--2015-12
（ 3 ） 神经退行性疾病相关的RNA结合蛋白TDP-43引起线粒体损伤的机制研究, 负责人, 国家任务, 2017-01--2020-12
（ 4 ） 精神分裂症遗传发育问题的临床基础研究, 参与, 国家任务, 2010-01--2014-08
（ 5 ） 遗传性早发型dystonia 相关蛋白torsinA 的结构与功能研究, 负责人, 国家任务, 2010-01--2010-12
（ 6 ） 与TDP-43相互作用的CHCHD10在线粒体的功能及在脑衰老和神经退行性疾病中的作用, 负责人, 国家任务, 2020-01--2023-12
（ 7 ） 细胞器稳态调控的蛋白质机器在神经退变的病理及功能解析, 参与, 国家任务, 2019-11--2024-10
（ 8 ） RNA结合蛋白进入线粒体的稳态调控机制及其在神经退行性疾病中的作用, 负责人, 国家任务, 2023-01--2026-12

（1）"Mitochondrial damage in RBP-induced neurodegeneration   第一届上海ALS与运动神经元病峰会   2023-03-18
（2）Mitochondrial Damage in TDP-43-induced Neurodegeneration   第七届iHuman论坛   2022-04-13
（3）MICAL2PV Suppresses TNT Formation & Modulates Mitochondrial Trafficking    第十九次中国暨国际生物物理大会   2021-07-23
（4）Neurodegenerative Diseases Associated with RNA Binding Proteins   第十八次中国暨国际生物物理大会   2020-11-15
（5）TDP-43 Induces Mitochondrial Damage and Activates the Mitochondrial Unfolded Protein Response   第十七次中国暨国际生物物理大会   2019-08-02
（6）FUS诱导神经退行性疾病中的线粒体损伤    中华预防医学会自由基预防医学专业委员会2018学术年会   2018-10-27
（7）Mitochondrial Damage in FUS-induced Neurodegeneration   第十五次中国暨国际生物物理大会   2017-11-03
（8）Mitochondrial Dysfunction in Neurodegenerative Diseases Associated with RNA Binding Proteins   2017-07-16
（9）Mitochondrial Dysfunction in Neurodegenerative Diseases Associated with RNA Binding Proteins   2017-07-02
（10）Mitochondria damage in FUS & TDP-43 proteinopathies   中美ALS临床与基础研究高峰会议   2017-06-26
（11）Mitochondrial Damage in Dementia and Motor Neuron Diseases Associated with RNA Binding Proteins   2016 世界生命科学大会   2016-11-01
（12）Mitochondria damage in TDP-43 and FUS proteinopathies   第三届全球华人遗传学大会   2016-09-24
（13）Development of Drosophila models for newly emerging neurodegenerative diseases, FTLD- and ALS- associated RNA binding proteins   北京果蝇会议   2013-12-11
（14）Neurotoxic TDP-43 Peptides Form Amyloid Fibrils, Adopting an Anti-parallel b-sheet Structure   国家自然科学基金委重大研究计划“情感和记忆的神经环路基础”2013年度总结会暨国际学术交流会   2013-10-14
（15）RNA binding protein TDP-43 is neurotoxic   国家自然科学基金委重大研究计划“情感和记忆的神经环路基础”2012年度总结会暨国际学术交流会   2012-10-31
（16）情感和记忆神经环路与额颞叶痴呆   国家自然科学基金委重大研究计划“情感和记忆的神经环路基础”项目启动会暨学术交流会   2012-02-25
（17）A Unique Redox-sensing Sensor-II Motif in TorsinA Plays a Critical Role in Nucleotide and Partner Binding   2011-09-26

已指导学生

马金法  博士研究生  071006-神经生物学  

现指导学生

王腈  博士研究生  071006-神经生物学  

何萍  硕士研究生  071006-神经生物学  

田丽洁  硕士研究生  071006-神经生物学  

许吾娴  硕士研究生  071006-神经生物学  

杨凌垚  博士研究生  071006-神经生物学  

贡沛轩  硕士研究生  071006-神经生物学