姚培圆，中国科学院青年创新促进会会员，研究员，2021年获得了英国皇家化学会Horizon Prize（该奖项皆在表彰全球因做出突破性成果而为相关领域开辟出新方向或新可能的团队与合作研究）。长期从事新型生物催化剂的发现与改造和生物催化反应的设计、机理及应用研究。旨在利用有机化学逆合成分析原理和酶催化机制，重构药物及精细化学品的合成途径；对酶分子模块进行定向进化和改造以实现传统化学法难以实现或污染严重的反应，从而促进相关药物及精细化学品生产技术的绿色升级。已在国际高水平学术期刊上发表论文50多篇，被引1000多次，H 指数18，以第一/通讯作者在Nat. Chem.、Angew. Chem.、ACS Catal.、Green Chem.、Chem. Sci.、Org. Lett.、Sci. China Chem.等高水平学术期刊上发表论文20多篇。

2018-09--2019-08   英国曼彻斯特大学   访问学者
2009-05--2010-04   美国葛兰素史克   访问学者
2007-09--2010-06   天津大学   博士
2004-09--2007-03   天津大学   硕士
2000-09--2004-06   南开大学   本科

2022.06-至今     中国科学院天津工业生物技术研究所任研究员

2016.10-2022.06   中国科学院天津工业生物技术研究所任副研究员

   （期间2018.09-2019.08 英国曼彻斯特大学访问学者）

2012.11-2016.10   中国科学院天津工业生物技术研究所任助理研究员

2012.09-2012.11   天津药明康德新药开发有限公司任高级研究员

2010.07-2012.08   山东省烟台市牟平区同泰药物研究所任研发总监

2009.05-2010.04   美国葛兰素史克公司(GSK)访问学者

   

（ 1 ） 手性稠环四氢异喹啉类生物碱及其类似物的合成方法, 发明专利, 2021, 第 1 作者, 专利号: CN113755552A

（ 2 ） 一种3-甾酮-Δ 1 -脱氢酶及其编码基因和应用, 发明专利, 2021, 第 5 作者, 专利号: CN113528474A

（ 3 ） 腈基水解酶突变体及其在(S)-单腈单酸合成中的应用, 发明专利, 2021, 第 2 作者, 专利号: CN111254134B

（ 4 ） 羰基还原酶突变体及在制备手性β’-羟基-β-氨基酸酯中的应用, 发明专利, 2021, 第 5 作者, 专利号: CN112941043A

（ 5 ） 手性1，3-二羟基-1-芳基丙酮化合物的合成方法, 发明专利, 2021, 第 1 作者, 专利号: CN112852793A

（ 6 ） 制备(S)-1-(2-甲氧基-3-溴苯基)乙醇的方法, 发明专利, 2021, 第 2 作者, 专利号: CN112852769A

（ 7 ） 酶催化合成手性氨基醇化合物, 发明专利, 2021, 第 1 作者, 专利号: CN112852771A

（ 8 ） 腈水解酶突变体及其应用, 专利授权, 2021, 第 2 作者, 专利号: CN112852789A

（ 9 ） 微生物发酵生产HIP-IPA的方法、基因工程菌及应用, 专利授权, 2021, 第 8 作者, 专利号: CN112029700B

（ 10 ） 腈水解酶突变蛋白及其在催化合成(R)-3-取代-4-氰基丁酸类化合物中的应用, 发明专利, 2021, 第 2 作者, 专利号: CN112210549A

（ 11 ） 酶催化不对称合成右美沙芬关键中间体的新方法, 发明专利, 2019, 第 1 作者, 专利号: CN110628841A

（ 12 ） 一种苏沃雷生关键中间体的酶法制备方法, 发明专利, 2019, 第 1 作者, 专利号: CN110272925A

（ 13 ） 3β-羟基甾体脱氢酶制备脱氢表雄酮（DHEA）, 发明专利, 2019, 第 2 作者, 专利号: CN109750051A

（ 14 ） 微生物发酵生产谷内酯的方法、工程菌及应用, 发明专利, 2019, 第 3 作者, 专利号: CN109722455A

（ 15 ） 可水解对苯二甲腈制备对氰基苯甲酸的腈水解酶, 发明专利, 2018, 第 1 作者, 专利号: CN107641622A

（ 16 ） 腈水解酶突变体及其应用, 发明专利, 2017, 第 2 作者, 专利号: CN107177576A

（ 17 ） 一种光学纯2-羟基丁酸的生物制备新方法, 发明专利, 2016, 第 1 作者, 专利号: CN105695519A

（ 18 ） 酶催化拆分1-(4-甲氧基苄基)-1,2,3,4,5,6,7,8-八氢异喹啉的新方法, 发明专利, 2016, 第 1 作者, 专利号: CN105524971A

（ 19 ） 酶催化高浓度3-羟基丙腈水解制备3-羟基丙酸的新方法, 发明专利, 2016, 第 1 作者, 专利号: CN105441491A

（ 20 ） (R)-3-羟基戊二酸单酯的生物合成方法, 发明专利, 2015, 第 3 作者, 专利号: CN104561142A

（ 21 ） 酶催化高浓度β-氨基丙腈水解制备β-丙氨酸的方法, 专利授权, 2014, 第 1 作者, 专利号: CN104195193A

（ 22 ） 一种生物合成(R)-3-羟基戊二酸单酯的新方法, 发明专利, 2014, 第 1 作者, 专利号: CN104152500A

   

[1] Yu Li, Peiyuan Yao, Shiqing Zhang, Jinhui Feng, Hao Su, Xiangtao Liu, Xiang Sheng, Qiaqing Wu, Dunming Zhu, Yanhe Ma. Creating a new benzaldehyde lyase for atom-economic synthesis of chiral 1,2,4-butanetriol and 2-aminobutane-1,4-diol from formaldehyde. CHEM CATALYSIS. 2023, 3(1): http://dx.doi.org/10.1016/j.checat.2022.11.006.
[2] Li, Ming, Cui, Yunfeng, Xu, Zefei, Chen, Xi, Feng, Jinhui, Wang, Min, Yao, Peiyuan, Wu, Qiaqing, Zhu, Dunming. Asymmetric Synthesis of N-Substituted gamma-Amino Esters and gamma-Lactams Containing alpha,gamma-Stereogenic Centers via a Stereoselective Enzymatic Cascade. ADVANCED SYNTHESIS & CATALYSIS[J]. 2022, 364(2): 372-379, http://dx.doi.org/10.1002/adsc.202100953.
[3] Zhan, Zhuangzhuang, Xu, Zefei, Yu, Shanshan, Feng, Jinhui, Liu, Fufeng, Yao, Peiyuan, Wu, Qiaqing, Zhu, Dunming. Stereocomplementary Synthesis of a Key Intermediate for Tofacitinib via Enzymatic Dynamic Kinetic Resolution-Reductive Amination. ADVANCED SYNTHESIS & CATALYSIS[J]. 2022, 364(14): 2380-2386, http://dx.doi.org/10.1002/adsc.202200361.
[4] Yang, Linsong, Li, Jianjiong, Xu, Zefei, Yao, Peiyuan, Wu, Qiaqing, Zhu, Dunming, Ma, Yanhe. Asymmetric Synthesis of Fused-Ring Tetrahydroisoquinolines and Tetrahydro-beta-carbolines from 2-Arylethylamines via a Chemoenzymatic Approach. ORGANIC LETTERS[J]. 2022, 24(36): 6531-6536, http://dx.doi.org/10.1021/acs.orglett.2c02466.
[5] Li, Jiacheng, Li, Jianjiong, Cui, Yunfeng, Wang, Min, Feng, Jinhui, Yao, Peiyuan, Wu, Qiaqing, Zhu, Dunming. Asymmetric Synthesis of Both Enantiomers of Dimethyl 2-Methylsuccinate by the Ene-Reductase-Catalyzed Reduction at High Substrate Concentration. CATALYSTS[J]. 2022, 12(10): http://dx.doi.org/10.3390/catal12101133.
[6] Li, Jianjiong, Yu, Shanshan, Wang, Yingang, Yao, Peiyuan, Wu, Qiaqing, Zhu, Dunming. Simultaneous Preparation of (S)-2-Aminobutane and D-Alanine or D-Homoalanine via Biocatalytic Transamination at High Substrate Concentration. ORGANIC PROCESS RESEARCH & DEVELOPMENT[J]. 2022, 26(7): 2013-2020, [7] Li, Yu, Hu, Na, Xu, Zefei, Cui, Yunfeng, Feng, Jinhui, Yao, Peiyuan, Wu, Qiaqing, Zhu, Dunming, Ma, Yanhe. Asymmetric Synthesis of N-Substituted 1,2-Amino Alcohols from Simple Aldehydes and Amines by One-Pot Sequential Enzymatic Hydroxymethylation and Asymmetric Reductive Amination. ANGEWANDTECHEMIEINTERNATIONALEDITION[J]. 2022, 61(17): http://dx.doi.org/10.1002/anie.202116344.
[8] Marshall, James R, Yao, Peiyuan, Montgomery, Sarah L, Finnigan, James D, Thorpe, Thomas W, Palmer, Ryan B, MangasSanchez, Juan, Duncan, Richard A M, Heath, Rachel S, Graham, Kirsty M, Cook, Darren J, Charnock, Simon J, Turner, Nicholas J. Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination. NATURE CHEMISTRY[J]. 2021, 13(2): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116802/.
[9] Peiyuan Yao, James R Marshall, Zefei Xu, Jesmine Lim, Simon J Charnock, Dunming Zhu, Nicholas J Turner. Asymmetric Synthesis of N ‐Substituted α‐Amino Esters from α‐Ketoesters via Imine Reductase‐Catalyzed Reductive Amination. ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH). 2021, 60(16): 8717-8721, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048798/.
[10] Wang, Yingang, Feng, Jinhui, Dong, Wenyue, Chen, Xi, Yao, Peiyuan, Wu, Qiaqing, Zhu, Dunming. Improving Catalytic Activity and Reversing Enantio-Specificity of omega-Transaminase by Semi-Rational Engineering en Route to Chiral Bulky beta-Amino Esters. CHEMCATCHEM[J]. 2021, 13(15): 3396-3400, http://dx.doi.org/10.1002/cctc.202100503.
[11] Yu, Shanshan, Li, Jinlong, Yao, Peiyuan, Feng, Jinhui, Cui, Yunfeng, Li, Jianjiong, Liu, Xiangtao, Wu, Qiaqing, Lin, Jianping, Zhu, Dunming. Inverting the Enantiopreference of Nitrilase-Catalyzed Desymmetric Hydrolysis of Prochiral Dinitriles by Reshaping the Binding Pocket with a Mirror-Image Strategy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(7): 3679-3684, http://dx.doi.org/10.1002/anie.202012243.
[12] Xu, Zefei, Yao, Peiyuan, Sheng, Xiang, Li, Jinlong, Li, Jianjiong, Yu, Shanshan, Feng, Jinhui, Wu, Qiaqing, Zhu, Dunming. Biocatalytic Access to 1,4-Diazepanes via Imine Reductase-Catalyzed Intramolecular Asymmetric Reductive Amination. ACS CATALYSIS[J]. 2020, 10(15): 8780-8787, http://dx.doi.org/10.1021/acscatal.0c02400.
[13] 董文玥, 姚培圆, 吴洽庆. 纳米材料固定化酶的研究进展. 微生物学通报[J]. 2020, 47(7): 2161-2176, http://lib.cqvip.com/Qikan/Article/Detail?id=7102497488.
[14] Dong, Yijie, Yao, Peiyuan, Cui, Yunfeng, Wu, Qiaqing, Zhu, Dunming, Li, Guangyue, Reetz, Manfred T. Manipulating the stereoselectivity of a thermostable alcohol dehydrogenase by directed evolution for efficient asymmetric synthesis of arylpropanols. BIOLOGICAL CHEMISTRY[J]. 2019, 400(3): 313-321, https://www.webofscience.com/wos/woscc/full-record/WOS:000458628400006.
[15] Yu, Shanshan, Yao, Peiyuan, Li, Jinlong, Feng, Jinhui, Wu, Qiaqing, Zhu, Dunming. Improving the catalytic efficiency and stereoselectivity of a nitrilase from Synechocystis sp. PCC6803 by semi-rational engineering en route to chiral gamma-amino acids. CATALYSIS SCIENCE & TECHNOLOGY[J]. 2019, 9(6): 1504-1510, https://www.webofscience.com/wos/woscc/full-record/WOS:000462662100016.
[16] Yao, Peiyuan, Xu, Zefei, Yu, Shanshan, Wu, Qiaqing, Zhu, Dunming. Imine Reductase-Catalyzed Enantioselective Reduction of Bulky alpha,beta-Unsaturated Imines en Route to a Pharmaceutically Important Morphinan Skeleton. ADVANCED SYNTHESIS & CATALYSIS[J]. 2019, 361(3): 556-561, https://www.webofscience.com/wos/woscc/full-record/WOS:000457795500024.
[17] Liu, Na, Feng, Jinhui, Zhang, Rui, Chen, Xi, Li, Xuemei, Yao, Peiyuan, Wu, Qiaqing, Ma, Yanhe, Zhu, Dunming. Efficient microbial synthesis of key steroidal intermediates from bio-renewable phytosterols by genetically modified Mycobacterium fortuitum strains. GREEN CHEMISTRY[J]. 2019, 21(15): 4076-4083, [18] Zhang, Mujiao, Yao, Peiyuan, Yu, Shanshan, Zhang, Tongcun, Wu, Qiaqing, Zhu, Dunming. Efficient selective hydrolysis of terephthalonitrile to 4-cyanobenzoic acid catalyzed by a novel nitrilase from Pantoea sp. PROCESS BIOCHEMISTRY[J]. 2018, 75: 152-156, http://dx.doi.org/10.1016/j.procbio.2018.09.020.
[19] Li, Xuemei, Chen, Xi, Wang, Yu, Yao, Peiyuan, Zhang, Rui, Feng, Jinhui, Wu, Qiaqing, Zhu, Dunming, Ma, Yanhe. New product identification in the sterol metabolism by an industrial strain Mycobacterium neoaurum NRRL B-3805. STEROIDS[J]. 2018, 132: 40-45, http://dx.doi.org/10.1016/j.steroids.2018.02.001.
[20] Gong, Rui, Yao, Peiyuan, Chen, Xi, Feng, Jinhui, Wu, Qiaqing, Lau, Peter C K, Zhu, Dunming. Accessing d-Valine Synthesis by Improved Variants of Bacterial Cyclohexylamine Oxidase. CHEMCATCHEM[J]. 2018, 10(2): 387-390, https://www.webofscience.com/wos/woscc/full-record/WOS:000423197900007.
[21] Zhang, Xuemei, Ren, Jie, Yao, Peiyuan, Gong, Rui, Wang, Min, Wu, Qiaqing, Zhu, Dunming. Biochemical characterization and substrate profiling of a reversible 2,3-dihydroxybenzoic acid decarboxylase for biocatalytic Kolbe-Schmitt reaction. ENZYME AND MICROBIAL TECHNOLOGY[J]. 2018, 113: 37-43, http://dx.doi.org/10.1016/j.enzmictec.2018.02.008.
[22] Qu, Ge, Lonsdale, Richard, Yao, Peiyuan, Li, Guangyue, Liu, Beibei, Reetz, Manfred T, Sun, Zhoutong. Methodology Development in Directed Evolution: Exploring Options when Applying Triple-Code Saturation Mutagenesis. CHEMBIOCHEM[J]. 2018, 19(3): 239-246, https://www.webofscience.com/wos/woscc/full-record/WOS:000424105700008.
[23] Yao, Peiyuan, Cong, Peiqian, Gong, Rui, Li, Jinlong, Li, Guangyue, Ren, Jie, Feng, Jinhui, Lin, Jianping, Lau, Peter C K, Wu, Qiaqing, Zhu, Dunming. Biocatalytic Route to Chiral 2-Substituted-1,2,3,4-Tetrahydroquinolines Using Cyclohexylamine Oxidase Muteins. ACS CATALYSIS[J]. 2018, 8(3): 1648-1652, https://www.webofscience.com/wos/woscc/full-record/WOS:000426804100004.
[24] Zhang, Yan, Yao, Peiyuan, Cui, Yunfeng, Wu, Qiaqing, Zhu, Dunming. One-Pot Enzymatic Synthesis of Cyclic Vicinal Diols from Aliphatic Dialdehydes via Intramolecular C-C Bond Formation and Carbonyl Reduction Using Pyruvate Decarboxylases and Alcohol Dehydrogenases. ADVANCED SYNTHESIS & CATALYSIS[J]. 2018, 360(21): 4191-4196, [25] Li, Guangyue, Yao, Peiyuan, Gong, Rui, Li, Jinlong, Liu, Pi, Lonsdale, Richard, Wu, Qiaqing, Lin, Jianping, Zhu, Dunming, Reetz, Manfred T. Simultaneous engineering of an enzyme's entrance tunnel and active site: the case of monoamine oxidase MAO-N. CHEMICAL SCIENCE[J]. 2017, 8(5): 4093-4099, https://www.webofscience.com/wos/woscc/full-record/WOS:000400553000096.
[26] Dai, Longhai, Li, Jiao, Yao, Peiyuan, Zhu, Yueming, Men, Yan, Zeng, Yan, Yang, Jiangang, Sun, Yuanxia. Exploiting the aglycon promiscuity of glycosyltransferase Bs-YjiC from Bacillus subtilis and its application in synthesis of glycosides. JOURNAL OF BIOTECHNOLOGY[J]. 2017, 248: 69-76, http://dx.doi.org/10.1016/j.jbiotec.2017.03.009.
[27] Yanyang Tao, Peiyuan Yao, Jing Yuan, Chao Han, Jinhui Feng, Min Wang, Qiaqing Wu, Dunming Zhu. Efficient biosynthesis of β-alanine with a tandem reaction strategy to eliminate amide by-product in the nitrilase-catalyzed hydrolysis. JOURNAL OF MOLECULAR CATALYSIS. B, ENZYMATIC. 2016, 133: S60-S67, http://dx.doi.org/10.1016/j.molcatb.2016.11.018.
[28] Li, Guangyue, Yao, Peiyuan, Cong, Peiqian, Ren, Jie, Wang, Lei, Feng, Jinhui, Lau, Peter C K, Wu, Qiaqing, Zhu, Dunming. New recombinant cyclohexylamine oxidase variants for deracemization of secondary amines by orthogonally assaying designed mutants with structurally diverse substrates. SCIENTIFIC REPORTS[J]. 2016, 6: http://www.irgrid.ac.cn/handle/1471x/1180909.
[29] Yao, Peiyuan, Cui, Yunfeng, Yu, Shanshan, Du, Yuncheng, Feng, Jinhui, Wu, Qiaqing, Zhu, Dunming. Efficient Biosynthesis of (R)- or (S)-2-Hydroxybutyrate from l-Threonine through a Synthetic Biology Approach. ADVANCED SYNTHESIS & CATALYSIS[J]. 2016, 358(18): 2923-2928, http://www.irgrid.ac.cn/handle/1471x/1180912.
[30] Ren, Jie, Yao, Peiyuan, Yu, Shanshan, Dong, Wenyue, Chen, Qijia, Feng, Jinhui, Wu, Qiaqing, Zhu, Dunming. An Unprecedented Effective Enzymatic Carboxylation of Phenols. ACS CATALYSIS[J]. 2016, 6(2): 564-567, http://www.irgrid.ac.cn/handle/1471x/1111576.
[31] Yu, Shanshan, Yao, Peiyuan, Li, Jianjiong, Ren, Jie, Yuan, Jing, Feng, Jinhui, Wang, Min, Wu, Qiaqing, Zhu, Dunming. Enzymatic synthesis of 3-hydroxypropionic acid at high productivity by using free or immobilized cells of recombinant Escherichia coli. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC[J]. 2016, 129: 37-42, http://dx.doi.org/10.1016/j.molcatb.2016.03.011.
[32] 王雷, 袁京, 姚培圆, 程丽华, 解美仙, 贾荣荣, 冯进辉, 王敏, 吴洽庆, 朱敦明. 一种来源于运动替斯崔纳菌KA081020-065的新型卤醇脱卤酶的表达纯化及性质分析. 生物工程学报[J]. 2015, 31(5): 659-669, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5428708&detailType=1.
[33] Yao, Peiyuan, Wang, Lei, Yuan, Jing, Cheng, Lihua, Jia, Rongrong, Xie, Meixian, Feng, Jinhui, Wang, Min, Wu, Qiaqing, Zhu, Dunming. Efficient Biosynthesis of Ethyl (R)-3-Hydroxyglutarate through a One-Pot Bienzymatic Cascade of Halohydrin Dehalogenase and Nitrilase. CHEMCATCHEM[J]. 2015, 7(9): 1438-1444, https://www.webofscience.com/wos/woscc/full-record/WOS:000353974300006.
[34] Zhang, Dalong, Chen, Xi, Zhang, Rui, Yao, Peiyuan, Wu, Qiaqing, Zhu, Dunming. Development of beta-Amino Acid Dehydrogenase for the Synthesis of beta-Amino Acids via Reductive Amination of beta-Keto Acids. ACS CATALYSIS[J]. 2015, 5(4): 2220-2224, http://124.16.173.210/handle/834782/1452.
[35] 姚培圆, 任杰, 吴洽庆, 朱敦明. 化学生物融合转化反应研究的最新进展及挑战. 中国科学. 化学[J]. 2015, 45(5): 479-500, https://www.sciengine.com/doi/10.1360/N032014-00283.
[36] Chao Han, Peiyuan Yao, Jing Yuan, Yitao Duan, Jinhui Feng, Min Wang, Qiaqing Wu, Dunming Zhu. Nitrilase-catalyzed hydrolysis of 3-aminopropionitrile at high concentration with a tandem reaction strategy for shifting the reaction to β-alanine formation. JOURNAL OF MOLECULAR CATALYSIS. B, ENZYMATIC. 2015, 115: 113-118, http://dx.doi.org/10.1016/j.molcatb.2015.02.007.
[37] Duan, Yitao, Yao, Peiyuan, Chen, Xi, Liu, Xiangtao, Zhang, Rui, Feng, Jinhui, Wu, Qiaqing, Zhu, Dunming. Exploring the synthetic applicability of a new carboxylic acid reductase from Segniliparus rotundus DSM 44985. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC[J]. 2015, 115: 1-7, http://dx.doi.org/10.1016/j.molcatb.2015.01.014.
[38] Yitao Duan, Peiyuan Yao, Yuncheng Du, Jinhui Feng, Qiaqing Wu, Dunming Zhu. Synthesis of α,β-unsaturated esters via a chemo-enzymatic chain elongation approach by combining carboxylic acid reduction and Wittig reaction. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY[J]. 2015, 11(1): https://doaj.org/article/cd2f3413b8fb42ac9e5441a8c2b67754.
[39] Yao, Peiyuan, Li, Jianjiong, Yuan, Jing, Han, Chao, Liu, Xiangtao, Feng, Jinhui, Wu, Qiaqing, Zhu, Dunming. Enzymatic Synthesis of a Key Intermediate for Rosuvastatin by Nitrilase-Catalyzed Hydrolysis of Ethyl (R)-4-Cyano-3-hydroxybutyate at High Substrate Concentration. CHEMCATCHEM[J]. 2015, 7(2): 271-275, https://www.webofscience.com/wos/woscc/full-record/WOS:000347781400012.
[40] Duan YiTao, Yao PeiYuan, Ren Jie, Han Chao, Li Qian, Yuan Jing, Feng JinHui, Wu QiaQing, Zhu DunMing. Biocatalytic desymmetrization of 3-substituted glutaronitriles by nitrilases. A convenient chemoenzymatic access to optically active (S)-Pregabalin and (R)-Baclofen. SCIENCE CHINA-CHEMISTRY[J]. 2014, 57(8): 1164-1171, http://www.irgrid.ac.cn/handle/1471x/930450.
[41] Li, Guangyue, Ren, Jie, Yao, Peiyuan, Duan, Yitao, Zhang, Hailing, Wu, Qiaqing, Feng, Jinhui, Lau, Peter C K, Zhu, Dunming. Deracemization of 2-Methyl-1,2,3,4-Tetrahydroquinoline Using Mutant Cyclohexylamine Oxidase Obtained by Iterative Saturation Mutagenesis. ACS CATALYSIS[J]. 2014, 4(3): 903-908, http://www.irgrid.ac.cn/handle/1471x/1111566.
[42] AlRashid, Ziyad F, Johnson, Whitney L, Hsung, Richard P, Wei, Yonggang, Yao, PeiYuan, Liu, Renhei, Zhao, Kang. Synthesis of alpha-Keto-Imides via Oxidation of Ynamides. JOURNAL OF ORGANIC CHEMISTRY[J]. 2008, 73(22): 8780-8784, https://www.webofscience.com/wos/woscc/full-record/WOS:000260923000012.
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（ 1 ） 环己胺氧化酶的催化机制及理性设计, 主持, 国家级, 2014-01--2016-12
（ 2 ） 降脂药关键中间体(R)-3-羟基戊二酸乙酯的生物制造, 主持, 省级, 2015-04--2017-03
（ 3 ） 腈水解酶催化潜手性二腈化合物去对称性水解反应的立体识别机理研究, 参与, 国家级, 2016-01--2019-12
（ 4 ） 新分子的生化反应设计与生物合成子课题, 主持, 国家级, 2020-01--2024-12
（ 5 ） 智能反应器设计与系统优化, 主持, 国家级, 2021-07--2025-06
（ 6 ） 亚胺还原酶对氨基β位的立体选择性控制机制及β-手性胺的精准构筑, 主持, 国家级, 2022-01--2025-12
（ 7 ） 化学原料药绿色生物合成及示范, 主持, 省级, 2021-03--2024-02

（1）Efficient biosynthesis of (R)- or (S)-2-hydroxybutyrate from L-threonine through a synthetic biology approach   2016-07-10
（2）EFFICIENT BIOSYNTHESIS OF CHIRAL 2-SUBSTITUTED-1, 2, 3, 4-TETRAHYDROQUINOLINE USING ENGINEERING CYCLOHEXYLAMINE OXIDASE   2015-07-26

已指导学生

杨林松  硕士研究生  085216-化学工程