基本信息
顾建文  男  博导  解放军第306医院
电子邮件: 2914081083@qq.com
通信地址: 北京市朝阳区安翔北里7号
邮政编码: 100226

招生信息

   
招生专业
1001J6-再生医学
招生方向
神经创伤与修复,神经电生理,颅内肿瘤,人工智能

教育背景

2000-09--2003-07   西安交通大学   博士
1983-09--1989-07   第四军医大学 空医系   硕士

工作经历

   
工作简历
2018-11~现在, 战略支援部队特色医学中心, 主任
2015-06~2018-10,解放军第306医院, 院长
2014-04~2015-07,解放军空军总医院, 副院长
2007-06~2014-04,成都军区总医院, 副院长
2003-06~2007-06,成都军区总医院神经外科, 主任
2000-09~2003-07,西安交通大学, 博士
1983-09~1989-07,第四军医大学 空医系, 硕士
社会兼职
2018-04-27-今,北京大学医学部神经外科学学系, 副主任委员
2017-09-01-今,中国医院协会, 理事
2015-12-01-2020-12-31,中华医学会第二十五届理事会, 理事
2015-09-23-今,中国研究型医院协会卫生应急专业委员, 常务副主任委员
2011-10-01-今,中央军委保健委员会, 委员
2011-07-01-今,中国医师协会神经外科医师分会, 委员
2008-09-01-今,中华医学会创伤学分会, 副组长
2006-03-01-今,全军神经外科专业委员会, 副主任委员

教授课程

颈椎病防护
加强“脑控”智能驱动武器研究
生物医用材料应用及前景

专利与奖励

   
奖励信息
(1) 颅脑创伤后过度兴奋应激损害的机制及防护基础研究, 一等奖, 省级, 2014
专利成果
( 1 ) 一种半面罩呼吸器、舒适型医用一次性防护服, 2021, 第 1 作者, 专利号: CN202022268264.9

( 2 ) 一种内置眼镜主视跟踪系统的角膜接触电极及工作方法, 2020, 第 2 作者, 专利号: 201910150034.1

( 3 ) 一种能同时测量瞳孔大小的角膜接触电极及工作方法, 2020, 第 2 作者, 专利号: 201910150452.0

( 4 ) 固定装置及实验定位装置, 2020, 第 2 作者, 专利号: CN201922049260.9

( 5 ) 一种用于治疗糖尿病或者减肥的药物制剂, 2019, 第 1 作者, 专利号: 201811520996.3

( 6 ) 一种GLP-1突变体及其制备方法和用途, 2019, 第 1 作者, 专利号: GY84819P4003

( 7 ) 双通道脑室外引流管, 2017, 第 2 作者, 专利号: 201720193972.6

( 8 ) 长条组织培养皿, 2017, 第 3 作者, 专利号: 201720194011.7

( 9 ) 脑血管硬化演示模型, 2016, 第 1 作者, 专利号: 201621443310.1

( 10 ) 悬浮脑片抗原修复压片夹, 2015, 第 3 作者, 专利号: 201310736656.5

( 11 ) 一种用于颅内压检测的装置, 2015, 第 2 作者, 专利号: 201310513050.5

( 12 ) 一种基于瞳孔反射的便携式颅内压无创检测装置, 2015, 第 2 作者, 专利号: 201310511704.0

( 13 ) 新型喹啉-4-甲酰胺衍生物、其制备方法以及含该衍生物的药物组合物及其医药用途, 2015, 第 1 作者, 专利号: CN201410805658.X

( 14 ) 一种改进的4-羟基间苯二甲酸的制备方法, 2015, 第 2 作者, 专利号: CN201410446058.9

( 15 ) 高原车载便携式制氧机, 2015, 第 1 作者, 专利号: CN201420553928.8

( 16 ) 单兵便携式高原急救面罩, 2015, 第 2 作者, 专利号: CN201420551470.2

( 17 ) 一种经蝶窦入路手术用鞍内吸引器, 2015, 第 2 作者, 专利号: CN201420554523.6

出版信息

   
发表论文
(1) Modulating Brain Activity with Invasive Brain-Computer Interface: A Narrative Review, BRAIN SCIENCES, 2023, 通讯作者
(2) The potential beneficial effects of Lactobacillus plantarum GM11 on rats with chronic unpredictable mild stress-induced depression., Nutr Neurosci, 2023, 通讯作者
(3) Post-COVID pain and quality of life in COVID-19 patients: protocol for a meta-analysis and systematic review, BMJ OPEN, 2022, 通讯作者
(4) The beneficial effects of genetically engineered Escherichia coli Nissle 1917 in obese C57BL/6J mice, INTERNATIONAL JOURNAL OF OBESITY, 2022, 通讯作者
(5) Establishment and Evaluation of a Novel High-Efficiency Model of Graded Traumatic Brain Injury in Mice, WORLD NEUROSURGERY, 2021, 通讯作者
(6) LncRNA CCAT1 Protects Astrocytes Against OGD/R-Induced Damage by Targeting the miR-218/NFAT5-Signaling Axis, CELLULAR AND MOLECULAR NEUROBIOLOGY, 2020, 通讯作者
(7) Improvement in cognitive dysfunction following blast induced traumatic brain injury by thymosin α1 in rats: Involvement of inhibition of tau phosphorylation at the Thr205 epitope, BRAIN RESEARCH, 2020, 通讯作者
(8) Prevention and control of coronavirus disease 2019 in Grade-III Class-A hospitals outside of Wuhan, Prevention and control of coronavirus disease 2019 in Grade-III Class-A hospitals outside of Wuhan, CHINESE MEDICAL JOURNAL, 2020, 通讯作者
(9) Gastrointestinal and liver involvement in patients with COVID-19, LANCET GASTROENTEROLOGY & HEPATOLOGY, 2020, 通讯作者
(10) Cardiac and Muscle Injury Might Partially Contribute to Elevated Aminotransferases in COVID-19 Patients, CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2020, 第 2 作者
(11) Genetically Engineered Escherichia coli Nissle 1917 Secreting GLP-1 Analog Exhibits Potential Antiobesity Effect in High-Fat Diet-Induced Obesity Mice, OBESITY, 2020, 通讯作者
(12) A novel model of blast induced traumatic brain injury caused by compressed gas produced sustained cognitive deficits in rats: involvement of phosphorylation of tau at the Thr205 epitope, BRAIN RESEARCH BULLETIN, 2020, 通讯作者
(13) 航天员中长期飞行骨骼健康管理研究现状, Current status of skeletal health management in middle and long duration astronauts, 中国骨质疏松杂志, 2020, 第 2 作者
(14) Timely blood glucose management for the outbreak of 2019 novel coronavirus disease (COVID-19) is urgently needed, DIABETES RESEARCH AND CLINICAL PRACTICE, 2020, 通讯作者
(15) Ag@TiO2 Nanoprisms with Highly Efficient Near-Infrared Photothermal Conversion for Melanoma Therapy, CHEMISTRY-AN ASIAN JOURNAL, 2020, 通讯作者
(16) Managing chronic wounds during novel coronavirus pneumonia outbreak, Managing chronic wounds during novel coronavirus pneumonia outbreak, BURNSTRAUMA, 2020, 通讯作者
(17) Comparison of the effects of nimodipine and deferoxamine on brain injury in rat with subarachnoid hemorrhage, BEHAVIOURAL BRAIN RESEARCH, 2019, 通讯作者
(18) 颅脑手术患者废弃脑组织中神经干细胞的培养与鉴定, Culture and identification of autologous neural stem cells from abandoned brain tissue in patients during craniocerebral operation, 解剖学杂志, 2019, 第 5 作者
(19) “神舟十一号”飞船舱前急救心肺复苏与应对策略, First aid cardiopulmonary resuscitation at the exit of capsule and strategy coping with the "Shenzhou 11"spacecraft, 中华急诊医学杂志, 2018, 第 13 作者
(20) Establishment of a novel rat model of blast-related diffuse axonal injury, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2018, 通讯作者
(21) 国产神经外科医疗机器人Remebot行无框架立体定向活检术的应用研究, Clinical application for domestic neurosurgery medical robot Remebot in biopsy of intracranial lesions, 中华神经医学杂志, 2017, 第 8 作者
(22) Epidemiological characteristics of Chinese paediatric traumatic brain injury inpatients, BRAIN INJURY, 2017, 通讯作者
(23) “老年脑”是什么意思,如何注意?, 老年健康, 2017, 第 1 作者
(24) Impacts of Blast-Induced Traumatic Brain Injury on Expressions of Hepatic Cytochrome P450 1A2, 2B1, 2D1, and 3A2 in Rats, CELLULAR AND MOLECULAR NEUROBIOLOGY, 2017, 通讯作者
(25) Mangiferin attenuates blast-induced traumatic brain injury via inhibiting NLRP3 inflammasome, CHEMICO-BIOLOGICAL INTERACTIONS, 2017, 通讯作者
(26) “神舟十一号载人航天飞船”主着陆场航天员的医疗保障, 中华卫生应急电子杂志, 2017, 第 14 作者
(27) 加强“脑控”智能驱动武器研究, 空军医学杂志, 2016, 第 1 作者
(28) Myocyte enhancer factor 2D promotes tumorigenicity in malignant glioma cells, TUMOR BIOLOGY, 2016, 通讯作者
(29) Propofol Inhibits NLRP3 Inflammasome and Attenuates Blast-Induced Traumatic Brain Injury in Rats, INFLAMMATION, 2016, 通讯作者
(30) A Surgical Method to Improve the Homeostasis of CSF for the Treatment of Alzheimer’s Disease, FRONTIERS IN AGING NEUROSCIENCE, 2016, 
(31) “神舟十一号”飞船航天员医疗救护保障特点与应对策略, The specialty and coping strategies of "ShenZhou 11" astronauts' rescue and medical aid, 中华急诊医学杂志, 2016, 第 2 作者
(32) microRNA-7 Protects Against 1-Methyl-4-Phenylpyridinium Iodide-Induced Cell Apoptosis in SH-SY5Y Cells by Directly Targeting Krupple-Like Factor 4, DNA AND CELL BIOLOGY, 2016, 通讯作者
(33) Cerebral vasospasm and corticospinal tract injury induced by a modified rat model of subarachnoid hemorrhage, JOURNAL OF THE NEUROLOGICAL SCIENCES, 2015, 通讯作者
(34) Emodin Inhibits Inducible Nitric Oxide Synthase in a Rat Model of Craniocerebral Explosive Injury, NEUROCHEMICAL RESEARCH, 2014, 通讯作者
(35) Gene expression profiles of patients with cerebral hematoma following spontaneous intracerebral hemorrhage, MOLECULAR MEDICINE REPORTS, 2014, 通讯作者
(36) Pharmacokinetics of Dexamethasone and Nefopam Administered Alone or in Combination Using a Newly Developed Prefilled Multi-Drug Injector in Rats, PHARMACOLOGY, 2014, 通讯作者
(37) Comparison of the safety and efficacy of propofol with midazolam for sedation of patients with severe traumatic brain injury: A meta-analysis, JOURNAL OF CRITICAL CARE, 2014, 通讯作者
(38) Overexpression of MACC1 protein and its clinical implications in patients with glioma, TUMOR BIOLOGY, 2014, 通讯作者
(39) Protein–protein interaction network analysis and gene set enrichment analysis in epilepsy patients with brain cancer, JOURNAL OF CLINICAL NEUROSCIENCE, 2014, 通讯作者
(40) Electrical Stimulation of the Substantia Nigra Pars Reticulata (SNr) Suppresses Chemically Induced Neocortical Seizures in Rats, JOURNAL OF MOLECULAR NEUROSCIENCE, 2014, 通讯作者
(41) Comparison of therapeutic effects between selective amygdalohippocampectomy and anterior temporal lobectomy for the treatment of temporal lobe epilepsy: A meta-analysis, BRITISH JOURNAL OF NEUROSURGERY, 2014, 通讯作者
(42) Epileptiform Discharges and Frontal Paroxysmal EEG Abnormality Act as Predictive Marker for Subsequent Epilepsy in Children With Complex Febrile Seizures, CLINICAL EEG AND NEUROSCIENCE, 2014, 通讯作者
(43) Anti-apoptotic and Anti-oxidative Roles of Quercetin After Traumatic Brain Injury, CELLULAR AND MOLECULAR NEUROBIOLOGY, 2014, 通讯作者

科研活动

   
科研项目
( 1 ) 磁共振分子影像动态载体观测脑损伤机制, 负责人, 国家任务, 2013-12--2017-06
( 2 ) 深部脑***********应用, 负责人, 其他国际合作项目, 2016-12--2021-12
( 3 ) 铁在脑出血认知障碍中的作用, 负责人, 中国科学院计划, 2016-12--2019-12
( 4 ) 颅底肿瘤精准外科治疗的临床研究, 负责人, 地方任务, 2015-12--2018-12
( 5 ) 颅脑爆炸冲击伤致伤机制及防护研究, 负责人, 国家任务, 2012-12--2017-12
( 6 ) 植物大黄成分治疗脑外伤后认知功能障碍效应通路研究, 负责人, 国家任务, 2018-01--2021-12
( 7 ) 一体式****的研发及生理指标评估, 负责人, 其他国际合作项目, 2020-03--2021-12
( 8 ) 航天临床医学*****实验室, 负责人, 其他国际合作项目, 2022-08--2024-08
( 9 ) 战略支援部队特殊******与防治研究, 负责人, 其他国际合作项目, 2023-03--2026-02