（1）海洋微生物次级代谢产物生物合成机制研究

（2）基因组信息指导的海洋微生物隐性次级代谢产物挖掘

2006-09--2011-06   华中农业大学   博士
2003-09--2006-06   河北大学   硕士
2000-08--2003-08   山东大学   学士

   

2020-01~现在, 中国科学院南海海洋研究所, 研究员
2014-01~2019-12,中国科学院南海海洋研究所, 副研究员
2011-07~2013-12,中国科学院南海海洋研究所, 助理研究员

中国科学院广州教育基地“优秀研究生导师”（2021年）

中科院南海海洋研究所优秀研究生指导教师（2020年）

"广东特支计划"科技创新青年拔尖人才（2019年），

中科院南海海洋研究"南海新星"（2017年）,

[1] Peng, jing, Zhang, Qingbo, Jiang, Xiaodong, Ma, Liang, Long, Ting, Cheng, Ziqian, Zhang, Changsheng, Zhu, Yiguang. New piericidin derivatives from a marine-derived Streptomyces sp. SCSIO 40063 with cytotoxicity activity. Natural Product Research[J]. 2021, [2] Zhu, Yiguang, Wang, Junfeng, Mou, Pengyun, Yan, Yan, Chen, Mengbin, Tang, Yi. Genome mining of cryptic tetronate natural products from a PKS-NRPS encoding gene cluster in Trichoderma harzianum t-22. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2021, 19(9): 1985-1990, [3] Mou, Pengyun, Zhang, Qingbo, Peng, Jing, Jiang, Xiaodong, Zhang, Liping, Zhou, Zhongbo, Zhang, Changsheng, Zhu, Yiguang. Antibacterial phenylspirodrimanes from the marine-derived fungus Stachybotrys sp. SCSIO 40434. FITOTERAPIA[J]. 2021, 152: [4] Ma, Liang, Zhang, Wenjun, Liu, Zhiwen, Huang, Yanbing, Zhang, Qingbo, Tian, Xinpeng, Zhang, Changsheng, Zhu, Yiguang. Complete genome sequence of Streptomyces sp. SCSIO 03032 isolated from Indian Ocean sediment, producing diverse bioactive natural products. MARINE GENOMICS[J]. 2021, 55: [5] Zhu, Yiguang, Zhang, Qingbo, Fang, Chunyan, Zhang, Yingli, Ma, Liang, Liu, Zhiwen, Zhai, Shilan, Peng, Jing, zhang, Liping, Zhu, Weiming, Zhang, Changsheng. Refactoring the concise biosynthetic pathway of cyanogramide unveils a P450 enzyme-catalyzed spirooxindole formation. Angewandte Chemie International Edition[J]. 2020, 59(33): 14065-14069, [6] Liu, Wei, Jannu, Vinay Gopal, Liu, Zhiwen, Zhang, Qingbo, Jiang, Xiaodong, Ma, Liang, Zhang, Wenjun, Zhang, Changsheng, Zhu, Yiguang. Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2020, 18(19): 3649-3653, [7] Huang, Chunshuai, Yang, Chunfang, Zhu, Yiguang, Zhang, Wenjun, Yuan, Chengshan, Zhang, Changsheng. Marine Bacterial Aromatic Polyketides From Host-Dependent Heterologous Expression and Fungal Mode of Cyclization. FRONTIERS IN CHEMISTRY[J]. 2018, 6: [8] Wang, Pengxia, Zhu, Yiguang, Zhang, Yuyang, Zhang, Chunyi, Xu, Jianyi, Deng, Yun, Peng, Donghai, Ruan, Lifang, Sun, Ming. Mob/oriT, a mobilizable site-specific recombination system for unmarked genetic manipulation in Bacillus thuringiensis and Bacillus cereus. MICROBIAL CELL FACTORIES[J]. 2016, 15(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000378575100008.
[9] Zhu, Yiguang, Picard, MarieEve, Zhang, Qingbo, Barma, Julie, Despres, Xavier Murphy, Mei, Xiangui, Zhang, Liping, Duvignaud, JeanBaptiste, Couture, Manon, Zhu, Weiming, Shi, Rong, Zhang, Changsheng. Flavoenzyme CrmK-mediated substrate recycling in caerulomycin biosynthesis. CHEMICAL SCIENCE[J]. 2016, 7(8): 4867-4874, [10] Zhu, Yiguang, Xu, Jinxin, Mei, Xiangui, Feng, Zhan, Zhang, Liping, Zhang, Qingbo, Zhang, Guangtao, Zhu, Weiming, Liu, Jinsong, Zhang, Changsheng. Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin Biosynthesis. ACS CHEMICAL BIOLOGY[J]. 2016, 11(4): 943-952, [11] Zhu, Yiguang, Zhang, Wenjun, Chen, Yaolong, Yuan, Chengshan, Zhang, Haibo, Zhang, Guangtao, Ma, Liang, Zhang, Qingbo, Tian, Xinpeng, Zhang, Si, Zhang, Changsheng. Characterization of Heronamide Biosynthesis Reveals a Tailoring Hydroxylase and Indicates Migrated Double Bonds. CHEMBIOCHEM[J]. 2015, 16(14): 2086-2093, [12] Chen, Yaolong, Zhang, Wenjun, Zhu, Yiguang, Zhang, Qingbo, Tian, Xinpeng, Zhang, Si, Zhang, Changsheng. Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis. ORGANIC LETTERS[J]. 2014, 16(3): 736-739, [13] Fu, Peng, Zhu, Yiguang, Mei, Xiangui, Wang, Yi, Jia, Haijian, Zhang, Changsheng, Zhu, Weiming. Acyclic Congeners from Actinoalloteichus cyanogriseus Provide Insights into Cyclic Bipyridine Glycoside Formation. ORGANIC LETTERS[J]. 2014, 16(16): 4264-4267, [14] Zhu, Yiguang, Zhang, Qingbo, Li, Sumei, Lin, Qinheng, Fu, Peng, Zhang, Guangtao, Zhang, Haibo, Shi, Rong, Zhu, Weiming, Zhang, Changsheng. Insights into Caerulomycin A Biosynthesis: A Two-Component Monooxygenase CrmH-Catalyzed Oxime Formation. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2013, 135(50): 18750-18753, [15] Zhu, Yiguang, Fu, Peng, Lin, Qinheng, Zhang, Guangtao, Zhang, Haibo, Li, Sumei, Ju, Jianhua, Zhu, Weiming, Zhang, Changsheng. Identification of Caerulomycin A Gene Cluster Implicates a Tailoring Amidohydrolase. ORGANIC LETTERS[J]. 2012, 14(11): 2666-2669, [16] Zhu, Yiguang, Ji, Fang, Shang, Hui, Zhu, Qian, Wang, Pengxia, Xu, Chengchen, Deng, Yun, Peng, Donghai, Ruan, Lifang, Sun, Ming. Gene Clusters Located on Two Large Plasmids Determine Spore Crystal Association (SCA) in Bacillus thuringiensis Subsp finitimus Strain YBT-020. PLOS ONE[J]. 2011, 6(11): [17] Zhu, Yiguang, Shang, Hui, Zhu, Qian, Ji, Fang, Wang, Pengxia, Fu, Jingjing, Deng, Yun, Xu, Chengchen, Ye, Weixing, Zheng, Jinshui, Zhu, Lei, Ruan, Lifang, Peng, Donghai, Sun, Ming. Complete Genome Sequence of Bacillus thuringiensis Serovar finitimus Strain YBT-020. JOURNAL OF BACTERIOLOGY[J]. 2011, 193(9): 2379-2380, 

   

（ 1 ） 以结构多样化为导向海洋来源放线菌生物碱cyanogramide生物合成研究, 主持, 国家级, 2017-01--2020-12
（ 2 ） 海洋放线菌次生代谢产物Cyanogrisides生物合成后修饰酶的功能研究, 主持, 国家级, 2015-01--2018-12
（ 3 ） 海洋放线菌Actinoalloteichus cyanogriseus WH1-2216-6 次级代谢产物挖掘与生物合成, 主持, 国家级, 2017-04--2020-03
（ 4 ） 生物碱cyanogramide和spiroindimicins螺环成环机制, 主持, 部委级, 2016-08--2021-07
（ 5 ） 海洋放线菌来源聚酮化合物nenestatin A生物合成 与结构多样化, 主持, 市地级, 2017-07--2022-06
（ 6 ） 海洋放线菌来源聚酮类化合物Pteridic acids生物合成机制研究, 主持, 省级, 2019-10--2022-09
（ 7 ） 聚酮天然产物合成体系的智能创建, 主持, 国家级, 2019-07--2024-06
（ 8 ） 生物碱cyanogramide生物合成中细胞色素P450酶CyaGHI的酶学机制研究, 主持, 国家级, 2022-01--2025-12