1. 点击化学/生物正交在生物体中的应用

2. 天然智能纳米材料及仿生纳米机器人的构建及疾病诊疗

3. 肿瘤新型免疫细胞疗法的开发及应用

   

071010-生物化学与分子生物学
0710J1-纳米科学与技术
0703Z1-化学生物学

纳米载药，代谢类探针，点击化学
化学生物学
肿瘤免疫学

2007-09--2012-07   山东大学   博士研究生/博士学位
2003-09--2007-07   大连理工大学   本科/学士学位

研究生

博士学位

   

2017-11~现在, 中国科学院深圳先进技术研究院, 副研究员
2012-07~2017-11,中国科学院深圳先进技术研究院, 助理研究员

2018-05-29-今,山东大学药学院硕士合作指导教师,

化学生物学进展
纳米生物学实验课
纳米技术导论
生物材料综合实验课

   

[1] 李文军, 张旭, 蔡林涛, 潘宏, 郑金玲, 王子茜, 沙依拜, 徐晓宇, 梁娜, 余时文. 一种基于生物正交技术的溶瘤病毒及其制备方法和应用. CN202310236863.8, 2023-03-13.
[2] 蔡林涛, 李文军, 孟丹丹, 潘宏, 徐晓宇, 梁振国, 张旭, 郑金玲, 王子茜. 一种氧化还原型纳米颗粒和活细胞载体及其应用. PCT/CN2022/137014, 2022-12-06.
[3] 蔡林涛, 梁娜, 李文军, 徐晓宇, 张旭, 郑金玲, 王子茜, 沙依拜, 余时文. 一种具有肿瘤微环境响应的乳酸杆菌载体及应用. CN202211515245.9, 2022-11-29.
[4] 蔡林涛, 李文军, 郑金玲, 徐晓宇, 张旭, 王子茜, 梁娜, 沙依拜, 余时文. 一种双靶向自组装纳米药物递送系统及其制备方法与应用. CN202211509420.3, 2022-11-29.
[5] 蔡林涛, 江鑫, 李文军, 贺伟, 潘宏, 张旭. 一种点击化学介导的靶向方法. CN: CN111718904A, 2020-09-29.
[6] 蔡林涛, 马轶凡, 潘宏, 金言, 李萍, 李文军. 一种病毒转染增效剂和基于点击化学的病毒转染应用. CN: CN111032869A, 2020-04-17.
[7] 蔡林涛, 潘宏, 马轶凡, 李文军, 罗英梅, 王芳芳. 人工靶向修饰的CAR-T细胞及其制备方法与应用. CN: CN110157682A, 2019-08-23.
[8] 蔡林涛, 潘宏, 郑明彬, 韩雨彤, 李文军, 陈泽, 罗英梅. 一种生物正交靶向的细胞膜仿生纳米颗粒及其制备方法和用途. CN: CN110101684A, 2019-08-09.
[9] 蔡林涛, 张佳丽, 龚萍, 孟晓青, 孙枝红, 李文军, 邓冠军, 李三朋, 周理华. 一种有机分子在制备肿瘤靶向、诊断以及治疗试剂的应用. CN: CN109954140A, 2019-07-02.
[10] 蔡林涛, 周理华, 龚萍, 孟晓青, 张佳丽, 李文军, 邓冠军. 一种肿瘤线粒体靶向磁纳米探针及其制备方法及应用. CN: CN109833485A, 2019-06-04.
[11] 蔡林涛, 李文军, 孟晓青, 潘宏, 龚萍, 马轶凡, 李三朋, 邓冠军. 单糖类似物及包含其的分子探针和该分子探针的应用. CN: CN109553643A, 2019-04-02.
[12] 蔡林涛, 李文军, 潘宏, 马轶凡, 龚萍. 促进生物体相互作用的方法及应用. CN: CN109504652A, 2019-03-22.
[13] 蔡林涛, 孟晓青, 龚萍, 张佳丽, 孙枝红, 李三朋, 邓冠军, 周理华, 李文军, 吴亚运, 郑明彬, 陈驰. 一种有机物及其制备方法和应用. CN: CN108264514A, 2018-07-10.
[14] 蔡林涛, 孟晓青, 龚萍, 李三朋, 孙枝红, 周理华, 张佳丽, 邓冠军, 李文军, 郑明彬. 吲哚菁绿衍生物及制备方法. CN: CN108264475A, 2018-07-10.
[15] 蔡林涛, 孟晓青, 龚萍, 李三朋, 孙枝红, 周理华, 张佳丽, 邓冠军, 李文军, 吴亚运, 郑明彬. 一种光致变色化合物及其制备方法. CN: CN108251101A, 2018-07-06.
[16] 蔡林涛, 龚萍, 李三朋, 李文军, 孟晓青, 孙枝红, 邓冠军, 倪大鹏, 张佳丽, 朱婷. 一种纳米载药胶束、纳米抗癌药物及其制备方法和应用. CN: CN106668873A, 2017-05-17.
[17] 蔡林涛, 李文军, 潘正银, 张鹏飞, 刘宏. 由染料分子标记的四嗪探针及其制备方法和应用. CN: CN106010507A, 2016-10-12.
[18] 蔡林涛, 李文军, 吴亚运. 一种纳米靶向载药胶束及其制备方法和一种抗癌药物及其制备方法. CN: CN105596294A, 2016-05-25.
[19] 蔡林涛, 李文军, 潘正银, 张鹏飞, 刘宏. 胆碱类似物及其制备方法和应用、由染料分子标记的四嗪探针及其制备方法和应用. CN: CN104744293A, 2015-07-01.
[20] 马轶凡, 潘宏, 张鹏飞, 李文军, 蔡林涛. 一种用于具有细胞膜结构的生物体的荧光标记方法. CN: CN104749369A, 2015-07-01.
[21] 蔡林涛, 刘宏, 潘正银, 张鹏飞, 李文军, 潘宏, 马轶凡. 对细胞进行原位标记的方法和应用. CN: CN103983764A, 2014-08-13.
[22] 蔡林涛, 潘正银, 李文军. 聚合物、光响应胶束、光响应载药胶束及其制备方法. CN: CN103951766A, 2014-07-30.
[23] 蔡林涛, 李文军, 潘正银. 纳米载药胶束和抗癌药物及其制备方法. CN: CN103599068A, 2014-02-26.

   

[1] Meng, Dandan, Pan, Hong, He, Wei, Jiang, Xing, Liang, Zhenguo, Zhang, Xu, Xu, Xiaoyu, Wang, Zixi, Zheng, Jinling, Gong, Ping, Li, Wenjun, Cai, Lintao. In Situ Activated NK Cell as Bio-Orthogonal Targeted Live-Cell Nanocarrier Augmented Solid Tumor Immunotherapy. ADVANCED FUNCTIONAL MATERIALS[J]. 2022, 32(29): http://dx.doi.org/10.1002/adfm.202202603.
[2] Pan, Hong, Li, Wenjun, Chen, Ze, Luo, Yingmei, He, Wei, Wang, Mengmeng, Tang, Xiaofan, He, Huamei, Liu, Lanlan, Zheng, Mingbin, Jiang, Xin, Yin, Ting, Liang, Ruijing, Ma, Yifan, Cai, Lintao. Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor. BIOACTIVE MATERIALS[J]. 2021, 6(4): 951-962, http://dx.doi.org/10.1016/j.bioactmat.2020.09.025.
[3] Han, Yutong, Pan, Hong, Li, Wenjun, Chen, Ze, Ma, Aiqing, Yin, Ting, Liang, Ruijing, Chen, Fuming, Ma, Nan, Jin, Yan, Zheng, Mingbin, Li, Baohong, Cai, Lintao. T Cell Membrane Mimicking Nanoparticles with Bioorthogonal Targeting and Immune Recognition for Enhanced Photothermal Therapy. ADVANCED SCIENCE[J]. 2019, 6(15): https://doaj.org/article/7cb0059b4e0e44bdb9a278463a7861cc.
[4] Ren, Qian, Liang, Zhenguo, Jiang, Xin, Gong, Ping, Zhou, Lihua, Sun, Zhihong, Xiang, Jingjing, Xu, Zhen, Peng, Xinghua, Li, Sanpeng, Li, Wenjun, Cai, Lintao, Tang, Jiaoning. Enzyme and pH dual-responsive hyaluronic acid nanoparticles mediated combination of photodynamic therapy and chemotherapy. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2019, 130: 845-852, http://dx.doi.org/10.1016/j.ijbiomac.2019.03.030.
[5] Li, Wenjun, Pan, Hong, He, Huamei, Meng, Xiaoqing, Ren, Qian, Gong, Ping, Jiang, Xin, Liang, Zhenguo, Liu, Lanlan, Zheng, Mingbin, Shao, Ximing, Ma, Yifan, Cai, Lintao. Bio-Orthogonal T Cell Targeting Strategy for Robustly Enhancing Cytotoxicity against Tumor Cells. SMALL[J]. 2019, 15(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000456849600008.
[6] Li, Sanpeng, Sun, Zhihong, Meng, Xiaoqing, Deng, Guanjun, Zhang, Jiali, Zhou, Kui, Li, Wenjun, Zhou, Lihua, Gong, Ping, Cai, Lintao. Targeted Methotrexate Prodrug Conjugated With Heptamethine Cyanine Dye Improving Chemotherapy and Monitoring Itself Activating by Dual-Modal Imaging. FRONTIERS IN MATERIALS[J]. 2018, 5: http://ir.siat.ac.cn:8080/handle/172644/14600.
[7] Zhou, Lihua, Wu, Yayun, Meng, Xiaoqing, Li, Sanpeng, Zhang, Jiali, Gong, Ping, Zhang, Pengfei, Jiang, Tao, Deng, Guanjun, Li, Wenjun, Sun, Zhihong, Cai, Lintao. Dye-Anchored MnO Nanoparticles Targeting Tumor and Inducing Enhanced Phototherapy Effect via Mitochondria-Mediated Pathway. SMALL[J]. 2018, 14(36): http://ir.siat.ac.cn:8080/handle/172644/14613.
[8] Cui, Haodong, Hu, Dehong, Zhang, Jingnan, Gao, Guanhui, Chen, Ze, Li, Wenjun, Gong, Ping, Sheng, Zonghai, Cai, Lintao. Gold Nanoclusters-Indocyanine Green Nanoprobes for Synchronous Cancer Imaging, Treatment, and Real-Time Monitoring Based on Fluorescence Resonance Energy Transfer. ACS APPLIED MATERIALS & INTERFACES[J]. 2017, 9(30): 25114-25127, [9] Li, Sanpeng, Sun, Zhihong, Deng, Guanjun, Meng, Xiaoqing, Li, Wenjun, Ni, Dapeng, Zhang, Jiali, Gong, Ping, Cai, Lintao. Dual-modal imaging-guided highly efficient photothermal therapy using heptamethine cyanine-conjugated hyaluronic acid micelles. BIOMATERIALS SCIENCE[J]. 2017, 5(6): 1122-1129, https://www.webofscience.com/wos/woscc/full-record/WOS:000402376000006.
[10] 孙枝红, 周理华, 邓冠军, 郑明彬, 言伟强, 李文军, 蔡林涛, 龚萍. 肿瘤靶向的磁性荧光IR780-Fe_3O_4纳米颗粒用于循环肿瘤细胞的检测. 分析化学[J]. 2017, 45(10): 1427-1433, http://lib.cqvip.com/Qikan/Article/Detail?id=673350866.
[11] Pan, Hong, Li, Wenjun, Yao, Xiangjie, Wu, Yayun, Liu, Lanlan, He, Huamei, Zhang, Renli, Ma, Yifan, Cai, Lintao. In Situ Bioorthogonal Metabolic Labeling for Fluorescence Imaging of Virus Infection In Vivo. SMALL[J]. 2017, 13(17): https://www.webofscience.com/wos/woscc/full-record/WOS:000400452200013.
[12] Meng, Xiaoqing, Li, Wenjun, Sun, Zhihong, Zhang, Jiali, Zhou, Lihua, Deng, Guanjun, Gong, Ping, Cai, Lintao. Tumor-targeted small molecule for dual-modal imaging-guided phototherapy upon near-infrared excitation. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2017, 5(47): 9405-9411, https://www.webofscience.com/wos/woscc/full-record/WOS:000417147300014.
[13] Meng, Xiaoqing, Yang, Yueting, Zhou, Lihua, Zhang, Li, Lv, Yalin, Li, Sanpeng, Wu, Yayun, Zheng, Mingbin, Li, Wenjun, Gao, Guanhui, Deng, Guanjun, Jiang, Tao, Ni, Dapeng, Gong, Ping, Cai, Lintao. Dual-Responsive Molecular Probe for Tumor Targeted Imaging and Photodynamic Therapy. THERANOSTICS[J]. 2017, 7(7): 1781-1794, https://www.webofscience.com/wos/woscc/full-record/WOS:000402093200001.
[14] Deng, Guanjun, Zhu, Ting, Zhou, Lihua, Zhang, Jingnan, Li, Sanpeng, Sun, Zhihong, Lai, Jiazheng, Meng, Xiaoqing, Li, Wenjun, Zhang, Pengfei, Wu, Yayun, Jiang, Tao, Ni, Dapeng, Yan, Weiqiang, Zheng, Mingbin, Gong, Ping, Cai, Lintao. Bovine serum albumin-loaded nano-selenium/ICG nanoparticles for highly effective chemo-photothermal combination therapy. RSC ADVANCES[J]. 2017, 7(49): 30717-30724, https://www.webofscience.com/wos/woscc/full-record/WOS:000403668900026.
[15] Sun ZhiHong, Zhou LiHua, Deng GuanJun, Zhegn MingBin, Yan WeiQiang, Li WenJun, Cai LinTao, Gong Ping. Tumor Targeting of Fluorescent Magnetic IR780-Fe3O4 Nanoparticles for Detection of Circulating Tumor Cells. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2017, 45(10): 1427-1433, https://www.webofscience.com/wos/woscc/full-record/WOS:000414957900002.
[16] 李文军. Living Cells Multi-Lifetime Encoding Based on Lifetime-Tunable Lattice-Strained Quantum Dots. ACS Appl. Mater. Interfaces. 2016, [17] Zhang, Li, Chen, Chi, Li, Wenjun, Gao, Guanhui, Gong, Ping, Cai, Lintao. Living Cell Multilifetime Encoding Based on Lifetime-Tunable Lattice Strained Quantum Dots. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 8(21): 13187-13191, https://www.webofscience.com/wos/woscc/full-record/WOS:000377150400002.
[18] Li, Wenjun, Zheng, Cuifang, Pan, Zhengyin, Chen, Chi, Hu, Dehong, Gao, Guanhui, Kang, Shendong, Cui, Haodong, Gong, Ping, Cai, Lintao. Smart hyaluronidase-actived theranostic micelles for dual-modal imaging guided photodynamic therapy. BIOMATERIALS[J]. 2016, 101: 10-19, http://dx.doi.org/10.1016/j.biomaterials.2016.05.019.
[19] Zhang, Pengfei, Pan, Hong, Gao, Duyang, Chen, Chi, Li, Wenjun, Wu, Yayun, Hu, Dehong, Li, Chuansheng, Gong, Ping, Sheng, Zonghai, Gao, Guanhui, Ma, Yifan, Cai, Lintao. Bioorthogonal multifunctional nanoprobes for biomedicine and theranostic applications. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINEnull. 2016, 12(2): 486-486, http://dx.doi.org/10.1016/j.nano.2015.12.114.
[20] Li, Wenjun, Pan, Zhengyin, Zheng, Cuifang, Liu, Peng, Zhang, Pengfei, Cai, Lintao. Tumor-targeting and hyaluronidase activatable nanoparticles for tumor tracer and photochemistry therapy. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINEnull. 2016, 12(2): 569-569, http://dx.doi.org/10.1016/j.nano.2015.12.342.
[21] 李文军. umor-targeting and hyaluronidase activatable nanoparticles for tumor tracer and photochemistry therapy. Nanomedicine: Nanotechnology, Biology and Medicine. 2016, [22] Chen, Chi, Zhang, Pengfei, Zhang, Li, Gao, Duyang, Gao, Guanhui, Yang, Yong, Li, Wenjun, Gong, Ping, Cai, Lintao. Long-decay near-infrared-emitting doped quantum dots for lifetime-based in vivo pH imaging. CHEMICAL COMMUNICATIONS[J]. 2015, 51(56): 11162-11165, https://www.webofscience.com/wos/woscc/full-record/WOS:000357173100002.
[23] Li, Wenjun, Zhan, Peng, De Clercq, Erik, Lou, Hongxiang, Liu, Xinyong. Current drug research on PEGylation with small molecular agents. PROGRESS IN POLYMER SCIENCEnull. 2013, 38(3-4): 421-444, http://dx.doi.org/10.1016/j.progpolymsci.2012.07.006.
[24] 李文军. Synthesis, Influence of Molecular Weight of PEG on Pharmaceutics and Anti-HIV Activity in Vitro. Int J Biol Macromol. 2012, [25] Li, Wenjun, Zhan, Peng, Wu, Jingde, Chang, Yu, Pannecouque, Christophe, De Clercq, Erik, Liu, Xinyong. Synthesis, Influence of Polymer Molecular Weight on Drug Release and Anti-HIV Activity of PEGylated AZT Conjugates. ANTIVIRAL RESEARCHnull. 2011, 90(2): A37-A37, http://dx.doi.org/10.1016/j.antiviral.2011.03.049.
[26] Li, Wenjun, Chang, Yu, Zhan, Peng, Zhang, Na, Liu, Xinyong, Pannecouque, Christophe, De Clercq, Erik. Synthesis, In Vitro and In Vivo Release Kinetics, and Anti-HIV Activity of A Sustained-Release Prodrug (mPEG-AZT) of 3 '-Azido-3 '-deoxythymidine (AZT, Zidovudine). CHEMMEDCHEM[J]. 2010, 5(11): 1893-1898, https://www.webofscience.com/wos/woscc/full-record/WOS:000284585500012.

   

（ 1 ） 基于透明质酸酶敏感纳 基于透明质酸酶敏感纳 米载药系统的肿瘤示踪 米载药系统的肿瘤示踪 与光化学治疗研究 光化学治疗研究 光化学治疗研究, 主持, 国家级, 2015-01--2017-12
（ 2 ） 基于沙门氏菌 于沙门氏菌 YB1YB1YB1联合 光动力纳米颗粒用于肿 光动力纳米颗粒用于肿 瘤活体成像及治疗的研 瘤活体成像及治疗的研 究, 主持, 省级, 2018-03--2020-03
（ 3 ） 趋磁菌/纳米颗粒复合载药体系的构建及抗肿瘤治疗研究, 主持, 省级, 2021-01--2023-12
（ 4 ） TiO2/Au纳米复合体结合Gln代谢抑制剂的抗肿瘤声动力-免疫协同治疗研究, 主持, 研究所（学校）, 2021-08--2023-07
（ 5 ） 基于溶酶体靶向嵌合体的新型仿生纳米粒用于治疗Alzheimer病的研究, 主持, 省级, 2021-12--2024-12

（1）点击化学在病毒示踪和细胞治疗的前沿研究   中国化学会第32届学术年会   蔡林涛，潘宏，李文军，张鹏飞，郑明彬   2021-04-16
（2）Paired bioorthogonal glycometabolic labeling for enhancing T cell targeting and cytotoxicity against lymphoma cells   2018-10-15
（3）Visual tracking of enterovirus infection behavior by bioorthogonal Near-infrared Quantum Dots   2017-07-29
（4）酶敏感纳米胶束的对肿瘤的活体示踪及光动力治疗研究   2016 中国化学会   2016-07-01
（5）Tumor-targeting and hyaluronidase activatable nanoparticles for tumor tracer and photochemistry therapy   2015-04-07

与法国波尔多凝聚态化学研究所（ICMCB）、山东大学、香港大学深圳医院、深圳市龙岗人民医院、深圳市第三人民医院建立长期稳定的合作关系。

已指导学生

梁振国  硕士研究生  0703Z1-化学生物学  

现指导学生

张旭  硕士研究生  086000-生物与医药  

马财兵  硕士研究生  086000-生物与医药  

王子茜  硕士研究生  086000-生物与医药  

沙依拜·沙比提  博士研究生  0703Z1-化学生物学