100701-药物化学
100703-生药学

海洋天然药物化学，药物化学

2010-09--2013-12   法国巴黎第六大学   获得博士学位
2007-09--2010-07   华东师范大学   获得硕士学位
2003-09--2007-07   天津大学   获得学士学位

   

2015-10~现在, 中国科学院上海药物研究所, 副研究员
2015-05~2015-09,中国科学院上海药物研究所, 助理研究员
2014-05~2015-04,瑞士苏黎世联邦理工学院, 博士后
2013-12~2014-05,法国国家科学研究中心, 研究助理

2017-11-01-今,上海市医药卫生青年联合会第二届委员会委员,
2016-10-03-今,中国药学会“中国海洋药物博士论坛”青年委员会委员,
2015-12-01-今,上海市药学会海洋药物专业委员会委员,
2015-11-02-今,《药学学报》中英文两刊青年编委,

Marine Natural Product Chemistry

   

（1） 赛诺菲-中国科学院上海生命科学研究院优秀青年人才奖励基金, 一等奖, 院级, 2017
（2） 上海市“浦江人才计划”, 一等奖, 省级, 2016
（3） 中国科学院青年创新促进会会员, 一等奖, 院级, 2016
（4） 中国科协“青年人才托举工程”, 一等奖, 部委级, 2016

[1] 李序文, 郭跃伟, 刘三宏, 付盼盼, 王群, 金洋. 一种含有2-氨基咪唑环的化合物及其制备方法和应用. 202211253177.3, 2022-10-13.
[2] 胡宇宏, 程凤莲, 郭跃伟, 李序文, 刘进. 柠檬苦素衍生物及其制备方法和用途. CN: CN113929730A, 2022-01-14.
[3] 郭跃伟, 李序文, 李松威, 吴祺豪, 姚励功, 罗成, 张豪. 吡喃酮类化合物的分离方法、吡喃酮类化合物及其用途. CN: CN113754644A, 2021-12-07.
[4] 郭跃伟, 李序文, 庞涛, 刘进, 高成龙, 侯桂革. 苯并氧杂卓-5-酮类化合物及其制备方法和用途. CN: CN112552276A, 2021-03-26.
[5] 郭跃伟, 唐炜, 李序文, 刘进, 李恒. 一类含有1,2,4-噁二唑环的化合物、其制备方法及其在免疫抑制药物中的应用. CN: CN110627778A, 2019-12-31.
[6] 郭跃伟, 蓝乐夫, 李序文, 陈菲菲, 刘进. 一类二聚吲哚生物碱类化合物、其制备方法及其在制备抗菌药物中的应用. CN: CN109651352A, 2019-04-19.

   

[1] Du, Yeqing, Yao, Ligong, Li, Xuwen, Guo, Yuewei. Yonarolide A, an unprece dente d furanobutenolide-containing norcembranoid derivative formed by photoinduced intramolecular 2+2 cycloaddition. CHINESE CHEMICAL LETTERS[J]. 2023, 34(2): http://dx.doi.org/10.1016/j.cclet.2022.05.026.
[2] Fu Panpan, Wang qun, Zhang Qing, Jin Yang, Liu Jin, Chen Kaixian, Guo Yuewei, Liu sanhong, Li Xuwen. Bioactivity-driven synthesis of the marine natural product naamidine J and its derivatives as potential tumor immunological agents by inhibiting programmed death-ligand 1. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2023, 66: 5427-5438, http://dx.doi.org/10.1021/acs.jmedchem.2c01702.
[3] Li, Chuchu, Han, Yuqiao, Wang, Zhengyang, Yu, Yanan, Wang, Chen, Ren, Ziwei, Guo, Yanzhi, Zhu, Tong, Li, XuWen, Dong, Suzhen, Ma, Mingliang. Function-oriented synthesis of Imidazo1,2-apyrazine and Imidazo1,2-b pyridazine derivatives as potent PI3K/mTOR dual inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2023, 247: http://dx.doi.org/10.1016/j.ejmech.2022.115030.
[4] Chen, ZiHui, Guo, YueWei, Li, XuWen. Recent advances on marine mollusk-derived natural products: chemistry, chemical ecology and therapeutical potential. NATURAL PRODUCT REPORTSnull. 2023, 40(3): 509-556, http://dx.doi.org/10.1039/d2np00021k.
[5] Shou-Mao Shen, Ming-Zhi Su, Dan-Dan Yu, Hui Luo, Xu-Wen LI, Yue-Wei Guo. Chemistry, Chemo-Ecology, and Biological Activities of Uncommon and Structurally Diverse Sesquiterpenoids from the Sanya Bay Nudibranch Hexabranchus sanguineus. Chemistry—A European Journal[J]. 2023, 29: doi.org/10.1002/chem.202300457.
[6] YeQing Du, Yuan Gao, Yi Zang, Jia Li, XuWen Li, YueWei Guo. Extending the record of dolabellane-type diterpenoids from the soft coral Clavularia viridis: Structures and stereochemistry. PHYTOCHEMISTRY. 2023, 210: http://dx.doi.org/10.1016/j.phytochem.2023.113671.
[7] SongWei Li, Qihao Wu, Heng Xu, LiGong Yao, Cheng Luo, Hong Wang, Hao Zhang, XuWen Li, YueWei Guo. Ocellatuperoxides A–F, Uncommon Anti-Tumoral γ -Pyrone Peroxides from a Photosynthetic Mollusk Placobranchus ocellatus. MARINE DRUGS[J]. 2022, 20(590): https://doaj.org/article/b3d6b20a7f8a4ed0a40aa457e9f1dfe4.
[8] Fu, PanPan, Jin, Yang, Yao, LiGong, Guo, YueWei, Li, XuWen. New diterpenoids from the South China Sea soft coral Sinularia pedunculata. TETRAHEDRON LETTERS[J]. 2022, 97: http://dx.doi.org/10.1016/j.tetlet.2022.153792.
[9] Li, Jiao, Cai, Zhenyu, Li, XuWen, Zhuang, Chunlin. Natural Product-Inspired Targeted Protein Degraders: Advances and Perspectives. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 65(20): 13533-13560, http://dx.doi.org/10.1021/acs.jmedchem.2c01223.
[10] LiLi Sun, XuWen Li, YueWei Guo. Ximaoornatins A–C, Polyoxygenated Diterpenoids from the Hainan Soft Coral Sinularia ornata. MARINE DRUGS[J]. 2022, 20(218): https://doaj.org/article/fdc93563ae2c4540b9dcb6fb2629ef99.
[11] Quan Xu, Ning Zhao, Jin Liu, JinQian Song, LiHua Huang, Hong Wang, XuWen Li, Tao Pang, YueWei Guo. Design, synthesis and in vitro biological evaluation of marine phidianidine derivatives as potential anti-inflammatory agents. BIOORGANIC & MEDICINAL CHEMISTRY. 2022, 71: http://dx.doi.org/10.1016/j.bmc.2022.116936.
[12] Yang Jin, LiGong Yao, YueWei Guo, XuWen Li. New Cladiellin-Type Diterpenoids from the South China Sea Soft Coral Cladiella krempfi : Structures and Molecular Docking Analysis in EGFRs. MARINE DRUGS[J]. 2022, 20(381): https://doaj.org/article/bec599f74479416188983b39c31f5f70.
[13] Liu, LaiXin, Gu, RuRong, Jin, Yang, Chen, XueQin, Li, XuWen, Zheng, YueMing, Gao, ZhaoBing, Guo, YueWei. Diversity-oriented synthesis of marine polybrominated diphenyl ethers as potential KCNQ potassium channel activators. BIOORGANIC CHEMISTRY[J]. 2022, 126: http://dx.doi.org/10.1016/j.bioorg.2022.105909.
[14] Gao, Yuan, Du, YeQing, Zang, Yi, Liu, HongChun, Wan, HaiYan, Li, Jia, Li, XuWen, Guo, YueWei. Dolabellane Diterpenoids from the Xisha Soft Coral Clavularia viridis. ACS OMEGA[J]. 2022, 7(3): 3052-3059, http://dx.doi.org/10.1021/acsomega.1c06156.
[15] Li, XiaoLu, Ru, Tong, NavarroVazquez, Armando, Lindemann, Peter, Nazare, Marc, Li, XuWen, Guo, YueWei, Sun, Han. Weizhouochrones: Gorgonian-Derived Symmetric Dimers and Their Structure Elucidation Using Anisotropic NMR Combined with DP4+Probability and CASE-3D. JOURNAL OF NATURAL PRODUCTS[J]. 2022, 85(7): 1730-1737, http://dx.doi.org/10.1021/acs.jnatprod.2c00257.
[16] Shen, ShouMao, Zhang, ZaiYong, Yao, LiGong, Wang, JianRong, Guo, YueWei, Li, XuWen. Nitrogenous Sesquiterpenoids from the South China Sea Nudibranch Hexabranchus sanguineus and Its Possible Sponge-Prey Acanthella cavernosa: Chiral Separation, Stereochemistry and Chemical Ecology. CHINESEJOURNALOFCHEMISTRY[J]. 2022, 40(2): 235-246, http://dx.doi.org/10.1002/cjoc.202100676.
[17] Chen BoRu, Gao ChengLong, Liu Jin, Guo YueWei, Jiang JianLan, Pang Tao, Li XuWen. Diversity-oriented synthesis of marine sponge derived hyrtioreticulins and their anti-inflammatory activities. CHINESE JOURNAL OF NATURAL MEDICINES[J]. 2022, 20(1): 74-80, http://dx.doi.org/10.1016/S1875-5364(22)60155-9.
[18] Chen, ZiHui, Lu, SiQi, Han, GuanYing, Li, XuWen, Guo, YueWei. Sinuhirtone A, An Uncommon 17,19-Dinorxeniaphyllanoid, and Nine Related New Terpenoids from the Hainan Soft Coral Sinularia hirta. MARINE DRUGS[J]. 2022, 20(4): http://dx.doi.org/10.3390/md20040272.
[19] Chen, ZiHui, Li, WangSheng, Zhang, ZaiYong, Luo, Hui, Wang, JianRong, Zhang, HaiYan, Zeng, ZiRong, Chen, Bao, Li, XuWen, Guo, YueWei. Sinusiaetone A, an Anti-inflammatory Norditerpenoid with a Bicyclo11.3.0hexadecane Nucleus from the Hainan Soft Coral Sinularia siaesensis. ORGANIC LETTERS[J]. 2021, 23(15): 5621-5625, http://dx.doi.org/10.1021/acs.orglett.1c01601.
[20] Liu, Jiao, Li, Heng, Wu, MengJun, Tang, Wei, Wang, JianRong, Gu, YuCheng, Wang, Hong, Li, XuWen, Guo, YueWei. Sinueretone A, a Diterpenoid with Unprecedented Tricyclo12.1.0.0(5,9) pentadecane Carbon Scaffold from the South China Sea Soft Coral Sinularia erecta. JOURNAL OF ORGANIC CHEMISTRY[J]. 2021, 86(16): 10975-10981, http://dx.doi.org/10.1021/acs.joc.0c02397.
[21] Chen, Bao, Li, WangSheng, Gu, YuCheng, Zhang, HaiYan, Luo, Hui, Wang, ChangYun, Guo, YueWei, Li, XuWen. New formamidobisabolene-type sesquiterpenoids from a Hainan Sponge Halichondria sp.. TETRAHEDRON[J]. 2021, 96: http://dx.doi.org/10.1016/j.tet.2021.132396.
[22] Zeng, ZiRong, Li, WangSheng, Nay, Bastien, Hu, Pei, Zhang, HaiYan, Wang, Hong, Li, XuWen, Guo, YueWei. Sinunanolobatone A, an Anti-inflammatory Diterpenoid with Bicyclo13.1.0pentadecane Carbon Scaffold, and Related Casbanes from the Sanya Soft Coral Sinularia nanolobata. ORGANIC LETTERS[J]. 2021, 23(19): 7575-7579, http://dx.doi.org/10.1021/acs.orglett.1c02772.
[23] Sun, LiLi, Li, WangSheng, Li, Jie, Zhang, HaiYan, Yao, LiGong, Luo, Hui, Guo, YueWei, Li, XuWen. Uncommon Diterpenoids from the South China Sea Soft Coral Sinularia humilis and Their Stereochemistry. JOURNAL OF ORGANIC CHEMISTRY[J]. 2021, 86(4): 3367-3376, http://dx.doi.org/10.1021/acs.joc.0c02742.
[24] Wu, Qihao, Li, SongWei, de Voogd, Nicole J, Wang, Hong, Yao, LiGong, Guo, YueWei, Li, XuWen. Marine alkaloids as the chemical marker for the prey-predator relationship of the sponge Xestospongia sp. and the nudibranch Jorunna funebris. MARINE LIFE SCIENCE & TECHNOLOGY[J]. 2021, 3(3): 375-381, http://dx.doi.org/10.1007/s42995-021-00096-w.
[25] Zhang, Cong, Li, Heng, Liu, Jin, Liu, Moting, Zhang, Hao, Chen, KaiXian, Guo, YueWei, Tang, Wei, Li, XuWen. Diversity-oriented synthesis of cembranoid derivatives as potential anti-inflammatory agents. BIOORGANIC CHEMISTRY[J]. 2021, 111: http://dx.doi.org/10.1016/j.bioorg.2021.104887.
[26] Li, Yufen, Li, Songwei, Cuadrado, Cristina, Gao, Chenglong, Wu, Qihao, Li, Xiaolu, Pang, Tao, Daranas, Antonio Hernandez, Guo, Yuewei, Li, Xuwen. Polyoxygenated anti-inflammatory biscembranoids from the soft coral Sarcophyton tortuosum and their stereochemistry. CHINESE CHEMICAL LETTERS[J]. 2021, 32(1): 271-276, http://dx.doi.org/10.1016/j.cclet.2020.11.037.
[27] Bao Chen, XiaJuan Huan, ZeHong Miao, Nicole Jde Voogd, YuCheng Gu, ChangYun Wang, YueWei Guo, XuWen Li. Uncommon Bis-quinolizidine Alkaloids from the Hainan Sponge Neopetrosia chaliniformis. CHINESE JOURNAL OF CHEMISTRY[J]. 2021, 39(7): 1838-1842, http://dx.doi.org/10.1002/cjoc.202100091.
[28] FangZhou Yin, XiaJuan Huan, Wayan Mudianta, ZeHong Miao, Hong Wang, YueWei Guo, XuWen Li. Polyoxygenated Cembranoids from Soft Coral Lobophytum Crassum and Their Anti-tumoral Activities. CHINESE JOURNAL OF CHEMISTRY[J]. 2021, 39(3): 640-646, http://dx.doi.org/10.1002/cjoc.202000539.
[29] Liu, Jiao, Wu, MengJun, Li, Heng, Wang, Hong, Tang, Wei, Gu, YuCheng, Li, XuWen, Guo, YueWei. Unusual polyoxygenated casbane diterpenoids from the South China Sea soft coral Sinularia erecta. BIOORGANIC CHEMISTRY[J]. 2021, 114: http://dx.doi.org/10.1016/j.bioorg.2021.105028.
[30] Gao, ChengLong, Hou, GuiGe, Liu, Jin, Ru, Tong, Xu, YaZhou, Zhao, ShunYi, Ye, Hui, Zhang, LuYong, Chen, KaiXian, Guo, YueWei, Pang, Tao, Li, XuWen. Synthesis and Target Identification of Benzoxepane Derivatives as Potential Anti-Neuroinflammatory Agents for Ischemic Stroke. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2020, 59(6): 2429-2439, https://www.webofscience.com/wos/woscc/full-record/WOS:000504475800001.
[31] Wu, Qihao, Li, SongWei, Xu, Heng, Wang, Hong, Hu, Pei, Zhang, Hao, Luo, Cheng, Chen, KaiXian, Nay, Bastien, Guo, YueWei, Li, XuWen. Complex Polypropionates from a South China Sea Photosynthetic Mollusk: Isolation and Biomimetic Synthesis Highlighting Novel Rearrangements. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2020, 59(29): 12105-12112, http://dx.doi.org/10.1002/anie.202003643.
[32] Ye Fei, Chen ZiHui, Gu YuCheng, Guo YueWei, Li XuWen. New lobane-type diterpenoids from the Xisha soft coral Sinularia polydactyla. CHINESEJOURNALOFNATURALMEDICINES[J]. 2020, 18(11): 839-843, http://lib.cqvip.com/Qikan/Article/Detail?id=7103587781.
[33] Hu, YuHong, Liu, Jin, Li, Heng, Tang, Wei, Li, XuWen, Guo, YueWei. Chemical Constituents from Citrus changshan-huyou and Their Anti-Inflammatory Activities. CHEMISTRY & BIODIVERSITY[J]. 2020, 17(11): https://www.webofscience.com/wos/woscc/full-record/WOS:000577602800001.
[34] Ye, Fei, Gu, YuCheng, Guo, YueWei, Li, XuWen. Absolute configurations of new cembrane-type diterpenoids from the Hainan soft coral Sarcophyton crassocaule. TETRAHEDRON LETTERS[J]. 2020, 61(25): http://dx.doi.org/10.1016/j.tetlet.2020.152008.
[35] Li XuWen. Chemical ecology-driven discovery of bioactive marine natural products as potential drug leads. CHINESE JOURNAL OF NATURAL MEDICINES[J]. 2020, 18(11): 837-838, http://lib.cqvip.com/Qikan/Article/Detail?id=7103587780.
[36] Ye, Miao, Xu, Wen, He, Qing, Wu, Xian, Lai, WenFang, Zhang, XiaoQin, Lin, Yu, Xu, Wei, Li, XuWen. Dammarane-Type Triterpenoids from the Roots of Rhus chinensis and Their Preventive Effects on Zebrafish Heart Failure and Thrombosis. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 83(2): 362-373, http://dx.doi.org/10.1021/acs.jnatprod.9b00857.
[37] Ye, Fei, Zhou, YuBo, Li, Jia, Gu, YuCheng, Guo, YueWei, Li, XuWen. New Steroids from the South China Sea Soft Coral Lobophytum sp.. CHEMISTRY & BIODIVERSITY[J]. 2020, 17(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000535582300001.
[38] Li, SongWei, Cui, WanXiang, Huan, XiaJuan, Gavagnin, Margherita, Mollo, Ernesto, Miao, ZeHong, Yao, LiGong, Li, XuWen, Guo, YueWei. A new bis-gamma-pyrone polypropionate of onchidiol family from marine pulmonate molluskOnchidiumsp. NATURAL PRODUCT RESEARCH[J]. 2020, 34(14): 1971-1976, https://www.webofscience.com/wos/woscc/full-record/WOS:000547162000003.
[39] Wu, Qihao, Nay, Bastien, Yang, Min, Ni, Yeke, Wang, Hong, Yao, Ligong, Li, Xuwen. Marine sponges of the genus Stelletta as promising drug sources: chemical and biological aspects. ACTA PHARMACEUTICA SINICA B[J]. 2019, 9(2): 237-257, http://lib.cqvip.com/Qikan/Article/Detail?id=89886689504849574850484854.
[40] Wu, Qihao, Gao, Yuan, Zhang, MengMeng, Sheng, Li, Li, Jia, Li, XuWen, Wang, Hong, Guo, YueWei. New sesquiterpenoids from the South China Sea soft corals Clavularia viridis and Lemnalia flava. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY[J]. 2019, 15(1): 695-702, https://doaj.org/article/ccae40ab1f39426ba5446a54c6fca46e.
[41] Yang, Min, Li, XiaoLu, Wang, JianRong, Lei, Xinxiang, Tang, Wei, Li, XuWen, Sun, Han, Guo, YueWei. Sarcomililate A, an Unusual Diterpenoid with Tricyclo11.3.0.0(2,16)hexadecane Carbon Skeleton, and Its Potential Biogenetic Precursors from the Hainan Soft Coral Sarcophyton mililatensis. JOURNAL OF ORGANIC CHEMISTRY[J]. 2019, 84(5): 2568-2576, [42] Li, Geng, Li, Heng, Tang, Wei, Guo, YueWei, Li, XuWen. Klyflaccilides A and B, Diterpenoids with 6/5/8/3 Fused Tetracyclic Carbon Skeleton from the Hainan Soft Coral Klyxum flaccidum. ORGANIC LETTERS[J]. 2019, 21(14): 5660-5664, https://www.webofscience.com/wos/woscc/full-record/WOS:000476957200060.
[43] Yang, Min, Li, Heng, Zhang, Quan, Wu, QiHao, Li, Geng, Chen, KaiXian, Guo, YueWei, Tang, Wei, Li, XuWen. Highly diverse cembranoids from the South China Sea soft coral Sinularia scabra as a new class of potential immunosuppressive agents. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2019, 27(15): 3469-3476, http://dx.doi.org/10.1016/j.bmc.2019.06.030.
[44] Zhang, Quan, Li, XuWen, Yao, LiGong, Wu, Bin, Guo, YueWei. Three new capnosane-type diterpenoids from the South China Sea soft coral Lobophytum sp.. FITOTERAPIA[J]. 2019, 133: 70-74, http://dx.doi.org/10.1016/j.fitote.2018.12.003.
[45] Zang, Yi, Gong, YiHua, Li, XuWen, Li, XiaoNian, Liu, JunJun, Chen, ChunMei, Zhou, Yuan, Gu, LiangHu, Luo, ZengWei, Wang, JianPing, Sun, WeiGuang, Zhu, HuCheng, Zhang, YongHui. Canescones A-E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens. ORGANIC CHEMISTRY FRONTIERS[J]. 2019, 6(18): 3274-3281, https://www.webofscience.com/wos/woscc/full-record/WOS:000484960000014.
[46] Wu, Qihao, Chen, WenTing, Li, SongWei, Ye, JianYu, Huan, XiaJuan, Gavagnin, Margherita, Yao, LiGong, Wang, Hong, Miao, ZeHong, Li, XuWen, Guo, YueWei. Cytotoxic Nitrogenous Terpenoids from Two South China Sea Nudibranchs Phyllidiella pustulosa, Phyllidia coelestis, and Their Sponge-Prey Acanthella cavernosa. MARINE DRUGS[J]. 2019, 17(1): https://doaj.org/article/ef232921ee0d456691cd7fc865356ab3.
[47] Wu, Qihao, Li, XuWen, Li, Heng, Yao, LiGong, Tang, Wei, Miao, ZeHong, Wang, Hong, Guo, YueWei. Bioactive polyoxygenated cembranoids from a novel Hainan chemotype of the soft coral Sinularia flexibilis. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2019, 29(2): 185-188, http://dx.doi.org/10.1016/j.bmcl.2018.12.004.
[48] Lu, SiQi, Li, XuWen, Li, SongWei, Cui, Zan, Guo, YueWei, Han, GuanYing. Sinuhirtins A and B, two uncommon norhumulene-type terpenoids from the South China Sea soft coral Sinularia hirta. TETRAHEDRON LETTERS[J]. 2019, 60(51): http://dx.doi.org/10.1016/j.tetlet.2019.151308.
[49] Liu, Jin, Chen, Yu, Li, JingYa, Luo, Cheng, Li, Jia, Chen, KaiXian, Li, XuWen, Guo, YueWei. Function-Oriented Synthesis of Marine Phidianidine Derivatives as Potential PTP1B Inhibitors with Specific Selectivity. MARINE DRUGS[J]. 2018, 16(3): https://doaj.org/article/39daa5aaff914ec59021b39a0df3e86b.
[50] Liu, Jin, Li, Heng, Chen, KaiXian, Zuo, JianPing, Guo, YueWei, Tang, Wei, Li, XuWen. Design and Synthesis of Marine Phidianidine Derivatives as Potential Immunosuppressive Agents. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 61(24): 11298-11308, https://www.webofscience.com/wos/woscc/full-record/WOS:000454751100023.
[51] Ye, Fei, Cai, MengHao, Chen, Bo, Xiao, Wei, Li, XuWen, Guo, YueWei. ABSOLUTE CONFIGURATION OF (2R,3R,6S,8R)-METHYL HOMONONACTATE, A POLYKETIDE FROM ACTINOMYCETES Streptomyces sp R-527F OF THE ARCTIC REGION. CHEMISTRY OF NATURAL COMPOUNDS[J]. 2018, 54(4): 821-825, https://www.webofscience.com/wos/woscc/full-record/WOS:000440423000058.
[52] Ye, Fei, Li, Jing, Wu, Yu, Zhu, ZhengDan, Mollo, Ernesto, Gavagnin, Margherita, Gu, YuCheng, Zhu, WeiLiang, Li, XuWen, Guo, YueWei. Sarinfacetamides A and B, Nitrogenous Diterpenoids with Tricyclo6.3.1.0(1,5)dodecane Scaffold from the South China Sea Soft Coral Sarcophyton infundibuliforme. ORGANIC LETTERS[J]. 2018, 20(9): 2637-2640, https://www.webofscience.com/wos/woscc/full-record/WOS:000431726900032.
[53] 孙冬宇, 龚景旭, 李序文, 韩冠英, 郭跃伟. Methyl Xestospongoate类似物的设计、合成和抗肿瘤活性. 中国药科大学学报[J]. 2018, 49(4): 413-, http://lib.cqvip.com/Qikan/Article/Detail?id=7000792910.
[54] Sun, DongYu, Han, GuanYing, Yang, NaNa, Lan, LeFu, Li, XuWen, Guo, YueWei. Racemic trinorsesquiterpenoids from the Beihai sponge Spongia officinalis: structure and biomimetic total synthesis. ORGANIC CHEMISTRY FRONTIERS[J]. 2018, 5(6): 1022-1027, [55] Liang, LinFu, Chen, WenTing, Li, XuWen, Wang, HeYao, Guo, YueWei. New Bicyclic Cembranoids from the South China Sea Soft Coral Sarcophyton trocheliophorum. SCIENTIFIC REPORTS[J]. 2017, 7: [56] Li, XiaoLu, Kurtan, Tibor, Hu, Jun Chi, Mandi, Attila, Li, Jia, Li, XuWen, Guo, YueWei. Structural and Stereochemical Studies of Laurokamurols A-C, Uncommon Bis-sesquiterpenoids from the Chinese Red Alga Laurencia okamurai Yamada. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2017, 65(8): 1550-1555, https://www.webofscience.com/wos/woscc/full-record/WOS:000395493500011.
[57] Sun, DongYu, Han, GuanYing, Gong, JingXu, Nay, Bastien, Li, XuWen, Guo, YueWei. Asymmetric Total Synthesis of Distaminolyne A and Revision of Its Absolute Configuration. ORGANIC LETTERS[J]. 2017, 19(3): 714-717, https://www.webofscience.com/wos/woscc/full-record/WOS:000393539900073.
[58] Li, XuWen, Chen, SiHan, Ye, Fei, Mollo, Ernesto, Zhu, WeiLiang, Liu, HaiLi, Guo, YueWei. Axiriabilines A-D, uncommon nitrogenous eudesmane-type sesquiterpenes from the Hainan sponge Axinyssa variabilis. TETRAHEDRON[J]. 2017, 73(34): 5239-5243, http://dx.doi.org/10.1016/j.tet.2017.07.027.
[59] Li XiaoLu, Kurtn Tibor, Hu JunChi, Mndi Attila, Li Jia, Li XuWen, Guo YueWei. Structural and Stereochemical Studies of Laurokamurols A–C, Uncommon Bis-sesquiterpenoids from the Chinese Red Alga Laurencia okamurai Yamada. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2017, [60] Xue, DuoQing, Liu, HaiLi, Chen, SiHan, Mollo, Ernesto, Gavagnin, Margherita, Li, Jia, Li, XuWen, Guo, YueWei. 5-Alkylpyrrole-2-carboxaldehyde derivatives from the Chinese sponge Mycale lissochela and their PTP1B inhibitory activities. CHINESE CHEMICAL LETTERS[J]. 2017, 28(6): 1190-1193, http://dx.doi.org/10.1016/j.cclet.2017.03.040.
[61] Li XuWen, Chen SiHan, Ye Fei, Mollo Ernesto, Zhu WeiLiang, Liu HaiLi, Guo YueWei. Axiriabilines A-D, uncommon nitrogenous eudesmane-type sesquiterpenes from the Hainan sponge Axinyssa variabilis. TETRAHEDRON[J]. 2017, [62] Ye, Fei, Zhu, ZhengDan, Chen, JunSheng, Li, Jing, Gu, YuCheng, Zhu, WeiLiang, Li, XuWen, Guo, YueWei. Xishacorenes A-C, Diterpenes with Bicyclo3.3.1nonane Nucleus from the Xisha Soft Coral Sinularia polydactyla. ORGANIC LETTERS[J]. 2017, 19(16): 4183-4186, https://www.webofscience.com/wos/woscc/full-record/WOS:000408285600008.
[63] Xue, DuoQing, Liu, HaiLi, Chen, SiHan, Mollo, Ernesto, Gavagnin, Margherita, Li, Jia, Li, XuWen, Guo, YueWei. 5-Alkylpyrrole-2-carboxaldehyde derivatives from the Chinese sponge Mycale lissochela and their PTP1B inhibitory activities. CHINESE CHEMICAL LETTERS[J]. 2017, 28(6): 1190-1193, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201903250011746LS.
[64] Liu, Jin, Li, XuWen, Guo, YueWei. Recent Advances in the Isolation, Synthesis and Biological Activity of Marine Guanidine Alkaloids. MARINEDRUGS[J]. 2017, 15(10): https://doaj.org/article/bf8c3546c5e7403388f6df6a9a3869ba.
[65] 李序文. 从基因到分子-真菌中活性聚酮化合物的发现，仿生合成及生物转化研究. 2016, 277-, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CPFD&dbname=CPFDLAST2017&filename=YYWS201609002053&v=MjczNzl2SGludFU3N05KMTRVUERUY2ZiRzRIOWZNcG85Rlp1c0tEeE5LdWhkaG5qOThUbmpxcXhkRWVNT1VLcmlmWmVa.
[66] Zhang, Li, Jiang, ChengShi, Gao, LiXin, Gong, JingXu, Wang, ZhongHua, Li, JingYa, Li, Jia, Li, XuWen, Guo, YueWei. Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2016, 26(3): 778-781, http://dx.doi.org/10.1016/j.bmcl.2015.12.097.
[67] Zhou, ZhenFang, Kurtan, Tibor, Mandi, Attila, Gu, YuCheng, Yao, LiGong, Xin, GuoRong, Li, XuWen, Guo, YueWei. Novel and Neuroprotective Tetranortriterpenoids from Chinese Mangrove Xylocarpus granatum Koenig. SCIENTIFIC REPORTS[J]. 2016, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000384043800001.
[68] Ye, Fei, Li, XuWen, Guo, YueWei. Recent Progress on the Mangrove Plants: Chemistry and Bioactivity. CURRENT ORGANIC CHEMISTRYnull. 2016, 20(18): 1923-1942, https://www.webofscience.com/wos/woscc/full-record/WOS:000380834200006.
[69] Huang, RenYong, Chen, WenTing, Kurtan, Tibor, Mandi, Attila, Ding, Jian, Li, Jia, Li, XuWen, Guo, YueWei. Bioactive isoquinolinequinone alkaloids from the South China Sea nudibranch Jorunna funebris and its sponge-prey Xestospongia sp.. FUTURE MEDICINAL CHEMISTRY[J]. 2016, 8(1): 17-27, https://www.webofscience.com/wos/woscc/full-record/WOS:000367193900004.
[70] Wei, Xiao, Qu, TingLi, Yang, YiFang, Xu, JinFang, Li, XuWen, Zhao, ZhengBao, Guo, YueWei. Design and synthesis of new tetrandrine derivatives and their antitumor activities. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2016, 18(10): 966-975, https://www.webofscience.com/wos/woscc/full-record/WOS:000381494000008.
[71] Gong, JingXu, Wang, HeYao, Yao, LiGong, Li, XuWen, Guo, YueWei. First Total Synthesis of the Marine Natural Brominated Polyunsaturated Lipid Xestospongenyne as a Potent Pancreatic Lipase Inhibitory Agent. SYNLETT[J]. 2016, 27(3): 391-394, https://www.webofscience.com/wos/woscc/full-record/WOS:000369724300011.
[72] Chen, Jing, Tao, LingXue, Xiao, Wei, Ji, ShaSha, Wang, JianRong, Li, XuWen, Zhang, HaiYan, Guo, YueWei. Design, synthesis and biological evaluation of novel chiral oxazino-indoles as potential and selective neuroprotective agents against A beta(25-35)-induced neuronal damage. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2016, 26(15): 3765-3769, https://www.webofscience.com/wos/woscc/full-record/WOS:000380574100074.
[73] Jing Chen, Ling-Xue Tao, Wei Xiao, Sha-Sha Ji, Jian-Rong Wang, Xu-Wen Li, Hai-Yan Zhang, Yue-Wei Guo. Design, synthesis and biological evaluation of novel chiral oxazino-indoles as potential and selective neuroprotective agents against Aβ25–35-induced neuronal damage. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2016, 26(15): 3765-3769, http://dx.doi.org/10.1016/j.bmcl.2016.05.061.
[74] Liu, HaiLi, Xue, DuoQing, Chen, SiHan, Li, XuWen, Guo, YueWei. New Highly Oxidized Formamidobisabolene-Derived Sesquiterpenes from a Hainan Sponge Axinyssa variabilis. HELVETICA CHIMICA ACTA[J]. 2016, 99(8): 650-653, https://www.webofscience.com/wos/woscc/full-record/WOS:000383473800012.
[75] Chen, WenTing, Yao, LiGong, Li, XuWen, Guo, YueWei. Sarcophytrols A-C, new capnosane diterpenoids from the South China Sea soft coral Sarcophyton trocheliophorum. TETRAHEDRON LETTERS[J]. 2015, 56(11): 1348-1352, http://dx.doi.org/10.1016/j.tetlet.2015.01.157.
[76] Chen, WenTing, Li, Jia, Wang, JianRong, Li, XuWen, Guo, YueWei. Structural diversity of terpenoids in the soft coral Sinularia flexibilis, evidenced by a collection from the South China Sea. RSC ADVANCES[J]. 2015, 5(30): 23973-23980, https://www.webofscience.com/wos/woscc/full-record/WOS:000351235800099.
[77] Li Xuwen. Structural diversity of terpenoids in the Soft Coral Sinularia flexibilis, evidence by a collection from the South China Sea. RSC Advances. 2015, [78] Li, XiaoLu, He, WenFei, Li, Jia, Lan, LeFu, Li, XuWen, Guo, YueWei. New laurane-type sesquiterpenoids from the Chinese red alga Laurencia okamurai Yamada. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2015, 17(12): 1146-1152, https://www.webofscience.com/wos/woscc/full-record/WOS:000368454000005.
[79] Li, XuWen, Nay, Bastien. Transition metal-promoted biomimetic steps in total syntheses. NATURAL PRODUCT REPORTSnull. 2014, 31(4): 533-549, http://dx.doi.org/10.1039/c3np70077a.
[80] Li, XuWen, Ear, Alexandre, Nay, Bastien. Hirsutellones and beyond: figuring out the biological and synthetic logics toward chemical complexity in fungal PKS-NRPS compounds. NATURAL PRODUCT REPORTSnull. 2013, 30(6): 765-782, http://dx.doi.org/10.1039/c3np70016j.
[81] Li, XuWen, Ear, Alexandre, Roger, Lukas, Riache, Nassima, Deville, Alexandre, Nay, Bastien. Bio-Inspired Formal Synthesis of Hirsutellones A-C Featuring an Electrophilic Cyclization Triggered by Remote Lewis Acid-Activation. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2013, 19(48): 16389-16393, http://dx.doi.org/10.1002/chem.201303570.
[82] Li, XuWen, Guo, ZiTao, Zhao, Yun, Zhao, Zheng, Hu, JinFeng. Chemical constituents from Saussurea cordifolia. PHYTOCHEMISTRY[J]. 2010, 71(5-6): 682-687, http://dx.doi.org/10.1016/j.phytochem.2009.12.016.

（1） From Biosynthesis to Total Synthesis: Strategies and Tactics for Natural Products (One Chapter: From Biosynthesis to Total Synthesis: An Introduction), WILEY, 2016-05, 第 2 作者

   

（ 1 ） 基于海洋来源的活性吲哚生物碱的发现，功能导向合成以及对糖尿病靶点PTP1B的选择性抑制活性研究, 主持, 国家级, 2017-01--2020-12
（ 2 ） 中国南海软珊瑚中活性西松烷型二萜的合成和肿瘤多靶点抑制活性筛选, 主持, 国家级, 2017-01--2019-12
（ 3 ） 中国南海软体动物中化学成分的发现，功能导向合成及肿瘤多靶点抑制活性的筛选, 主持, 国家级, 2018-01--2020-12
（ 4 ） 中国科学院青年创新促进会会员, 主持, 部委级, 2016-01--2019-12
（ 5 ） 中国科协“青年人才托举工程”, 主持, 国家级, 2015-05--2018-04
（ 6 ） 上海市浦江人才计划, 主持, 省级, 2016-07--2018-06