基本信息
陈全姣  女  博导  中国科学院武汉病毒研究所
电子邮件: chenqj@wh.iov.cn
通信地址: 湖北省武汉市江夏区郑店街道黄金工业园金龙大街262号中国科学院武汉病毒研究所
邮政编码: 430207

教育背景

2015-05--2015-07   Insrem Jean Merieux BSL4 Laboratory   BSL-4实验室体外感染实验培训
2003-09--2007-07   中国科学院武汉病毒研究所   博士
2000-09--2003-07   华中农业大学   硕士
1993-09--1997-07   华中农业大学   学士

教授课程

华中农业大学案例课程
分子生物学
新发传染病与生物安全培训

专利与奖励

   
专利成果
( 1 ) 尼帕病毒检测试剂盒及其专用引物, 专利授权, 2020, 第 2 作者, 专利号: CN109022621B

( 2 ) 一种甲肝病毒定量检测试剂盒, 发明专利, 2014, 第 1 作者, 专利号: CN103805716A

( 3 ) 一种基于混合纤维素酯膜富集水体甲肝病毒的方法, 发明专利, 2014, 第 1 作者, 专利号: CN103789275A

出版信息

   
发表论文
(1) Highly Pathogenic Avian Influenza A (H5N1) Virus in Swans, Central China, 2021, Microbiol Spectr, 2022, 通讯作者
(2) Genetic and Pathogenic Characterization of Avian Influenza Virus in Migratory Birds between 2015 and 2019 in Central China, Microbiol Spectr, 2022, 通讯作者
(3) G Protein Subunit β1 Facilitates Influenza A Virus Replication by Promoting the Nuclear Import of PB2, Journal of Virology, 2022, 通讯作者
(4) Emerging highly pathogenic avian influenza (H5N8) virus in migratory birds in Central China, 2020, EMERGING MICROBES AND INFECTIONS, 2021, 通讯作者
(5) Direct evidence of active SARS-CoV-2 replication in the intestine, CLINICAL INFECTIOUS DISEASES: AN OFFICIAL PUBLICATION OF THE INFECTIOUS DISEASES SOCIETY OF AMERICA, 2021, 通讯作者
(6) 自然杀伤性T细胞(NKT细胞)的LIGHT通过减少保护性的肺泡巨噬细胞加剧严重流感性肺炎, LIGHT of pulmonary NKT cells annihilates tissue protective alveolar macrophages in augmenting severe influenza pneumonia, 科学通报:英文版, 2021, 第 10 作者
(7) 一种可能起源于蝙蝠的新型冠状病毒有关的肺炎暴发, A pneumonia outbreak associated with a new coronavirus of probable bat origin, Nature, 2020, 第 19 作者
(8) Dominant subtype switch in avian influenza viruses during 2016-2019 in China, NATURE COMMUNICATIONS, 2020, 通讯作者
(9) Statistical Binding Matching between Influenza A Virus and Dynamic Glycan Clusters Determines Its Adhesion onto Lipid Membranes, LANGMUIR, 2020, 第 4 作者
(10) Circulation, Evolution and Transmission of H5N8 virus, 2016–2018, JOURNAL OF INFECTION, 2019, 第 7 作者
(11) Continued reassortment of avian h6 influenza viruses from southern china, 2014-2016, TRANSBOUNDARY AND EMERGING DISEASES, 2019, 第 6 作者
(12) Low pathogenic avian influenza a (h5n7) virus isolated from a domestic duck in dongting lake wetland of china, 2016, VIROLOGICA SINICA, 2019, 通讯作者
(13) Rapid and Specific Detection of All Known Nipah virus Strains’ Sequences With Reverse Transcription-Loop-Mediated Isothermal Amplification, FRONTIERS IN MICROBIOLOGY, 2019, 通讯作者
(14) 2015年湖南部分地区H9N2亚型流感病毒HA和NA基因遗传进化, Genetic evolution of HA and NA genes of H9N2 influenza viruses isolated in regions of Hunan Province,China,in 2015, 生物工程学报, 2018, 第 2 作者
(15) Three amino acid substitutions in the NS1 protein change the virus replication of H5N1 influenza virus in human cells, VIROLOGY, 2018, 第 3 作者
(16) Two genetically diverse H7N7 avian influenza viruses isolated from migratory birds in central China, EMERGING MICROBES & INFECTIONS, 2018, 第 10 作者
(17) Two reassortant types of highly pathogenic H5N8 avian influenza virus from wild birds in Central China in 2016, EMERGING MICROBES & INFECTIONS, 2018, 通讯作者
(18) Phylogeography, Transmission, and Viral Proteins of Nipah Virus, VIROLOGICA SINICA, 2018, 第 4 作者
(19) CASCIRE Surveillance Network and Work on Avian Influenza Viruses, SCIENCE CHINA-LIFE SCIENCES, 2017, 第 4 作者
(20) Linear dna vaccine prepared by large-scale pcr provides protective immunity against h1n1 influenza virus infection in mice, VETERINARY MICROBIOLOGY, 2017, 第 2 作者
(21) 清开灵软胶囊制剂前体体外抗H1N1、H5N1和H7N9流感病毒作用, 中医杂志, 2016, 第 2 作者
(22) Comparison of concentration methods for detection of hepatitis A virus in water samples, VIROLOGICA SINICA, 2016, 通讯作者
(23) Novel Avian Influenza A (H5N6) Viruses Isolated in Migratory Waterfowl Before the First Human Case Reported in China, 2014, SCIENTIFIC REPORTS, 2016, 通讯作者
(24) Changes in the Length of the Neuraminidase Stalk Region Impact H7N9 Virulence in Mice, JOURNAL OF VIROLOGY, 2016, 第 3 作者
(25) First documented case of avian influenza (H5N1) virus infection in a lion, EMERGING MICROBES & INFECTIONS, 2016, 第 1 作者
(26) Deep sequencing reveals the viral adaptation process of environment-derived H10N8 in mice, INFECTION GENETICS AND EVOLUTION, 2016, 通讯作者
(27) Genesis, evolution and prevalence of h5n6 avian influenza viruses in china, CELL HOST & MICROBE, 2016, 第 2 作者
(28) 清开灵注射液体对H1N1、H5N1和H7N9流感病毒的作用研究, Anti-viral Effects of Qingkailing Injection Against Influenza H1 N1,H5N1,and H7N9 Virus in Vitro, 中药新药与临床药理, 2015, 第 2 作者
(29) Two novel reassortants of avian influenza A (H5N6) virus in China, JOURNAL OF GENERAL VIROLOGY, 2015, 第 10 作者
(30) Comparative analysis of antibody induction and protection against influenza virus infection by DNA immunization with HA, HAe, and HA1 in mice, ARCHIVES OF VIROLOGY, 2014, 第 3 作者
(31) Evaluation of neutralizing efficacy of monoclonal antibodies specific for 2009 pandemic H1N1 influenza A virus in vitro and in vivo, ARCHIVES OF VIROLOGY, 2014, 第 3 作者
(32) A simple and efficient method for detecting avian influenza virus in water samples, JOURNAL OF VIROLOGICAL METHODS, 2014, 第 2 作者
(33) Human Infection with Influenza Virus A(H10N8) from Live Poultry Markets, China, 2014, EMERGING INFECTIOUS DISEASES, 2014, 第 9 作者
(34) Genotype Diversity of H9N2 Viruses Isolated from Wild Birds and Chickens in Hunan Province, China, PLOS ONE, 2014, 通讯作者
(35) An adjuvanted inactivated murine cytomegalovirus (MCMV) vaccine induces potent and long-term protective immunity against a lethal challenge with virulent MCMV, BMC INFECTIOUS DISEASES, 2014, 第 5 作者
(36) Fusion-Related Host Proteins Are Actively Regulated by NA during Influenza Infection as Revealed by Quantitative Proteomics Analysis, PLOS ONE, 2014, 通讯作者
(37) Serological study of antibodies to influenza A viruses among general population in Wuhan city China, JOURNAL OF CLINICAL VIROLOGY, 2014, 第 7 作者
(38) Serological evidence of H7, H5 and H9 avian influenza virus co-infection among herons in a city park in Jiangxi, China, SCIENTIFIC REPORTS, 2014, 第 6 作者
(39) 免疫磁珠富集与SYB RGreen荧光定量PCR技术联合检测水体中甲肝病毒, DETECTION ON HEPATITIS A VIRUS IN WATER SAMPLE USING IMMUNOMAGNETIC BEADS-BASED CONCENTRATION COMBINED WITH SYBR GREEN REAL-TIME PCR, 内蒙古农业大学学报:自然科学版, 2014, 第 4 作者
(40) Perpetuation of H5N1 and H9N2 avian influenza viruses in natural water bodies, JOURNAL OF GENERAL VIROLOGY, 2014, 第 4 作者
(41) Immunization with Cytomegalovirus Envelope Glycoprotein M and Glycoprotein N DNA Vaccines can Provide Mice with Complete Protection against a Lethal Murine Cytomegalovirus Challenge, Immunization with Cytomegalovirus Envelope Glycoprotein M and Glycoprotein N DNA Vaccines can Provide Mice with Complete Protection against a Lethal Murine Cytomegalovirus Challenge, 中国病毒学:英文版, 2013, 第 4 作者
(42) NA Proteins of Influenza A Viruses H1N1/2009, H5N1, and H9N2 Show Differential Effects on Infection Initiation, Virus Release, and Cell-Cell Fusion, PLOS ONE, 2013, 通讯作者
(43) Avian Influenza A(H7N9) Virus Screening in Patients with Fever and Flu-Like Symptoms in a Tertiary Hospital in an Area with Confirmed Cases, PLOS ONE, 2013, 第 8 作者
(44) A Second CRM1-Dependent Nuclear Export Signal in the Influenza A Virus NS2 Protein Contributes to the Nuclear Export of Viral Ribonucleoproteins, JOURNAL OF VIROLOGY, 2013, 第 3 作者
(45) Immunization with Cytomegalovirus Envelope Glycoprotein M and Glycoprotein N DNA Vaccines can Provide Mice with Complete Protection against a Lethal Murine Cytomegalovirus Challenge, Immunization with Cytomegalovirus Envelope Glycoprotein M and Glycoprotein N DNA Vaccines can Provide Mice with Complete Protection against a Lethal Murine Cytomegalovirus Challenge, 中国病毒学:英文版, 2013, 第 4 作者
(46) Characterization of low-pathogenic H6N6 avian influenza viruses in central China, ARCHIVES OF VIROLOGY, 2013, 第 3 作者
(47) Induction of cross-protection against influenza A virus by DNA prime-intranasal protein boost strategy based on nucleoprotein, VIROLOGY JOURNAL, 2012, 第 9 作者
(48) Complete Genome Sequence of an H9N2 Avian Influenza Virus Isolated from Egret in Lake Dongting Wetland, JOURNAL OF VIROLOGY, 2012, 通讯作者
(49) Characterization of an H4N2 avian influenza virus isolated from domestic duck in Dongting Lake wetland in 2009, VIRUS GENES, 2012, 第 2 作者
(50) Characterization of h9n2 influenza viruses isolated from dongting lake wetland in 2007, ARCHIVES OF VIROLOGY, 2011, 第 3 作者
(51) Characterization of an H10N8 influenza virus isolated from Dongting lake wetland, VIROLOGY JOURNAL, 2011, 第 3 作者
(52) Protection against multiple influenza a virus subtypes by intranasal administration of recombinant nucleoprotein, ARCHIVES OF VIROLOGY, 2010, 第 7 作者
(53) Cross-protection against influenza virus infection by intranasal administration of M1-based vaccine with chitosan as an adjuvant, VACCINE, 2010, 第 2 作者
(54) A live bivalent influenza vaccine based on a H9N2 virus strain, VACCINE, 2010, 第 6 作者
(55) Cross-protection against influenza virus infection by intranasal administration of m2-based vaccine with chitosan as an adjuvant, ARCHIVES OF VIROLOGY, 2010, 第 2 作者
(56) Generation and evaluation of an h9n1 influenza vaccine derived by reverse genetics that allows utilization of a diva strategy for control of h9n2 avian influenza, ARCHIVES OF VIROLOGY, 2009, 第 2 作者
(57) Characterization of h5n1 influenza a viruses isolated from domestic green-winged teal, VIRUS GENES, 2009, 第 3 作者
(58) Comparing the ability of a series of viral protein-expressing plasmid dnas to protect against h5n1 influenza virus, VIRUS GENES, 2009, 第 1 作者
(59) 禽流感病毒HA部分基因的克隆及其表达, The Cloning and Expressing of the Main Epitope of ha gene Fragement of Avian Influenza Virus, 中国病毒学, 2005, 第 1 作者
(60) 禽流感疫苗研究进展, Research Progress on Avian Influenza Vaccine, 中国生物工程杂志, 2004, 第 1 作者
(61) 鸡副黏病毒YM毒株F基因的克隆及遗传进化关系研究, The Choning and Sequence Analysis of F gene of Chicken paramyxovirus virulent YM Isolate, 动物医学进展, 2004, 第 1 作者
(62) Circulation, Evolution and Transmission of Highly Pathogenic Avian Influenza A (H5N8) virus, 2016-2018, JOURNAL OF INFECTION, 第 7 作者

科研活动

   
科研项目
( 1 ) 环境监测关键计量标准及测量技术研究, 参与, 国家任务, 2013-01--2016-12
( 2 ) 中国科学院流感研究与预警中心, 参与, 中国科学院计划, 2015-01--2017-12
( 3 ) 抗菌肽抗H9N2和H5N1亚型禽流感病毒研究, 负责人, 其他任务, 2013-06--2016-12
( 4 ) 候鸟非连续式传播与家禽连续式传播要素演变规律分析, 负责人, 国家任务, 2010-01--2014-12
( 5 ) H5N1流感病毒NEP/NS2与hNup98、hNup214相互作用介导vRNPs出核的机理研究, 负责人, 国家任务, 2011-01--2013-12
( 6 ) A型流感病毒节段4 mRNA通过TAP-p15途径出核的分子机制, 负责人, 国家任务, 2012-01--2014-12
( 7 ) 人感染H7N9禽流感疫情研究, 参与, 中国科学院计划, 2013-05--2014-12
( 8 ) “一带一路”传染病防控保障关键技术研发--中亚地区重要传染病防控保障技术研究, 参与, 国家任务, 2018-01--2021-06
( 9 ) 新冠肺炎病人排毒规律与新冠病毒环境耐受性 研究, 参与, 国家任务, 2020-03--2020-06
( 10 ) 流感病毒变异变迁追踪及有效防控研究, 负责人, 国家任务, 2020-01--2021-06
( 11 ) RJM等药物抗新冠和流感病毒体内和体外药效学研究, 负责人, 企业委托, 2020-08--2022-12
( 12 ) 同科同属病毒进化和感染共性研究, 负责人, 国家任务, 2022-11--2025-10
参与会议
(1)水体中甲肝病毒的富集技术研究   湖北省CDC系统通报信息会   2016-12-06
(2)A型流感病毒:新的研究进程   “流感前沿科学问题”的第95期双清论坛   陈全姣   2015-05-28
(3)Non-continuous and continuous transmission of influenza virus: migratory birds and poultry   中-俄地区国际流感研讨会   陈全姣   2014-05-08

合作情况

   
项目合作单位

中国科学院微生物研究所 ;中国计量科学研究院; 北京师范大学; 深圳华大基因研究院

联合培养学生单位
湖北大学 湖南师范大学 江西农业大学

指导学生

已指导学生

郑华斌  博士研究生  071005-微生物学  

桂锐  博士研究生  071010-生物化学与分子生物学  

周豪  硕士研究生  085238-生物工程  

现指导学生

马莉萍  博士研究生  100103-病原生物学  

姚中子  博士研究生  100103-病原生物学  

熊加松  博士研究生  100103-病原生物学  

唐洋宇  硕士研究生  086000-生物与医药  

叶昶  博士研究生  100103-病原生物学  

刘仁怡  博士研究生  100103-病原生物学