对环境与健康问题开展系统性研究，以理清环境化学物质与目前严重影响国民健康的环境关联疾病的关系为出发点，探讨危害途径和分子作用机理，为预防环境污染物质诱发各类疾病提供理论与技术支持。

      主要从疾病细胞模型和动物模型入手，包括四个方面的研究内容：
一. 环境污染物和动脉粥样硬化发生关系的分子机理；
二. 海洋马达卡鱼在环境污染物健康风险评估方面的应用；
三. 地区性癌症多发的环境因素及其分子机理；
四. 中药资源在环境健康方面的应用。

招收环境科学、分子毒理、环境与健康效应方面硕士和博士生；
欢迎相关博士后来所工作和交流，并给优秀者提供出国学习工作机会。

083001-环境科学
100405-卫生毒理学

环境污染与健康
分子细胞毒理学

   

博士，2001,4-2004,3，东京农工大学，生物工学；
硕士，1998,4-2001,3，日本筑波大学，系统生物学；
学士，1986,9-1990,7，中国农业大学，动物遗传与育种专业。

博士学位，2004,3，东京农工大学，生物工学；
硕士学位，2001,3，日本筑波大学，系统生物学；
学士学位，1990,7，中国农业大学，动物遗传与育种专业。

硕士，1998,4-2001,3，日本筑波大学，系统生物学；
博士，2001,4-2004,3，东京农工大学，生物工学；
博士后，2004,4-2007,3，日本产业技术综合研究所；
特任研究员，2007,4-2009,5，日本国际统合医科学研究所。

   

2009-06~现在, 中国科学院城市环境研究所, 研究员
2007-04~2009-05,日本国际统合医科学研究所, 特任研究员
2004-05~2007-03,日本产业技术综合研究所, 特别研究员
1993-05~1998-04,北京万里科技发展公司, 技术部经理
1990-07~1993-04,北京华都育种公司, 育种部

2014-10-23-今,厦门大学兼职教授, 教授
2014-04-01-今,生态毒理学报编委, 编委

2009年入选中国科学院“****”

专利：
1. Evaluating activity of Chinese drug or its active ingredient, by administering Chinese drug or its active ingredient to subject, comparing expression profile of gene e.g. mitochondrial phosphoenolpyruvate carboxykinase 2 in subject （专利号: JP2007319051-A 发明人: DONG S J, KIYAMA R）
2.Evaluation of bioactivity of traditional Chinese medicines using cDNA microarray assay (2006001742, 2006-151189; AIST, Japan) (Kiyama R and Dong S).
3.Expression of human Fuc-O-proteins in methylotrophic yeast (2005001960, 2004-118146; AIST, Japan) (Jigami Y, Tigira Y, Gao XD and Dong S).
4.Extract useful as health supplement, and for treating diseases associated with estrogen deficiency e.g. arteriosclerosis and hyperlipidemia, obtained by extracting Agaricus blazei mycelium and/or its processed material with solvent （专利号: WO2010 125891-A1; JP2010275294-A发明人: MATSUOKA RUMIKO, KIYAMA RYOICHI, DONG SIJUN ）

（1） 中国科学院BHPB导师科研奖, 国家级, 2014

      代表论文
1. Huang Q, Chen Y, Chi Y, Lin Y, Zhang H, Fang C, Dong S*. Immunotoxic effects of perfluorooctane sulfonate and di(2-ethylhexyl) phthalate on the marine fish Oryzias melastigma. Fish Shellfish Immunol. 2015; 44(1):302-6.
2. Sun X,Lin Y,Huang Q,Shi P,Qiu L,Kang M,Chen Y, Fang C, Ye T, Dong S* Di(2-ethylhexyl) phthalate-induced apoptosis in rat INS-1 cells is dependent on activation of endoplasmic reticulum stress and suppression of antioxidant protection. J Cell Mol Med. 2015; 19(3):581-94.
3. Chen Y, Huang Q, Chen Q, Lin Y, Sun X, Zhang H, Zhu M, Dong S*. The inflammation and estrogen metabolism impacts of polychlorinated biphenyls on endometrial cancer cells. Toxicol In Vitro. 2014; 29(2):308-313.
4. Fang C，Ning B, Waqar AB, Niimi M, Li S, Sato Kane, Shiomi M, Ye T, Sun X, Lin Y, Huang Q, Dong S*, Jianglin Fan. Bisphenol A exposure enhances atherosclerosis in WHHL rabbits. PLOS ONE. 2014; 9(10):e110977.
5. Yu Q, Liu Z, Waqar AB, Ning B, Yang X, Shiomi M, Rosanne M. Crooke, Liu E, Dong S, and Fan J.Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL Rabbits,“ Mediators of Inflammation. 2014. Article ID 979132.
6. Dong S*, Kang M, Wu X, Ye T. Development of a Promising Fish Model (Oryzias melastigma) for Assessing Multiple Responses to Stresses in the Marine Environment. Biomed Res Int. 2014; 2014:563131.
7. Ye T, Kang M, Huang Q, Fang C, Chen Y, Liu L, Dong S*. Accumulation of di(2-ethylhexyl) phthalate causes endocrine-disruptive effects in marine medaka (Oryzias melastigma) embryos. Environ Toxicol. 2014 Jul 28. doi: 10.1002/tox.22028.
8. Lin Y, Sun X, Qiu L, Wei J, Huang Q, Fang C, Ye T, Kang M, Dong S*. Exposure to Bisphenol A Induces Dysfunction of Insulin Secretion and Apoptosis through the Damage of Mitochondria in Rat Insulinoma (INS-1) Cells. Cell Death and Disease 2013, 4, e460.
9. Dong S, Furutani Y, Kimura S, Zhu Y, Kawabata K, Furutani M, Nishikawa T, Tanaka T, Masaki T, Matsuoka R, Kiyama R. Brefeldin A is an estrogenic, Erk1/2-activating component in the extract of Agaricus blazei mycelia. J Agric Food Chem. 2013 61, 128-136
10. Huang Q, Fang C, Chen Y, Wu X, Ye T, Lin Y, Dong S*. Embryonic exposure to low concentration of bisphenol A affects the development of Oryzias melastigma larvae. Environ Sci Pollut Res Int. 2011, 19(7):2506-14.
11. Huang Q, Dong S*, Fang C, Wu X, Ye T, Lin Y. Deep sequencing-based transcriptome profiling analysis of Oryzias melastigma exposed to PFOS. Aquat Toxicol. 2012, 120-121:54-8.
12. Wang J, Liao Y, Fan J, Ye T, Sun X, Dong S*. Apigenin inhibits the expression of IL-6, IL-8, and ICAM-1 in DEHP-stimulated human umbilical vein endothelial cells and in vivo. Inflammation. 2012, 35(4):1466-76.
13. Wu X, Huang Q, Fang C, Ye T, Qiu L, Dong S*. PFOS induced precocious hatching of Oryzias melastigma--from molecular level to individual level. Chemosphere. 2012, 87(7):703-8.
14. Liao Y, Wang J, Huang QS, Fang C, Kiyama R, Shen H, Dong S*. Evaluation of cellular response to perfluorooctane sulfonate in human umbilical vein endothelial cells. Toxicol In Vitro. 2012, 26(3):421-8.
15. Fang C, Wu X, Huang Q, Liao Y, Liu L, Qiu L, Shen H, Dong S*. PFOS elicits transcriptional responses of the ER, AHR and PPAR pathways in Oryzias melastigma in a stage-specific manner. Aquat Toxicol. 2012, 106-107:9-19.
16. Dong S, et al. Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract .Microbiol Res. 2012, 167(4):231-7.
17. Wang J, Dong S*. ICAM-1 and IL-8 are expressed by DEHP and suppressed by curcumin through ERK and p38 MAPK in human umbilical vein endothelial cells. Inflammation. 2012, 35(3):859-70.
18. Huang Q, Fang C, Wu X, Fan J, Dong S*. Perfluorooctane sulfonate impairs the cardiac development of a marine medaka (Oryzias melastigma). Aquat Toxicol. 2011, 105(1-2):71-7.
19. Dong S, Terasaka S, Kiyama R. Bisphenol A induces a rapid activation of Erk1/2 through GPR30 in human breast cancer cells. Environ Pollut. 2011, 159(1):212-8.
20. Liao Y, Dong S*. Cai P, Huang QS, Fang C, Kiyama R, Shen H. Flos Lonicerae extracts and chlorogenic acid protect human umbilical vein endothelial cells from the toxic damage of perfluorooctane sulphonate. Inflammation 2013;36(3):767-79
21. Fang C, Wu X, Huang Q, Liao Y, Liu L, Qiu L, Shen H, Dong S*. Embryonic exposure to PFOS induced immunosuppression in the fish larvae of marine medaka . Ecotoxicology and Environmental Safety 2013 Jun;92:104-11.
22. Ye T, Kang M, Huang Q, Dong S*. Exposure to DEHP and MEHP from hatching to adulthood causes reproductive dysfunction and endocrine disruption in marine medaka (Oryzias melastigma).Aquat Toxicol. 2014 Jan;146:115-26
23. Lin Y，Huang Q, Fang C, Wu X, Fan J, Dong S*. The combined effects of DEHP and PCBs on the phospholipase in mice model. Environmental Toxicology 2013 Jun 26. doi: 10.1002/tox.21885.
24. Shen H, Xu W, Zhang J, Chen M, Martin FL, Xia Y, Liu L, Dong S, Zhu YG. Urinary metabolic biomarkers link oxidative stress indicators associated with general arsenic exposure to male infertility in a han chinese population. Environ Sci Technol. 2013 ;47(15):8843-51.
25. Dong S, Kiyama R. Characterization of Estrogenic Activity of Ginsenosides in MCF-7 Cells using a Customized DNA Microarray. Food Chem. 2009. 113: 672-678.
26. Dong S, Ying S, Kojima T, Shiraiwa M, Mechin MC, et. al. Crucial Role of MZF1 and Sp1 for the transcriptional regulation of the Peptidylarginine Deiminase Type I Gene (PADI1) in Human Keratinocytes. Journal of Investigative Dermatology 2008.128(3):549-557.
27. Dong S, Inoue A, Zhu Y, Tanji M, Kiyama R. Activation of rapid signaling pathways and the subsequent transcriptional regulation for the proliferation of breast cancer MCF-7 cells by the treatment with an extract of glycyrrhiza glabra root. Food and Chemical Toxicology 2007. 45: 2470–2478.
28. Dong S, Zhang Z, Takahara H. Estrogen-enhanced PADI4 expression in MCF-7 cells mediated by ER？-promoted transfactors AP-1, NF-Y and SP1. Molecular Endocrinology 2007. 21: 1617-1629
29. Dong S, Kanno T, Yamaki A, Kojima T, Shirawa M, et. al. NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine deiminase type III gene (PADI3) in human keratinocytes. Biochemical Journal 2006.397(3):449-459
30. Dong S, Kojima T, Shiraiwa M, Mechin MC, Chavanas S, Serre G, Simon M, Kawada A, Kawada A, and Takahara H. Regulation of the expression of peptidylarginine deiminase type II gene (PADI2) in human keratinocytes involves Sp1 and Sp3 transcription factors. Journal of Investigative Dermatology 2005. 124(5):1026-1033.
31. Ying S, Dong S, Kawada A, Kojima T, Chavanas S, Mechin MC, Adoue V, Serre G, Simon M, Takahara H. Transcriptional Regulation of Peptidylargine Deiminase Expression in Human Keratinocytes. J Dermatol Sci. 2009. 53(1):2-9.
32. Zhou Y, Kogiso M, Asakawa M, Dong S, Kiyama R, Shimizu T. Antimicrobial Nanotubes as Delivery Vehicles Consisting of Ag-Embedded Peptidic Lipid-Bilayer Membranes. Adv. Mater. 2009. 21, 1-4.


* 通讯作者。

（1） 再生水的雌激素污染生物分析评价技术, In situ combined chemical and biological assessment of estrogenic pollution in a water recycling system, J Environ Sci, 2016, 通讯作者
（2） 新生产大中型客车内VOC的检测, Evaluation of Volatile Organic Compounds and Carbonyl Compounds Present in the Cabins of Newly Produced, Medium- and Large-Size Coaches in China, Int J Environ Res Public Health, 2016, 通讯作者
（3） Biological impact of environmental polycyclic aromatic hydrocarbons (ePAHs) as endocrine disruptors, Environ Pollut., 2016, 第 2 作者
（4） The Inflammation Response to DEHP through PPARγ in Endometrial Cells, Int J Environ Res Public Health., 2016, 通讯作者
（5） Accumulation of di(2-ethylhexyl) phthalate causes endocrine-disruptive effects in marine medaka (Oryzias melastigma) embryos, Environ Toxicol., 2016, 通讯作者
（6） Immunotoxic effects of perfluorooctane sulfonate and di(2-ethylhexyl) phthalate on the marine fish Oryzias melastigma., Fish Shellfish Immunol., 2015, 通讯作者
（7） Bisphenol A exposure induces metabolic disorders and enhances atherosclerosis in hyperlipidemic rabbits., J Appl Toxicol., 2015, 通讯作者
（8） The inflammation and estrogen metabolism impacts of polychlorinated biphenyls on endometrial cancer cells, Toxicol In Vitro., 2015, 通讯作者
（9） Di(2-ethylhexyl) phthalate-induced apoptosis in rat INS-1 cells is dependent on activation of endoplasmic reticulum stress and suppression of antioxidant protection, J Cell Mol Med., 2015, 通讯作者
（10） The combined effects of DEHP and PCBs on phospholipase in the livers of mice, Environ Toxicol., 2015, 通讯作者
（11） Diastereoisomer-specific effects of hexabromocyclododecanes on hepatic aryl hydrocarbon receptors and cytochrome P450s in zebrafish (Danio rerio), Chemosphere., 2015, 第 4 作者
（12） Bisphenol A exposure enhances atherosclerosis in WHHL rabbits, PLoS One., 2014, 通讯作者
（13） Development of a promising fish model (Oryzias melastigma) for assessing multiple responses to stresses in the marine environment, Biomed Res Int., 2014, 第 1 作者
（14） Exposure to DEHP and MEHP from hatching to adulthood causes reproductive dysfunction and endocrine disruption in marine medaka (Oryzias melastigma), Aquat Toxicol., 2014, 通讯作者
（15） Embryonic exposure to PFOS induces immunosuppression in the fish larvae of marine medaka, Ecotoxicol Environ Saf, 2013, 通讯作者
（16） Brefeldin A is an estrogenic, Erk1/2-activating component in the extract of Agaricus blazei mycelia, J Agric Food Chem., 2013, 第 1 作者
（17） Flos lonicerae extracts and chlorogenic acid protect human umbilical vein endothelial cells from the toxic damage of perfluorooctane sulphonate, Inflammation, 2013, 通讯作者
（18） Deep sequencing-based transcriptome profiling analysis of Oryzias melastigma exposed to PFOS,  Aquatic Toxicology, 2012, 通讯作者
（19） Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract., Microbiol. Res. , 2012, 第 1 作者
（20） The metabonomics of combined dietary exposure to phthalates and polychlorinated biphenyls in mice, J. Pharm. Biomed. Anal, 2012, 通讯作者
（21） Apigenin Inhibits the Expression of IL-6, IL-8, and ICAM-1 in DEHP-Stimulated Human Umbilical VeinEndothelialCells and In Vivo, Inflammation. , 2012, 通讯作者
（22） PFOS elicits transcriptional responses of the ER, AHR and PPAR pathways in Oryzias melastigma in a stage-specific manner, Aquat. Toxicol. , 2012, 通讯作者
（23） PFOS induced precocious hatching of Oryzias melastigma-from molecular level to individual level, Chemosphere, 2012, 通讯作者
（24） Evaluation of a cytotoxic potential of perfluorooctane sulfonate in human umbilical vein endothelial cells, Toxicol. In. Vitro., 2012, 通讯作者
（25） ICAM-1 and IL-8 Are Expressed by DEHP and Suppressed by Curcumin Through ERK and p38 MAPK in Human Umbilical Vein Endothelial Cells, Inflammation. , 2012, 通讯作者
（26） DEHP毒理与健康效应研究进展, 生态毒理学报, 2012, 通讯作者
（27） 新兴海洋生态毒理学研究模型——海洋青鳉鱼, 生态毒理学报, 2012, 通讯作者
（28） Bisphenol A induces a rapid activation of Erk1/2 through GPR30 in human breast cancer cells,  Environ. Pollut., 2011, 第 1 作者
（29） Perfluorooctane sulfonate impairs the cardiac development of a marine medaka, Aquat. Toxicol., 2011, 通讯作者
（30） Application of Fluolid-Orange-labeled probes for DNA microarray and immunological assays, Biotechnol. Lett., 2011, 第 4 作者

现在承担科研项目
1. 国家自然科学基金重大项目课题，“主要环境介质的污染特征与源汇关系 ”
2. 国家自然科学基金面上项目，“结合多种模型系统研究全氟辛烷磺酸的心脏发育毒性”
3. 国家自然科学基金面上项目， “从胰岛素信号转导通路探讨BPA促进动脉粥样硬化的作用机制”
4. 国家自然科学基金面上项目，“近岸水域盐度影响下的全氟化合物鳃毒性及机制研究”
5. 环保部公益性行业科研专项课题 ，“极高持久性和生物蓄积性化学品筛查办法和清单研究”
6. 企业横向课题，“酵素液功能成分提取新技术及新产品研发”
7. 企业横向课题，“海洋菌多糖复合益生元配方与制备工艺研发” 

参与会议
特邀会议发表:
1. A marine medaka model for environmental toxicology studies. Xiamen, Chinese 1st International Workshop on Environment and Health. 13-16 December 2011
2．Anti-atherosclerotic activity and dual roles in cell signaling of an Agaricus blazei extract 日本东京 Future aspects of medical science and education 2010,2
3. 环境内分泌干扰物与心血管疾病相关的分子作用基础 厦门大学 两岸三地环境论坛 2010,6
4. 室内空气质量的健康效应 上海分院 交叉学科论坛第18期 2010,12
5. 海西经济建设的新领域—海洋生物医药 厦门海洋三所 厦门民盟首届发展蓝色经济研讨会 2010,12

一般国际学术会议报告:
1. 2008 Annual Meeting of JSBBA (Nagoya, Japan).
2. 2009 Frontiers in Integrated Medical Sciences Research(Tokyo, Japan).
3. 2007 annual meeting of The Society for Investigative Dermatology (SID) (Los Angeles, USA).
4. The 78th Annual Meeting of the Zoological Society of Japan (Hirosaki, Japan).
5. 20th IUBMB International Congress of Biochemistry and Molecular Biology.
6. 25th FEBS Congress (Yokohama, Japan).
7. The 34th Annual Meeting of the Molecular Biology Society of Japan Yokohama, 12-16 December 2011

国际合作单位

*日本产业技术综合研究所，生物医学研究机构
*日本山梨大学， 医学院 

福建万芳生态农林科技有限公司

已指导学生

伍辛泷  硕士研究生  083001-环境科学  

王佳  博士研究生  083001-环境科学  

康美  硕士研究生  085229-环境工程  

孙霞  博士研究生  083001-环境科学  

方超  博士研究生  083001-环境科学  

陈亚檞  硕士研究生  085229-环境工程  

叶婷  博士研究生  083001-环境科学  

现指导学生

卢艳阳  博士研究生  083001-环境科学  

王泓鸥  博士研究生  083001-环境科学  

池毓烺  博士研究生  083001-环境科学  

高菡  博士研究生  083001-环境科学