微生物次级代谢产物的生物合成与调控；抗肿瘤药物研发；抗过敏药物研发；

研究领域为微生物次级代谢产物的生物合成与调控、抗肿瘤以及抗过敏药物的研发。采用基因工程、仪器分析和和蛋白质酶学等手段对微生物次级代谢产物的生物合成和调控机制进行解析，以获得新型的活性化合物和前体药物，并建立细胞和动物活性检测模型进行化合物筛选和活性优化。曾经从事的研究项目有链霉菌中信号分子介导的抗生素生物合成与调控、新型过敏反应中信号转导途径的阻断研究以及真菌活性次级代谢产物的分析等。有关研究成果发表在J. Allergy. Clin. Immun.、Allergy、 Future Med. Chem. 以及 Mol. Microbiol. 等知名国际刊物上。在应用研究领域获得了抗过敏的候选药物和国际PCT专利，其中一项PCT国际专利已经在美国、中国、日本、澳大利亚等8个国家授权，另一项正处于受理当中。

2013/11 至今：中国科学院微生物研究所，微生物遗传学，副研究员

2003/05-2013/10： 英国伦敦大学，圣-乔治生物医学部, 博士后，生物项目主管

1999/09-2002/05：中国科学院微生物研究所, 分子遗传学, 博士后

代表性论文 (* 通讯作者； # 共同第一作者)

1. Dong Li, Jihui Zhang*, Yuqing Tian, Huarong Tan*, Enhancement of salinomycin production by ribosome engineering in Streptomyces albus,  Science China Life sciences, 2019, 60, 968-979 (IF 3.085)

2. Wenxi Wang#, Jihui Zhang#*, Xiang Liu,  Dong Li,  Yue Li,  Yuqing Tian,  Huarong Tan*. Identification of a butenolide signaling system that regulates nikkomycin biosynthesis in Streptomyces.  Journal of Biological Chemistry. 2018, 293(52): 20029 –20040. (IF4.2)

3. Jihui Zhang#, Jie Chen#, Kimberley Allen-Philbey, Chathuri Perera Baruhupolage, Theresa Tachie-Menson, Shannon C. Mangat, David R. Garrod, Clive Robinson. Innate Generation of Thrombin and Intracellular Oxidants in Airway Epithelium by Allergen Der p 1.The Journal of Allergy and Clinical Immunology, 2016, 138(4): 1224–1227. (IF13.3) 

4. Jie Chen#, Jihui Zhang#, Theresa Tachie-Menson, Neha Shukla, David R. Garrod, Clive Robinson. Allergen-dependent oxidant formation requires purinoceptor activation of ADAM 10 and prothrombin. The Journal of Allergy and Clinical Immunology,  2017, 139( 6): 2023–2026.  (IF13.3)

5. Lu Cheng, Liao Guojian, Zhang Jihui* and Tan Huarong*. Identification of novel tylosin analogues generated by awblAdisruption mutant inStreptomyces ansochromogenes.Microbial Cell Fact. 2015;14(1):1-11. (IF4.6)

6. Bing Li, Xiaofang Tian, Chunlan Wang, Xu Zeng, Yongmei Xing,  Hong Ling,  Wanqiang Yin,  Lixia Tian，Zhixia Meng, Jihui Zhang*, Shunxing Guo*. SWATH label-free proteomics analyses revealed the roles of oxidative stress and antioxidant defensing system in sclerotia formation of Polyporus umbellatus. Scientific Report.  2017, 7: 41283. (IF 4.5)

7. Jihui Zhang, J.M. Saint-Remy, D. R. Garrod, C. Robinson. Comparative enzymology of native and recombinant house dust mite allergen Der p 1.Allergy, 2009, 64(3): 469-77. (IF6.3)

8. Jihui Zhang, J.M. Hamilton,D. R. Garrod,C. Robinson.Interactions between mature Der p 1 and its free prodomain indicate membership of a new family of C1 peptidases. Allergy，2007， 62: 1302–1309. (IF6.3)

9. Jihui Zhang, Jie Chen, Gary K. Newton, Trevor R. Perrior, Clive Robinson*. Allergen Delivery Inhibitors: A Rationale for Targeting Sentinel Innate Immune Signaling of Group 1 House Dust Mite Allergens through Structure-Based Protease Inhibitor Design.  Molecular Pharmacology. 2018, 94(3): 1007-1030.  (IF 3.777)

10. Jihui Zhang, Jie Chen, Jie Zuo, Newton Gary K., Stewart Mark R., Perrior Trevor R., Garrod David R., Clive Robinson*. Allergen Delivery Inhibitors: Characterisation of Potent and Selective Inhibitors of Der p 1 and Their Attenuation of Airway Responses to House Dust Mite Allergens.   International Journal of Molecular Sciences.  2018, 19(10):3166. (IF4.331)

11. Jihui Zhang, Jie Chen, Clive Robinson*. Cellular and molecular events in the airway epithelium defining the interaction between House Dust Mite Group 1 allergens and innate defences.   International Journal of Molecular Sciences. 2018, 19 (11): 3549. (IF4.331)

12. Guoqing Niu, Keith F. Chater,, Yuqing Tian, Jihui Zhang and Huarong Tan*. Specialised metabolites regulating antibiotic biosynthesis in Streptomyces spp. FEMS Microbiology Reviews, 2016, 40(4): 554-73  (IF13.6)

13. Xu Jingjing, Zhang Jihui, Zhuo Jiming, Li Yue, Tian Yuqing*, and Tan Huarong*,Activation and molecular mechanism of a cryptic oviedomycin biosynthetic gene cluster via the disruption of a global regulatory gene--adpA in Streptomyces ansochromogenes, The Journal of biological chemistry, 2017,  292(48) 19708 –19720, IF 4.323

14. Jiazhen Zheng#, Yue Li#*, Hanye Guan, Jihui Zhang, Huarong Tan*. Enhancement of neomycin production by engineering the entire biosynthetic gene cluster and feeding key precursors in Streptomyces fradiae CGMCC 4.576. Applied Microbiology and Biotechnology. 2019,103, 2263–2275. (IF3.889)

15. Li Yue, LiJingjing,TianZhenhua, XuYu, Zhang Jihui, Liu Wen* andTan Huarong.*Coordinative Modulation of Chlorothricin Biosynthesis by Binding of the Glycosylated Intermediates and End Product to A Responsive Regulator ChlF1.Journal of Biological Chemistry.2016;291(10):5406-17. (IF4.6)

16. Gary K. Newton,Trevor R. Perrior,Kerry Jenkins,Meriel R. Major,Rebekah E. Key,Mark R. Stewart,Stuart Firth-Clark,Steven M. Lloyd, Jihui Zhang, Nicola J. Francis-Newton, Jonathan P. Richardson, Jie Chen, Pei Lai, David R. Garrod, and Clive Robinson.The Discovery of Potent, Selective, and Reversible Inhibitors of the House Dust Mite Peptidase Allergen Der p 1: An Innovative Approach to the Treatment of Allergic Asthma. J Med Chem.2014;57(22): 9447–9462 (IF5.4)

17. Zou Z, Du D, Zhang Y, Zhang J, Niu G, Tan H. A γ-butyrolactone-sensing activator/repressor, JadR3, controls a regulatory mini-network for jadomycin biosynthesis.Molecular Microbiology.2014;94(3):490-505. (IF4.7)

18. Clive Robinson, Jihui Zhang, etc.Editorial:Special Focus: Inhalation by Design.Future inhaled drugs by virtual innovation: allergen delivery inhibitors.Future Med. Chem.2011: 3(13), 1567–1570. (IF3.3)

19. Clive Robinson, Jihui Zhang, Gary K Newton,Trevor R Perrior.Non-human targets in allergic lung conditions.Future Med. Chem.2013 5(2), 147-161. (IF3.3)

著作

1. Jihui Zhang, Clive Robinson. Chapter 14: Novel Method for the Purification of House Dust Mite Allergen Der p 1 and Its Use in Structure-Based Chemical Design of Novel Inhibitors. In: Lympany P., Jones M. (eds) Allergy. Methods in Molecular Biology. ISSN 1940-6029, ISBN978-1-4939-9591-2. Humana, New York, NY. Vol(2020). (https://link.springer.com/protocol/10.1007/978-1-4939-9591-2_14)  online 2019.06.09. 185-205.

2. Clive Robinson, Jihui Zhang and Geoffrey A. Stewart. Interactions between Allergens and the Airway Epithelium.‘The Pulmonary Epithelium in Health and Disease’D. Proud. Publisher, Wiley. 2008.

3. G. A. Stewart, Jihui Zhang and C. Robinson. The structure and function of allergens. In:‘Middleton’s Allergy Principles and Practice’7^thEdition, Chapter 35, volume 2 pp35.1-35.36. Philadelphia, 2008.

1、国家重点研发计划 “合成生物学”  重点专项: “微生物天然产物的智能创制与改良”

课题编号: 2018YFA0901904

课题名称: 重要药物先导化合物的智能制造

2、国家重点基础研究发展计划 （973计划）课题： 微生物群体感应通讯系统与病害防控基础研究

课题编号：2015CB150602

课题名称：细菌群体感应通讯系统的网络解析

1. ROBINSON Clive;  ZHANG, Jihui; GARROD, David, Ronald; PERRIOR, Trevor, Robert; NEWTON, Gary, Karl; JENKINS, Kerry; BEEVERS, Rebekah, Elisabeth; MAJOR, Meriel, Ruth; STEWART, Mark, Richard. Pyruvamide compounds as inhibitors of dust mite group 1 peptidase allergen and their use. Sept. 24, 2013, United States, US 8541363 B2, PCT/GB2011/000079
2. ROBINSON Clive; ZHANG, Jihui; GARROD, David, Ronald; PERRIOR, Trevor Robert; NEWTON, Gary Karl; JENKINS, Kerry; Meriel Ruth; BEEVERS, Rebekha Elisabeth; FIRTH-CLARK Stuard. Amino-ethyl-amide compounds as inhibitors of dust mite group 1 peptidase allergen and their use. 15 Jan 2013, Refilled as PCT/GB2013/050077