细胞分子生物学、化学生物学、生物信息学及组学等多学科交叉为研究基础，在疾病发生发展过程中，探索生物分子的功能解析和分子机制，以及开展基于化学生物学的生物大小分子相互结合靶点研究。

Ø代谢稳态和癌症代谢的功能解析与分子机制研究 
Ø基于生物分子相互作用的化学生物学研究 
Ø基于人工智能、机器学习及生物信息学的生物分子功能研究

对代谢稳态、癌症代谢、化学生物学、生物信息学相关科学研究感兴趣的同学，

欢迎加入我们团队一起探索科学的奥秘！

细胞分子生物学，肿瘤生物学，癌症代谢，化学生物学

06/2015-present   Professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
02/2014-05/2015   Associate Professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences

   

   

[1] Sang, Lingjie, Ju, Huaiqiang, Yang, Zuozhen, Ge, Qiwei, Zhang, Zhen, Liu, Fangzhou, Yang, Luojia, Gong, Hangdi, Shi, Chengyu, Qu, Lei, Chen, Hui, Wu, Minjie, Chen, Hao, Li, Ruihua, Zhuang, Qianqian, Piao, Hailong, Yan, Qingfeng, Yu, Weishi, Wang, Liangjing, Shao, Jianzhong, Liu, Jian, Wang, Wenqi, Zhou, Tianhua, Lin, Aifu. Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress. NATURE METABOLISM[J]. 2021, 3(1): 90-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000606519500003.
[2] Zhang, Liwen, Zhu, Zijing, Yan, Huiwen, Wang, Wen, Wu, Zhenzhen, Zhang, Fei, Zhang, Qixiang, Shi, Guizhi, Du, Junfeng, Cai, Huiyun, Zhang, Xuanxuan, Hsu, David, Gao, Pu, Piao, Hailong, Chen, Gang, Bu, Pengcheng. Creatine promotes cancer metastasis through activation of Smad2/3. CELL METABOLISM[J]. 2021, 33(6): 1111-+, http://dx.doi.org/10.1016/j.cmet.2021.03.009.
[3] Li, Mengqi, Zhang, ChenSong, Feng, JinWei, Wei, Xiaoyan, Zhang, Cixiong, Xie, Changchuan, Wu, Yaying, Hawley, Simon A, Atrih, Abdelmadjid, Lamont, Douglas J, Wang, Zhichao, Piao, HaiLong, Hardie, D Grahame, Lin, ShengCai. Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1. CELL RESEARCH. 2021, 31(4): 478-481, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115481/.
[4] 王稳, 陈迪, 朴海龙. 基于超高效液相色谱-飞行时间质谱法测定LAMTOR1在肝脏炎症恶性转化中调控的代谢物. 色谱[J]. 2021, 39(10): 1118-1127, http://lib.cqvip.com/Qikan/Article/Detail?id=7105506368.
[5] Guo, Xin, Wang, Aman, Wang, Wen, Wang, Ya, Chen, Huan, Liu, Xiaolong, Xia, Tian, Zhang, Aijia, Chen, Di, Qi, Huan, Ling, Ting, Piao, Hailong, Wang, Hongjiang. HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple-negative breast cancer. MOLECULAR ONCOLOGY[J]. 2021, 15(2): 642-656, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858277/.
[6] Wang, Yawei, Qi, Huan, Liu, Yu, Duan, Chao, Liu, Xiaolong, Xia, Tian, Chen, Di, Piao, Hailong, Liu, HongXu. The double-edged roles of ROS in cancer prevention and therapy. THERANOSTICSnull. 2021, 11(10): 4839-4857, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7978298/.
[7] Chen, Di, Zhang, Yiran, Wang, Wen, Chen, Huan, Ling, Ting, Yang, Renyu, Wang, Yawei, Duan, Chao, Liu, Yu, Guo, Xin, Fang, Lei, Liu, Wuguang, Liu, Xiumei, Liu, Jing, Otkur, Wuxiyar, Qi, Huan, Liu, Xiaolong, Xia, Tian, Liu, HongXu, Piao, HaiLong. Identification and Characterization of Robust Hepatocellular Carcinoma Prognostic Subtypes Based on an Integrative Metabolite-Protein Interaction Network. ADVANCED SCIENCE[J]. 2021, 8(17): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000671658500001.
[8] Liu, Xiumei, Chen, Di, Chen, Huan, Wang, Wen, Liu, Yu, Wang, Yawei, Duan, Chao, Ning, Zhen, Guo, Xin, Otkur, Wuxiyar, Liu, Jing, Qi, Huan, Liu, Xiaolong, Lin, Aifu, Xia, Tian, Liu, Hongxu, Piao, Hailong. YB1 regulates miR-205/200b-ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma. CANCER COMMUNICATIONS[J]. 2021, 41(7): 576-595, http://dx.doi.org/10.1002/cac2.12164.
[9] Shen, Di, Jin, Wenhan, Bai, Yulong, Huang, Yanan, Lyu, Haochen, Zeng, Lianggang, Wang, Mengdie, Tang, Yuqi, Wan, Wang, Dong, Xuepeng, Gao, Zhenming, Piao, HaiLong, Liu, Xiaojing, Liu, Yu. Rational Design of Crystallization-Induced-Emission Probes To Detect Amorphous Protein Aggregation in Live Cells. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(29): 16067-16076, http://dx.doi.org/10.1002/anie.202103674.
[10] Zhang, XueXiang, Qi, Huan, Lu, MeiHeng, Yang, SongQiu, Li, Peng, Piao, Hailong, Han, KeLi. Semi-Quantitatively Designing Two-Photon High-Performance Fluorescent Probes for Glutathione S-Transferases. RESEARCH[J]. 2020, 2020(1): 1191-1201, http://dx.doi.org/10.34133/2020/7043124.
[11] Li, Kuikui, Qi, Huan, Liu, Qishun, Li, Tang, Chen, Wei, Li, Shuguang, Piao, Hailong, Yin, Heng. Preparation and antitumor activity of selenium-modified glucomannan oligosaccharides. JOURNAL OF FUNCTIONAL FOODS[J]. 2020, 65: http://dx.doi.org/10.1016/j.jff.2019.103731.
[12] Wang, Wen, Liu, Xiaolong, Chen, Huan, Ling, Ting, Xia, Tian, Liu, Xiumei, Liu, Jing, Otkur, Wuxiyar, Shi, Xianzhe, Qi, Huan, Chen, Di, Piao, HaiLong. Cholesterol as a functional metabolite cooperates with metadherin in cancer cells. CHINESE CHEMICAL LETTERS[J]. 2020, 31(7): 1831-1834, http://lib.cqvip.com/Qikan/Article/Detail?id=7103028900.
[13] Hai-Long Piao. Semi-Quantitatively Designing Two-Photon High-Sensitive Fluorescent Probes for Glutathione S-Transferases with Negligible Background Noise. RESEARCH. 2020, [14] Tekcham, Dinesh Singh, Chen, Di, Liu, Yu, Ling, Ting, Zhang, Yi, Chen, Huan, Wang, Wen, Otkur, Wuxiyar, Qi, Huan, Xia, Tian, Liu, Xiaolong, Piao, Hailong, Liu, Hongxu. F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects. THERANOSTICSnull. 2020, 10(9): 4150-4167, https://www.webofscience.com/wos/woscc/full-record/WOS:000518773300022.
[15] Yu, Zujiang, Li, Jingjing, Ren, Zhigang, Sun, Ranran, Zhou, Yang, Zhang, Qi, Wang, Qiongye, Cui, Guangying, Li, Juan, Li, Ang, Duan, Zhenfeng, Xu, Yuming, Wang, Zhichao, Yin, Peiyuan, Piao, Hailong, Lv, Jun, Liu, Xiaorui, Wang, Yanfang, Fang, Ming, Zhuang, Zhengping, Xu, Guowang, Kan, Quancheng. Switching from Fatty Acid Oxidation to Glycolysis Improves the Outcome of Acute-On-Chronic Liver Failure. ADVANCED SCIENCE[J]. 2020, 7(7): https://doaj.org/article/5811c5313d63476293fb46d3a4f26143.
[16] Zhang, XueXiang, Qi, Huan, Liu, YaLan, Yang, SongQiu, Li, Peng, Qiao, Yan, Zhang, PeiYu, Wen, ShuHao, Piao, Hailong, Han, KeLi. A fluorophore's electron-deficiency does matter in designing high-performance near-infrared fluorescent probes. CHEMICAL SCIENCE[J]. 2020, 11(41): 11205-11213, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162715/.
[17] Chen, Di, Ning, Zhen, Chen, Huan, Lu, Chang, Liu, Xiaolong, Xia, Tian, Qi, Huan, Wang, Wen, Ling, Ting, Guo, Xin, Tekcham, Dinesh Singh, Liu, Xiumei, Liu, Jing, Wang, Aman, Yan, Qiu, Liu, JiWei, Tan, Guang, Piao, Hailong. An integrative pan-cancer analysis of biological and clinical impacts underlying ubiquitin-specific-processing proteases. ONCOGENE[J]. 2020, 39(3): 587-602, http://dx.doi.org/10.1038/s41388-019-1002-4.
[18] Wang, Zhichao, Chen, Di, Piao, HaiLong, Hua, Xiangdong. PTEN-deficient cells prefer glutamine for metabolic synthesis. ACTA BIOCHIMICA ET BIOPHYSICA SINICA[J]. 2020, 52(3): 251-258, http://lib.cqvip.com/Qikan/Article/Detail?id=7101881663.
[19] Chen, Di, Zhao, Xinjie, Sui, Zhigang, Niu, Huan, Chen, Luonan, Hu, Cheng, Xuan, Qiuhui, Hou, Xuhong, Zhang, Rong, Zhou, Lina, Li, Yanli, Yuan, Huiming, Zhang, Yukui, Wu, Jiarui, Zhang, Lihua, Wu, Renan, Piao, HaiLong, Xu, Guowang, Jia, Weiping. A multi-omics investigation of the molecular characteristics and classification of six metabolic syndrome relevant diseases. THERANOSTICS[J]. 2020, 10(5): 2029-2046, https://www.webofscience.com/wos/woscc/full-record/WOS:000508008300004.
[20] He, Hui, Chen, Di, Cui, Shimeng, Wu, Gang, Piao, Hailong, Wang, Xun, Ye, Peng, Jin, Shi. HDNA methylation data-based molecular subtype classification related to the prognosis of patients with hepatocellular carcinoma. BMC MEDICAL GENOMICS[J]. 2020, 13(1): http://dx.doi.org/10.1186/s12920-020-00770-5.
[21] Zeng, Jun, Wang, Zhichao, Huang, Xin, Eckstein, Sabine S, Lin, Xiaohui, Piao, Hailong, Weigert, Cora, Yin, Peiyuan, Lehmann, Rainer, Xu, Guowang. Comprehensive Profiling by Non-targeted Stable Isotope Tracing Capillary Electrophoresis-Mass Spectrometry: A New Tool Complementing Metabolomic Analyses of Polar Metabolites. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2019, 25(21): 5427-5432, http://cas-ir.dicp.ac.cn/handle/321008/165522.
[22] 颜敏, 刘静, 夏天, 许国旺, 朴海龙. 细胞蛋白质组学和代谢组学整合策略表征散斑型BTB/POZ蛋白质突变调控的关键代谢通路. 色谱[J]. 2019, 37(8): 887-896, http://lib.cqvip.com/Qikan/Article/Detail?id=7002627642.
[23] Yan, Min, Qi, Huan, Xia, Tian, Zhao, Xinjie, Wang, Wen, Wang, Zhichao, Lu, Chang, Ning, Zhen, Chen, Huan, Li, Tongming, Tekcham, Dinesh Singh, Liu, Xiumei, Liu, Jing, Chen, Di, Liu, Xiaolong, Xu, Guowang, Piao, Hailong. Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPK alpha. METABOLISM-CLINICAL AND EXPERIMENTAL[J]. 2019, 91: 18-29, https://www.webofscience.com/wos/woscc/full-record/WOS:000470301900003.
[24] Xu, Fangfang, Zhou, Han, Liu, Xiumei, Zhang, Xiuli, Wang, Zhiwei, Hou, Tao, Wang, Jixia, Qu, Lala, Zhang, Pengyu, Piao, Hailong, Liang, Xinmiao. Label-free cell phenotypic study of FFA4 and FFA1 and discovery of novel agonists of FFA4 from natural products. RSC ADVANCES[J]. 2019, 9(26): 15073-15083, http://dx.doi.org/10.1039/c9ra02142f.
[25] Wang ZhiChao, Liu Jing, Piao HaiLong. Capillary Electrophoresis-Mass Spectrometry Based Metabolomics Analysis of Metabolic Reprogramming Induced by Phosphatase and Tensin Homolog. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2019, 47(1): 59-66, https://www.webofscience.com/wos/woscc/full-record/WOS:000470997900007.
[26] Chen, Di, Liu, Xiaolong, Xia, Tian, Tekcham, Dinesh Singh, Wang, Wen, Chen, Huan, Li, Tongming, Lu, Chang, Ning, Zhen, Liu, Xiumei, Liu, Jing, Qi, Huan, He, Hui, Piao, Hailong. A Multidimensional Characterization of E3 Ubiquitin Ligase and Substrate Interaction Network. ISCIENCE[J]. 2019, 16: 177-+, http://dx.doi.org/10.1016/j.isci.2019.05.033.
[27] Min Yan, Huan Qi, Tian Xia, Xinjie Zhao, Wen Wang, Zhichao Wang, Chang Lu, Zhen Ning, Huan Chen, Tongming Li, Dinesh Singh Tekcham, Xiumei Liu, Jing Liu, Di Chen, Xiaolong Liu, Guowang Xu, Hailong Piao. Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPKα. METABOLISM. 2019, 91: 18-29, http://dx.doi.org/10.1016/j.metabol.2018.11.010.
[28] Zhou, Lina, Wang, Zhichao, Hu, Chunxiu, Zhang, Chaoqi, KovatchevaDatchary, Petia, Yu, Di, Liu, Shasha, Ren, Feifei, Wang, Xiaolin, Li, Yanli, Hou, Xiaoli, Piao, Hailong, Lu, Xin, Zhang, Yi, Xu, Guowang. Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation. JOURNAL OF PROTEOME RESEARCH[J]. 2019, 18(3): 960-969, http://cas-ir.dicp.ac.cn/handle/321008/165894.
[29] Li, Mengqi, Zhang, ChenSong, Zong, Yue, Feng, JinWei, Ma, Teng, Hu, Meiqin, Lin, Zhizhong, Li, Xiaotong, Xie, Changchuan, Wu, Yaying, Jiang, Dong, Li, Ying, Zhang, Cixiong, Tian, Xiao, Wang, Wen, Yang, Yanyan, Chen, Jie, Cui, Jiwen, Wu, YuQing, Chen, Xin, Liu, QingFeng, Wu, Jianfeng, Lin, ShuYong, Ye, Zhiyun, Liu, Ying, Piao, HaiLong, Yu, Li, Zhou, Zhuan, Xie, XiaoSong, Hardie, D Grahame, Lin, ShengCai. Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK. CELL METABOLISM[J]. 2019, 30(3): 508-+, http://dx.doi.org/10.1016/j.cmet.2019.05.018.
[30] Zong Yue, Zhang Chensong, Li Mengqi, Wang Wen, Wang Zhichao, Hawley Simon A, Ma Teng, Feng Jinwei, Tian Xiao, Qi Qu, Wu Yuqing, Zhang Cixiong, Ye Zhiyun, Lin Shuyong, Piao Hailong, Hardie D Grahame, Lin Shengcai. Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress. CELL RESEARCH[J]. 2019, 29(6): 460-473, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6509057&detailType=1.
[31] He, Hui, Chen, Di, Cui, Shimeng, Piao, Hailong, Tang, Haibo, Wang, Xun, Ye, Peng, Jin, Shi. Identification of a long non-coding RNA-mediated competitive endogenous RNA network in hepatocellular carcinoma. ONCOLOGY REPORTS[J]. 2019, 42(2): 745-752, [32] Yue Zong, ChenSong Zhang, Mengqi Li, Wen Wang, Zhichao Wang, Simon A Hawley, Teng Ma, JinWei Feng, Xiao Tian, Qu Qi, YuQing Wu, Cixiong Zhang, Zhiyun Ye, ShuYong Lin, HaiLong Piao, D Grahame Hardie, ShengCai Lin. Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress. 细胞研究:英文版[J]. 2019, 29(6): 460-473, http://lib.cqvip.com/Qikan/Article/Detail?id=7002400717.
[33] Jixia Wang, Huan Qi, Xiuli Zhang, Wei Si, Fangfang Xu, Tao Hou, Han Zhou, Anhui Wang, Guohui Li, Yanfang Liu, Ye Fang, Hailong Piao, Xinmiao Liang. Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting β-catenin signaling. BIOMEDICINE & PHARMACOTHERAPY. 2018, 108: 724-733, http://dx.doi.org/10.1016/j.biopha.2018.09.038.
[34] Shao, Yaping, Ye, Guozhu, Ren, Shancheng, Piao, HaiLong, Zhao, Xinjie, Lu, Xin, Wang, Fubo, Ma, Wang, Li, Jia, Yin, Peiyuan, Xia, Tian, Xu, Chuanliang, Yu, Jane J, Sun, Yinghao, Xu, Guowang. Metabolomics and transcriptomics profiles reveal the dysregulation of the tricarboxylic acid cycle and related mechanisms in prostate cancer. INTERNATIONAL JOURNAL OF CANCER[J]. 2018, 143(2): 396-407, http://dx.doi.org/10.1002/ijc.31313.
[35] Wang, Jixia, Qi, Huan, Zhang, Xiuli, Si, Wei, Xu, Fangfang, Hou, Tao, Zhou, Han, Wang, Anhui, Li, Guohui, Liu, Yanfang, Fang, Ye, Piao, Hailong, Liang, Xinmiao. Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting beta-catenin signaling. BIOMEDICINE & PHARMACOTHERAPY[J]. 2018, 108: 724-733, http://cas-ir.dicp.ac.cn/handle/321008/166658.
[36] Lu, Chang, Ning, Zhen, Wang, Aman, Ghen, Di, Liu, Xiaolong, Xia, Tian, Tekcham, Dinesh Singh, Wang, Wen, Li, Tongming, Liu, Xiumei, Liu, Jing, Qi, Huan, Luo, Haifeng, Du, Jian, Ma, Chi, Yan, Qiu, Liu, Jiwei, Xu, Guowang, Piao, Hailong, Tan, Guang. USP10 suppresses tumor progression by inhibiting mTOR activation in hepatocellular carcinoma. CANCER LETTERS[J]. 2018, 436: 139-148, http://dx.doi.org/10.1016/j.canlet.2018.07.032.
[37] Kim, Jongchan, Piao, HaiLong, Kim, BeomJun, Yao, Fan, Han, Zhenbo, Wang, Yumeng, Xiao, Zhenna, Siverly, Ashley N, Lawhon, Sarah E, Ton, Baochau N, Lee, Hyemin, Zhou, Zhicheng, Gan, Boyi, Nakagawa, Shinichi, Ellis, Matthew J, Liang, Han, Hung, MienChie, You, M James, Sun, Yutong, Ma, Li. Long noncoding RNA MALAT1 suppresses breast cancer metastasis. NATURE GENETICS[J]. 2018, 50(12): 1705-+, http://www.corc.org.cn/handle/1471x/2373015.
[38] Sang, Lingjie, Ju, Huaiqiang, Liu, Guangping, Tian, Tian, Ma, Guolin, Lu, Yunxin, Liu, Zexian, Pan, Ruolang, Li, Ruihua, Piao, Hailong, Marks, Jeffrey R, Yang, Luojia, Yan, Qingfeng, Wang, Wenqi, Shao, Jianzhong, Zhou, Yubin, Zhou, Tianhua, Lin, Aifu. LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling. MOLECULAR CELL[J]. 2018, 72(1): 71-+, http://dx.doi.org/10.1016/j.molcel.2018.08.014.
[39] Wei, Lai, Hou, Tao, Lu, Chang, Wang, Jixia, Zhang, Xiuli, Fang, Ye, Zhao, Yaopeng, Feng, Jiatao, Li, Jiaqi, Qu, Lala, Piao, Hailong, Liang, Xinmiao. SAR Studies of N-2-(1H-Tetrazol-5-yl)phenylbenzamide Derivatives as Potent G Protein-Coupled Receptor-35 Agonists. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2018, 9(5): 422-427, https://www.webofscience.com/wos/woscc/full-record/WOS:000432205400006.
[40] Wang, Wen, Tekcham, Dinesh Singh, Yan, Min, Wang, Zhichao, Qi, Huan, Liu, Xiaolong, Piao, HaiLong. Biochemical reactions in metabolite-protein interaction. CHINESE CHEMICAL LETTERS[J]. 2018, 29(5): 645-647, http://lib.cqvip.com/Qikan/Article/Detail?id=675219411.
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[44] 朴海龙, 许国旺. Mass spectrometry-based metabolomics for precision medicine. 2017, http://cas-ir.dicp.ac.cn/handle/321008/160487.
[45] Zhang, ChenSong, Hawley, Simon A, Zong, Yue, Li, Mengqi, Wang, Zhichao, Gray, Alexander, Ma, Teng, Cui, Jiwen, Feng, JinWei, Zhu, Mingjiang, Wu, YuQing, Li, Terytty Yang, Ye, Zhiyun, Lin, ShuYong, Yin, Huiyong, Piao, HaiLong, Hardie, D G Rahame, Lin, ShengCai. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. NATURE[J]. 2017, 548(7665): 112-+, http://cas-ir.dicp.ac.cn/handle/321008/149824.
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